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Conserved domains on  [gi|7305647|ref|NP_038872|]
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zinc finger protein 68 isoform a [Mus musculus]

Protein Classification

KRAB_A-box and COG5048 domain-containing protein( domain architecture ID 12204379)

protein containing domains KRAB_A-box, COG5048, and zf-H2C2_2

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
10-70 1.40e-27

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 105.37  E-value: 1.40e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7305647      10 VSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFLGHCKTKPELIFNLEQRLGSWI 70
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-475 7.26e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 7.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  234 RVKSFECNVSEINCSKSDLNENEPTHMGEKHYKCSNFENpfIIESYLPKHKGQHEKLFIQKEYEFSQQSEVSLHQKIRRG 313
Cdd:COG5048 209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSS--LSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGF 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  314 KKTYECKICGKCFYWKTSFNRHQST--HTGE--KPYECTE--CSKAFCQKSHLTQHQRVHTGERPYICFECR-------K 380
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspL 366

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  381 AFYRKSELTDHQRIHTGEKPYEC--KECGKAFCQKPQLTLHQRIHTGEKPYEC--AECGKAFSTKSYLTVHQRTHTGEKP 456
Cdd:COG5048 367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                       250
                ....*....|....*....
gi 7305647  457 YECTVCRKSFICKSSFSHH 475
Cdd:COG5048 447 LLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
513-586 7.72e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.72e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7305647  513 YECQLCQKAFYCTSHLIVHQRTHTGEKPYEC--KECRKAFYDKSNLKRHQKIHSMKKASESKQSNNFFLSDTSQHQ 586
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-524 4.58e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*
gi 7305647    500 LTRHQRTHTGDKRYECQLCQKAFYC 524
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
10-70 1.40e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 105.37  E-value: 1.40e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7305647      10 VSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFLGHCKTKPELIFNLEQRLGSWI 70
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.35e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.35e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 7305647      9 LVSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFLG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-49 5.11e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 5.11e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7305647   10 VSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFL 49
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-475 7.26e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 7.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  234 RVKSFECNVSEINCSKSDLNENEPTHMGEKHYKCSNFENpfIIESYLPKHKGQHEKLFIQKEYEFSQQSEVSLHQKIRRG 313
Cdd:COG5048 209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSS--LSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGF 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  314 KKTYECKICGKCFYWKTSFNRHQST--HTGE--KPYECTE--CSKAFCQKSHLTQHQRVHTGERPYICFECR-------K 380
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspL 366

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  381 AFYRKSELTDHQRIHTGEKPYEC--KECGKAFCQKPQLTLHQRIHTGEKPYEC--AECGKAFSTKSYLTVHQRTHTGEKP 456
Cdd:COG5048 367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                       250
                ....*....|....*....
gi 7305647  457 YECTVCRKSFICKSSFSHH 475
Cdd:COG5048 447 LLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
513-586 7.72e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.72e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7305647  513 YECQLCQKAFYCTSHLIVHQRTHTGEKPYEC--KECRKAFYDKSNLKRHQKIHSMKKASESKQSNNFFLSDTSQHQ 586
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-410 3.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.60e-04
                          10        20
                  ....*....|....*....|....
gi 7305647    387 ELTDHQRIHTGEKPYECKECGKAF 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
527-550 6.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.61e-04
                          10        20
                  ....*....|....*....|....
gi 7305647    527 HLIVHQRTHTGEKPYECKECRKAF 550
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-524 4.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*
gi 7305647    500 LTRHQRTHTGDKRYECQLCQKAFYC 524
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
10-70 1.40e-27

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 105.37  E-value: 1.40e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7305647      10 VSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFLGHCKTKPELIFNLEQRLGSWI 70
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 9-50 1.35e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.83  E-value: 1.35e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 7305647      9 LVSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFLG 50
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 10-49 5.11e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.51  E-value: 5.11e-17
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 7305647   10 VSFEDIAVEFTWQEWQDLNEGQRTLYRDVMLENYSNLLFL 49
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
234-475 7.26e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 7.26e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  234 RVKSFECNVSEINCSKSDLNENEPTHMGEKHYKCSNFENpfIIESYLPKHKGQHEKLFIQKEYEFSQQSEVSLHQKIRRG 313
Cdd:COG5048 209 YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSS--LSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGF 286

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  314 KKTYECKICGKCFYWKTSFNRHQST--HTGE--KPYECTE--CSKAFCQKSHLTQHQRVHTGERPYICFECR-------K 380
Cdd:COG5048 287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLNssskfspL 366

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  381 AFYRKSELTDHQRIHTGEKPYEC--KECGKAFCQKPQLTLHQRIHTGEKPYEC--AECGKAFSTKSYLTVHQRTHTGEKP 456
Cdd:COG5048 367 LNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446

                       250
                ....*....|....*....
gi 7305647  457 YECTVCRKSFICKSSFSHH 475
Cdd:COG5048 447 LLCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
513-586 7.72e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 7.72e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7305647  513 YECQLCQKAFYCTSHLIVHQRTHTGEKPYEC--KECRKAFYDKSNLKRHQKIHSMKKASESKQSNNFFLSDTSQHQ 586
Cdd:COG5048  34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSS 109
zf-H2C2_2 pfam13465
Zinc-finger double domain;
387-410 3.60e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.60e-04
                          10        20
                  ....*....|....*....|....
gi 7305647    387 ELTDHQRIHTGEKPYECKECGKAF 410
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
399-585 5.93e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.76  E-value: 5.93e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  399 KPYECKECGKAFCQKPQLTLHQR--IHTGE--KPYECAE--CGKAFSTKSYLTVHQRTHTGEKPYECtvcrKSFICKSSF 472
Cdd:COG5048 288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKE----KLLNSSSKF 363

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  473 SHhwrthtgekpyeckqcmKTFYRKSGLTRHQRTHTGDKRYECQL--CQKAFYCTSHLIVHQRTHTGEKPYECK--ECRK 548
Cdd:COG5048 364 SP-----------------LLNNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 7305647  549 AFYDKSNLKRHQKIHSMKKASESKQSNNFFLSDTSQH 585
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSN 463
zf-H2C2_2 pfam13465
Zinc-finger double domain;
443-468 6.17e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.17e-04
                          10        20
                  ....*....|....*....|....*.
gi 7305647    443 YLTVHQRTHTGEKPYECTVCRKSFIC 468
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
416-440 6.55e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.55e-04
                          10        20
                  ....*....|....*....|....*
gi 7305647    416 LTLHQRIHTGEKPYECAECGKAFST 440
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
527-550 6.61e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.61e-04
                          10        20
                  ....*....|....*....|....
gi 7305647    527 HLIVHQRTHTGEKPYECKECRKAF 550
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
399-459 7.43e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 42.38  E-value: 7.43e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7305647  399 KPYECKECGKAFCQKPQLTLHQRIHTGEKPYECA--ECGKAFSTKSYLTVHQRTHTGEKPYEC 459
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
343-403 1.35e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.35e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7305647  343 KPYECTECSKAFCQKSHLTQHQRVHTGERPYICF--ECRKAFYRKSELTDHQRIHTGEKPYEC 403
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLN 94
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
460-576 1.88e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 1.88e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7305647  460 TVCRKSFICKSSFSHHWRThtgeKPYECKQCMKTFYRKSGLTRHQRT--HTGDKRYECQ----LCQKAFYCTSHLIVHQR 533
Cdd:COG5048 269 SSQSSSPNESDSSSEKGFS----LPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFScpysLCGKLFSRNDALKRHIL 344

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 7305647  534 THTGEKPYECK--ECRKAFYDKSNLKRHQKIHSMKKASESKQSNN 576
Cdd:COG5048 345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSET 389
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 429-451 2.14e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 2.14e-03
                          10        20
                  ....*....|....*....|...
gi 7305647    429 YECAECGKAFSTKSYLTVHQRTH 451
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-354 3.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.15e-03
                          10        20
                  ....*....|....*....|....
gi 7305647    331 SFNRHQSTHTGEKPYECTECSKAF 354
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 541-563 3.53e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.53e-03
                          10        20
                  ....*....|....*....|...
gi 7305647    541 YECKECRKAFYDKSNLKRHQKIH 563
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
500-524 4.58e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.58e-03
                          10        20
                  ....*....|....*....|....*
gi 7305647    500 LTRHQRTHTGDKRYECQLCQKAFYC 524
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 345-367 4.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 4.69e-03
                          10        20
                  ....*....|....*....|...
gi 7305647    345 YECTECSKAFCQKSHLTQHQRVH 367
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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