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Conserved domains on  [gi|7382480|ref|NP_038267|]
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rho GTPase-activating protein 6 isoform 4 [Homo sapiens]

Protein Classification

rho GTPase-activating 6 family protein( domain architecture ID 10138145)

rho GTPase-activating 6 family protein (RhoGAP6-like) such as RhoGAP6, also known as ArhGAP6, which is both a GTPase-activating protein (GAP) with specificity for RhoA and a cytoskeletal protein that promotes actin remodelling, and RhoGAP36 (ArhGAP36) which is a potent antagonist of PKA signaling

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 199-405 3.35e-132

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


:

Pssm-ID: 239841  Cd Length: 206  Bit Score: 390.65  E-value: 3.35e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  199 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 278
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  279 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 358
Cdd:cd04376  81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 7382480  359 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 405
Cdd:cd04376 161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 199-405 3.35e-132

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 390.65  E-value: 3.35e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  199 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 278
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  279 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 358
Cdd:cd04376  81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 7382480  359 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 405
Cdd:cd04376 161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 205-395 1.39e-57

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 193.64  E-value: 1.39e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480     205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID-VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480     284 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADdniskdgqevtGNKMTSLNLATIFGPNLLHk 362
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLLR- 148

                          170       180       190
                   ....*....|....*....|....*....|...
gi 7382480     363 qkSSDKEfsvqsSARAEESTAIIAVVQKMIENY 395
Cdd:smart00324 149 --PPDGE-----VASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 208-361 2.17e-56

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 189.68  E-value: 2.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480    208 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7382480    287 INTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145
 
Name Accession Description Interval E-value
RhoGAP_ARHGAP6 cd04376
RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 199-405 3.35e-132

RhoGAP_ARHGAP6: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP6-like proteins. ArhGAP6 shows GAP activity towards RhoA, but not towards Cdc42 and Rac1. ArhGAP6 is often deleted in microphthalmia with linear skin defects syndrome (MLS); MLS is a severe X-linked developmental disorder. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239841  Cd Length: 206  Bit Score: 390.65  E-value: 3.35e-132
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  199 SLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLL 278
Cdd:cd04376   1 SLNPIARQVPRLVESCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVVLDENHSVHDVAALLKEFFRDMPDPLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  279 TRELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNISKDGQEVTGNKMTSLNLATIFGPN 358
Cdd:cd04376  81 PRELYTAFIGTALLEPDEQLEALQLLIYLLPPCNCDTLHRLLKFLHTVAEHAADSIDEDGQEVSGNKMTSLNLATIFGPN 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 7382480  359 LLHKQKSSDKEFsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDL 405
Cdd:cd04376 161 LLHKQKSGEREF-VQASLRIEESTAIINVVQTMIDNYEELFMVSPEL 206
RhoGAP smart00324
GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac ...
 205-395 1.39e-57

GTPase-activator protein for Rho-like GTPases; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases. etter domain limits and outliers.


Pssm-ID: 214618  Cd Length: 174  Bit Score: 193.64  E-value: 1.39e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480     205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID-VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:smart00324   1 KPIPIIVEKCIEYLEKRGLDTEGIYRVSGSKSRVKELRDAFDSGPDpDLDLSEYDVHDVAGLLKLFLRELPEPLITYELY 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480     284 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADdniskdgqevtGNKMTSLNLATIFGPNLLHk 362
Cdd:smart00324  81 EEFIEAAKLEdETERLRALRELLSLLPPANRATLRYLLAHLNRVAEHSE-----------ENKMTARNLAIVFGPTLLR- 148

                          170       180       190
                   ....*....|....*....|....*....|...
gi 7382480     363 qkSSDKEfsvqsSARAEESTAIIAVVQKMIENY 395
Cdd:smart00324 149 --PPDGE-----VASLKDIRHQNTVIEFLIENA 174
RhoGAP pfam00620
RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.
 208-361 2.17e-56

RhoGAP domain; GTPase activator proteins towards Rho/Rac/Cdc42-like small GTPases.


Pssm-ID: 459875  Cd Length: 148  Bit Score: 189.68  E-value: 2.17e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480    208 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:pfam00620   1 PLIVRKCVEYLEKRGLDTEGIFRVSGSASRIKELREAFDRGPDVDLDlEEEDVHVVASLLKLFLRELPEPLLTFELYEEF 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7382480    287 INTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:pfam00620  81 IEAAKLPdEEERLEALRELLRKLPPANRDTLRYLLAHLNRVAQNSDV-----------NKMNAHNLAIVFGPTLLR 145
RhoGAP cd00159
RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like ...
 208-394 1.65e-55

RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when bound to GDP. The Rho family of small G proteins, which includes Cdc42Hs, activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. G proteins generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude. The RhoGAPs are one of the major classes of regulators of Rho G proteins.


Pssm-ID: 238090 [Multi-domain]  Cd Length: 169  Bit Score: 187.89  E-value: 1.65e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  208 PRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFI 287
Cdd:cd00159   1 PLIIEKCIEYLEKNGLNTEGIFRVSGSASKIEELKKKFDRGEDIDDLEDYDVHDVASLLKLYLRELPEPLIPFELYDEFI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  288 NTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQKSS 366
Cdd:cd00159  81 ELAkIEDEEERIEALKELLKSLPPENRDLLKYLLKLLHKISQNSEV-----------NKMTASNLAIVFAPTLLRPPDSD 149

                       170       180
                ....*....|....*....|....*...
gi 7382480  367 DKEFsvqssaraEESTAIIAVVQKMIEN 394
Cdd:cd00159 150 DELL--------EDIKKLNEIVEFLIEN 169
RhoGAP_ARHGAP18 cd04391
RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-409 3.07e-37

RhoGAP_ARHGAP18: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP18-like proteins. The function of ArhGAP18 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239856  Cd Length: 216  Bit Score: 139.02  E-value: 3.07e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR--GIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04391  22 VPLIFQKLINKLEERGLETEGILRIPGSAQRVKFLCQELEAkfYEGTFLWDQVKQHDAASLLKLFIRELPQPLLTVEYLP 101

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  285 AFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL--H 361
Cdd:cd04391 102 AFYSVQGLpSKKDQLQALNLLVLLLPEANRDTLKALLEFLQKVVDHEEK-----------NKMNLWNVAMIMAPNLFppR 170

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 7382480  362 KQKSSDKEfSVQSSARAEESTAIIavVQKMIENYEALFMVPPDLQNEV 409
Cdd:cd04391 171 GKHSKDNE-SLQEEVNMAAGCANI--MRLLIRYQDLLWTVPSFLINQV 215
RhoGAP_ARAP cd04385
RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 207-395 9.81e-34

RhoGAP_ARAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in ARAPs. ARAPs (also known as centaurin deltas) contain, besides the RhoGAP domain, an Arf GAP, ankyrin repeat ras-associating, and PH domains. Since their ArfGAP activity is PIP3-dependent, ARAPs are considered integration points for phosphoinositide, Arf and Rho signaling. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239850  Cd Length: 184  Bit Score: 127.81  E-value: 9.81e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDR-GIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04385  15 IPVIVDKCIDFITQHGLMSEGIYRKNGKNSSVKKLLEAFRKdARSVQLREgEYTVHDVADVLKRFLRDLPDPLLTSELHA 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  285 AFINTLLLEPE-EQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04385  95 EWIEAAELENKdERIARYKELIRRLPPINRATLKVLIGHLYRVQKHSDE-----------NQMSVHNLALVFGPTLFQTD 163

                       170       180       190
                ....*....|....*....|....*....|..
gi 7382480  364 KssdkefsvQSSARAEEStaiIAVVQKMIENY 395
Cdd:cd04385 164 E--------HSVGQTSHE---VKVIEDLIDNY 184
RhoGAP_fLRG1 cd04397
RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 183-405 1.51e-33

RhoGAP_fLRG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal LRG1-like proteins. Yeast Lrg1p is required for efficient cell fusion, and mother-daughter cell separation, possibly through acting as a RhoGAP specifically regulating 1,3-beta-glucan synthesis. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239862  Cd Length: 213  Bit Score: 128.25  E-value: 1.51e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  183 PAEAQSKKEKArDKKLSLNPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVS--LEEEHSVH 260
Cdd:cd04397   4 PLEILVEKFGA-DSTLGVGPGKLRIPALIDDIISAMRQMDMSVEGVFRKNGNIRRLKELTEEIDKNPTEVpdLSKENPVQ 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  261 dVAALLKEFLRDMPDPLLTRELYTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVA--RHADdniskd 337
Cdd:cd04397  83 -LAALLKKFLRELPDPLLTFKLYRLWISSQKIEdEEERKRVLHLVYCLLPKYHRDTMEVLFSFLKWVSsfSHID------ 155

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7382480  338 gqEVTGNKMTSLNLATIFGPNLLHKQKSSDKEfsvqssarAEESTAIIAVVQKMIENYEALFMVPPDL 405
Cdd:cd04397 156 --EETGSKMDIHNLATVITPNILYSKTDNPNT--------GDEYFLAIEAVNYLIENNEEFCEVPDEL 213
RhoGAP_ARHGAP21 cd04395
RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-359 8.73e-33

RhoGAP_ARHGAP21: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP21-like proteins. ArhGAP21 is a multi-domain protein, containing RhoGAP, PH and PDZ domains, and is believed to play a role in the organization of the cell-cell junction complex. It has been shown to function as a GAP of Cdc42 and RhoA, and to interact with alpha-catenin and Arf6. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239860  Cd Length: 196  Bit Score: 125.59  E-value: 8.73e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04395  18 VPLIVEVCCNIVEARGLETVGIYRVPGNNAAISALQEELNRGgfdIDLQDPRWRDVNVVSSLLKSFFRKLPEPLFTNELY 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7382480  284 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNL 359
Cdd:cd04395  98 PDFIEANRIEdPVERLKELRRLIHSLPDHHYETLKHLIRHLKTVADNSEV-----------NKMEPRNLAIVFGPTL 163
RhoGAP-p50rhoGAP cd04404
RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 201-399 9.86e-33

RhoGAP-p50rhoGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p50RhoGAP-like proteins; p50RhoGAP, also known as RhoGAP-1, contains a C-terminal RhoGAP domain and an N-terminal Sec14 domain which binds phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). It is ubiquitously expressed and preferentially active on Cdc42. This subgroup also contains closely related ARHGAP8. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239869 [Multi-domain]  Cd Length: 195  Bit Score: 125.14  E-value: 9.86e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  201 NPIYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTR 280
Cdd:cd04404  17 NPEQEPIPPVVRETVEYLQAHALTTEGIFRRSANTQVVKEVQQKYNMGEPVDFDQYEDVHLPAVILKTFLRELPEPLLTF 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  281 ELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04404  97 DLYDDIVGFLNVDKEERVERVKQLLQTLPEENYQVLKYLIKFLVQVSAHSDQ-----------NKMTNSNLAVVFGPNLL 165

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 7382480  361 HKQKssdkefsvqSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04404 166 WAKD---------ASMSLSAINPINTFTKFLLDHQDEIF 195
RhoGAP_DLC1 cd04375
RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-405 6.55e-32

RhoGAP_DLC1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of DLC1-like proteins. DLC1 shows in vitro GAP activity towards RhoA and CDC42. Beside its C-terminal GAP domain, DLC1 also contains a SAM (sterile alpha motif) and a START (StAR-related lipid transfer action) domain. DLC1 has tumor suppressor activity in cell culture. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239840  Cd Length: 220  Bit Score: 123.68  E-value: 6.55e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04375  20 LPRSIQQAMRWLRNNALDQVGLFRKSGVKSRIQKLRSMIESSTDNVNYDGQQAYDVADMLKQYFRDLPEPLLTNKLSETF 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  287 INTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHaddniskdgqeVTGNKMTSLNLATIFGPNLLHKQKS 365
Cdd:cd04375 100 IAIFqYVPKEQRLEAVQCAILLLPDENREVLQTLLYFLSDVAAN-----------SQENQMTATNLAVCLAPSLFHLNTS 168

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7382480  366 SdkeFSVQSSARAE---------------ESTAIIAVVQKMIENYEALFMVPPDL 405
Cdd:cd04375 169 R---RENSSPARRMqrkkslgkpdqkelsENKAAHQCLAYMIEECNTLFMVPKEM 220
RhoGAP_myosin_IX cd04377
RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 205-377 1.01e-31

RhoGAP_myosin_IX: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in class IX myosins. Class IX myosins contain a characteristic head domain, a neck domain, a tail domain which contains a C6H2-zinc binding motif and a RhoGAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239842  Cd Length: 186  Bit Score: 122.16  E-value: 1.01e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04377  13 RSVPLVLEKLLEHIEMHGLYTEGIYRKSGSANKIKELRQGLDTDPDSVNLEDYPIHVITSVLKQWLRELPEPLMTFELYE 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  285 AFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04377  93 NFLRAMeLEEKQERVRALYSVLEQLPRANLNTLERLIFHLVRVALQEEV-----------NRMSANALAIVFAPCILRCP 161

                       170
                ....*....|....
gi 7382480  364 KSSDKEFSVQSSAR 377
Cdd:cd04377 162 DTADPLQSLQDVSK 175
RhoGAP_fRGD1 cd04398
RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-399 9.98e-30

RhoGAP_fRGD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD1-like proteins. Yeast Rgd1 is a GAP protein for Rho3 and Rho4 and plays a role in low-pH response. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239863  Cd Length: 192  Bit Score: 116.35  E-value: 9.98e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSL-----EEEHSVHDVAALLKEFLRDMPDPLLTRE 281
Cdd:cd04398  16 VPNIVYQCIQAIENFGLNLEGIYRLSGNVSRVNKLKELFDKDPLNVLlispeDYESDIHSVASLLKLFFRELPEPLLTKA 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  282 LYTAFINTLLLEPEEQL-GTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04398  96 LSREFIEAAKIEDESRRrDALHGLINDLPDANYATLRALMFHLARIKEHESV-----------NRMSVNNLAIIWGPTLM 164

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 7382480  361 HkqkssdkefsvQSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04398 165 N-----------AAPDNAADMSFQSRVIETLLDNAYQIF 192
RhoGAP_FAM13A1a cd04393
RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-361 2.21e-29

RhoGAP_FAM13A1a: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of FAM13A1, isoform a-like proteins. The function of FAM13A1a is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by up several orders of magnitude.


Pssm-ID: 239858 [Multi-domain]  Cd Length: 189  Bit Score: 115.25  E-value: 2.21e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04393  20 VPAVVRHIVEYLEQHGLEQEGLFRVNGNAETVEWLRQRLDSGEEVDLSKEADVCSAASLLRLFLQELPEGLIPASLQIRL 99

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7382480  287 INTL--LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLH 361
Cdd:cd04393 100 MQLYqdYNGEDEFGRKLRDLLQQLPPVNYSLLKFLCHFLSNVASQHHENR-----------MTAENLAAVFGPDVFH 165
RhoGAP-ARHGAP11A cd04394
RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 202-402 7.72e-29

RhoGAP-ARHGAP11A: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP11A-like proteins. The mouse homolog of human ArhGAP11A has been detected as a gene exclusively expressed in immature ganglion cells, potentially playing a role in retinal development. The exact function of ArhGAP11A is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239859 [Multi-domain]  Cd Length: 202  Bit Score: 114.49  E-value: 7.72e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  202 PIYRQVPRLVDSCCQHLEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVsLEEEHSVhDVAALLKEFLRDMPDPLLTRE 281
Cdd:cd04394  15 PEYGNVPKFLVDACTFLLDH-LSTEGLFRKSGSVVRQKELKAKLEGGEAC-LSSALPC-DVAGLLKQFFRELPEPLLPYD 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  282 LYTAFINTLLLEPEEQLGTLQLLIY-LLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04394  92 LHEALLKAQELPTDEERKSATLLLTcLLPDEHVNTLRYFFSFLYDVAQRCSE-----------NKMDSSNLAVIFAPNLF 160

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 7382480  361 HkqkSSDKEFSVQSSarAEESTAI-IAVVQKMIENYEALFMVP 402
Cdd:cd04394 161 Q---SEEGGEKMSSS--TEKRLRLqAAVVQTLIDNASNIGIVP 198
RhoGAP_nadrin cd04386
RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 205-399 2.97e-28

RhoGAP_nadrin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Nadrin-like proteins. Nadrin, also named Rich-1, has been shown to be involved in the regulation of Ca2+-dependent exocytosis in neurons and recently has been implicated in tight junction maintenance in mammalian epithelium. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239851  Cd Length: 203  Bit Score: 112.55  E-value: 2.97e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVSLEEEHS-VHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04386  18 REIALPIEACVMCLLETGMNEEGLFRVGGGASKLKRLKAALDAGtFSLPLDEFYSdPHAVASALKSYLRELPDPLLTYNL 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  283 YTAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLh 361
Cdd:cd04386  98 YEDWVQAANKPdEDERLQAIWRILNKLPRENRDNLRYLIKFLSKLAQKSDE-----------NKMSPSNIAIVLAPNLL- 165

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 7382480  362 kqksSDKEFSVQSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04386 166 ----WAKNEGSLAEMAAGTSVHVVAIVELIISHADWFF 199
RhoGAP_ARHGAP20 cd04402
RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-399 7.79e-28

RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces inactivation of Rho, which in turn leads to neurite outgrowth. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239867  Cd Length: 192  Bit Score: 111.24  E-value: 7.79e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEhSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04402  15 LPKPILDMLSLLYQKGPSTEGIFRRSANAKACKELKEKLNSGVEVDLKAE-PVLLLASVLKDFLRNIPGSLLSSDLYEEW 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  287 INTLLLEPEEQ-LGTLQLLIYLLPPCNcdtlHRLLQFLsIVARHaddNISKDGQEvtgNKMTSLNLATIFGPNLLHKQKS 365
Cdd:cd04402  94 MSALDQENEEEkIAELQRLLDKLPRPN----VLLLKHL-ICVLH---NISQNSET---NKMDAFNLAVCIAPSLLWPPAS 162

                       170       180       190
                ....*....|....*....|....*....|....
gi 7382480  366 SDKEfsvqssarAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04402 163 SELQ--------NEDLKKVTSLVQFLIENCQEIF 188
RhoGAP_ARHGAP27_15_12_9 cd04403
RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 207-366 5.38e-27

RhoGAP_ARHGAP27_15_12_9: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP27 (also called CAMGAP1), ARHGAP15, 12 and 9-like proteins; This subgroup of ARHGAPs are multidomain proteins that contain RhoGAP, PH, SH3 and WW domains. Most members that are studied show GAP activity towards Rac1, some additionally show activity towards Cdc42. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239868 [Multi-domain]  Cd Length: 187  Bit Score: 108.63  E-value: 5.38e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLR--EEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04403  16 VPKFVRLCIEAVEKRGLDVDGIYRVSGNLAVIQKLRfaVDHDEKLDLDDSKWEDIHVITGALKLFFRELPEPLFPYSLFN 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  285 AFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04403  96 DFVAAIKLsDYEQRVSAVKDLIKSLPKPNHDTLKMLFRHLCRVIEHGEK-----------NRMTTQNLAIVFGPTLLRPE 164


                ...
gi 7382480  364 KSS 366
Cdd:cd04403 165 QET 167
RhoGAP_fSAC7_BAG7 cd04396
RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 203-360 7.44e-27

RhoGAP_fSAC7_BAG7: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal SAC7 and BAG7-like proteins. Both proteins are GTPase activating proteins of Rho1, but differ functionally in vivo: SAC7, but not BAG7, is involved in the control of Rho1-mediated activation of the PKC-MPK1 pathway. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239861  Cd Length: 225  Bit Score: 109.42  E-value: 7.44e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  203 IYRQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDV--SLEEE-HSVHDVAALLKEFLRDMPDPLLT 279
Cdd:cd04396  28 VYGYIPVVVAKCGVYLKENATEVEGIFRVAGSSKRIRELQLIFSTPPDYgkSFDWDgYTVHDAASVLRRYLNNLPEPLVP 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  280 RELYTAFINTLLLEP------------------EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqev 341
Cdd:cd04396 108 LDLYEEFRNPLRKRPrilqymkgrineplntdiDQAIKEYRDLITRLPNLNRQLLLYLLDLLAVFARNSDKNL------- 180

                       170
                ....*....|....*....
gi 7382480  342 tgnkMTSLNLATIFGPNLL 360
Cdd:cd04396 181 ----MTASNLAAIFQPGIL 195
RhoGAP_ARHGAP22_24_25 cd04390
RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 205-399 1.94e-26

RhoGAP_ARHGAP22_24_25: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ARHGAP22, 24 and 25-like proteins; longer isoforms of these proteins contain an additional N-terminal pleckstrin homology (PH) domain. ARHGAP25 (KIA0053) has been identified as a GAP for Rac1 and Cdc42. Short isoforms (without the PH domain) of ARHGAP24, called RC-GAP72 and p73RhoGAP, and of ARHGAP22, called p68RacGAP, has been shown to be involved in angiogenesis and endothelial cell capillary formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239855 [Multi-domain]  Cd Length: 199  Bit Score: 107.14  E-value: 1.94e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04390  20 RLVPILVEQCVDFIREHGLKEEGLFRLPGQANLVKQLQDAFDAGERPSFDSDTDVHTVASLLKLYLRELPEPVIPWAQYE 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  285 AFI---NTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLh 361
Cdd:cd04390 100 DFLscaQLLSKDEEKGLGELMKQVSILPKVNYNLLSYICRFLDEVQSNSSV-----------NKMSVQNLATVFGPNIL- 167

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 7382480  362 KQKSSDKEfsvqssARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04390 168 RPKVEDPA------TIMEGTPQIQQLMTVMISKHEPLF 199
RhoGAP_chimaerin cd04372
RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 206-399 4.58e-25

RhoGAP_chimaerin: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of chimaerins. Chimaerins are a family of phorbolester- and diacylglycerol-responsive GAPs specific for the Rho-like GTPase Rac. Chimaerins exist in two alternative splice forms that each contain a C-terminal GAP domain, and a central C1 domain which binds phorbol esters, inducing a conformational change that activates the protein; one splice form is lacking the N-terminal Src homology-2 (SH2) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239837 [Multi-domain]  Cd Length: 194  Bit Score: 103.37  E-value: 4.58e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG---IDVSLEEEHSVHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04372  15 QRPMVVDMCIREIEARGLQSEGLYRVSGFAEEIEDVKMAFDRDgekADISATVYPDINVITGALKLYFRDLPIPVITYDT 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  283 YTAFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLH 361
Cdd:cd04372  95 YPKFIDAAKIsNPDERLEAVHEALMLLPPAHYETLRYLMEHLKRVTLHEKD-----------NKMNAENLGIVFGPTLMR 163

                       170       180       190
                ....*....|....*....|....*....|....*...
gi 7382480  362 KQKSSdkefsvqSSARAEESTAIIAVVQKMIENYEALF 399
Cdd:cd04372 164 PPEDS-------ALTTLNDMRYQILIVQLLITNEDVLF 194
RhoGAP_GMIP_PARG1 cd04378
RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-374 1.69e-24

RhoGAP_GMIP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein) and PARG1 (PTPL1-associated RhoGAP1). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239843  Cd Length: 203  Bit Score: 101.73  E-value: 1.69e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04378  16 VPFIIKKCTSEIENRALGVQGIYRVSGSKARVEKLCQAFENGKDLVELSELSPHDISSVLKLFLRQLPEPLILFRLYNDF 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  287 I---NTLLLEPEEQLG------------TLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNL 351
Cdd:cd04378  96 IalaKEIQRDTEEDKApntpievnriirKLKDLLRQLPASNYNTLQHLIAHLYRVAEQFEE-----------NKMSPNNL 164

                       170       180
                ....*....|....*....|...
gi 7382480  352 ATIFGPNLLhKQKSSDKEFSVQS 374
Cdd:cd04378 165 GIVFGPTLI-RPRPGDADVSLSS 186
RhoGAP_fBEM3 cd04400
RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of ...
 205-359 2.82e-24

RhoGAP_fBEM3: RhoGAP (GTPase-activator [GAP] protein for Rho-like small GTPases) domain of fungal BEM3-like proteins. Bem3 is a GAP protein of Cdc42, and is specifically involved in the control of the initial assembly of the septin ring in yeast bud formation. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239865 [Multi-domain]  Cd Length: 190  Bit Score: 100.90  E-value: 2.82e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHG-LQTVGIFRVGSSKKRVRQLREEFDRGIDVSL---EEEHSVHDVAALLKEFLRDMPDPLLTR 280
Cdd:cd04400  20 RDLPSVVYRCIEYLDKNRaIYEEGIFRLSGSASVIKQLKERFNTEYDVDLfssSLYPDVHTVAGLLKLYLRELPTLILGG 99

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  281 ELYTAF--INTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPN 358
Cdd:cd04400 100 ELHNDFkrLVEENHDRSQRALELKDLVSQLPQANYDLLYVLFSFLRKIIEHSDV-----------NKMNLRNVCIVFSPT 168


                .
gi 7382480  359 L 359
Cdd:cd04400 169 L 169
RhoGAP_ARHGAP19 cd04392
RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 218-409 6.88e-24

RhoGAP_ARHGAP19: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP19-like proteins. The function of ArhGAP19 is unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239857  Cd Length: 208  Bit Score: 100.23  E-value: 6.88e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  218 LEKHgLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELYTAFI--------- 287
Cdd:cd04392  20 LEKN-LRVEGLFRKPGNSARQQELRDLLNSGTDLDLESgGFHAHDCATVLKGFLGELPEPLLTHAHYPAHLqiadlcqfd 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  288 ----NTLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04392  99 ekgnKTSAPDKERLLEALQLLLLLLPEENRNLLKLILDLLYQTAKHEDK-----------NKMSADNLALLFTPHLICPR 167

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 7382480  364 KssdkefsVQSSARAEESTAIIAVVQKMIENYEALFMVPPDLQNEV 409
Cdd:cd04392 168 N-------LTPEDLHENAQKLNSIVTFMIKHSQKLFKAPAYLREDA 206
RhoGAP_MgcRacGAP cd04382
RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-404 7.57e-24

RhoGAP_MgcRacGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in MgcRacGAP proteins. MgcRacGAP plays an important dual role in cytokinesis: i) it is part of centralspindlin-complex, together with the mitotic kinesin MKLP1, which is critical for the structure of the central spindle by promoting microtuble bundling. ii) after phosphorylation by aurora B MgcRacGAP becomes an effective regulator of RhoA and plays an important role in the assembly of the contractile ring and the initiation of cytokinesis. MgcRacGAP-like proteins contain a N-terminal C1-like domain, and a C-terminal RhoGAP domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239847  Cd Length: 193  Bit Score: 99.68  E-value: 7.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04382  17 IPALIVHCVNEIEARGLTEEGLYRVSGSEREVKALKEKFLRGKTVPNLSKVDIHVICGCLKDFLRSLKEPLITFALWKEF 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  287 IN-TLLLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARhaddniSKDgqevtgNKMTSLNLATIFGPNLL-HKQK 364
Cdd:cd04382  97 MEaAEILDEDNSRAALYQAISELPQPNRDTLAFLILHLQRVAQ------SPE------CKMDINNLARVFGPTIVgYSVP 164

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 7382480  365 SSDKEFSVQssaraeestaiIAVVQKMIenYEALFMVPPD 404
Cdd:cd04382 165 NPDPMTILQ-----------DTVRQPRV--VERLLEIPSD 191
RhoGAP_myosin_IXB cd04407
RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-377 7.59e-24

RhoGAP_myosin_IXB: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXB. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239872 [Multi-domain]  Cd Length: 186  Bit Score: 99.30  E-value: 7.59e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04407  15 VPIVLEKLLEHVEMHGLYTEGIYRKSGSANRMKELHQLLQADPENVKLENYPIHAITGLLKQWLRELPEPLMTFAQYNDF 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  287 INTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADdniskdgqevtGNKMTSLNLATIFGPNLLHKQKS 365
Cdd:cd04407  95 LRAVELpEKQEQLQAIYRVLEQLPTANHNTLERLIFHLVKVALEED-----------VNRMSPNALAIVFAPCLLRCPDS 163

                       170
                ....*....|..
gi 7382480  366 SDKEFSVQSSAR 377
Cdd:cd04407 164 SDPLTSMKDVAK 175
RhoGAP_GMIP cd04408
RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP ...
 206-367 9.66e-23

RhoGAP_GMIP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of GMIP (Gem interacting protein). GMIP plays important roles in neurite growth and axonal guidance, and interacts with Gem, a member of the RGK subfamily of the Ras small GTPase superfamily, through the N-terminal half of the protein. GMIP contains a C-terminal RhoGAP domain. GMIP inhibits RhoA function, but is inactive towards Rac1 and Cdc41. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239873  Cd Length: 200  Bit Score: 96.81  E-value: 9.66e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTA 285
Cdd:cd04408  15 EVPFVVVRCTAEIENRALGVQGIYRISGSKARVEKLCQAFENGRDLVDLSGHSPHDITSVLKHFLKELPEPVLPFQLYDD 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  286 FI---NTLLLEPEEQLGT----------LQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLA 352
Cdd:cd04408  95 FIalaKELQRDSEKAAESpsiveniirsLKELLGRLPVSNYNTLRHLMAHLYRVAERFED-----------NKMSPNNLG 163

                       170
                ....*....|....*
gi 7382480  353 TIFGPNLLHKQKSSD 367
Cdd:cd04408 164 IVFGPTLLRPLVGGD 178
RhoGAP_CdGAP cd04384
RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-371 1.27e-22

RhoGAP_CdGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of CdGAP-like proteins; CdGAP contains an N-terminal RhoGAP domain and a C-terminal proline-rich region, and it is active on both Cdc42 and Rac1 but not RhoA. CdGAP is recruited to focal adhesions via the interaction with the scaffold protein actopaxin (alpha-parvin). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239849 [Multi-domain]  Cd Length: 195  Bit Score: 96.03  E-value: 1.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTvGIFRVGSSKKRVRQLREEFDRGIDVSLEEE---HSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04384  18 VPQVLKSCTEFIEKHGIVD-GIYRLSGIASNIQRLRHEFDSEQIPDLTKDvyiQDIHSVSSLCKLYFRELPNPLLTYQLY 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  284 TAFINTLLLEP-EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHaddniskdgQEVTGnkMTSLNLATIFGPNLLHK 362
Cdd:cd04384  97 EKFSEAVSAASdEERLEKIHDVIQQLPPPHYRTLEFLMRHLSRLAKY---------CSITN--MHAKNLAIVWAPNLLRS 165


                ....*....
gi 7382480  363 QKSSDKEFS 371
Cdd:cd04384 166 KQIESACFS 174
RhoGAP_srGAP cd04383
RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 207-361 3.27e-21

RhoGAP_srGAP: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in srGAPs. srGAPs are components of the intracellular part of Slit-Robo signalling pathway that is important for axon guidance and cell migration. srGAPs contain an N-terminal FCH domain, a central RhoGAP domain and a C-terminal SH3 domain; this SH3 domain interacts with the intracellular proline-rich-tail of the Roundabout receptor (Robo). This interaction with Robo then activates the rhoGAP domain which in turn inhibits Cdc42 activity. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239848  Cd Length: 188  Bit Score: 91.71  E-value: 3.27e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDvSLEEEHSVHD---VAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04383  18 IPLVVESCIRFINLYGLQHQGIFRVSGSQVEVNDIKNAFERGED-PLADDQNDHDinsVAGVLKLYFRGLENPLFPKERF 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7382480  284 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLH 361
Cdd:cd04383  97 EDLMSCVKLEnPTERVHQIREILSTLPRSVIIVMRYLFAFLNHLSQFSDENM-----------MDPYNLAICFGPTLMP 164
RhoGAP_SYD1 cd04379
RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 205-393 2.35e-20

RhoGAP_SYD1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in SYD-1_like proteins. Syd-1, first identified and best studied in C.elegans, has been shown to play an important role in neuronal development by specifying axonal properties. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239844  Cd Length: 207  Bit Score: 89.83  E-value: 2.35e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRG-IDVSLEEEH--SVHDVAALLKEFLRDMPDPLLTRE 281
Cdd:cd04379  16 RDVPIVLQKCVQEIERRGLDVIGLYRLCGSAAKKKELRDAFERNsAAVELSEELypDINVITGVLKDYLRELPEPLITPQ 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  282 LYTAFINTLLLEPE---EQLGTLQL-LIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGP 357
Cdd:cd04379  96 LYEMVLEALAVALPndvQTNTHLTLsIIDCLPLSAKATLLLLLDHLSLVLSNSER-----------NKMTPQNLAVCFGP 164

                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 7382480  358 NLL-HKQKSSDKEFSVQSSARAEESTAI---IAVVQKMIE 393
Cdd:cd04379 165 VLMfCSQEFSRYGISPTSKMAAVSTVDFkqhIEVLHYLLQ 204
RhoGap_RalBP1 cd04381
RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 206-359 1.46e-19

RhoGap_RalBP1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in RalBP1 proteins, also known as RLIP, RLIP76 or cytocentrin. RalBP1 plays an important role in endocytosis during interphase. During mitosis, RalBP1 transiently associates with the centromere and has been shown to play an essential role in the proper assembly of the mitotic apparatus. RalBP1 is an effector of the Ral GTPase which itself is an effector of Ras. RalBP1 contains a RhoGAP domain, which shows weak activity towards Rac1 and Cdc42, but not towards Ral, and a Ral effector domain binding motif. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239846 [Multi-domain]  Cd Length: 182  Bit Score: 87.11  E-value: 1.46e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEeHSVHDVAALLKEFLRDMPDPLLTRELYTA 285
Cdd:cd04381  19 DLPLVFRECIDYVEKHGMKCEGIYKVSGIKSKVDELKAAYNRRESPNLEE-YEPPTVASLLKQYLRELPEPLLTKELMPR 97

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7382480  286 FINTLLLEPE-EQLGTLQLLIYLLPPCNcdtlhRLLqfLSIVARHADDNISKDGQevtgNKMTSLNLATIFGPNL 359
Cdd:cd04381  98 FEEACGRPTEaEREQELQRLLKELPECN-----RLL--LAWLIVHMDHVIAQELE----TKMNIQNISIVLSPTV 161
RhoGAP_myosin_IXA cd04406
RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 205-387 2.32e-19

RhoGAP_myosin_IXA: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in myosins IXA. Class IX myosins contain a characteristic head domain, a neck domain and a tail domain which contains a C6H2-zinc binding motif and a Rho-GAP domain. Class IX myosins are single-headed, processive myosins that are partly cytoplasmic, and partly associated with membranes and the actin cytoskeleton. Class IX myosins are implicated in the regulation of neuronal morphogenesis and function of sensory systems, like the inner ear. There are two major isoforms, myosin IXA and IXB with several splice variants, which are both expressed in developing neurons. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239871  Cd Length: 186  Bit Score: 86.59  E-value: 2.32e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYT 284
Cdd:cd04406  13 RSVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDANSVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYE 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  285 AFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARhaddniskdgQEVTgNKMTSLNLATIFGPNLLHKQ 363
Cdd:cd04406  93 EFLRAMgLQERRETVRGVYSVIDQLSRTHLNTLERLIFHLVRIAL----------QEET-NRMSANALAIVFAPCILRCP 161

                       170       180
                ....*....|....*....|....
gi 7382480  364 KSSDKEFSVQSSARAEESTAIIAV 387
Cdd:cd04406 162 DTTDPLQSVQDISKTTTCVELIVC 185
RhoGAP_Bcr cd04387
RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr ...
 206-368 2.66e-19

RhoGAP_Bcr: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of Bcr (breakpoint cluster region protein)-like proteins. Bcr is a multidomain protein with a variety of enzymatic functions. It contains a RhoGAP and a Rho GEF domain, a Ser/Thr kinase domain, an N-terminal oligomerization domain, and a C-terminal PDZ binding domain, in addition to PH and C2 domains. Bcr is a negative regulator of: i) RacGTPase, via the Rho GAP domain, ii) the Ras-Raf-MEK-ERK pathway, via phosphorylation of the Ras binding protein AF-6, and iii) the Wnt signaling pathway through binding beta-catenin. Bcr can form a complex with beta-catenin and Tcf1. The Wnt signaling pathway is involved in cell proliferation, differentiation, and cell renewal. Bcr was discovered as a fusion partner of Abl. The Bcr-Abl fusion is characteristic for a large majority of chronic myelogenous leukemias (CML). Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239852 [Multi-domain]  Cd Length: 196  Bit Score: 86.52  E-value: 2.66e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  206 QVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGID--VSLEEEHSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04387  15 KVPYIVRQCVEEVERRGMEEVGIYRISGVATDIQALKAAFDTNNKdvSVMLSEMDVNAIAGTLKLYFRELPEPLFTDELY 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  284 TAFINTLLL-EPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVArhaddniskDGQEVtgNKMTSLNLATIFGPNLLHK 362
Cdd:cd04387  95 PNFAEGIALsDPVAKESCMLNLLLSLPDPNLVTFLFLLHHLKRVA---------EREEV--NKMSLHNLATVFGPTLLRP 163


                ....*.
gi 7382480  363 QKSSDK 368
Cdd:cd04387 164 SEKESK 169
RhoGAP_Graf cd04374
RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase ...
 211-394 7.08e-19

RhoGAP_Graf: GTPase-activator protein (GAP) domain for Rho-like GTPases found in GRAF (GTPase regulator associated with focal adhesion kinase); Graf is a multi-domain protein, containing SH3 and PH domains, that binds focal adhesion kinase and influences cytoskeletal changes mediated by Rho proteins. Graf exhibits GAP activity toward RhoA and Cdc42, but only weakly activates Rac1. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239839  Cd Length: 203  Bit Score: 85.52  E-value: 7.08e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  211 VDSCCQHLEKHGLQTVGIFRVGSSKKRVRQL------REEFDRGiDVSLE-EEHSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04374  32 VRKCIEAVETRGINEQGLYRVVGVNSKVQKLlslgldPKTSTPG-DVDLDnSEWEIKTITSALKTYLRNLPEPLMTYELH 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  284 TAFINTLLLE-PEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtgNKMTSLNLATIFGPNLLHK 362
Cdd:cd04374 111 NDFINAAKSEnLESRVNAIHSLVHKLPEKNREMLELLIKHLTNVSDHSKK-----------NLMTVSNLGVVFGPTLLRP 179

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 7382480  363 QkssdkefsvqssaraEESTAIIA-------VVQKMIEN 394
Cdd:cd04374 180 Q---------------EETVAAIMdikfqniVVEILIEN 203
RhoGAP_p190 cd04373
RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 205-371 5.16e-17

RhoGAP_p190: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of p190-like proteins. p190, also named RhoGAP5, plays a role in neuritogenesis and axon branch stability. p190 shows a preference for Rho, over Rac and Cdc42, and consists of an N-terminal GTPase domain and a C-terminal GAP domain. The central portion of p190 contains important regulatory phosphorylation sites. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239838  Cd Length: 185  Bit Score: 79.81  E-value: 5.16e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEE-EHSVHDVAALLKEFLRDMPDPLLTRELY 283
Cdd:cd04373  13 KPIPIFLEKCVEFIEATGLETEGIYRVSGNKTHLDSLQKQFDQDHNLDLVSkDFTVNAVAGALKSFFSELPDPLIPYSMH 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  284 TAFINTL-LLEPEEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLHK 362
Cdd:cd04373  93 LELVEAAkINDREQRLHALKELLKKFPPENFDVFKYVITHLNKVSQNSKVNL-----------MTSENLSICFWPTLMRP 161


                ....*....
gi 7382480  363 QKSSDKEFS 371
Cdd:cd04373 162 DFTSMEALS 170
RhoGAP_PARG1 cd04409
RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 207-374 1.06e-16

RhoGAP_PARG1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of PARG1 (PTPL1-associated RhoGAP1). PARG1 was originally cloned as an interaction partner of PTPL1, an intracellular protein-tyrosine phosphatase. PARG1 interacts with Rap2, also a member of the Ras small GTPase superfamily whose exact function is unknown, and shows strong preference for Rho. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239874  Cd Length: 211  Bit Score: 79.47  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  207 VPRLVDSCCQHLEKHGLQTVGIFRVGSSKKRVRQLREEFDRGIDVSLEEEHSVHDVAALLKEFLRDMPDPLLTRELYTAF 286
Cdd:cd04409  16 IPFIIKKCTSEIESRALCLKGIYRVNGAKSRVEKLCQAFENGKDLVELSELSPHDISNVLKLYLRQLPEPLILFRLYNEF 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  287 I-------------NTLLLEPEEQLGT----------LQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevtg 343
Cdd:cd04409  96 IglakesqhvnetqEAKKNSDKKWPNMctelnrillkSKDLLRQLPAPNYNTLQFLIVHLHRVSEQAEE----------- 164

                       170       180       190
                ....*....|....*....|....*....|.
gi 7382480  344 NKMTSLNLATIFGPNLLhKQKSSDKEFSVQS 374
Cdd:cd04409 165 NKMSASNLGIIFGPTLI-RPRPTDATVSLSS 194
RhoGAP_KIAA1688 cd04389
RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in ...
 204-360 1.54e-15

RhoGAP_KIAA1688: GTPase-activator protein (GAP) domain for Rho-like GTPases found in KIAA1688-like proteins; KIAA1688 is a protein of unknown function that contains a RhoGAP domain and a myosin tail homology 4 (MyTH4) domain. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239854  Cd Length: 187  Bit Score: 75.51  E-value: 1.54e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  204 YRQVPRLVDSCCQH-LEKHGLQTVGIFRVGSSKKRVRQLREEFDRGiDVSLEEEHSVHDVAALLKEFLRDMPDPLLTREL 282
Cdd:cd04389  18 ELKLPWILTFLSEKvLALGGFQTEGIFRVPGDIDEVNELKLRVDQW-DYPLSGLEDPHVPASLLKLWLRELEEPLIPDAL 96

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7382480  283 YTAFINTlLLEPEEQLGTLQlliyLLPPCNCDTLHRLLQFLSIVARHAddNISKdgqevtgNKMTSLNLATIFGPNLL 360
Cdd:cd04389  97 YQQCISA-SEDPDKAVEIVQ----KLPIINRLVLCYLINFLQVFAQPE--NVAH-------TKMDVSNLAMVFAPNIL 160
RhoGAP_OCRL1 cd04380
RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 195-366 4.97e-08

RhoGAP_OCRL1: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in OCRL1-like proteins. OCRL1 (oculocerebrorenal syndrome of Lowe 1)-like proteins contain two conserved domains: a central inositol polyphosphate 5-phosphatase domain and a C-terminal Rho GAP domain, this GAP domain lacks the catalytic residue and therefore maybe inactive. OCRL-like proteins are type II inositol polyphosphate 5-phosphatases that can hydrolyze lipid PI(4,5)P2 and PI(3,4,5)P3 and soluble Ins(1,4,5)P3 and Ins(1,3,4,5)P4, but their individual specificities vary. The functionality of the RhoGAP domain is still unclear. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239845  Cd Length: 220  Bit Score: 54.27  E-value: 4.97e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  195 DKKLSLNPIYRQVP--------RLVDsccqHLEKHGLQTVGIFRVGS----SKKRVRQLREEFDRGIDVSLEeeHSVHDV 262
Cdd:cd04380  34 QLELGDNPDYSEVPlsipkeiwRLVD----YLYTRGLAQEGLFEEPGlpsePGELLAEIRDALDTGSPFNSP--GSAESV 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  263 AALLKEFLRDMPDPLLTRELYTAFINTLLLEPEEQlgtLQLLIYLLPPCNCDTLHRLLQFLSIVARHADDniskdgqevt 342
Cdd:cd04380 108 AEALLLFLESLPDPIIPYSLYERLLEAVANNEEDK---RQVIRISLPPVHRNVFVYLCSFLRELLSESAD---------- 174

                       170       180
                ....*....|....*....|....
gi 7382480  343 gNKMTSLNLATIFGPNLLHKQKSS 366
Cdd:cd04380 175 -RGLDENTLATIFGRVLLRDPPRA 197
RhoGAP_p85 cd04388
RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present ...
 218-403 9.09e-05

RhoGAP_p85: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain present in the p85 isoforms of the regulatory subunit of the class IA PI3K (phosphatidylinositol 3'-kinase). This domain is also called Bcr (breakpoint cluster region protein) homology (BH) domain. Class IA PI3Ks are heterodimers, containing a regulatory subunit (p85) and a catalytic subunit (p110) and are activated by growth factor receptor tyrosine kinases (RTKs); this activation is mediated by the p85 subunit. p85 isoforms, alpha and beta, contain a C-terminal p110-binding domain flanked by two SH2 domains, an N-terminal SH3 domain, and a RhoGAP domain flanked by two proline-rich regions. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239853  Cd Length: 200  Bit Score: 44.09  E-value: 9.09e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  218 LEKHGLQTVGIFRVGSSKKR--VRQLREEFDRGIDVsleEEHSVHDVAALLKEFLRDMPDPLLTRELYTAFIN--TLLLE 293
Cdd:cd04388  26 IEKKGLESSTLYRTQSSSSLteLRQILDCDAASVDL---EQFDVAALADALKRYLLDLPNPVIPAPVYSEMISraQEVQS 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  294 PEEQLGTLQLLIY--LLPPCNCDTLHRLLQFLSIVARHADDNIskdgqevtgnkMTSLNLATIFGPNLLhkqkssdkEFS 371
Cdd:cd04388 103 SDEYAQLLRKLIRspNLPHQYWLTLQYLLKHFFRLCQSSSKNL-----------LSARALAEIFSPLLF--------RFQ 163

                       170       180       190
                ....*....|....*....|....*....|...
gi 7382480  372 VQSSARAEESTAIIAV-VQKMIENYEALFMVPP 403
Cdd:cd04388 164 PASSDSPEFHIRIIEVlITSEWNERQAAPALPP 196
RhoGAP_BRCC3-like cd04405
RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain ...
 272-327 2.00e-03

RhoGAP_BRCC3-like: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of BRCC3-like proteins. This subgroup also contains two groups of closely related proteins, BRCC3 and DEPDC7, which both contain a C-terminal RhoGAP-like domain and an N-terminal DEP (Disheveled, Egl-10, and Pleckstrin) domain. The function(s) of BRCC3 and DEPDC7 are unknown. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239870  Cd Length: 235  Bit Score: 40.39  E-value: 2.00e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  272 DMPDPLLTRELYTAFINTL-LLEP---EEQLGTLQLLIYLLPPCNCDTLHRLLQFLSIVA 327
Cdd:cd04405 118 QLKEPLLTFHLFDIFVGILeLLGNgkeEVALEALQLCLLLLPPASRRELRRLLRFMARAA 177
RhoGAP_fRGD2 cd04399
RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ...
 205-316 4.57e-03

RhoGAP_fRGD2: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of fungal RGD2-like proteins. Yeast Rgd2 is a GAP protein for Cdc42 and Rho5. Small GTPases cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when GDP-bound. The Rho family of GTPases activates effectors involved in a wide variety of developmental processes, including regulation of cytoskeleton formation, cell proliferation and the JNK signaling pathway. GTPases generally have a low intrinsic GTPase hydrolytic activity but there are family-specific groups of GAPs that enhance the rate of GTP hydrolysis by several orders of magnitude.


Pssm-ID: 239864  Cd Length: 212  Bit Score: 39.24  E-value: 4.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7382480  205 RQVPRLVDSCCQHLEKHGLQTVG------IFRVGSSKKRVRQLREEFDRGIDVSLEEEHS----VHDVAALLKEFLRDMP 274
Cdd:cd04399  14 KVVPLIVSAILSYLDQLYPDLINdevrrnVWTDPVSLKETHQLRNLLNKPKKPDKEVIILkkfePSTVASVLKLYLLELP 93

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 7382480  275 DPLLT-------RELYTAFINTLLLEPEEQLGTLQLLIYLLPPCNCDTL 316
Cdd:cd04399  94 DSLIPhdiydliRSLYSAYPPSQEDSDTARIQGLQSTLSQLPKSHIATL 142
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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