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Conserved domains on  [gi|7019483|ref|NP_037495|]
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procollagen C-endopeptidase enhancer 2 precursor [Homo sapiens]

Protein Classification

CUB domain-containing protein( domain architecture ID 10035952)

CUB (complement C1r/C1s, Uegf, Bmp1) domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 292-415 4.13e-77

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


:

Pssm-ID: 239631  Cd Length: 124  Bit Score: 234.97  E-value: 4.13e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  292 PTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLR 371
Cdd:cd03576   1 PTAALCQQKCRRTGTLESNYCSSEFVITGTVISMTRGPGSLHATVSIIKLYKEGRLAITQAGKTMSVKITVVCKQCPLLR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 7019483  372 RGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC 415
Cdd:cd03576  81 RGLNYILMGQVDEEGRGVIPPESFVMLYKTKHQKLLAALSNKKC 124
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-143 2.85e-39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 136.77  E-value: 2.85e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483   33 CGGILTGE-SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-HANGQRIGRFCGTF 110
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 7019483  111 RPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 154-267 2.92e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


:

Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.08  E-value: 2.92e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  154 CGG-LLDRPSGSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNdARRIGKYCG 232
Cdd:cd00041   1 CGGtLTASTSGTISSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTS-SPLLGRFCG 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 7019483  233 DSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIF 267
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
 
Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 292-415 4.13e-77

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


Pssm-ID: 239631  Cd Length: 124  Bit Score: 234.97  E-value: 4.13e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  292 PTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLR 371
Cdd:cd03576   1 PTAALCQQKCRRTGTLESNYCSSEFVITGTVISMTRGPGSLHATVSIIKLYKEGRLAITQAGKTMSVKITVVCKQCPLLR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 7019483  372 RGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC 415
Cdd:cd03576  81 RGLNYILMGQVDEEGRGVIPPESFVMLYKTKHQKLLAALSNKKC 124
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-143 2.85e-39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 136.77  E-value: 2.85e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483   33 CGGILTGE-SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-HANGQRIGRFCGTF 110
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 7019483  111 RPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 154-267 2.92e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.08  E-value: 2.92e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  154 CGG-LLDRPSGSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNdARRIGKYCG 232
Cdd:cd00041   1 CGGtLTASTSGTISSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTS-SPLLGRFCG 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 7019483  233 DSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIF 267
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
154-265 2.24e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 131.65  E-value: 2.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483    154 CGGLLDRPSGSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEvNDARRIGKYCGD 233
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN-PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPS-ASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 7019483    234 SPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 163-265 4.73e-34

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 122.50  E-value: 4.73e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483     163 GSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNgGEVNDARRIGKYCGDS-PPAPIVS 241
Cdd:smart00042   1 GTITSPNYPQ-SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYD-GPSASSPLLGRFCGSEaPPPVISS 78

                           90       100
                   ....*....|....*....|....
gi 7019483     242 ERNELLIQFLSDLSLTADGFIGHY 265
Cdd:smart00042  79 SSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
33-141 8.59e-33

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 119.32  E-value: 8.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483     33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGH-ANGQRIGRFCGTFR 111
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPsASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 7019483    112 PGALVSSGNKMMVQMISDANTAGNGFMAMF 141
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 42-139 7.70e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 116.72  E-value: 7.70e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483      42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSS-G 119
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSAsSPLLGRFCGSEAPPPVISSsS 80

                           90       100
                   ....*....|....*....|
gi 7019483     120 NKMMVQMISDANTAGNGFMA 139
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSA 100
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 310-412 2.10e-22

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 91.25  E-value: 2.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483    310 NYCS-SDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTvVCKqCPLLRRGLNYIIMGQVG-EDGR 387
Cdd:pfam01759   2 KACKgSDYVYKVKVLSVEEEGSFDKYTVKVKEVLKEGTDKIQRGKVRLFLKRG-DCR-CPQLRLGKEYLIMGKVGdLEGR 79

                          90       100
                  ....*....|....*....|....*..
gi 7019483    388 GKIM--PNSFIMMFKTKNQKLLDALKN 412
Cdd:pfam01759  80 GRYVldKNSWVEPWPTKWECKLRELQK 106
C345C smart00643
Netrin C-terminal Domain;
308-412 4.40e-19

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 82.41  E-value: 4.40e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483     308 EGNYCSS--DFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVV-CKQCPLLRRGLNYIIMGQ--- 381
Cdd:smart00643   1 LEKACKSdvDYVYKVKVLSVEEEGGFDKYTVKILEVIKSGTDELVRGKNKLRVFISRAsCRCPLLLKLGKSYLIMGKsgd 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 7019483     382 ---VGEDGRGKIMPNSFIMMFKTKNQKLLDALKN 412
Cdd:smart00643  81 lwdAKGRGQYVLGKNSWVEEWPTEEECRLRRLQK 114
 
Name Accession Description Interval E-value
NTR_PCOLCE cd03576
NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are ...
 292-415 4.13e-77

NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.


Pssm-ID: 239631  Cd Length: 124  Bit Score: 234.97  E-value: 4.13e-77
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  292 PTVALCQQKCRRTGTLEGNYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVVCKQCPLLR 371
Cdd:cd03576   1 PTAALCQQKCRRTGTLESNYCSSEFVITGTVISMTRGPGSLHATVSIIKLYKEGRLAITQAGKTMSVKITVVCKQCPLLR 80

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 7019483  372 RGLNYIIMGQVGEDGRGKIMPNSFIMMFKTKNQKLLDALKNKQC 415
Cdd:cd03576  81 RGLNYILMGQVDEEGRGVIPPESFVMLYKTKHQKLLAALSNKKC 124
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 33-143 2.85e-39

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 136.77  E-value: 2.85e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483   33 CGGILTGE-SGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNG-HANGQRIGRFCGTF 110
Cdd:cd00041   1 CGGTLTAStSGTISSPNYPNNYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGpSTSSPLLGRFCGST 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 7019483  111 RPGALVSSGNKMMVQMISDANTAGNGFMAMFSA 143
Cdd:cd00041  81 LPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB cd00041
CUB domain; extracellular domain; present in proteins mostly known to be involved in ...
 154-267 2.92e-38

CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.


Pssm-ID: 238001 [Multi-domain]  Cd Length: 113  Bit Score: 134.08  E-value: 2.92e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  154 CGG-LLDRPSGSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEVNdARRIGKYCG 232
Cdd:cd00041   1 CGGtLTASTSGTISSPNYPN-NYPNNLNCVWTIEAPPGYRIRLTFEDFDLESSPNCSYDYLEIYDGPSTS-SPLLGRFCG 78

                        90       100       110
                ....*....|....*....|....*....|....*
gi 7019483  233 DSPPAPIVSERNELLIQFLSDLSLTADGFIGHYIF 267
Cdd:cd00041  79 STLPPPIISSGNSLTVRFRSDSSVTGRGFKATYSA 113
CUB pfam00431
CUB domain;
154-265 2.24e-37

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 131.65  E-value: 2.24e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483    154 CGGLLDRPSGSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNGGEvNDARRIGKYCGD 233
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPN-PYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPS-ASSPLLGRFCGS 78

                          90       100       110
                  ....*....|....*....|....*....|..
gi 7019483    234 SPPAPIVSERNELLIQFLSDLSLTADGFIGHY 265
Cdd:pfam00431  79 GIPEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 163-265 4.73e-34

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 122.50  E-value: 4.73e-34
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483     163 GSFKTPNWPDrDYPAGVTCVWHIVAPKNQLIELKFEKFDVERDNYCRYDYVAVFNgGEVNDARRIGKYCGDS-PPAPIVS 241
Cdd:smart00042   1 GTITSPNYPQ-SYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYD-GPSASSPLLGRFCGSEaPPPVISS 78

                           90       100
                   ....*....|....*....|....
gi 7019483     242 ERNELLIQFLSDLSLTADGFIGHY 265
Cdd:smart00042  79 SSNSLTLTFVSDSSVQKRGFSARY 102
CUB pfam00431
CUB domain;
33-141 8.59e-33

CUB domain;


Pssm-ID: 395345 [Multi-domain]  Cd Length: 110  Bit Score: 119.32  E-value: 8.59e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483     33 CGGILTGESGFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGH-ANGQRIGRFCGTFR 111
Cdd:pfam00431   1 CGGVLTDSSGSISSPNYPNPYPPNKDCVWLIRAPPGFRVKLTFQDFELEDHDECGYDYVEIRDGPsASSPLLGRFCGSGI 80

                          90       100       110
                  ....*....|....*....|....*....|
gi 7019483    112 PGALVSSGNKMMVQMISDANTAGNGFMAMF 141
Cdd:pfam00431  81 PEDIVSSSNQMTIKFVSDASVQKRGFKATY 110
CUB smart00042
Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found ...
 42-139 7.70e-32

Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein; This domain is found mostly among developmentally-regulated proteins. Spermadhesins contain only this domain.


Pssm-ID: 214483 [Multi-domain]  Cd Length: 102  Bit Score: 116.72  E-value: 7.70e-32
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483      42 GFIGSEGFPGVYPPNSKCTWKITVPEGKVVVLNFRFIDLESDNLCRYDFVDVYNGHAN-GQRIGRFCGTFRPGALVSS-G 119
Cdd:smart00042   1 GTITSPNYPQSYPNNLDCVWTIRAPPGYRIELQFTDFDLESSDNCEYDYVEIYDGPSAsSPLLGRFCGSEAPPPVISSsS 80

                           90       100
                   ....*....|....*....|
gi 7019483     120 NKMMVQMISDANTAGNGFMA 139
Cdd:smart00042  81 NSLTLTFVSDSSVQKRGFSA 100
NTR pfam01759
UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein ...
 310-412 2.10e-22

UNC-6/NTR/C345C module; Sequence similarity between netrin UNC-6 and C345C complement protein family members, and hence the existence of the UNC-6 module, was first reported in. Subsequently, many additional members of the family were identified on the basis of sequence similarity between the C-terminal domains of netrins, complement proteins C3, C4, C5, secreted frizzled-related proteins, and type I pro-collagen C-proteinase enhancer proteins (PCOLCEs), which are homologous with the N-terminal domains of tissue inhibitors of metalloproteinases (TIMPs). The TIMPs are classified as a separate family in Pfam (pfam00965). This expanded domain family has been named as the NTR module.


Pssm-ID: 396359  Cd Length: 106  Bit Score: 91.25  E-value: 2.10e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483    310 NYCS-SDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTvVCKqCPLLRRGLNYIIMGQVG-EDGR 387
Cdd:pfam01759   2 KACKgSDYVYKVKVLSVEEEGSFDKYTVKVKEVLKEGTDKIQRGKVRLFLKRG-DCR-CPQLRLGKEYLIMGKVGdLEGR 79

                          90       100
                  ....*....|....*....|....*..
gi 7019483    388 GKIM--PNSFIMMFKTKNQKLLDALKN 412
Cdd:pfam01759  80 GRYVldKNSWVEPWPTKWECKLRELQK 106
C345C smart00643
Netrin C-terminal Domain;
308-412 4.40e-19

Netrin C-terminal Domain;


Pssm-ID: 214759  Cd Length: 114  Bit Score: 82.41  E-value: 4.40e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483     308 EGNYCSS--DFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVV-CKQCPLLRRGLNYIIMGQ--- 381
Cdd:smart00643   1 LEKACKSdvDYVYKVKVLSVEEEGGFDKYTVKILEVIKSGTDELVRGKNKLRVFISRAsCRCPLLLKLGKSYLIMGKsgd 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 7019483     382 ---VGEDGRGKIMPNSFIMMFKTKNQKLLDALKN 412
Cdd:smart00643  81 lwdAKGRGQYVLGKNSWVEEWPTEEECRLRRLQK 114
NTR_like cd03523
NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in ...
 310-403 2.68e-11

NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the domain plays a role in controlling axon branching in neural development, while the common function of these modules in TIMPs appears to be binding to metzincins. A subset of this family is also known as the C345C domain because it occurs as a C-terminal domain in complement C3, C4 and C5. In C5, the domain interacts with various partners during the formation of the membrane attack complex.


Pssm-ID: 239600  Cd Length: 105  Bit Score: 60.18  E-value: 2.68e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  310 NYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKN--MSARLTVVCkqCPLLRRGLNYIIMGQVGEDGR 387
Cdd:cd03523   2 AFCKSDYVVRAKIKEIKEENDDVKYEVKIIKIYKTGKAKADKADLRfyYTAPACCPC--HPILNPGREYLIMGKEEDSQG 79

                        90
                ....*....|....*..
gi 7019483  388 GKIM-PNSFIMMFKTKN 403
Cdd:cd03523  80 GLVLdPLSFVEPWSPLS 96
NTR_netrin-1_like cd03579
NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called ...
 310-397 7.14e-03

NTR domain, Netrin-1-like subfamily; The C-terminal NTR domain of netrins is also called domain C in the context of C. elegans netrin UNC-6. Netrins are secreted proteins that function as tropic cues in the direction of axon growth and cell migration during neural development. These proteins may be chemoattractive to some neurons and chemorepellant for others. In the case of netrin-1, attraction and repulsion responses are mediated by the DCC and UNC-5 receptor families. The biological activities of C. elegans UNC-6, which may either attract or repel migrating cells or axons, are mediated by its different domains. The C-terminal NTR domain of UNC-6 has been shown to inhibit axon branching activity.


Pssm-ID: 239634  Cd Length: 115  Bit Score: 36.07  E-value: 7.14e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7019483  310 NYCSSDFVLAGTVITTITRDGSLHATVSIINIYKEGNLAIQQAGKNMSARLTVV-CKqCPLLRRGLNYIIMGQV-GEDGR 387
Cdd:cd03579   3 KYCKKDYAVQAQVLSRETAGEWAKFTVNVQTVYKRGTSRLRRGDQPLWVPRKDLaCK-CPKLKVGKSYLLLGKDeDSPER 81

                        90
                ....*....|..
gi 7019483  388 GKIM--PNSFIM 397
Cdd:cd03579  82 GGLIldKRSLVI 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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