transforming growth factor beta-3 proprotein preproprotein [Rattus norvegicus]
List of domain hits
Name | Accession | Description | Interval | E-value | ||||
TGF_beta_TGFB3 | cd19386 | transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ... |
312-412 | 2.88e-75 | ||||
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. : Pssm-ID: 381656 Cd Length: 101 Bit Score: 229.13 E-value: 2.88e-75
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TGFb_propeptide | pfam00688 | TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ... |
24-231 | 1.45e-42 | ||||
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein. : Pssm-ID: 459906 Cd Length: 239 Bit Score: 149.39 E-value: 1.45e-42
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Name | Accession | Description | Interval | E-value | ||||
TGF_beta_TGFB3 | cd19386 | transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ... |
312-412 | 2.88e-75 | ||||
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Pssm-ID: 381656 Cd Length: 101 Bit Score: 229.13 E-value: 2.88e-75
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TGFb_propeptide | pfam00688 | TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ... |
24-231 | 1.45e-42 | ||||
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein. Pssm-ID: 459906 Cd Length: 239 Bit Score: 149.39 E-value: 1.45e-42
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TGF_beta | pfam00019 | Transforming growth factor beta like domain; |
314-411 | 1.26e-33 | ||||
Transforming growth factor beta like domain; Pssm-ID: 459632 Cd Length: 102 Bit Score: 121.28 E-value: 1.26e-33
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TGFB | smart00204 | Transforming growth factor-beta (TGF-beta) family; Family members are active as ... |
315-412 | 6.09e-33 | ||||
Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Pssm-ID: 214556 Cd Length: 102 Bit Score: 119.30 E-value: 6.09e-33
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PHA02913 | PHA02913 | TGF-beta-like protein; Provisional |
308-411 | 1.76e-21 | ||||
TGF-beta-like protein; Provisional Pssm-ID: 177497 Cd Length: 172 Bit Score: 90.85 E-value: 1.76e-21
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DNRLRE_dom | NF033679 | DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in ... |
131-223 | 4.88e-03 | ||||
DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480. Pssm-ID: 468137 [Multi-domain] Cd Length: 164 Bit Score: 37.74 E-value: 4.88e-03
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Name | Accession | Description | Interval | E-value | ||||
TGF_beta_TGFB3 | cd19386 | transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ... |
312-412 | 2.88e-75 | ||||
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-3 (TGF-beta-3) and similar proteins; TGF-beta-3 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Pssm-ID: 381656 Cd Length: 101 Bit Score: 229.13 E-value: 2.88e-75
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TGF_beta_TGFB2 | cd19385 | transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ... |
315-411 | 1.27e-67 | ||||
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-2 (TGF-beta-2) and similar proteins; TGF-beta-2, also termed BSC-1 cell growth inhibitor, or cetermin, or glioblastoma-derived T-cell suppressor factor (G-TSF), or polyergin, is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. Pssm-ID: 381655 Cd Length: 97 Bit Score: 209.50 E-value: 1.27e-67
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TGF_beta_TGFB1 | cd19384 | transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ... |
314-412 | 3.53e-61 | ||||
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1) and similar proteins; TGF-beta-1 is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. Pssm-ID: 381654 Cd Length: 99 Bit Score: 193.16 E-value: 3.53e-61
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TGF_beta_TGFbeta1_2_3 | cd13753 | transforming growth factor beta (TGF-beta) like domain found in transforming growth factor ... |
315-411 | 5.52e-61 | ||||
transforming growth factor beta (TGF-beta) like domain found in transforming growth factor beta-1 (TGF-beta-1), beta-2 (TGF-beta-2), beta-3 (TGF-beta-3) and similar proteins; The family includes TGF-beta-1, TGF-beta-2 and TGF-beta-3, which are polypeptide members of the transforming growth factor beta superfamily of cytokines. TGF-beta-1 is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation, and apoptosis. TGF-beta-2 is a secreted protein that performs many cellular functions and has a vital role during embryonic development. It can suppress the effects of interleukin-2 dependent T-cell growth. TGF-beta-3 is involved in embryogenesis and cell differentiation. It regulates molecules involved in cellular adhesion and extracellular matrix (ECM) formation during the process of palate development. Pssm-ID: 381631 Cd Length: 97 Bit Score: 192.52 E-value: 5.52e-61
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TGFb_propeptide | pfam00688 | TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. ... |
24-231 | 1.45e-42 | ||||
TGF-beta propeptide; This propeptide is known as latency associated peptide (LAP) in TGF-beta. LAP is a homodimer which is disulfide linked to TGF-beta binding protein. Pssm-ID: 459906 Cd Length: 239 Bit Score: 149.39 E-value: 1.45e-42
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TGF_beta | pfam00019 | Transforming growth factor beta like domain; |
314-411 | 1.26e-33 | ||||
Transforming growth factor beta like domain; Pssm-ID: 459632 Cd Length: 102 Bit Score: 121.28 E-value: 1.26e-33
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TGFB | smart00204 | Transforming growth factor-beta (TGF-beta) family; Family members are active as ... |
315-412 | 6.09e-33 | ||||
Transforming growth factor-beta (TGF-beta) family; Family members are active as disulphide-linked homo- or heterodimers. TGFB is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. Pssm-ID: 214556 Cd Length: 102 Bit Score: 119.30 E-value: 6.09e-33
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TGF_beta_INHB | cd13752 | transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), ... |
315-411 | 1.13e-27 | ||||
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), E chain (INHBE) and similar proteins; The family includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress. Pssm-ID: 381630 Cd Length: 100 Bit Score: 105.04 E-value: 1.13e-27
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TGF_beta_SF | cd08698 | transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ... |
315-411 | 2.97e-27 | ||||
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer. Pssm-ID: 381627 Cd Length: 100 Bit Score: 104.10 E-value: 2.97e-27
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TGF_beta_BMPs_GDFs | cd13756 | transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP ... |
315-411 | 5.52e-27 | ||||
transforming growth factor beta (TGF-beta) like domain found in the BMP/GDF family; The BMP/GDF family consists of bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs) and similar proteins. BMPs are a group of growth factors also known as cytokines and as metabologens. They induce the formation of bone and cartilage and functions as pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. GDFs have functions predominantly in development. Pssm-ID: 381634 Cd Length: 102 Bit Score: 103.55 E-value: 5.52e-27
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TGF_beta_GDF15 | cd19376 | transforming growth factor beta (TGF-beta) like domain found in mammalian growth ... |
313-412 | 9.00e-26 | ||||
transforming growth factor beta (TGF-beta) like domain found in mammalian growth/differentiation factor 15 (GDF-15) and similar proteins; GDF-15, also termed macrophage inhibitory cytokine 1 (MIC-1), or NSAID-activated gene 1 protein (NAG-1), or NSAID-regulated gene 1 protein (NRG-1), or placental TGF-beta, or placental bone morphogenetic protein, or prostate differentiation factor, regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Pssm-ID: 381646 Cd Length: 101 Bit Score: 100.08 E-value: 9.00e-26
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TGF_beta_GDF8_like | cd13751 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, ... |
315-411 | 5.51e-24 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factors, GDF8 and GDF11, and similar proteins; The family includes GDF8 and GDF11. GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Pssm-ID: 381629 Cd Length: 96 Bit Score: 95.03 E-value: 5.51e-24
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TGF_beta_GDF8 | cd19388 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
312-412 | 1.20e-23 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 8 (GDF8) and similar proteins; GDF8, also termed myostatin, acts specifically as a negative regulator of skeletal muscle growth. Pssm-ID: 381658 Cd Length: 108 Bit Score: 94.72 E-value: 1.20e-23
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TGF_beta_BMP5_like | cd13761 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins ... |
315-411 | 1.06e-22 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins BMP-5, BMP-6, BMP-7, BMP-8A/B and similar proteins; The family includes BMP-5, BMP-6, BMP-7 and BMP-8A/B, which may induce cartilage and bone formation. Pssm-ID: 381639 Cd Length: 103 Bit Score: 91.87 E-value: 1.06e-22
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PHA02913 | PHA02913 | TGF-beta-like protein; Provisional |
308-411 | 1.76e-21 | ||||
TGF-beta-like protein; Provisional Pssm-ID: 177497 Cd Length: 172 Bit Score: 90.85 E-value: 1.76e-21
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TGF_beta_GDF1_3_like | cd13764 | transforming growth factor beta (TGF-beta) like domain found in embryonic growth ... |
315-411 | 3.12e-21 | ||||
transforming growth factor beta (TGF-beta) like domain found in embryonic growth/differentiation factor 1 (GDF1), factor 3 (GDF3) and similar proteins; The family includes GDF-1 and GDF-3. GDF1 may mediate cell differentiation events during embryonic development. GDF3 is a growth factor involved in early embryonic development and adipose-tissue homeostasis. The family also contains protein DVR-1, also termed vegetal hemisphere VG1 protein (VG-1), which serves to facilitate the differentiation of either mesoderm or endoderm either as a cofactor in an instructive signal or by providing permissive environment. Pssm-ID: 381642 Cd Length: 102 Bit Score: 87.91 E-value: 3.12e-21
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TGF_beta_maverick | cd13755 | transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ... |
315-411 | 3.69e-21 | ||||
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster maverick and similar proteins; Maverick, also termed MAV, is a novel member of the TGF-beta superfamily in Drosophila. It's a bone morphogenetic protein (BMP)/TGF-beta related ligand. Pssm-ID: 381633 Cd Length: 102 Bit Score: 87.37 E-value: 3.69e-21
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TGF_beta_BMP2 | cd19390 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ... |
314-412 | 1.92e-20 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2) and similar proteins; BMP-2, also termed BMP-2A, induces cartilage and bone formation. It stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. Pssm-ID: 381660 Cd Length: 103 Bit Score: 85.80 E-value: 1.92e-20
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TGF_beta_GDF5_6_7 | cd13766 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
315-412 | 2.28e-20 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5), factor 6 (GDF6), factor 7 (GDF7) and similar proteins; The family includes GDF5, GDF6 and GDF7. GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. GDF6, also termed bone morphogenetic protein 13 (BMP-13), or growth/differentiation factor 16, is a growth factor that controls proliferation and cellular differentiation in the retina and bone formation. GDF7, also termed bone morphogenetic protein 12 (BMP-12), may play an active role in the motor area of the primate neocortex. Pssm-ID: 381644 Cd Length: 102 Bit Score: 85.56 E-value: 2.28e-20
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TGF_beta_BMP3_like | cd13763 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ... |
315-411 | 8.18e-20 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3), growth/differentiation factor 10 (GDF10) and similar proteins; The family includes BMP-3 (also known as BMP-3A or osteogenin) and GDF10 (also known as BMP-3B). BMP-3 negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. GDF10 is a growth factor involved in osteogenesis and adipogenesis. Pssm-ID: 381641 Cd Length: 103 Bit Score: 83.95 E-value: 8.18e-20
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TGF_beta_INHBC_E | cd19406 | transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), ... |
315-412 | 1.41e-19 | ||||
transforming growth factor beta (TGF-beta) like domain found in inhibin beta C chain (INHBC), inhibin beta E chain (INHBE) and similar proteins; The family includes INHBC and INHBE. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress. Pssm-ID: 381676 Cd Length: 104 Bit Score: 83.28 E-value: 1.41e-19
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TGF_beta_GDF11 | cd19389 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
312-412 | 1.93e-19 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 11 (GDF11) and similar proteins; GDF11, also termed bone morphogenetic protein 11 (BMP-11), is a secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. Pssm-ID: 381659 Cd Length: 109 Bit Score: 83.16 E-value: 1.93e-19
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TGF_beta_INHA_B_like | cd19377 | transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), ... |
315-411 | 2.57e-19 | ||||
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA), beta chain (INHB) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. INHB includes inhibin beta A chain (INHBA), B chain (INHBB), C chain (INHBC), and E chain (INHBE). INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. INHBC, also termed activin beta-C chain, might play important roles in carcinogenesis. It may function as a negative regulator of liver growth. INHBE, also termed activin beta-E chain, is a possible insulin resistance-associated hepatokine with hepatic gene expression that positively correlated with insulin resistance and body mass index in humans. It also acts as a possible new marker for drug-induced endoplasmic reticulum stress. Pssm-ID: 381647 Cd Length: 101 Bit Score: 82.52 E-value: 2.57e-19
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TGF_beta_BMP7 | cd19397 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 ... |
311-411 | 1.09e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins; BMP-7, also termed osteogenic protein 1 (OP-1), or eptotermin alfa, induces cartilage and bone formation. It may act as the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis and play a role in calcium regulation and bone homeostasis. Pssm-ID: 381667 Cd Length: 107 Bit Score: 80.86 E-value: 1.09e-18
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TGF_beta_INHBB | cd19405 | transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) ... |
315-412 | 1.13e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in inhibin beta B chain (INHBB) and similar proteins; INHBB, also termed activin beta-B chain, is a component of inhibin B, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Pssm-ID: 381675 Cd Length: 107 Bit Score: 80.74 E-value: 1.13e-18
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TGF_beta_INHBA | cd19404 | transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) ... |
315-412 | 1.55e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in inhibin beta A chain (INHBA) and similar proteins; INHBA, also termed activin beta-A chain, or erythroid differentiation protein (EDF), is a component of inhibin A, activin A, or activin AB. Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Pssm-ID: 381674 Cd Length: 108 Bit Score: 80.35 E-value: 1.55e-18
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TGF_beta_univin | cd19387 | transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus ... |
315-411 | 1.71e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in Strongylocentrotus purpuratus univin and similar proteins; Univin may have a critical role in early developmental decisions in the sea urchin embryo. Pssm-ID: 381657 Cd Length: 104 Bit Score: 80.24 E-value: 1.71e-18
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TGF_beta_BMP6 | cd19396 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 ... |
315-411 | 2.45e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 6 (BMP-6) and similar proteins; BMP-6, also termed VG-1-related protein, or VG-1-R, or VGR-1, induces cartilage and bone formation. Pssm-ID: 381666 Cd Length: 103 Bit Score: 79.70 E-value: 2.45e-18
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TGF_beta_ADMP | cd13765 | transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic ... |
315-411 | 2.56e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in anti-dorsalizing morphogenetic protein (ADMP) and similar proteins; ADMP is a bone morphogenetic protein (BMP)-like transforming growth factor beta ligand, functions in the trunk organizer to antagonize head formation, thereby regulating organizer patterning. It negatively affects the formation of the organizer, although it is robustly expressed within the organizer itself. The organizer-promoting signal of ADMP is mediated by the activin A type I receptor, ACVR1 (also known as activin receptor-like kinase-2, ALK2). Pssm-ID: 381643 Cd Length: 105 Bit Score: 79.71 E-value: 2.56e-18
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TGF_beta_BMP9_like | cd13767 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, ... |
314-411 | 2.58e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic proteins, BMP-9, BMP-10 and similar proteins; The family includes BMP9 (also known as GDF2) and BMP10. BMP-9 is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines. Pssm-ID: 381645 Cd Length: 105 Bit Score: 79.71 E-value: 2.58e-18
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TGF_beta_BMP8 | cd19398 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A ... |
315-411 | 3.43e-18 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 8A (BMP-8A), 8B (BMP-8B) and similar proteins; BMP-8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. BMP-8B, also termed BMP-8, or osteogenic protein 2 (OP-2), may act as secreted factor in cancer progression. It also plays an essential role in bone metabolism and can regulate thermogenesis and energy balance. Like BMP-8A, BMP-8B plays a role in spermatogenesis and placental development. Mutation in either of the genes encoding BMP-8A or BMP-8B causes postnatal depletion of spermatogonia in mice. Pssm-ID: 381668 Cd Length: 105 Bit Score: 79.58 E-value: 3.43e-18
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TGF_beta_DPP | cd19392 | transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster ... |
309-411 | 1.44e-17 | ||||
transforming growth factor beta (TGF-beta) like domain found in Drosophila melanogaster protein decapentaplegic (Dpp) and similar proteins; decapentaplegic (Dpp) and similar proteins Dpp, also termed as protein DPP-C, is required later in embryogenesis for dorsal closure and patterning of the hindgut. It also functions postembryonically as a long-range morphogen during imaginal disk development and is responsible for the progression of the morphogenetic furrow during eye development. Pssm-ID: 381662 Cd Length: 109 Bit Score: 77.95 E-value: 1.44e-17
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TGF_beta_BMP2_like | cd13760 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 ... |
315-411 | 4.76e-17 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 2 (BMP-2), 4 (BMP-4) and similar proteins; The family includes BMP2 and BMP4 (also known as BMP2B), both of which induce cartilage and bone formation. BMP-2 stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP-4 acts in mesoderm induction, tooth development, limb formation and fracture repair. Pssm-ID: 381638 Cd Length: 102 Bit Score: 75.99 E-value: 4.76e-17
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TGF_beta_DAF7 | cd19378 | transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ... |
315-411 | 9.73e-17 | ||||
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels. Pssm-ID: 381648 Cd Length: 100 Bit Score: 75.06 E-value: 9.73e-17
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TGF_beta_GDF5 | cd19399 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
315-411 | 2.84e-16 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 5 (GDF5) and similar proteins; GDF5, also termed bone morphogenetic protein 14 (BMP-14), or cartilage-derived morphogenetic protein 1 (CDMP-1), or lipopolysaccharide-associated protein 4 (LAP-4), or LPS-associated protein 4, or radotermin, is a growth factor involved in bone and cartilage formation. Pssm-ID: 381669 Cd Length: 103 Bit Score: 73.89 E-value: 2.84e-16
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TGF_beta_BMP10 | cd19401 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 ... |
305-411 | 7.92e-16 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 10 (BMP-10) and similar proteins; BMP-10 is required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. It inhibits endothelial cell migration and growth. It may reduce cell migration and cell matrix adhesion in breast cancer cell lines. Pssm-ID: 381671 Cd Length: 105 Bit Score: 72.97 E-value: 7.92e-16
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TGF_beta_NODAL | cd13759 | transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; ... |
313-411 | 3.96e-15 | ||||
transforming growth factor beta (TGF-beta) like domain found in Nodal (NODAL)-related proteins; NODAL is essential for mesoderm formation and axial patterning during embryonic development. Pssm-ID: 381637 Cd Length: 103 Bit Score: 70.80 E-value: 3.96e-15
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TGF_beta_GDP9_9B_like | cd13762 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
315-411 | 7.02e-15 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9), growth/differentiation factor 9B (GDF-9B) and similar proteins; The family includes GDF-9B (also known as BMP15) and GDF9. GDF-9B acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation. Pssm-ID: 381640 Cd Length: 104 Bit Score: 70.17 E-value: 7.02e-15
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TGF_beta_BMP4_BMP2B | cd19391 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 ... |
309-411 | 2.40e-14 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 4 (BMP-4) and similar proteins; BMP-4, also termed BMP-2B, induces cartilage and bone formation. It also acts in mesoderm induction, tooth development, limb formation and fracture repair. Pssm-ID: 381661 Cd Length: 107 Bit Score: 68.93 E-value: 2.40e-14
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TGF_beta_BMP5 | cd19395 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 ... |
312-411 | 2.41e-14 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 5 (BMP-5) and similar proteins; BMP-5 induces cartilage and bone formation. Pssm-ID: 381665 Cd Length: 113 Bit Score: 68.96 E-value: 2.41e-14
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TGF_beta_BMP3 | cd19393 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 ... |
314-411 | 3.32e-14 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 3 (BMP-3) and similar proteins; BMP-3, also termed BMP-3A, or osteogenin, negatively regulates bone density. It antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Pssm-ID: 381663 Cd Length: 110 Bit Score: 68.52 E-value: 3.32e-14
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TGF_beta_LEFTY1_2 | cd13758 | transforming growth factor beta (TGF-beta) like domain found in left-right determination ... |
315-411 | 1.78e-13 | ||||
transforming growth factor beta (TGF-beta) like domain found in left-right determination factor 1 (lefty-1), factor 2 (lefty-2) and similar proteins; Lefty-1, also termed left-right determination factor B, or protein lefty-B, is required for left-right axis determination as a regulator of Lefty-2 and NODAL. Lefty-2, also termed endometrial bleeding-associated factor, or left-right determination factor A, or protein lefty-A, or transforming growth factor beta-4 (TGF-beta-4), is required for left-right (L-R) asymmetry determination of organ systems in mammals. It may play a role in endometrial bleeding. Pssm-ID: 381636 Cd Length: 90 Bit Score: 65.85 E-value: 1.78e-13
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TGF_beta_BMP9 | cd19400 | transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 ... |
305-411 | 2.21e-10 | ||||
transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 9 (BMP-9) and similar proteins; BMP-9, also termed growth/differentiation factor 2 (GDF-2), is a potent circulating inhibitor of angiogenesis. It signals through the type I activin receptor ACVRL1 but not other activin receptor-like kinases (ALKs). Pssm-ID: 381670 Cd Length: 105 Bit Score: 57.58 E-value: 2.21e-10
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TGF_beta_AMH | cd13757 | transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) ... |
315-411 | 2.60e-10 | ||||
transforming growth factor beta (TGF-beta) like domain found in anti-Muellerian hormone (AMH) and similar proteins; AMH, also termed Muellerian-inhibiting factor, or Muellerian-inhibiting substance (MIS), is a glycoprotein that causes regression of the Muellerian duct. It can also inhibit the growth of tumors derived from tissues of Muellerian duct origin. Pssm-ID: 381635 Cd Length: 99 Bit Score: 56.99 E-value: 2.60e-10
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TGF_beta_GDF10 | cd19394 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
315-411 | 3.00e-10 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 10 (GDF10) and similar proteins; GDF10, also termed bone morphogenetic protein 3B (BMP-3B), or bone-inducing protein (BIP), is a growth factor involved in osteogenesis and adipogenesis. Pssm-ID: 381664 Cd Length: 112 Bit Score: 57.23 E-value: 3.00e-10
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TGF_beta_GDF9B | cd19402 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
314-411 | 2.71e-09 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9B (GDF-9B) and similar proteins; GDF-9B, also termed bone morphogenetic protein 15 (BMP15), acts as oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Pssm-ID: 381672 Cd Length: 104 Bit Score: 54.44 E-value: 2.71e-09
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TGF_beta_GSDF | cd19379 | transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic ... |
315-390 | 1.36e-05 | ||||
transforming growth factor beta (TGF-beta) like domain found in Danio rerio gonadal somatic cell derived factor (GSDF) and similar proteins; GSDF is a new member of transforming growth factor beta (TGF-beta) superfamily. It is a teleost- and gonad-specific growth factor that controls sex determination in some fish and plays an important role in mediating germ cell/soma signaling. Pssm-ID: 381649 Cd Length: 94 Bit Score: 43.51 E-value: 1.36e-05
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TGF_beta_GDF9 | cd19403 | transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor ... |
312-411 | 5.84e-04 | ||||
transforming growth factor beta (TGF-beta) like domain found in growth/differentiation factor 9 (GDF-9) and similar proteins; GDF-9 is required for ovarian folliculogenesis. It promotes primordial follicle development and stimulates granulosa cell proliferation. Pssm-ID: 381673 Cd Length: 106 Bit Score: 39.07 E-value: 5.84e-04
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TGF_beta_INHA | cd13754 | transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and ... |
314-412 | 3.05e-03 | ||||
transforming growth factor beta (TGF-beta) like domain found in inhibin alpha chain (INHA) and similar proteins; INHA is a component of inhibins (inhibin A or inhibin B) that inhibit the secretion of follitropin by the pituitary gland. Pssm-ID: 381632 Cd Length: 89 Bit Score: 36.66 E-value: 3.05e-03
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DNRLRE_dom | NF033679 | DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in ... |
131-223 | 4.88e-03 | ||||
DNRLRE domain; The DNRLRE domain, with a length of about 160 amino acids, appears typically in large, repetitive surface proteins of bacteria and archaea, sometimes repeated several times. It occurs, notably, three times in the C-terminal region of the enzyme disaggregatase from the archaeal species Methanosarcina mazei, each time with the motif DNRLRE, for which the domain is named. Archaeal proteins within this family are described particularly well by the currently more narrowly defined Pfam model, PF06848. Note that the catalytic region of disaggregatase, in the N-terminal portion of the protein, is modeled by a different HMM, PF08480. Pssm-ID: 468137 [Multi-domain] Cd Length: 164 Bit Score: 37.74 E-value: 4.88e-03
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