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Conserved domains on  [gi|401709965|ref|NP_036955|]
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annexin A3 [Rattus norvegicus]

Protein Classification

annexin( domain architecture ID 10446041)

annexin belongs to a family of calcium- and phospholipid-binding proteins that have been implicated in many cellular processes, including channel formation, membrane fusion, vesicle transport, and regulation of phospholipase A2 activity

CATH:  1.10.220.10
Gene Ontology:  GO:0005509|GO:0005544|GO:0048306|GO:0003723
PubMed:  15059252|1646719
SCOP:  4001063
TCDB:  1.A.31

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 95-160 3.97e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 98.31  E-value: 3.97e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401709965   95 FDAKQLKKSMRGMGTDEDTLIEILTTRTSRQMKEISQAYYTAYKKNLRDDISSETSGDFRKALLTL 160
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 179-244 8.03e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 8.03e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401709965  179 DAQTLYDAgEKKWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAV 244
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 24-88 1.36e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.77  E-value: 1.36e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 401709965   24 DAEAIRKAIKGIGTDEKTLINILTERSNAQRQLIVKQYQEAYEQALKADLKGDLSGHFEHVMVAL 88
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 256-319 8.61e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


:

Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 8.61e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 401709965  256 AGRLHQALKGAGTDEFTLNRIMVSRSEIDLLDIRREFKKHYGCSLYSAIQSDTSGDYRTVLLKI 319
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 95-160 3.97e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 98.31  E-value: 3.97e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401709965   95 FDAKQLKKSMRGMGTDEDTLIEILTTRTSRQMKEISQAYYTAYKKNLRDDISSETSGDFRKALLTL 160
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 179-244 8.03e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 8.03e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401709965  179 DAQTLYDAgEKKWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAV 244
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 24-88 1.36e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.77  E-value: 1.36e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 401709965   24 DAEAIRKAIKGIGTDEKTLINILTERSNAQRQLIVKQYQEAYEQALKADLKGDLSGHFEHVMVAL 88
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 256-319 8.61e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 8.61e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 401709965  256 AGRLHQALKGAGTDEFTLNRIMVSRSEIDLLDIRREFKKHYGCSLYSAIQSDTSGDYRTVLLKI 319
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
108-160 3.91e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 84.77  E-value: 3.91e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 401709965   108 GTDEDTLIEILTTRTSRQMKEISQAYYTAYKKNLRDDISSETSGDFRKALLTL 160
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
267-317 5.99e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 5.99e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 401709965   267 GTDEFTLNRIMVSRSEIDLLDIRREFKKHYGCSLYSAIQSDTSGDYRTVLL 317
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
ANX smart00335
Annexin repeats;
192-244 1.16e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.22  E-value: 1.16e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 401709965   192 GTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAV 244
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-88 1.22e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.52  E-value: 1.22e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 401709965    36 GTDEKTLINILTERSNAQRQLIVKQYQEAYEQALKADLKGDLSGHFEHVMVAL 88
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Name Accession Description Interval E-value
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 95-160 3.97e-26

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 98.31  E-value: 3.97e-26
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401709965   95 FDAKQLKKSMRGMGTDEDTLIEILTTRTSRQMKEISQAYYTAYKKNLRDDISSETSGDFRKALLTL 160
Cdd:pfam00191   1 YDAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 179-244 8.03e-25

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 94.85  E-value: 8.03e-25
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 401709965  179 DAQTLYDAgEKKWGTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAV 244
Cdd:pfam00191   2 DAELLRKA-MKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 24-88 1.36e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 91.77  E-value: 1.36e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 401709965   24 DAEAIRKAIKGIGTDEKTLINILTERSNAQRQLIVKQYQEAYEQALKADLKGDLSGHFEHVMVAL 88
Cdd:pfam00191   2 DAELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
Annexin pfam00191
Annexin; This family of annexins also includes giardin that has been shown to function as an ...
 256-319 8.61e-23

Annexin; This family of annexins also includes giardin that has been shown to function as an annexin.


Pssm-ID: 395139  Cd Length: 66  Bit Score: 89.45  E-value: 8.61e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 401709965  256 AGRLHQALKGAGTDEFTLNRIMVSRSEIDLLDIRREFKKHYGCSLYSAIQSDTSGDYRTVLLKI 319
Cdd:pfam00191   3 AELLRKAMKGLGTDESTLIEILATRSNAQLQAIREAYKKLYGKDLEKDIKSETSGDFEKLLLAL 66
ANX smart00335
Annexin repeats;
108-160 3.91e-21

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 84.77  E-value: 3.91e-21
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 401709965   108 GTDEDTLIEILTTRTSRQMKEISQAYYTAYKKNLRDDISSETSGDFRKALLTL 160
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
267-317 5.99e-19

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.99  E-value: 5.99e-19
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 401709965   267 GTDEFTLNRIMVSRSEIDLLDIRREFKKHYGCSLYSAIQSDTSGDYRTVLL 317
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLL 51
ANX smart00335
Annexin repeats;
192-244 1.16e-18

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 78.22  E-value: 1.16e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 401709965   192 GTDEDKFTEILCLRSFPQLKLTFDEYRNISQKDIEDSIKGELSGHFEDLLLAV 244
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
ANX smart00335
Annexin repeats;
36-88 1.22e-17

Annexin repeats;


Pssm-ID: 197661  Cd Length: 53  Bit Score: 75.52  E-value: 1.22e-17
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 401709965    36 GTDEKTLINILTERSNAQRQLIVKQYQEAYEQALKADLKGDLSGHFEHVMVAL 88
Cdd:smart00335   1 GTDEKTLIEILASRSNAQLQAIKQAYKKRYGKDLEDDIKSETSGDFEKLLLAL 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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