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Conserved domains on  [gi|6978427|ref|NP_036950|]
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serotonin N-acetyltransferase [Rattus norvegicus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10006981)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
35-182 8.48e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


:

Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.49  E-value: 8.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978427   35 FRCLTPEDATSAFEIEREAFisVSGTCPLHLDEIRHFLTLcpELSLGWFEEGCLVAFIIGSLWDkerltqesltlHRPGG 114
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVD-----------IDGEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6978427  115 RTAHLHVLAVHRTFRQQGKGSVLLW---RYLHHLGsqpaVRRAVLMCENALVPFYEKFGFQAMGPCAITMG 182
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRaalEAARERG----ARAVVLLGDPSLLPFYERFGFRPAGELGLTLG 132
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
35-182 8.48e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.49  E-value: 8.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978427   35 FRCLTPEDATSAFEIEREAFisVSGTCPLHLDEIRHFLTLcpELSLGWFEEGCLVAFIIGSLWDkerltqesltlHRPGG 114
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVD-----------IDGEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6978427  115 RTAHLHVLAVHRTFRQQGKGSVLLW---RYLHHLGsqpaVRRAVLMCENALVPFYEKFGFQAMGPCAITMG 182
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRaalEAARERG----ARAVVLLGDPSLLPFYERFGFRPAGELGLTLG 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 45-171 4.92e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978427     45 SAFEIEREAFISVSGTCPLhlDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKErltqesltlhrpgGRTAHLHVLAV 124
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPL--DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDE-------------PPVGEIEGLAV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 6978427    125 HRTFRQQGKGSVLLWRYLHHLGSQPAVRR--AVLMCENALVPFYEKFGF 171
Cdd:pfam00583  68 APEYRGKGIGTALLQALLEWARERGCERIflEVAADNLAAIALYEKLGF 116
 
Name Accession Description Interval E-value
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
35-182 8.48e-14

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 65.49  E-value: 8.48e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978427   35 FRCLTPEDATSAFEIEREAFisVSGTCPLHLDEIRHFLTLcpELSLGWFEEGCLVAFIIGSLWDkerltqesltlHRPGG 114
Cdd:COG3153   1 IRPATPEDAEAIAALLRAAF--GPGREAELVDRLREDPAA--GLSLVAEDDGEIVGHVALSPVD-----------IDGEG 65

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6978427  115 RTAHLHVLAVHRTFRQQGKGSVLLW---RYLHHLGsqpaVRRAVLMCENALVPFYEKFGFQAMGPCAITMG 182
Cdd:COG3153  66 PALLLGPLAVDPEYRGQGIGRALMRaalEAARERG----ARAVVLLGDPSLLPFYERFGFRPAGELGLTLG 132
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 45-171 4.92e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.53  E-value: 4.92e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978427     45 SAFEIEREAFISVSGTCPLhlDEIRHFLTLCPELSLGWFEEGCLVAFIIGSLWDKErltqesltlhrpgGRTAHLHVLAV 124
Cdd:pfam00583   3 ALYELLSEEFPEPWPDEPL--DLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDE-------------PPVGEIEGLAV 67

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 6978427    125 HRTFRQQGKGSVLLWRYLHHLGSQPAVRR--AVLMCENALVPFYEKFGF 171
Cdd:pfam00583  68 APEYRGKGIGTALLQALLEWARERGCERIflEVAADNLAAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 109-172 4.22e-07

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 46.29  E-value: 4.22e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6978427    109 LHRPGGRTAHLHVLAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVLMCENALVPFYEKFGFQ 172
Cdd:pfam13508  21 LPLDDEGALAELRLAVHPEYRGQGIGRALL-EAAEAAAKEGGIKLLELETTNRAAAFYEKLGFE 83
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 115-176 5.62e-07

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 46.88  E-value: 5.62e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6978427    115 RTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAVRRAVLMceNA---LVPFYEKFGFQAMGP 176
Cdd:pfam13673  50 DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSELTV--NAspyAVPFYEKLGFRATGP 112
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 111-175 1.01e-06

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 45.42  E-value: 1.01e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6978427  111 RPGGRTAHLHVLAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVLMCEN---ALVPFYEKFGFQAMG 175
Cdd:COG0456   8 VDGGDEAEIEDLAVDPEYRGRGIGRALL-EAALERARERGARRLRLEVREdneAAIALYEKLGFEEVG 74
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
109-176 1.27e-06

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 45.95  E-value: 1.27e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6978427  109 LHRPGGRTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPAvRRAVLMCENALVPFYEKFGFQAMGP 176
Cdd:COG2153  51 LLPPGDGEAKIGRVAVLPEYRGQGLGRALMEAAIEEARERGA-RRIVLSAQAHAVGFYEKLGFVPVGE 117
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 109-176 7.83e-06

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 43.83  E-value: 7.83e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6978427  109 LHRPGGRTAHLHVLAVHRTFRQQGKGSVLLwRYLHHLGSQPAVRRAVLMCENALVPFYEKFGFQAMGP 176
Cdd:COG1246  45 LHPLDEDLAELRSLAVHPDYRGRGIGRRLL-EALLAEARELGLKRLFLLTTSAAIHFYEKLGFEEIDK 111
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
34-175 1.28e-05

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 43.83  E-value: 1.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6978427   34 EFRCLTPEDATSAFEIEREAFISVSGT---CPLHLDEIRHFLTLCPELSLGWF---EEGCLVAFIIGSLWDKerltqesl 107
Cdd:COG1247   3 TIRPATPEDAPAIAAIYNEAIAEGTATfetEPPSEEEREAWFAAILAPGRPVLvaeEDGEVVGFASLGPFRP-------- 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6978427  108 tlhRPGGRTAHLHVLAVHRTFRQQGKGSVLLWRYLHHLGSQPaVRRAVLMC--EN-ALVPFYEKFGFQAMG 175
Cdd:COG1247  75 ---RPAYRGTAEESIYVDPDARGRGIGRALLEALIERARARG-YRRLVAVVlaDNeASIALYEKLGFEEVG 141
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 107-175 9.88e-05

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 40.81  E-value: 9.88e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6978427  107 LTLHRPGGRTAHLHVLAVHRTFRQQGKGSVLL---WRYLHHLGsqpaVRRAVLMCEN---ALVPFYEKFGFQAMG 175
Cdd:COG0454  49 AGLRRLDDKVLELKRLYVLPEYRGKGIGKALLealLEWARERG----CTALELDTLDgnpAAIRFYERLGFKEIE 119
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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