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Conserved domains on  [gi|6912534|ref|NP_036474|]
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BMP and activin membrane-bound inhibitor homolog precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BAMBI_C pfam19337
BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the ...
 123-260 1.54e-95

BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


:

Pssm-ID: 437169  Cd Length: 138  Bit Score: 276.44  E-value: 1.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534    123 QGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHH 202
Cdd:pfam19337   1 VGSRHQSDSNRNLITKVQELASAKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6912534    203 SKKGQVAKLDLECMVPVSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV 260
Cdd:pfam19337  81 AKKGAVLKLDLECMVPVGGHENCCLTCDKTRPSDLSNDGILSLVHWGMYSGHGKLEFV 138
BAMBI super family cl05626
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of ...
 4-111 5.02e-70

BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


The actual alignment was detected with superfamily member pfam06211:

Pssm-ID: 283793  Cd Length: 107  Bit Score: 210.59  E-value: 5.02e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534      4 HSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAK 83
Cdd:pfam06211   1 HSSLVSIWLQLELCAMAVLLTKGEIRCYCDAPHCVATGYMCKSELNACFTRLLDPQNTNSPLTHGCLDSLLNSGDICHSK 80

                          90       100
                  ....*....|....*....|....*...
gi 6912534     84 QARNHSGTTIPtLECCHEDMCNYRGLHD 111
Cdd:pfam06211  81 QAFDHSGGSAP-LECCHEDMCNYRGLHD 107
 
Name Accession Description Interval E-value
BAMBI_C pfam19337
BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the ...
 123-260 1.54e-95

BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 437169  Cd Length: 138  Bit Score: 276.44  E-value: 1.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534    123 QGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHH 202
Cdd:pfam19337   1 VGSRHQSDSNRNLITKVQELASAKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6912534    203 SKKGQVAKLDLECMVPVSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV 260
Cdd:pfam19337  81 AKKGAVLKLDLECMVPVGGHENCCLTCDKTRPSDLSNDGILSLVHWGMYSGHGKLEFV 138
BAMBI pfam06211
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of ...
 4-111 5.02e-70

BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 283793  Cd Length: 107  Bit Score: 210.59  E-value: 5.02e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534      4 HSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAK 83
Cdd:pfam06211   1 HSSLVSIWLQLELCAMAVLLTKGEIRCYCDAPHCVATGYMCKSELNACFTRLLDPQNTNSPLTHGCLDSLLNSGDICHSK 80

                          90       100
                  ....*....|....*....|....*...
gi 6912534     84 QARNHSGTTIPtLECCHEDMCNYRGLHD 111
Cdd:pfam06211  81 QAFDHSGGSAP-LECCHEDMCNYRGLHD 107
TFP_LU_ECD_BAMBI cd23576
extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and ...
 27-106 1.32e-33

extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and similar proteins; BAMBI (also called non-metastatic gene A protein (NMA), or putative transmembrane protein NMA) is a transmembrane protein that acts as an important regulator of trabecular meshwork extracellular matrix and ocular hypertension. It negatively regulates the signaling activity of transforming growth factor (TGF)-beta, activin, and bone morphogenetic protein (BMP). BAMBI can function as a positive regulator of the Wnt/beta-catenin pathway to promote cell proliferation. It may be a reactive oxygen regulator to affect adipogenesis, thereby controlling obesity and metabolic syndrome. BAMBI contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467106  Cd Length: 80  Bit Score: 116.78  E-value: 1.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534   27 EIRCYCDAAHCVATGYMCKSELsACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHS-GTTIPTLECCHEDMCN 105
Cdd:cd23576   1 EIRCYCNLPECVSTGYMCKSRG-GCFSELVDSSNTSSRSTHGCLESLPNKPELCEEKLESNKKtSSKVPLLLCCKEDMCN 79


                .
gi 6912534  106 Y 106
Cdd:cd23576  80 Y 80
 
Name Accession Description Interval E-value
BAMBI_C pfam19337
BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the ...
 123-260 1.54e-95

BMP and activin membrane-bound inhibitor homolog C-terminus; This family represents the C-terminal domain of BMP and activin membrane-bound inhibitor homolog (BAMBI) which contains the transmembrane domain and a short intracellular domain that, unlike all other known TGF-beta type I or type II receptors, does not encode a serine/threonine-kinase domain. However, it shares sequence homology with the E6 and catalytic loops of receptor serine/threonine kinases. BAMBI is an essential regulator of cell proliferation and differentiation that represses transforming growth factor-beta and enhances Wnt/beta-catenin signalling in various cell types. It stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 437169  Cd Length: 138  Bit Score: 276.44  E-value: 1.54e-95
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534    123 QGNRYQHDGSRNLITKVQELTSSKELWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLQDQRQQMLSRLHYSFHGHH 202
Cdd:pfam19337   1 VGSRHQSDSNRNLITKVQELASAKEVWFRAAVIAVPIAGGLILVLLIMLALRMLRSENKRLRDQRQQMLSRLHYSFHGHH 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 6912534    203 SKKGQVAKLDLECMVPVSGHENCCLTCDKMRQADLSNDKILSLVHWGMYSGHGKLEFV 260
Cdd:pfam19337  81 AKKGAVLKLDLECMVPVGGHENCCLTCDKTRPSDLSNDGILSLVHWGMYSGHGKLEFV 138
BAMBI pfam06211
BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of ...
 4-111 5.02e-70

BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain; This family consists of several eukaryotic BMP and activin membrane-bound inhibitor (BAMBI) proteins. Members of the transforming growth factor-beta (TGF-beta) superfamily, including TGF-beta, bone morphogenetic proteins (BMPs), activins and nodals, are vital for regulating growth and differentiation. BAMBI is related to TGF-beta-family type I receptors but lacks an intracellular kinase domain. BAMBI is co-expressed with the ventralising morphogen BMP4 during Xenopus embryogenesis and requires BMP signalling for its expression. The protein stably associates with TGF-beta-family receptors and inhibits BMP and activin as well as TGF-beta signalling.


Pssm-ID: 283793  Cd Length: 107  Bit Score: 210.59  E-value: 5.02e-70
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534      4 HSSYIFIWLQLELCAMAVLLTKGEIRCYCDAAHCVATGYMCKSELSACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAK 83
Cdd:pfam06211   1 HSSLVSIWLQLELCAMAVLLTKGEIRCYCDAPHCVATGYMCKSELNACFTRLLDPQNTNSPLTHGCLDSLLNSGDICHSK 80

                          90       100
                  ....*....|....*....|....*...
gi 6912534     84 QARNHSGTTIPtLECCHEDMCNYRGLHD 111
Cdd:pfam06211  81 QAFDHSGGSAP-LECCHEDMCNYRGLHD 107
TFP_LU_ECD_BAMBI cd23576
extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and ...
 27-106 1.32e-33

extracellular domain (ECD) found in BMP and activin membrane-bound inhibitor (BAMBI) and similar proteins; BAMBI (also called non-metastatic gene A protein (NMA), or putative transmembrane protein NMA) is a transmembrane protein that acts as an important regulator of trabecular meshwork extracellular matrix and ocular hypertension. It negatively regulates the signaling activity of transforming growth factor (TGF)-beta, activin, and bone morphogenetic protein (BMP). BAMBI can function as a positive regulator of the Wnt/beta-catenin pathway to promote cell proliferation. It may be a reactive oxygen regulator to affect adipogenesis, thereby controlling obesity and metabolic syndrome. BAMBI contains an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467106  Cd Length: 80  Bit Score: 116.78  E-value: 1.32e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534   27 EIRCYCDAAHCVATGYMCKSELsACFSRLLDPQNSNSPLTHGCLDSLASTTDICQAKQARNHS-GTTIPTLECCHEDMCN 105
Cdd:cd23576   1 EIRCYCNLPECVSTGYMCKSRG-GCFSELVDSSNTSSRSTHGCLESLPNKPELCEEKLESNKKtSSKVPLLLCCKEDMCN 79


                .
gi 6912534  106 Y 106
Cdd:cd23576  80 Y 80
TFP_LU_ECD_ALK2 cd23535
extracellular domain (ECD) found in activin receptor-like kinase 2 (ALK-2) and similar ...
 28-105 3.46e-05

extracellular domain (ECD) found in activin receptor-like kinase 2 (ALK-2) and similar proteins; ALK-2 (EC 2.7.11.30, also called ACVRLK2, or activin receptor type-1 (ACVR1), or activin receptor type I (ACTR-I), or serine/threonine-protein kinase receptor R1 (SKR1), or TGF-B superfamily receptor type I (TSR-I)) is bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, ALK-2 forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A, or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, ALK-2 suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, it can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. This model corresponds to the extracellular domain (ECD) of ALK-2, which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467065  Cd Length: 71  Bit Score: 40.83  E-value: 3.46e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6912534   28 IRCYCDAAHCVATGYmCKSElsACFSRLlDPQNSNSPLTHGCLDSLASTTDICQAKQARNHSgttiptLECCHEDMCN 105
Cdd:cd23535   1 FECVCEGSSCPGGDR-CEGQ--QCFSSL-SVEDGGAVVQKGCLEGEEQGRMTCKTPPSPDLA------VECCSGHLCN 68
TFP_LU_ECD_BMPR1 cd23532
extracellular domain (ECD) found in the family of bone morphogenetic protein receptor type-1 ...
 28-106 8.80e-04

extracellular domain (ECD) found in the family of bone morphogenetic protein receptor type-1 (BMPR1); The BMPR1 family includes BMPR-1A (also known as activin receptor-like kinase 3/ALK-3, or serine/threonine-protein kinase receptor R5/SKR5, or CD292) and BMPR-1B (also known as activin receptor-like kinase 6/ALK-6, or CDw293). They form a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. BMPR-1A is the receptor for BMP2, BMP4, GDF5, and GDF6. It positively regulates chondrocyte differentiation through GDF5 interaction and mediates induction of adipogenesis by GDF6. BMPR-1B is the receptor for BMP7/OP-1 and GDF5. It positively regulates chondrocyte differentiation through GDF5 interaction. Members in this family contain an extracellular domain (ECD), which belongs to Ly-6 antigen/uPA receptor-like (LU) superfamily and exhibits a snake toxin-like fold (also known as three-finger toxin/3FTx fold or three-fingered protein/TFP domain fold).


Pssm-ID: 467062  Cd Length: 90  Bit Score: 37.71  E-value: 8.80e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912534   28 IRCYCDAaHCVATGYM--CKSEL-SACFSRLLDPQNSNSP---LTHGCLDSLASTTDICQAKQARNHSGTTIptlECC-H 100
Cdd:cd23532   1 LRCYCNP-HCPDGAVNntCTTKPgGKCFAAIEEVEDGGEKeeeVTYGCLPPEESGILQCKGHLVPHLIPKSI---ECCnD 76


                ....*.
gi 6912534  101 EDMCNY 106
Cdd:cd23532  77 SDLCND 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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