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Conserved domains on  [gi|111160500|ref|NP_036362|]
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POM121 and ZP3 fusion protein isoform 1 [Homo sapiens]

Protein Classification

zona pellucida domain-containing protein( domain architecture ID 1903244)

zona pellucida (ZP) domain-containing protein may function as a structural component of egg coats, appendicularian mucous houses, and nematode dauer larvae, or as a mechanotransducer in flies, or as a receptor in mammals and nonmammals

CATH:  2.60.40.4100|2.60.40.3210
Gene Ontology:  GO:0031012
PubMed:  15952882|29853186|20598543

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZP super family cl42957
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 77-141 1.80e-11

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


The actual alignment was detected with superfamily member smart00241:

Pssm-ID: 214579  Cd Length: 252  Bit Score: 60.86  E-value: 1.80e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111160500    77 CLVDGLTDASSAFkvPRPGPDTLQFTVDVFHFANdsRNMIYITCHLKVTLAEQDPDELNKACSFS 141
Cdd:smart00241 192 CPVDGYLDSTIPY--NSNPLHRARFSVKVFKFAD--RSLVYFHCQIRLCDKDDGSSCDGPACSSR 252
POM121 super family cl21092
POM121 family;
56-96 1.41e-04

POM121 family;


The actual alignment was detected with superfamily member pfam15229:

Pssm-ID: 464572 [Multi-domain]  Cd Length: 226  Bit Score: 41.19  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 111160500   56 KKRTVEEED-QIFLDGQENKRSClVDGLTDASSAFK-----------VPRPGP 96
Cdd:pfam15229   4 RKRTVKDEDgQSVTEGQDSKRRR-PDSSGSAQSAFRpllangvpssfVPKPGP 55
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 77-141 1.80e-11

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 60.86  E-value: 1.80e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111160500    77 CLVDGLTDASSAFkvPRPGPDTLQFTVDVFHFANdsRNMIYITCHLKVTLAEQDPDELNKACSFS 141
Cdd:smart00241 192 CPVDGYLDSTIPY--NSNPLHRARFSVKVFKFAD--RSLVYFHCQIRLCDKDDGSSCDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
65-139 9.09e-11

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 59.16  E-value: 9.09e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 111160500   65 QIFLDGqenkrsCLVDGltDASSAFKVPRPGPDT-LQFTVDVFHFANDSRNMIYITCHLKVTLAeqDPDELNKACS 139
Cdd:pfam00100 189 QLIVNG------CPNDG--DSTYPVSSLSNGPSHyVRFSFKAFRFVGSSISQVYLHCSVSVCSS--DSNSCGKSCS 254
POM121 pfam15229
POM121 family;
56-96 1.41e-04

POM121 family;


Pssm-ID: 464572 [Multi-domain]  Cd Length: 226  Bit Score: 41.19  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 111160500   56 KKRTVEEED-QIFLDGQENKRSClVDGLTDASSAFK-----------VPRPGP 96
Cdd:pfam15229   4 RKRTVKDEDgQSVTEGQDSKRRR-PDSSGSAQSAFRpllangvpssfVPKPGP 55
 
Name Accession Description Interval E-value
ZP smart00241
Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona ...
 77-141 1.80e-11

Zona pellucida (ZP) domain; ZP proteins are responsible for sperm-adhesion fo the zona pellucida. ZP domains are also present in multidomain transmembrane proteins such as glycoprotein GP2, uromodulin and TGF-beta receptor type III (betaglycan).


Pssm-ID: 214579  Cd Length: 252  Bit Score: 60.86  E-value: 1.80e-11
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 111160500    77 CLVDGLTDASSAFkvPRPGPDTLQFTVDVFHFANdsRNMIYITCHLKVTLAEQDPDELNKACSFS 141
Cdd:smart00241 192 CPVDGYLDSTIPY--NSNPLHRARFSVKVFKFAD--RSLVYFHCQIRLCDKDDGSSCDGPACSSR 252
Zona_pellucida pfam00100
Zona pellucida-like domain;
65-139 9.09e-11

Zona pellucida-like domain;


Pssm-ID: 459673 [Multi-domain]  Cd Length: 254  Bit Score: 59.16  E-value: 9.09e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 111160500   65 QIFLDGqenkrsCLVDGltDASSAFKVPRPGPDT-LQFTVDVFHFANDSRNMIYITCHLKVTLAeqDPDELNKACS 139
Cdd:pfam00100 189 QLIVNG------CPNDG--DSTYPVSSLSNGPSHyVRFSFKAFRFVGSSISQVYLHCSVSVCSS--DSNSCGKSCS 254
POM121 pfam15229
POM121 family;
56-96 1.41e-04

POM121 family;


Pssm-ID: 464572 [Multi-domain]  Cd Length: 226  Bit Score: 41.19  E-value: 1.41e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 111160500   56 KKRTVEEED-QIFLDGQENKRSClVDGLTDASSAFK-----------VPRPGP 96
Cdd:pfam15229   4 RKRTVKDEDgQSVTEGQDSKRRR-PDSSGSAQSAFRpllangvpssfVPKPGP 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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