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Conserved domains on  [gi|52630440|ref|NP_036313|]
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peptidyl-prolyl cis-trans isomerase FKBP8 isoform 1 [Homo sapiens]

Protein Classification

FKBP_C and TPR domain-containing protein( domain architecture ID 11991378)

FKBP_C and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
113-202 1.79e-22

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 90.72  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   113 GSSRPVKGQVVTVHLQTSLENGTRVQ----EEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPY 188
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDssydRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGPV 80

                          90
                  ....*....|....
gi 52630440   189 IPPHAALCLEVTLK 202
Cdd:pfam00254  81 IPPNATLVFEVELL 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
220-347 2.07e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.49  E-value: 2.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 220 ALANRkrecGNAHYQRADFVLAANSYDLAIKAITSSAKVdmtfeeeaqllqlkvkcLNNLAASQLKLDHYRAALRSCSLV 299
Cdd:COG0457  10 AYNNL----GLAYRRLGRYEEAIEDYEKALELDPDDAEA-----------------LYNLGLAYLRLGRYEEALADYEQA 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52630440 300 LEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG0457  69 LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
113-202 1.79e-22

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 90.72  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   113 GSSRPVKGQVVTVHLQTSLENGTRVQ----EEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPY 188
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDssydRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGPV 80

                          90
                  ....*....|....
gi 52630440   189 IPPHAALCLEVTLK 202
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 102-201 4.56e-13

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 64.82  E-value: 4.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 102 LRKKTLVPGppGSSRPVKGQVVTVHLQTSLENGT----RVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKY 177
Cdd:COG0545   1 LQYKVLKEG--TGAKPKAGDTVTVHYTGTLLDGTvfdsSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPEL 78

                        90       100
                ....*....|....*....|....
gi 52630440 178 CYGPQGSrSPYIPPHAALCLEVTL 201
Cdd:COG0545  79 AYGERGA-GGVIPPNSTLVFEVEL 101
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
220-347 2.07e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.49  E-value: 2.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 220 ALANRkrecGNAHYQRADFVLAANSYDLAIKAITSSAKVdmtfeeeaqllqlkvkcLNNLAASQLKLDHYRAALRSCSLV 299
Cdd:COG0457  10 AYNNL----GLAYRRLGRYEEAIEDYEKALELDPDDAEA-----------------LYNLGLAYLRLGRYEEALADYEQA 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52630440 300 LEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG0457  69 LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-353 2.54e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   236 ADFVLAANSYDLAIKAitssakvdmtFEEEAQLLQLKVKCLNNLAASQLKLDHYRA---ALRScslvLEHQPDNIKALFR 312
Cdd:TIGR02917 777 AELYLAQKDYDKAIKH----------YQTVVKKAPDNAVVLNNLAWLYLELKDPRAleyAERA----LKLAPNIPAILDT 842

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 52630440   313 KGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKK 353
Cdd:TIGR02917 843 LGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLA 883
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 278-340 4.44e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.93  E-value: 4.44e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52630440 278 NLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:cd24142   5 EKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG 67
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 307-340 7.23e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 7.23e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 52630440    307 IKALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
307-340 8.28e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 8.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 52630440   307 IKALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
113-202 1.79e-22

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 90.72  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   113 GSSRPVKGQVVTVHLQTSLENGTRVQ----EEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYGPQGSRSPY 188
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDssydRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGPV 80

                          90
                  ....*....|....
gi 52630440   189 IPPHAALCLEVTLK 202
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 102-201 4.56e-13

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 64.82  E-value: 4.56e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 102 LRKKTLVPGppGSSRPVKGQVVTVHLQTSLENGT----RVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKY 177
Cdd:COG0545   1 LQYKVLKEG--TGAKPKAGDTVTVHYTGTLLDGTvfdsSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPEL 78

                        90       100
                ....*....|....*....|....
gi 52630440 178 CYGPQGSrSPYIPPHAALCLEVTL 201
Cdd:COG0545  79 AYGERGA-GGVIPPNSTLVFEVEL 101
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
220-347 2.07e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.49  E-value: 2.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 220 ALANRkrecGNAHYQRADFVLAANSYDLAIKAITSSAKVdmtfeeeaqllqlkvkcLNNLAASQLKLDHYRAALRSCSLV 299
Cdd:COG0457  10 AYNNL----GLAYRRLGRYEEAIEDYEKALELDPDDAEA-----------------LYNLGLAYLRLGRYEEALADYEQA 68

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52630440 300 LEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG0457  69 LELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
230-347 3.60e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.10  E-value: 3.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 230 NAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEeaqllqlkvkCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKA 309
Cdd:COG0457  43 EALYNLGLAYLRLGRYEEALADYEQALELDPDDAE----------ALNNLGLALQALGRYEEALEDYDKALELDPDDAEA 112

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 52630440 310 LFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG0457 113 LYNLGLALLELGRYDEAIEAYERALELDPDDADALYNL 150
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 220-347 5.80e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.24  E-value: 5.80e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 220 ALANRKRECGNAHYQRADFVLAANSYDLAIKAITSSAKVdmtfeeeaqllqlkvkcLNNLAASQLKLDHYRAALRSCSLV 299
Cdd:COG3914  76 LLAALLELAALLLQALGRYEEALALYRRALALNPDNAEA-----------------LFNLGNLLLALGRLEEALAALRRA 138

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 52630440 300 LEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG3914 139 LALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNL 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 276-347 3.20e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 3.20e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52630440 276 LNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG4783   7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL 78
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
179-340 1.02e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.31  E-value: 1.02e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 179 YGPQGSRSPYIPPHAALCLEVTLktAVDGPDLEMLTGQERVALANRkrecGNAHYQRADFVLAANSYDLAIKAITSSAKV 258
Cdd:COG4785  36 ALAIALADLALALAAAALAAAAL--AAERIDRALALPDLAQLYYER----GVAYDSLGDYDLAIADFDQALELDPDLAEA 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 259 dmtfeeeaqllqlkvkcLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEP 338
Cdd:COG4785 110 -----------------YNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDP 172


                ..
gi 52630440 339 SN 340
Cdd:COG4785 173 ND 174
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 229-340 1.08e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 53.47  E-value: 1.08e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 229 GNAHYQRADFVLAANSYDLAIKAITSSAKVDmtfEEEAQLLqlkvkclNNLAASQLKLDHYRAALRSCSLVLEHQPDNIK 308
Cdd:COG4235  17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLD---PDNADAL-------LDLAEALLAAGDTEEAEELLERALALDPDNPE 86

                        90       100       110
                ....*....|....*....|....*....|..
gi 52630440 309 ALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:COG4235  87 ALYLLGLAAFQQGDYAEAIAAWQKLLALLPAD 118
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 231-372 1.51e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.43  E-value: 1.51e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 231 AHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKAL 310
Cdd:COG5010  12 LYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELY 91

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52630440 311 FRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNP 372
Cdd:COG5010  92 YNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 231-377 1.91e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.54  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 231 AHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKAL 310
Cdd:COG3914  36 ALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEAL 115

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 311 FRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLvkkHAAQRSTETAL--YRKMLG-NPSRLPA 377
Cdd:COG3914 116 FNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEA---LRRLGRLEEAIaaLRRALElDPDNAEA 182
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 230-373 4.57e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.96  E-value: 4.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 230 NAHYQRADFVLAANSYDLAIKaitssakvdmTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKA 309
Cdd:COG2956 111 EALRLLAEIYEQEGDWEKAIE----------VLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA 180

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52630440 310 LFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNPS 373
Cdd:COG2956 181 LLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS 244
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 227-372 5.56e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.35  E-value: 5.56e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 227 ECGNAHYQRADFVLAANSYDLAIKAITSSAKVDmtfEEEAQLLqlkvkclNNLAASQLKLDHYRAALRSCSLVLEHQPDN 306
Cdd:COG4783   2 ACAEALYALAQALLLAGDYDEAEALLEKALELD---PDNPEAF-------ALLGEILLQLGDLDEAIVLLHEALELDPDE 71

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 52630440 307 IKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALYRKMLGNP 372
Cdd:COG4783  72 PEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 233-369 7.91e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 53.19  E-value: 7.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 233 YQRADFVLAANSYDLAIKAITSSAKVDmTFEEEAQLlqlkvkclnNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFR 312
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELD-PETVEAHL---------ALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLE 81

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 52630440 313 KGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLvkkHAAQRSTETAL--YRKML 369
Cdd:COG2956  82 LAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEI---YEQEGDWEKAIevLERLL 137
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
283-369 9.01e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 9.01e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 283 QLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPiLRAALKLEPSNKTIHAELSKLvkkHAAQRSTET 362
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAEL---LLELGDYDE 77


                ....*....
gi 52630440 363 A--LYRKML 369
Cdd:COG3063  78 AlaYLERAL 86
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 278-347 9.22e-08

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.77  E-value: 9.22e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 278 NLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG4235  22 LLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLL 91
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 221-369 1.16e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 221 LANRKRECGNAHYQRADFVLAANSYDLAIKAITssakvdmtfeeeaQLLQLKVKCLN---NLAASQLKLDHYRAALRSCS 297
Cdd:COG2956 136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALE-------------KALKLDPDCARallLLAELYLEQGDYEEAIAALE 202

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52630440 298 LVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNktihAELSKLVKKHAAQRSTETA--LYRKML 369
Cdd:COG2956 203 RALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD----DLLLALADLLERKEGLEAAlaLLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 231-377 1.27e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.81  E-value: 1.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 231 AHYQRADFVLAANSYDLAIKAITSSAKVDmtfEEEAQLLQlkvkclnNLAASQLKLDHYRAALRSCSLVLEHQPDNIKAL 310
Cdd:COG2956  44 AHLALGNLYRRRGEYDRAIRIHQKLLERD---PDRAEALL-------ELAQDYLKAGLLDRAEELLEKLLELDPDDAEAL 113

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 311 FRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLvkkHAAQRSTETAL--YRKMLG-NPSRLPA 377
Cdd:COG2956 114 RLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAEL---YLEQGDYDEAIeaLEKALKlDPDCARA 180
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 231-340 1.08e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 47.88  E-value: 1.08e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 231 AHYQRADFVLAANSYDLAIKAITSSAKVDmtfEEEAQLLqlkvkclNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKAL 310
Cdd:COG4783  40 AFALLGEILLQLGDLDEAIVLLHEALELD---PDEPEAR-------LNLGLALLKAGDYDEALALLEKALKLDPEHPEAY 109

                        90       100       110
                ....*....|....*....|....*....|
gi 52630440 311 FRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:COG4783 110 LRLARAYRALGRPDEAIAALEKALELDPDD 139
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 221-377 1.09e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.73  E-value: 1.09e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 221 LANRKRECGNAHYQRADFVLAANSYDLAIKAitssakvdmtFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVL 300
Cdd:COG2956  68 LLERDPDRAEALLELAQDYLKAGLLDRAEEL----------LEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLL 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 301 EHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLvkkHAAQRSTETAL--YRKMLG-NPSRLPA 377
Cdd:COG2956 138 KLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAEL---YLEQGDYEEAIaaLERALEqDPDYLPA 214
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 231-349 1.65e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 46.52  E-value: 1.65e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 231 AHYQRADFVLAANSYDLAIKAITSSAKVDmtfeeEAQLLqlkvkclnnLAASQLKLDHYRAALRSCSLVLEHQPDNIK-- 308
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLKRYPNSPLAP-----DALYW---------LGEAYYALGDYDEAAEAFEKLLKRYPDSPKap 67

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 52630440 309 -ALFRKGKVLAQQGEYSEAIPILRAALKLEPsnKTIHAELSK 349
Cdd:COG1729  68 dALLKLGLSYLELGDYDKARATLEELIKKYP--DSEAAKEAR 107
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
276-339 2.17e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.55  E-value: 2.17e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 52630440 276 LNNLAASQLKLDHYRAALRsCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPS 339
Cdd:COG3063  29 LNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
230-365 2.37e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 48.46  E-value: 2.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 230 NAHYQRADFVLAANSYDLAIKAITSSAKVDMTFEEeaqllqlkvkCLNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKA 309
Cdd:COG0457  77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAE----------ALYNLGLALLELGRYDEAIEAYERALELDPDDADA 146

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 52630440 310 LFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTETALY 365
Cdd:COG0457 147 LYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLALLLA 202
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 236-353 2.54e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.62  E-value: 2.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   236 ADFVLAANSYDLAIKAitssakvdmtFEEEAQLLQLKVKCLNNLAASQLKLDHYRA---ALRScslvLEHQPDNIKALFR 312
Cdd:TIGR02917 777 AELYLAQKDYDKAIKH----------YQTVVKKAPDNAVVLNNLAWLYLELKDPRAleyAERA----LKLAPNIPAILDT 842

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 52630440   313 KGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKK 353
Cdd:TIGR02917 843 LGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLALALLA 883
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 291-347 2.60e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 2.60e-05
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 52630440 291 AALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDL 57
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 229-378 4.43e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 4.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   229 GNAHYQRADFVLAANSYDLAIK-------AITSSAKVDMTFEEEAQLLQL----------KVKCLNNLAASQLKLDHYRA 291
Cdd:TIGR02917 132 GLAYLGLGQLELAQKSYEQALAidprslyAKLGLAQLALAENRFDEARALidevltadpgNVDALLLKGDLLLSLGNIEL 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   292 ALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKL---EPSNKTIHAELSKLVKKHAAQRSTETALYRKm 368
Cdd:TIGR02917 212 ALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKapnSPLAHYLKALVDFQKKNYEDARETLQDALKS- 290

                         170
                  ....*....|
gi 52630440   369 lgNPSRLPAK 378
Cdd:TIGR02917 291 --APEYLPAL 298
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 278-340 4.44e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.93  E-value: 4.44e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 52630440 278 NLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:cd24142   5 EKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDG 67
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 213-377 6.43e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.97  E-value: 6.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   213 LTGQERVALANRKRECGNAHYQRADFVLAANSYDLAIKAitssaKVDMTFeeeaqllqlkvkcLNNLAASQLKLDHYRAA 292
Cdd:TIGR00990 118 LSEEERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAIEC-----KPDPVY-------------YSNRAACHNALGDWEKV 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   293 LRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRA-ALKLEPSNKTIHAELSKLVKKHAaqrstETALYRKMLGN 371
Cdd:TIGR00990 180 VEDTTAALELDPDYSKALNRRANAYDGLGKYADALLDLTAsCIIDGFRNEQSAQAVERLLKKFA-----ESKAKEILETK 254


                  ....*.
gi 52630440   372 PSRLPA 377
Cdd:TIGR00990 255 PENLPS 260
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 307-340 7.23e-05

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 39.74  E-value: 7.23e-05
                           10        20        30
                   ....*....|....*....|....*....|....
gi 52630440    307 IKALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
307-340 8.28e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 39.33  E-value: 8.28e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 52630440   307 IKALFRKGKVLAQQGEYSEAIPILRAALKLEPSN 340
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
300-347 1.23e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 43.46  E-value: 1.23e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 52630440 300 LEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAEL 347
Cdd:COG0457   1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
TPR_11 pfam13414
TPR repeat;
314-353 2.28e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 38.22  E-value: 2.28e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 52630440   314 GKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKK 353
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYK 40
TPR_19 pfam14559
Tetratricopeptide repeat;
289-350 2.74e-04

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 38.72  E-value: 2.74e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 52630440   289 YRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKL 350
Cdd:pfam14559   4 YAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLAKL 65
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 308-338 4.85e-04

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 37.12  E-value: 4.85e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 52630440   308 KALFRKGKVLAQQGEYSEAIPILRAALKLEP 338
Cdd:pfam07719   2 EALYNLGLAYYKLGDYEEALEAYEKALELDP 32
TPR_8 pfam13181
Tetratricopeptide repeat;
307-339 2.55e-03

Tetratricopeptide repeat;


Pssm-ID: 404131 [Multi-domain]  Cd Length: 33  Bit Score: 35.07  E-value: 2.55e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 52630440   307 IKALFRKGKVLAQQGEYSEAIPILRAALKLEPS 339
Cdd:pfam13181   1 AEAYYNLGLIYLKLGDYEEAKEYYEKALELDPD 33
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 221-364 2.68e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   221 LANRKRECGNAHYQRADFVLAANSYDLAIKAITSSA--KVDMTfeeEAQLLQLKVKCLNNLAASQLKLDHYraalrscsl 298
Cdd:TIGR02917 627 LLALQPDSALALLLLADAYAVMKNYAKAITSLKRALelKPDNT---EAQIGLAQLLLAAKRTESAKKIAKS--------- 694

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440   299 vLEHQPDNIKALFR-KGKVLAQQGEYSEAIPILRAALKLEPSNKTI---HAELSKLVKKHAAQRSTETAL 364
Cdd:TIGR02917 695 -LQKQHPKAALGFElEGDLYLRQKDYPAAIQAYRKALKRAPSSQNAiklHRALLASGNTAEAVKTLEAWL 763
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 282-364 2.87e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 37.28  E-value: 2.87e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 282 SQLKLDHYRAALRSCSLVLEHQPDNI---KALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQR 358
Cdd:COG1729   2 ALLKAGDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLELG 81


                ....*.
gi 52630440 359 STETAL 364
Cdd:COG1729  82 DYDKAR 87
SirB1 COG2912
Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal ...
 276-357 5.62e-03

Regulator of sirC expression, contains transglutaminase-like and TPR domains [Signal transduction mechanisms];


Pssm-ID: 442156 [Multi-domain]  Cd Length: 264  Bit Score: 38.27  E-value: 5.62e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 52630440 276 LNNLAASQLKLDHYRAALRSCSLVLEHQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSnktihAELSKLVKKHA 355
Cdd:COG2912 182 LRNLKAAYLREKDWERALRVVERLLLLDPDDPYEIRDRGLLYAQLGCYQAALEDLEYFLEQCPE-----DPDAELIKEQL 256


                ..
gi 52630440 356 AQ 357
Cdd:COG2912 257 EE 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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