NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6912278|ref|NP_036203|]
View 

COMM domain-containing protein 3 [Homo sapiens]

Protein Classification

COMM domain-containing protein 3( domain architecture ID 10140830)

COMM domain-containing protein 3 (COMMD3) may modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes, down-regulate activation of NF-kappa-B, and modulate Na(+) transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits

Gene Symbol:  COMMD3
Gene Ontology:  GO:0006814
PubMed:  15799966
SCOP:  4005215

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 98-194 7.89e-44

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


:

Pssm-ID: 240099  Cd Length: 95  Bit Score: 141.33  E-value: 7.89e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912278   98 ELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDspSYPEISFSCSMEQLQD 177
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGE--NKPDINFTCTLEQLQD 78

                        90
                ....*....|....*..
gi 6912278  178 LVGKLKDASKSLERATQ 194
Cdd:cd04751  79 LVNKLKDAAKNIERAAQ 95
 
Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 98-194 7.89e-44

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 141.33  E-value: 7.89e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912278   98 ELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDspSYPEISFSCSMEQLQD 177
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGE--NKPDINFTCTLEQLQD 78

                        90
                ....*....|....*..
gi 6912278  178 LVGKLKDASKSLERATQ 194
Cdd:cd04751  79 LVNKLKDAAKNIERAAQ 95
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 121-185 1.12e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 65.65  E-value: 1.12e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6912278    121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSyPEISFSCSMEQLQDLVGKLKDA 185
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSS-EEVTFELSKEQLQDLLNELEEA 64
 
Name Accession Description Interval E-value
Commd3 cd04751
COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of ...
 98-194 7.89e-44

COMM_Domain containing protein 3. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240099  Cd Length: 95  Bit Score: 141.33  E-value: 7.89e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912278   98 ELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDspSYPEISFSCSMEQLQD 177
Cdd:cd04751   1 EIFAKQYQKKKEVLENKLKSIGISFPHITDVNWRLDYVVSSKHLGKVNQPIYLIQLSTENGE--NKPDINFTCTLEQLQD 78

                        90
                ....*....|....*..
gi 6912278  178 LVGKLKDASKSLERATQ 194
Cdd:cd04751  79 LVNKLKDAAKNIERAAQ 95
Commd cd04748
COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene ...
 104-189 3.63e-15

COMM_Domain, a family of domains found at the C-terminus of HCarG, the copper metabolism gene MURR1 product, and related proteins. Presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB. Murr1/Commd1 is a protein involved in copper homeostasis, which has also been identified as a regulator of the human delta epithelial sodium channel. HCaRG, a nuclear protein that might be involved in cell proliferation, is negatively regulated by extracellular calcium concentration, and its basal mRNA levels are higher in hypertensive animals.


Pssm-ID: 240096  Cd Length: 87  Bit Score: 67.33  E-value: 3.63e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912278  104 YQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVGKLK 183
Cdd:cd04748   2 LTENKAEIEELLSKQSLSLPQLVDFDWRLDVQISSSSLAKVKQPTILVQLKLQVGDNNSSEKICFEMTKEELQNFLNKLK 81


                ....*.
gi 6912278  184 DASKSL 189
Cdd:cd04748  82 KIKAQL 87
COMM_domain pfam07258
COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a ...
 121-185 1.12e-14

COMM domain; The leucine-rich, 70-85 amino acid long COMM domain is predicted to form a beta-sheet and an extreme C-terminal alpha- helix. The COMM domain containing proteins are about 200 residues in length and passed the C-terminal COMM domain.


Pssm-ID: 462125  Cd Length: 64  Bit Score: 65.65  E-value: 1.12e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6912278    121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDSPSyPEISFSCSMEQLQDLVGKLKDA 185
Cdd:pfam07258   1 SLPQLVDLDWRLDVQLSSSSLSKVNEPVVLLELKLSDGDGSS-EEVTFELSKEQLQDLLNELEEA 64
Commd4 cd04752
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of ...
 65-185 1.30e-09

COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240100 [Multi-domain]  Cd Length: 174  Bit Score: 54.74  E-value: 1.30e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912278   65 AAATYIL-EAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHR 143
Cdd:cd04752  46 AVLSFILsSAAKYNVDGESLSSELQQLGLPKEHATSLCRSYEEKQSKLQESLRANSLRLSRLESVDWRVDYILSSSELQE 125

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6912278  144 MYRPAYLVTLSVQNTDSPSYPEISFSCSMEQLQDLVGKLKDA 185
Cdd:cd04752 126 VNEPLVQLRLKVRNADTGEITPHPFSVSADKFRVLLAELKQA 167
Commd2 cd04750
COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of ...
 66-153 3.52e-06

COMM_Domain containing protein 2. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240098 [Multi-domain]  Cd Length: 166  Bit Score: 45.00  E-value: 3.52e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6912278   66 AATYIL-EAGKHRADKSTLSTYLEDCKFDRERIELFCTEYQNNKNSLEILLGSIGRSLPHITDVSWRLEYQIKTNQLHRM 144
Cdd:cd04750  39 ALVYLLiESTKLKLSERDFQDSIEFLGFSDDLNEILLQLYESNRKEIRNILKELSPDLPHYHNLEWRLDVQIASRSLRSQ 118


                ....*....
gi 6912278  145 YRPAYLVTL 153
Cdd:cd04750 119 VKPVITMKL 127
Commd9 cd04757
COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of ...
 121-184 3.01e-04

COMM_Domain containing protein 9. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.


Pssm-ID: 240105  Cd Length: 108  Bit Score: 38.70  E-value: 3.01e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6912278  121 SLPHITDVSWRLEYQIKTNQLHRMYRPAYLVTLSVQNTDS-----PSYPEISFSCSMEQLQDLV---GKLKD 184
Cdd:cd04757  30 SLPKLVDHDWRVDIKTSSDSLGRMAVPTCLLQMKIQEAPSlcgllPPLSTLTMELSKETLDTMLdglGRIRD 101
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH