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Conserved domains on  [gi|213385289|ref|NP_036071|]
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mitogen-activated protein kinase-binding protein 1 isoform 2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-729 3.68e-37

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 3.68e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  291 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 370
Cdd:COG2319    96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  371 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 449
Cdd:COG2319   152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  450 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 529
Cdd:COG2319   200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  530 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 609
Cdd:COG2319   258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  610 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 689
Cdd:COG2319   301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 213385289  690 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-422 4.90e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  242 RGEKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLHFLST 310
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  311 LpRPHalgtdiasiteasrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 390
Cdd:cd00200   215 L-RGH----------------ENGVN-------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 213385289  391 EVYPEIKDshqaclppssFITCSSDNTIRLWN 422
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.38e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 213385289   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200   222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-729 3.68e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 3.68e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  291 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 370
Cdd:COG2319    96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  371 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 449
Cdd:COG2319   152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  450 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 529
Cdd:COG2319   200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  530 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 609
Cdd:COG2319   258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  610 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 689
Cdd:COG2319   301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 213385289  690 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-422 4.90e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  242 RGEKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLHFLST 310
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  311 LpRPHalgtdiasiteasrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 390
Cdd:cd00200   215 L-RGH----------------ENGVN-------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 213385289  391 EVYPEIKDshqaclppssFITCSSDNTIRLWN 422
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-726 1.26e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 1.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  344 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWN 422
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  423 TESSGVHgSTLHrnilsndlikiiyvdgntqalldtelpgGDKADgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHE 502
Cdd:cd00200    80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  503 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 582
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  583 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 662
Cdd:cd00200   196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 213385289  663 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 726
Cdd:cd00200   226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 687-725 2.46e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.46e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 213385289    687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
688-725 6.92e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 6.92e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 213385289   688 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.38e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 213385289   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200   222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-121 3.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.47e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 213385289     80 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 121
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 117-207 3.51e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  117 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 196
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                          90
                  ....*....|.
gi 213385289  197 GNRHIKFWYLD 207
Cdd:PLN00181  636 GSADHKVYYYD 646
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 73-151 6.98e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.26  E-value: 6.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289    73 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAERSQVAElQEHKYGVACvAFSPSAKYIV 151
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 94-150 9.66e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 9.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 213385289   94 ITALAFSPDGKYLVTGESG--HMPAVRVWDVAERSQVaELQEHKYGVACVAFSPSAKYI 150
Cdd:COG4946   434 ISDLAWSPDSKWLAYSKPGpnQLSQIFLYDVETGKTV-QLTDGRYDDGSPAFSPDGKYL 491
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
291-729 3.68e-37

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.44  E-value: 3.68e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  291 GCADGTVRLFNPSNLHFLSTLpRPHalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRD 370
Cdd:COG2319    96 ASADGTVRLWDLATGLLLRTL-TGH----------------TGAVRS-------VAFSPDGKTLASGSADGTVRLWDLAT 151

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  371 PKKVGKVYSalyHSSCVWSVevypeikdshqACLPPSSFI-TCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvd 449
Cdd:COG2319   152 GKLLRTLTG---HSGAVTSV-----------AFSPDGKLLaSGSDDGTVRLWDLAT----GKLLRT-------------- 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  450 gntqalldteLPGGDKAdgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDt 529
Cdd:COG2319   200 ----------LTGHTGA----------VRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFS-PD- 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  530 GlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGqvrmiscgadksiyfrtaqksgegvqftrthhvv 609
Cdd:COG2319   258 G-RLLASGSADGTVRLWDL-ATGELLRTLTGHSGGVNSVAFSP-DG---------------------------------- 300

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  610 rkttlydmdvepswKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTlikVQTDPSGIYIATSCSDKNLSIFDFSSGE 689
Cdd:COG2319   301 --------------KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS---VAFSPDGKTLASGSDDGTVRLWDLATGE 363

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 213385289  690 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   364 LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
16-505 5.66e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 136.19  E-value: 5.66e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   16 LLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSG-LVAYPAGCVVVLFNPRKHKQHHILNSSRKTI 94
Cdd:COG2319    44 ASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRlLASASADGTVRLWDLATGLLLRTLTGHTGAV 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   95 TALAFSPDGKYLVTGESGHmpAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVWAWKKNIVVAS 174
Cdd:COG2319   124 RSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSD--DGTVRLWDLATGKLLRT 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  175 -NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWyldDSKTSKVNATVPllGRSGLLgelrnnlfTDVAcgrgekadstfci 252
Cdd:COG2319   200 lTGHTGAVRSVAFSPDGKLLASGSaDGTVRLW---DLATGKLLRTLT--GHSGSV--------RSVA------------- 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  253 tssgllceFS-DRRLLdkwvelrttvahcisVTqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlf 331
Cdd:COG2319   254 --------FSpDGRLL---------------AS------GSADGTVRLWDLATGELLRTLTGH----------------- 287

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  332 SGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDSHQaclppssFIT 411
Cdd:COG2319   288 SGGVN-------SVAFSPDGKLLASGSDDGTVRLWDLATGKLL-RTLTG--HTGAVRSVAFSP---DGKT-------LAS 347

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  412 CSSDNTIRLWNTESSGvhgstlhrnilsndlikiiyvdgntqalLDTELPGGDKAdgslmdprvgIRSVCISPNGQHLAS 491
Cdd:COG2319   348 GSDDGTVRLWDLATGE----------------------------LLRTLTGHTGA----------VTSVAFSPDGRTLAS 389

                         490
                  ....*....|....
gi 213385289  492 GDRMGTLRIHELQS 505
Cdd:COG2319   390 GSADGTVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
25-548 7.71e-34

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 135.81  E-value: 7.71e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   25 RRSKAGNRREDLSSKVTLEKVLGVTVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGK 104
Cdd:COG2319    12 ASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGR 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  105 YLVTGesGHMPAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHdmIVNVWAWKKNIVVAS-NKVSSRVTA 183
Cdd:COG2319    92 LLASA--SADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADG--TVRLWDLATGKLLRTlTGHSGAVTS 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  184 VSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGLLgelrnnlfTDVAcgrgekadstfcitssgllceFS 262
Cdd:COG2319   168 VAFSPDGKLLASGSdDGTVRLWDLATGKLLRT-----LTGHTGAV--------RSVA---------------------FS 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  263 -DRRLLdkwvelrttvahcisvtqeyiFCGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNarypd 341
Cdd:COG2319   214 pDGKLL---------------------ASGSADGTVRLWDLATGKLLRTLTGH-----------------SGSVR----- 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  342 tiALTFDPTNQWLSCVYNDHSIYVWDVRDPKkvgKVYSALYHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLW 421
Cdd:COG2319   251 --SVAFSPDGRLLASGSADGTVRLWDLATGE---LLRTLTGHSGGVNSVAFSP---DGKL-------LASGSDDGTVRLW 315

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  422 NTESsgvhGSTLHrnilsndlikiiyvdgntqalldtelpggdkadgSLMDPRVGIRSVCISPNGQHLASGDRMGTLRIH 501
Cdd:COG2319   316 DLAT----GKLLR----------------------------------TLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*..
gi 213385289  502 ELQSLSEMLKVEAHDSEILCLEYSkPDtGlKLLASASRDRLIHVLDA 548
Cdd:COG2319   358 DLATGELLRTLTGHTGAVTSVAFS-PD-G-RTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
413-749 2.68e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 134.27  E-value: 2.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  413 SSDNTIRLWNTES-------SGVHGSTLHRNILSNDLIKIIYVDGNTQALLDTElpgGDKADGSLMDPRVGIRSVCISPN 485
Cdd:COG2319    55 AGDLTLLLLDAAAgallatlLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLA---TGLLLRTLTGHTGAVRSVAFSPD 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  486 GQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDtGlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSI 565
Cdd:COG2319   132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFS-PD-G-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAV 207

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  566 TAVKFAAsDGQvRMISCGADKSIYFRTAQkSGEGVQFTRTHHvvrkTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQ 645
Cdd:COG2319   208 RSVAFSP-DGK-LLASGSADGTVRLWDLA-TGKLLRTLTGHS----GSVRSVAFSPDGRLLASGSADGTVRLWDLATGEL 280

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  646 KKLFKgsqGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:COG2319   281 LRTLT---GHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357

                         330       340
                  ....*....|....*....|....
gi 213385289  726 RLSSemtismRQRLAELRQRQRGI 749
Cdd:COG2319   358 DLAT------GELLRTLTGHTGAV 375
WD40 COG2319
WD40 repeat [General function prediction only];
83-588 1.20e-32

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 132.34  E-value: 1.20e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   83 QHHILNSSRKTITALAFSPDGKYLVTGESGHmpAVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVN 162
Cdd:COG2319    28 LLLLLLGLAAAVASLAASPDGARLAAGAGDL--TLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASA--DGTVR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  163 VWAWK-KNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRH-IKFWyldDSKTSKVNATvpLLGRSGLLgelrnnlfTDVAc 240
Cdd:COG2319   104 LWDLAtGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGtVRLW---DLATGKLLRT--LTGHSGAV--------TSVA- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  241 grgekadstfcitssgllceFS-DRRLLdkwvelrttvahcisVTqeyifcGCADGTVRLFNPSNLHFLSTLPRPhalgt 319
Cdd:COG2319   170 --------------------FSpDGKLL---------------AS------GSDDGTVRLWDLATGKLLRTLTGH----- 203

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  320 diasiteasrlfSGGVNArypdtiaLTFDPTNQWLSCVYNDHSIYVWDVRDPKKVgKVYSAlyHSSCVWSVEVYPeikDS 399
Cdd:COG2319   204 ------------TGAVRS-------VAFSPDGKLLASGSADGTVRLWDLATGKLL-RTLTG--HSGSVRSVAFSP---DG 258

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  400 HQaclppssFITCSSDNTIRLWNTESsgvhGSTLHRnilsndlikiiyvdgntqalldtelpggdkadgsLMDPRVGIRS 479
Cdd:COG2319   259 RL-------LASGSADGTVRLWDLAT----GELLRT----------------------------------LTGHSGGVNS 293

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  480 VCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAgREYSLQQTLD 559
Cdd:COG2319   294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS-PDG--KTLASGSDDGTVRLWDL-ATGELLRTLT 369

                         490       500
                  ....*....|....*....|....*....
gi 213385289  560 EHSSSITAVKFAAsDGQvRMISCGADKSI 588
Cdd:COG2319   370 GHTGAVTSVAFSP-DGR-TLASGSADGTV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 84-422 4.90e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 127.45  E-value: 4.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   84 HHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNV 163
Cdd:cd00200     2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGT--IKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSS--DKTIRL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  164 WAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAG-NRHIKFWYLDDSKTSKVnatvpLLGRSGllgelrnnlftDVACG 241
Cdd:cd00200    78 WDLETGECVRTlTGHTSYVSSVAFSPDGRILSSSSrDKTIKVWDVETGKCLTT-----LRGHTD-----------WVNSV 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  242 RGEKaDSTFcITSSGllcefSDR--RL--LDKWVELRTTVAH-------CISVTQEYIFCGCADGTVRLFNPSNLHFLST 310
Cdd:cd00200   142 AFSP-DGTF-VASSS-----QDGtiKLwdLRTGKCVATLTGHtgevnsvAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGT 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  311 LpRPHalgtdiasiteasrlfSGGVNarypdtiALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSV 390
Cdd:cd00200   215 L-RGH----------------ENGVN-------SVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSG---HTNSVTSL 267

                         330       340       350
                  ....*....|....*....|....*....|..
gi 213385289  391 EVYPEIKDshqaclppssFITCSSDNTIRLWN 422
Cdd:cd00200   268 AWSPDGKR----------LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 344-726 1.26e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 126.30  E-value: 1.26e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  344 ALTFDPTNQWLSCVYNDHSIYVWDVRDpkkvGKVYSALY-HSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWN 422
Cdd:cd00200    14 CVAFSPDGKLLATGSGDGTIKVWDLET----GELLRTLKgHTGPVRDVAASA---DGTY-------LASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  423 TESSGVHgSTLHrnilsndlikiiyvdgntqalldtelpgGDKADgslmdprvgIRSVCISPNGQHLASGDRMGTLRIHE 502
Cdd:cd00200    80 LETGECV-RTLT----------------------------GHTSY---------VSSVAFSPDGRILSSSSRDKTIKVWD 121

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  503 LQSLSEMLKVEAHDSEILCLEYSKPDTglkLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFaaSDGQVRMISC 582
Cdd:cd00200   122 VETGKCLTTLRGHTDWVNSVAFSPDGT---FVASSSQDGTIKLWDL-RTGKCVATLTGHTGEVNSVAF--SPDGEKLLSS 195

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  583 GADKSIyfrtaqksgegvqftrthhvvrkttlydmdvepswkytaigcqdrniRIFNISSGKQKKLFkgsQGEDGTLIKV 662
Cdd:cd00200   196 SSDGTI-----------------------------------------------KLWDLSTGKCLGTL---RGHENGVNSV 225

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 213385289  663 QTDPSGiYIATSCS-DKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWR 726
Cdd:cd00200   226 AFSPDG-YLLASGSeDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 476-730 1.01e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 1.01e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  476 GIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEAHDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREYSLQ 555
Cdd:cd00200    11 GVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAAS-ADG--TYLASGSSDKTIRLWDLETGECVR 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  556 qTLDEHSSSITAVKFAASDgqvRMI-SCGADKSIYFRTAQkSGEGVQFTRTHhvvrKTTLYDMDVEPSWKYTAIGCQDRN 634
Cdd:cd00200    88 -TLTGHTSYVSSVAFSPDG---RILsSSSRDKTIKVWDVE-TGKCLTTLRGH----TDWVNSVAFSPDGTFVASSSQDGT 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  635 IRIFNISSGKQKKLFKGSQGEdgtLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLI 714
Cdd:cd00200   159 IKLWDLRTGKCVATLTGHTGE---VNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLA 235

                         250
                  ....*....|....*.
gi 213385289  715 SVSGDSCIFVWRLSSE 730
Cdd:cd00200   236 SGSEDGTIRVWDLRTG 251
WD40 COG2319
WD40 repeat [General function prediction only];
116-642 4.80e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.56  E-value: 4.80e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  116 AVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDmIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVT 195
Cdd:COG2319    17 ALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLT-LLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLAS 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  196 AGNRH-IKFWYLDDSKTskvnaTVPLLGRSGllgelrnnlftdvacgrgekadstfcitssgllcefsdrrlldkWVelr 274
Cdd:COG2319    96 ASADGtVRLWDLATGLL-----LRTLTGHTG--------------------------------------------AV--- 123

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  275 TTVAhcISVTQEYIFCGCADGTVRLFNPSNLHFLSTLPRPhalgtdiasiteasrlfSGGVNArypdtiaLTFDPTNQWL 354
Cdd:COG2319   124 RSVA--FSPDGKTLASGSADGTVRLWDLATGKLLRTLTGH-----------------SGAVTS-------VAFSPDGKLL 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  355 SCVYNDHSIYVWDVRDPKKVGKVYSalyHSSCVWSVEVYPeikDSHQaclppssFITCSSDNTIRLWNTEssgvhgstlh 434
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTG---HTGAVRSVAFSP---DGKL-------LASGSADGTVRLWDLA---------- 234

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  435 rnilsndlikiiyvdgnTQALLDTelpggdkadgsLMDPRVGIRSVCISPNGQHLASGDRMGTLRIHELQSLSEMLKVEA 514
Cdd:COG2319   235 -----------------TGKLLRT-----------LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTG 286

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  515 HDSEILCLEYSkPDtGlKLLASASRDRLIHVLDAgREYSLQQTLDEHSSSITAVKFAAsDGQvRMISCGADKSIYFRTAQ 594
Cdd:COG2319   287 HSGGVNSVAFS-PD-G-KLLASGSDDGTVRLWDL-ATGKLLRTLTGHTGAVRSVAFSP-DGK-TLASGSDDGTVRLWDLA 360

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 213385289  595 KSGEGVQFTRTHHVVrkttlYDMDVEPSWKYTAIGCQDRNIRIFNISS 642
Cdd:COG2319   361 TGELLRTLTGHTGAV-----TSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 515-733 4.68e-27

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 112.81  E-value: 4.68e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  515 HDSEILCLEYSkPDTglKLLASASRDRLIHVLDAGREySLQQTLDEHSSSITAVKFAASDGQvrMISCGADKSIYFRTAQ 594
Cdd:cd00200     8 HTGGVTCVAFS-PDG--KLLATGSGDGTIKVWDLETG-ELLRTLKGHTGPVRDVAASADGTY--LASGSSDKTIRLWDLE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  595 KSGEGVQFTrtHHvvrKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGedgTLIKVQTDPSGIYIATS 674
Cdd:cd00200    82 TGECVRTLT--GH---TSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD---WVNSVAFSPDGTFVASS 153

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 213385289  675 CSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTI 733
Cdd:cd00200   154 SQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-204 6.42e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.91  E-value: 6.42e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   75 LFNPRKHKQHHILNSSRKTITALAFSPDG-KYLVTGESGHmpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSV 153
Cdd:cd00200   161 LWDLRTGKCVATLTGHTGEVNSVAFSPDGeKLLSSSSDGT---IKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 213385289  154 GyqHDMIVNVWAWKKNIVVAS-NKVSSRVTAVSFSEDCSYFVTAGNRH-IKFW 204
Cdd:cd00200   238 S--EDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGtIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-165 2.85e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.98  E-value: 2.85e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   75 LFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSV 153
Cdd:cd00200   203 LWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGsEDGT---IRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASG 279

                          90
                  ....*....|..
gi 213385289  154 GyqHDMIVNVWA 165
Cdd:cd00200   280 S--ADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
533-729 2.80e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 70.33  E-value: 2.80e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  533 LLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAvkfAASDGQVRMISCGADKSIYFRTAQKSGEGVQFTRTHHVVRKT 612
Cdd:COG2319     8 ALAAASADLALALLAAALGALLLLLLGLAAAVASL---AASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSV 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  613 TlydmdVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFkgsQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVA 692
Cdd:COG2319    85 A-----FSPDGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLR 156

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 213385289  693 TMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSS 729
Cdd:COG2319   157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 73-219 2.16e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 2.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289   73 VVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVS 152
Cdd:cd00200   117 IKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGT--IKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  153 VGyqHDMIVNVWAWKKNIVVASNKV-SSRVTAVSFSEDcSYFVTAG--NRHIKFWyldDSKTSKVNATVP 219
Cdd:cd00200   195 SS--SDGTIKLWDLSTGKCLGTLRGhENGVNSVAFSPD-GYLLASGseDGTIRVW---DLRTGECVQTLS 258
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 687-725 2.46e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.46  E-value: 2.46e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 213385289    687 SGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
688-725 6.92e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 6.92e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 213385289   688 GECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVW 725
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 45-121 2.38e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 45.02  E-value: 2.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 213385289   45 VLGVTVSGGRGLacdprsgLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:cd00200   222 VNSVAFSPDGYL-------LASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGT--IRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 80-121 3.47e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 3.47e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 213385289     80 KHKQHHILNSSRKTITALAFSPDGKYLVTG-ESGHmpaVRVWD 121
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGsDDGT---IKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 117-207 3.51e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 45.08  E-value: 3.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289  117 VRVWDVAERSQVAELQEHKYGVACVAFSPSAKYIVSVGyQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTA 196
Cdd:PLN00181  557 VQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASG-SDDGSVKLWSINQGVSIGTIKTKANICCVQFPSESGRSLAF 635

                          90
                  ....*....|.
gi 213385289  197 GNRHIKFWYLD 207
Cdd:PLN00181  636 GSADHKVYYYD 646
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 73-151 6.98e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 42.26  E-value: 6.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 213385289    73 VVLFNPRKHKQHHILNSSRKTItalAFSPDGKYLVTGESGHMP-AVRVWDVAERSQVAElQEHKYGVACvAFSPSAKYIV 151
Cdd:pfam08662   85 VSFFDLKGNVIHSFGEQPRNTI---FWSPFGRLVLLAGFGNLAgDIEFWDVVNKKKIAT-AEASNATLC-EWSPDGRYFL 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 125-164 7.34e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 7.34e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 213385289    125 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 164
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSD--DGTIKLW 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 690-730 9.56e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 43.09  E-value: 9.56e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 213385289  690 CVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSE 730
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETG 41
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 94-150 9.66e-04

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 43.87  E-value: 9.66e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 213385289   94 ITALAFSPDGKYLVTGESG--HMPAVRVWDVAERSQVaELQEHKYGVACVAFSPSAKYI 150
Cdd:COG4946   434 ISDLAWSPDSKWLAYSKPGpnQLSQIFLYDVETGKTV-QLTDGRYDDGSPAFSPDGKYL 491
WD40 pfam00400
WD domain, G-beta repeat;
82-121 1.97e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 37.32  E-value: 1.97e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 213385289    82 KQHHILNSSRKTITALAFSPDGKYLVTGESGHMpaVRVWD 121
Cdd:pfam00400    2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGT--VKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
125-164 6.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 6.06e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 213385289   125 RSQVAELQEHKYGVACVAFSPSAKYIVSVGYqhDMIVNVW 164
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSD--DGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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