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Conserved domains on  [gi|6755773|ref|NP_035705|]
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trefoil factor 3 precursor [Mus musculus]

Protein Classification

Trefoil domain-containing protein( domain architecture ID 10635785)

Trefoil domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 32-76 1.82e-16

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


:

Pssm-ID: 197472  Cd Length: 46  Bit Score: 65.87  E-value: 1.82e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6755773     32 QCMVPANVRVDCGYPSVTSEQCNNRGCCFDSSIPNVPWCFKPLQE 76
Cdd:smart00018  2 QCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
 
Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 32-76 1.82e-16

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 65.87  E-value: 1.82e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6755773     32 QCMVPANVRVDCGYPSVTSEQCNNRGCCFDSSIPNVPWCFKPLQE 76
Cdd:smart00018  2 QCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 32-73 6.05e-16

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 64.67  E-value: 6.05e-16
                       10        20        30        40
               ....*....|....*....|....*....|....*....|..
gi 6755773  32 QCMVPANVRVDCGYPSVTSEQCNNRGCCFDSSIPNVPWCFKP 73
Cdd:cd00111  2 WCSVPPSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
35-73 1.67e-12

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 55.79  E-value: 1.67e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 6755773    35 VPANVRVDCGYPSVTSEQCNNRGCCFDSSI-PNVPWCFKP 73
Cdd:pfam00088  4 VPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
 
Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 32-76 1.82e-16

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 65.87  E-value: 1.82e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 6755773     32 QCMVPANVRVDCGYPSVTSEQCNNRGCCFDSSIPNVPWCFKPLQE 76
Cdd:smart00018  2 QCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 32-73 6.05e-16

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 64.67  E-value: 6.05e-16
                       10        20        30        40
               ....*....|....*....|....*....|....*....|..
gi 6755773  32 QCMVPANVRVDCGYPSVTSEQCNNRGCCFDSSIPNVPWCFKP 73
Cdd:cd00111  2 WCSVPPSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
35-73 1.67e-12

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 55.79  E-value: 1.67e-12
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 6755773    35 VPANVRVDCGYPSVTSEQCNNRGCCFDSSI-PNVPWCFKP 73
Cdd:pfam00088  4 VPPSDRFDCGYPGITQEECEARGCCWDPSVdPGVPWCFYP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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