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Conserved domains on  [gi|114326469|ref|NP_035059|]
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neurogenic locus notch homolog protein 4 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1614-1818 1.04e-39

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1693
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1694 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1773
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1774 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1818
Cdd:COG0666   231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1437-1511 8.37e-25

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411988  Cd Length: 92  Bit Score: 100.16  E-value: 8.37e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114326469 1437 SANQLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKALK 1511
Cdd:cd21705    20 VAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGEDAIGLKPLK 92
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1253-1281 1.46e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.46e-08
                           10        20
                   ....*....|....*....|....*....
gi 114326469  1253 QYCRDHFHNGHCEKGCNNAECGWDGGDCR 1281
Cdd:pfam00066    7 PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-470 6.12e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 6.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 114326469  429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE 470
Cdd:cd00054     1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-584 1.81e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114326469  548 DMDECSST-PCANGGRCRDQPGAFYCECLPGFEGPHCE 584
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-350 4.56e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 114326469  311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGWGGAGCE 350
Cdd:cd00054     1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 6.91e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 6.91e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 114326469  1207 WKGCPPhSQCWLLFRDGRCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCPY-PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-546 1.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.38e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  511 VNECTS-NPCLNQAACHDLLNGFQCLCLPGFTGARCE 546
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
191-222 1.49e-06

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 114326469   191 DINECFLEPGPCPQGTSCHNTLGSYQCLCPVG 222
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 114326469  966 DACQSQ-PCHNHGTCTSRPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 926-961 5.72e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYEGQNC 961
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 587-622 1.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  587 VDECLS-DPCPVGASCLDLPGAFFCLCRPGFTGQLCE 622
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 472-508 3.66e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.66e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114326469  472 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGRLCE 508
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-800 3.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQGLHCE 800
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 892-924 1.58e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 114326469  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQ 924
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1002-1040 5.40e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 114326469 1002 DVDECLDR-PCHPSGTaaCHSLANAFYCQCLPGHTGQRCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-723 7.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....*...
gi 114326469  696 PCAHGGTCHPQPSGYNCTCPAGYMGLTC 723
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD super family cl08449
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 1.19e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


The actual alignment was detected with superfamily member pfam06816:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 38.65  E-value: 1.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 114326469  1291 PSLAL----LVVLRPPaldQQLLALA----RVLSLTLRVGLWVRKDSEGRNMVFPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDP---EELLNNSvqflRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.72e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  352 NLDDCAAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLC 387
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-839 3.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.24e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 114326469  810 SPCRNKATCQDTPRGARCLCSPGYTGSSCQ 839
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP super family cl06639
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1415 3.62e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


The actual alignment was detected with superfamily member pfam07684:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 37.64  E-value: 3.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 114326469  1375 AGFVVVMGVDLSRCGPEHpaSRCPWDSGLLLRFLAAMAAVG 1415
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKG 40
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-189 8.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 114326469  158 SANPCANGGVCLATYPQIQCRCPPGFEGHTCE 189
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1614-1818 1.04e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1693
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1694 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1773
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1774 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1818
Cdd:COG0666   231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1437-1511 8.37e-25

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 100.16  E-value: 8.37e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114326469 1437 SANQLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKALK 1511
Cdd:cd21705    20 VAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGEDAIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1633-1726 4.50e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469  1633 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDartEDGTTPLMLAARLAVEDLV 1712
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 114326469  1713 EELIAARADVGARD 1726
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1606-1786 1.91e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.64  E-value: 1.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1606 GNLEPWEPLLDRGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASR 1685
Cdd:PHA02875   13 GELDIARRLLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1686 QTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTP 1765
Cdd:PHA02875   92 KFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTP 171

                         170       180
                  ....*....|....*....|.
gi 114326469 1766 LFLAAREGAVEVAQLLLELGA 1786
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGA 192
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1253-1281 1.46e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.46e-08
                           10        20
                   ....*....|....*....|....*....
gi 114326469  1253 QYCRDHFHNGHCEKGCNNAECGWDGGDCR 1281
Cdd:pfam00066    7 PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-470 6.12e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 6.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 114326469  429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE 470
Cdd:cd00054     1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-584 1.81e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114326469  548 DMDECSST-PCANGGRCRDQPGAFYCECLPGFEGPHCE 584
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1252-1280 2.43e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 2.43e-07
                            10        20
                    ....*....|....*....|....*....
gi 114326469   1252 DQYCRDHFHNGHCEKGCNNAECGWDGGDC 1280
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
429-470 3.52e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.52e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 114326469    429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYT-GSRCE 470
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-350 4.56e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 114326469  311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGWGGAGCE 350
Cdd:cd00054     1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1629-1734 5.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1629 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHTAVAADAREVCQLLLASRQTTVDARTED------ 1695
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 114326469 1696 -------GTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALH 1734
Cdd:cd22192   129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 6.91e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 6.91e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 114326469  1207 WKGCPPhSQCWLLFRDGRCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCPY-PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1203-1241 1.04e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 46.94  E-value: 1.04e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469   1203 VPDPWKGCPpHSQCWLLFRDGRCHPQCDSEECLFDGYDC 1241
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-546 1.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.38e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  511 VNECTS-NPCLNQAACHDLLNGFQCLCLPGFTGARCE 546
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
191-222 1.49e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 114326469   191 DINECFLEPGPCPQGTSCHNTLGSYQCLCPVG 222
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
311-350 3.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 114326469    311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGW-GGAGCE 350
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 114326469  966 DACQSQ-PCHNHGTCTSRPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
548-584 3.85e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.85e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    548 DMDECSST-PCANGGRCRDQPGAFYCECLPGFE-GPHCE 584
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 926-961 5.72e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYEGQNC 961
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
191-229 9.21e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.21e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114326469    191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVG-QEGPQCK 229
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 587-622 1.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  587 VDECLS-DPCPVGASCLDLPGAFFCLCRPGFTGQLCE 622
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 191-229 1.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 114326469  191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCK 229
Cdd:cd00054     1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-546 3.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    510 EVNECTS-NPCLNQAACHDLLNGFQCLCLPGFT-GARCE 546
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 472-508 3.66e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.66e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114326469  472 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGRLCE 508
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-800 3.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQGLHCE 800
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
926-961 1.04e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 114326469    926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYE-GQNC 961
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 892-924 1.58e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 114326469  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQ 924
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 2.49e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   968 CQSQPCHNHGTCTSRPGGFHCACPPGFVGLR 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1000 3.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.67e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 114326469    966 DACQS-QPCHNHGTCTSRPGGFHCACPPGFV-GLRCE 1000
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
311-343 3.77e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 3.77e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 114326469   311 DIDECeARGPPRCRNGGTCQNTAGSFHCVCVSG 343
Cdd:pfam07645    1 DVDEC-ATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 930-960 4.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.96e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   930 CEPNPCHHGSTCVPQPSGYVCQCAPGYEGQN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1002-1040 5.40e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 114326469 1002 DVDECLDR-PCHPSGTaaCHSLANAFYCQCLPGHTGQRCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-800 5.60e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 5.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 114326469    765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQ-GLHCE 800
Cdd:smart00179    2 IDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-622 5.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 5.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    586 EVDECLS-DPCPVGASCLDLPGAFFCLCRPGFT-GQLCE 622
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
472-508 7.02e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.02e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    472 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GRLCE 508
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-723 7.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....*...
gi 114326469  696 PCAHGGTCHPQPSGYNCTCPAGYMGLTC 723
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 1.19e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 38.65  E-value: 1.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 114326469  1291 PSLAL----LVVLRPPaldQQLLALA----RVLSLTLRVGLWVRKDSEGRNMVFPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDP---EELLNNSvqflRELSTVLRTNVRFKKDENGNPMIYPWYG 56
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.72e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  352 NLDDCAAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLC 387
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
429-463 1.73e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 114326469   429 DLDECQmaqQGPSPCEHGGSCINTPGSFNCLCLPG 463
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 514-544 1.81e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.81e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   514 CTSNPCLNQAACHDLLNGFQCLCLPGFTGAR 544
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
892-924 2.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 114326469    892 EISGLCQNGGLCIDTGSSYFCRCPPGFQ-GKLCQ 924
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-582 2.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   552 CSSTPCANGGRCRDQPGAFYCECLPGFEGPH 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-839 3.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.24e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 114326469  810 SPCRNKATCQDTPRGARCLCSPGYTGSSCQ 839
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1415 3.62e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 37.64  E-value: 3.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 114326469  1375 AGFVVVMGVDLSRCGPEHpaSRCPWDSGLLLRFLAAMAAVG 1415
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKG 40
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-381 6.69e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 6.69e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 114326469    352 NLDDCA-AATCAPGSTCIDRVGSFSCLCPPG 381
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-189 8.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 114326469  158 SANPCANGGVCLATYPQIQCRCPPGFEGHTCE 189
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 897-921 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|....*
gi 114326469   897 CQNGGLCIDTGSSYFCRCPPGFQGK 921
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGK 30
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1614-1818 1.04e-39

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 150.10  E-value: 1.04e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1693
Cdd:COG0666    72 LLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLE-AGADVNAQD 150

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1694 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1773
Cdd:COG0666   151 NDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENG 230

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1774 AVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1818
Cdd:COG0666   231 NLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLAL 275
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1605-1837 9.13e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 141.63  E-value: 9.13e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1605 LGNLEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAs 1684
Cdd:COG0666    30 LLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLE- 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1685 RQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQT 1764
Cdd:COG0666   109 AGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGET 188

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 114326469 1765 PLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAA 1837
Cdd:COG0666   189 PLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAA 261
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1614-1797 5.72e-36

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 139.32  E-value: 5.72e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVGtGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDART 1693
Cdd:COG0666   106 LLEAGADVNARDKD-GETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLE-AGADVNARD 183

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1694 EDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREG 1773
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263

                         170       180
                  ....*....|....*....|....
gi 114326469 1774 AVEVAQLLLELGAARGLRDQAGLA 1797
Cdd:COG0666   264 AALIVKLLLLALLLLAAALLDLLT 287
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1633-1837 7.12e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 112.74  E-value: 7.12e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1633 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLV 1712
Cdd:COG0666    24 LLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIV 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1713 EELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRD 1792
Cdd:COG0666   104 KLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARD 183

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1793 QAGLAPGDVARQRSHWDLLTLLEGAGpttqeARAHARTTPGGGAA 1837
Cdd:COG0666   184 NDGETPLHLAAENGHLEIVKLLLEAG-----ADVNAKDNDGKTAL 223
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1437-1511 8.37e-25

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 100.16  E-value: 8.37e-25
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114326469 1437 SANQLPWPILCSPVVGVLLLALGALLVLQLIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKALK 1511
Cdd:cd21705    20 VAAQLPWPLVCSSVAGVLALVLGALLGVQLIRRRQREHGALWLPPGFARHRDPN--PHRRREPVGEDAIGLKPLK 92
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1571-1733 1.69e-20

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 94.25  E-value: 1.69e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1571 DVDTCGPDGVTPLMSAVFCGgvqsttgaspqRLGLGNLepwepLLDRGACPQAHTvGTGETPLHLAARFSRPTAARRLLE 1650
Cdd:COG0666   145 DVNAQDNDGNTPLHLAAANG-----------NLEIVKL-----LLEAGADVNARD-NDGETPLHLAAENGHLEIVKLLLE 207

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1651 AGANPNQPDRAGRTPLHTAVAADAREVCQLLLAsRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGK 1730
Cdd:COG0666   208 AGADVNAKDNDGKTALDLAAENGNLEIVKLLLE-AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLL 286


                  ...
gi 114326469 1731 TAL 1733
Cdd:COG0666   287 TLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1633-1726 4.50e-17

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 4.50e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469  1633 LHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDartEDGTTPLMLAARLAVEDLV 1712
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77

                           90
                   ....*....|....
gi 114326469  1713 EELIAARADVGARD 1726
Cdd:pfam12796   78 KLLLEKGADINVKD 91
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1648-1818 1.05e-16

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 82.69  E-value: 1.05e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1648 LLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDK 1727
Cdd:COG0666     6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1728 RGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSH 1807
Cdd:COG0666    86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGN 165

                         170
                  ....*....|.
gi 114326469 1808 WDLLTLLEGAG 1818
Cdd:COG0666   166 LEIVKLLLEAG 176
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1606-1786 1.91e-13

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 74.64  E-value: 1.91e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1606 GNLEPWEPLLDRGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASR 1685
Cdd:PHA02875   13 GELDIARRLLDIGINPN-FEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLG 91

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1686 QTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTP 1765
Cdd:PHA02875   92 KFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTP 171

                         170       180
                  ....*....|....*....|.
gi 114326469 1766 LFLAAREGAVEVAQLLLELGA 1786
Cdd:PHA02875  172 LIIAMAKGDIAICKMLLDSGA 192
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
 1466-1510 7.55e-13

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 65.86  E-value: 7.55e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1466 LIRRRRREHGALWLPPGFIRRPQTQqaPHRRRPPLGEDNIGLKAL 1510
Cdd:cd21701    43 LVARKRRRHGTLWFPEGFPRTRASR--RSRRRDPVGQDSVGLKNL 85
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1614-1772 1.03e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 72.61  E-value: 1.03e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTvDART 1693
Cdd:PHA02878  153 LLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAST-DARD 231

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1694 EDGTTPLMLA-ARLAVEDLVEELIAARADVGARDK-RGKTALHwaAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAR 1771
Cdd:PHA02878  232 KCGNTPLHISvGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVK 309


                  .
gi 114326469 1772 E 1772
Cdd:PHA02878  310 Q 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1700-1786 1.57e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 62.06  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469  1700 LMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQaGADKDAQDSReQTPLFLAAREGAVEVAQ 1779
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDNG-RTALHYAARSGHLEIVK 78


                   ....*..
gi 114326469  1780 LLLELGA 1786
Cdd:pfam12796   79 LLLEKGA 85
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1646-1786 1.76e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 68.90  E-value: 1.76e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1646 RRLLEAGANPNQPDRAGRTPLHTAVA---ADAREVCQLLLASrQTTVDARTEDGTTPLMLAARLA-VEDLVEELIAARAD 1721
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHLYLHyssEKVKDIVRLLLEA-GADVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 114326469 1722 VGARDKRGKTALHWAAAVNNARAA--RSLLQAGADKDAQDSREQTPL--FLAAREGAVEVAQLLLELGA 1786
Cdd:PHA03095  110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGA 178
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1468-1511 2.76e-11

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 61.35  E-value: 2.76e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 114326469 1468 RRRRREHGALWLPPGFIrrpQTQQAPHRRRPPLGEDNIGLKALK 1511
Cdd:cd21702    39 RKRRREHGQLWFPEGFK---VSEPSKKKRREPVGEDSVGLKPLK 79
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1614-1771 4.16e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.74  E-value: 4.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVgTGETPLHLAARFSRPTAA--RRLLEAGANPNQPDRAGRTPLHT-AVAADAREVCQLLLASRQTTVD 1690
Cdd:PHA03095  138 LLRKGADVNALDL-YGMTPLAVLLKSRNANVEllRLLIDAGADVYAVDDRFRSLLHHhLQSFKPRARIVRELIRAGCDPA 216

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1691 ARTEDGTTPLMLAARLAVED--LVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFL 1768
Cdd:PHA03095  217 ATDMLGNTPLHSMATGSSCKrsLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSL 296


                  ...
gi 114326469 1769 AAR 1771
Cdd:PHA03095  297 MVR 299
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1614-1844 7.71e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.59  E-value: 7.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVgTGETPLHLAARFS-RPTAARRLLEAGANPNQPDRAGRTPLH---TAVAADArEVCQLLLAsRQTTV 1689
Cdd:PHA03095   69 LLEAGADVNAPER-CGFTPLHLYLYNAtTLDVIKLLIKAGADVNAKDKVGRTPLHvylSGFNINP-KVIRLLLR-KGADV 145

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1690 DARTEDGTTPL----------------MLAA---RLAVED------------------LVEELIAARADVGARDKRGKTA 1732
Cdd:PHA03095  146 NALDLYGMTPLavllksrnanvellrlLIDAgadVYAVDDrfrsllhhhlqsfkprarIVRELIRAGCDPAATDMLGNTP 225

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1733 LHWAAAVNNARAA--RSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDL 1810
Cdd:PHA03095  226 LHSMATGSSCKRSlvLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRA 305

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 114326469 1811 L-TLLEGAGPTTQEARAHARTTPGGGAAPRCRTLS 1844
Cdd:PHA03095  306 VrAALAKNPSAETVAATLNTASVAGGDIPSDATRL 340
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1631-1822 6.96e-10

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 63.53  E-value: 6.96e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1631 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLH-----TAVAADAREVCQLLLaSRQTTVDARTEDGTTPLMLAAR 1705
Cdd:PHA03100   37 LPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLL-EYGANVNAPDNNGITPLLYAIS 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1706 LAVED--LVEELIAARADVGARDKRGKTALHWAAAVNNARAARS------------------LLQAGADKDAQDSREQTP 1765
Cdd:PHA03100  116 KKSNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKILkllidkgvdinaknrvnyLLSYGVPINIKDVYGFTP 195

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 114326469 1766 LFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQ 1822
Cdd:PHA03100  196 LHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIK 252
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1466-1510 2.67e-09

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 55.54  E-value: 2.67e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1466 LIRRRRREHGALWLPPGFIRRPQTQQapHRRRPPLGEDNIGLKAL 1510
Cdd:cd21703    40 LVAKRKRKHGPLWFPEGFILNKENSN--RKRREPVGQDAVGMKNL 82
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1629-1734 5.06e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 60.81  E-value: 5.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1629 GETPLHLAARFS---RPTAARRLLEAGANPNQPDRAGRTPLHTAV-AADAREVCQLLL---ASrqttVDARTEDGTTPL- 1700
Cdd:PHA03095   47 GKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIkagAD----VNAKDKVGRTPLh 122

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 114326469 1701 -MLAARLAVEDLVEELIAARADVGARDKRGKTALH 1734
Cdd:PHA03095  123 vYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLA 157
Ank_4 pfam13637
Ankyrin repeats (many copies);
1631-1682 5.47e-09

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.82  E-value: 5.47e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 114326469  1631 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLL 1682
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1648-1786 9.05e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 60.46  E-value: 9.05e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1648 LLEAGANPNQPDRAGRTPLHTAVAADA--REVCQLLlaSRQTTVDARTEDGTTPLMLAARLAVE-DLVEELIAARADVGA 1724
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSlsRLVPKLL--ERGADVNAKNIKGETPLYLMAKNGYDtENIRTLIMLGADVNA 336

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 114326469 1725 RDKRGKTALHWAAAVNNARAAR-SLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGA 1786
Cdd:PHA02876  337 ADRLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGA 399
COG3903 COG3903
Predicted ATPase [General function prediction only];
1600-1919 9.41e-09

Predicted ATPase [General function prediction only];


Pssm-ID: 443109 [Multi-domain]  Cd Length: 933  Bit Score: 60.80  E-value: 9.41e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1600 PQRLGLGNLEPWEPLLdRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGAnpnqpDRAGRTPLHTAVAADAREVCQ 1679
Cdd:COG3903   513 DQLAWLARLDAEHDNL-RAALRWALAHGDAELALRLAAALAPFWFLRGLLREGR-----RWLERALAAAGEAAAALAAAA 586

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1680 LLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGAdkdAQD 1759
Cdd:COG3903   587 ALAAAAAAARAAAAAAAAAAAAAAAAAAAAAAAAAALLLLAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA---AAA 663

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1760 SREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAAPR 1839
Cdd:COG3903   664 AALAAAAAAAAAAAAAAAAAAAALAAAAAALAAAAAAAALAAAAAAALAAAAAAAAAAAAAAALLAAAAAAALAAAAAAA 743

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1840 CRTLSAGARPRGGGACLQARTWSVDLGARGGKVYARCRSRSGSCGGPTTRGRRFSAGSRGRRGARASQDDWPRDWVALEA 1919
Cdd:COG3903   744 ALALAAAAAAAAAAAAAAALAAAAAAAALAALLLALAAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAA 823
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1253-1281 1.46e-08

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 52.14  E-value: 1.46e-08
                           10        20
                   ....*....|....*....|....*....
gi 114326469  1253 QYCRDHFHNGHCEKGCNNAECGWDGGDCR 1281
Cdd:pfam00066    7 PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1614-1691 3.13e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 58.76  E-value: 3.13e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114326469 1614 LLDRGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDA 1691
Cdd:PTZ00322  101 LLTGGADPNCRDY-DGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1680-1818 3.21e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 57.27  E-value: 3.21e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1680 LLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQD 1759
Cdd:COG0666     5 LLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKD 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326469 1760 SREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAG 1818
Cdd:COG0666    85 DGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAG 143
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 429-470 6.12e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 6.12e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 114326469  429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYTGSRCE 470
Cdd:cd00054     1 DIDECAS----GNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1614-1669 1.08e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 50.04  E-value: 1.08e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 114326469  1614 LLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTA 1669
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1629-1684 1.56e-07

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 50.88  E-value: 1.56e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 114326469  1629 GETPLHLAARFSRPTAARRLLEaGANPNQPDRaGRTPLHTAVAADAREVCQLLLAS 1684
Cdd:pfam12796   30 GRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVKLLLEK 83
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 548-584 1.81e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.17  E-value: 1.81e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114326469  548 DMDECSST-PCANGGRCRDQPGAFYCECLPGFEGPHCE 584
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1629-1733 1.97e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 1.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1629 GETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADaREVCQLLLASRqtTVDARTEDGTTPLMLAARLAV 1708
Cdd:PHA02874  190 GESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHN-RSAIELLINNA--SINDQDIDGSTPLHHAINPPC 266

                          90       100
                  ....*....|....*....|....*.
gi 114326469 1709 E-DLVEELIAARADVGARDKRGKTAL 1733
Cdd:PHA02874  267 DiDIIDILLYHKADISIKDNKGENPI 292
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1748-1828 2.22e-07

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 56.06  E-value: 2.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1748 LLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVARQRSHWDLLTLLEGAGPTTQEARAH 1827
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFELGAN 180


                  .
gi 114326469 1828 A 1828
Cdd:PTZ00322  181 A 181
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1252-1280 2.43e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 2.43e-07
                            10        20
                    ....*....|....*....|....*....
gi 114326469   1252 DQYCRDHFHNGHCEKGCNNAECGWDGGDC 1280
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
429-470 3.52e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 3.52e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 114326469    429 DLDECQMaqqgPSPCEHGGSCINTPGSFNCLCLPGYT-GSRCE 470
Cdd:smart00179    1 DIDECAS----GNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1614-1792 4.16e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 55.07  E-value: 4.16e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVgTGETPLHLAARFSRPTA-ARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDAR 1692
Cdd:PHA02876  293 LLERGADVNAKNI-KGETPLYLMAKNGYDTEnIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNAR 371

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1693 TEDGTTPLMLAA--------------RLAVEDL--------------------VEELIAARADVGARDKRGKTALHWAAA 1738
Cdd:PHA02876  372 DYCDKTPIHYAAvrnnvviintlldyGADIEALsqkigtalhfalcgtnpymsVKTLIDRGANVNSKNKDLSTPLHYACK 451

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 114326469 1739 VNNARAARS-LLQAGADKDAQDSREQTPLFLAAreGAVEVAQLLLELGAArgLRD 1792
Cdd:PHA02876  452 KNCKLDVIEmLLDNGADVNAINIQNQYPLLIAL--EYHGIVNILLHYGAE--LRD 502
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
 1466-1508 4.23e-07

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 49.75  E-value: 4.23e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 114326469 1466 LIRRRRREHGALWLPPGFIRRPQTqqAPHRRRPPLGEDNIGLK 1508
Cdd:cd21704    46 LVARRKREHSTLWFPEGFFLKKES--SNKNRREPVGQDALGMK 86
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 311-350 4.56e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.56e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 114326469  311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGWGGAGCE 350
Cdd:cd00054     1 DIDECASGNP--CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1629-1734 5.09e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 54.63  E-value: 5.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1629 GETPLHLAARFSRPTAARRLLEAGanP---NQPDR----AGRTPLHTAVAADAREVCQLLLASRQTTVDARTED------ 1695
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAA--PelvNEPMTsdlyQGETALHIAVVNQNLNLVRELIARGADVVSPRATGtffrpg 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 114326469 1696 -------GTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALH 1734
Cdd:cd22192   129 pknliyyGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLH 174
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
 1207-1242 6.91e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 47.14  E-value: 6.91e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 114326469  1207 WKGCPPhSQCWLLFRDGRCHPQCDSEECLFDGYDCE 1242
Cdd:pfam00066    1 WPNCPY-PYCWDKFGNGVCDEECNNAECLWDGGDCS 35
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1631-1798 8.74e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.81  E-value: 8.74e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1631 TPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLasrqttvdartEDGTTPLMLAARLAVED 1710
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLI-----------DNGVDTSILPIPCIEKD 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1711 LVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGL 1790
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185


                  ....*...
gi 114326469 1791 RDQAGLAP 1798
Cdd:PHA02874  186 KDNNGESP 193
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
 1203-1241 1.04e-06

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 46.94  E-value: 1.04e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469   1203 VPDPWKGCPpHSQCWLLFRDGRCHPQCDSEECLFDGYDC 1241
Cdd:smart00004    1 PQDPWSRCE-DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 511-546 1.38e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.48  E-value: 1.38e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  511 VNECTS-NPCLNQAACHDLLNGFQCLCLPGFTGARCE 546
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
191-222 1.49e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.08  E-value: 1.49e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 114326469   191 DINECFLEPGPCPQGTSCHNTLGSYQCLCPVG 222
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 1614-1786 1.52e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 52.75  E-value: 1.52e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1614 LLDRGACPQAHTVGTgETPLHLAARF-----SRPTAARRLLEAGANPNQPDRAGRTPLHTAVAadaREVCQL----LLAS 1684
Cdd:PHA03100   54 LLDNGADINSSTKNN-STPLHYLSNIkynltDVKEIVKLLLEYGANVNAPDNNGITPLLYAIS---KKSNSYsiveYLLD 129

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1685 RQTTVDARTEDGTTPLMLAAR------------------LAVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAAR 1746
Cdd:PHA03100  130 NGANVNIKNSDGENLLHLYLEsnkidlkilkllidkgvdINAKNRVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVK 209

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 114326469 1747 SLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGA 1786
Cdd:PHA03100  210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGP 249
EGF_CA smart00179
Calcium-binding EGF-like domain;
311-350 3.04e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.04e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 114326469    311 DIDECEARGPprCRNGGTCQNTAGSFHCVCVSGW-GGAGCE 350
Cdd:smart00179    1 DIDECASGNP--CQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 966-1000 3.27e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 45.32  E-value: 3.27e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 114326469  966 DACQSQ-PCHNHGTCTSRPGGFHCACPPGFVGLRCE 1000
Cdd:cd00054     3 DECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
548-584 3.85e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.32  E-value: 3.85e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    548 DMDECSST-PCANGGRCRDQPGAFYCECLPGFE-GPHCE 584
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 926-961 5.72e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.72e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYEGQNC 961
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 1630-1766 7.59e-06

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 50.78  E-value: 7.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1630 ETPLHLAARFSRPTAARRLLE-AGANPNQPDRAGRTPLHTAVAADAREVCQLLL-ASRQTTVDARTED---GTTPLMLAA 1704
Cdd:cd22192    18 ESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMeAAPELVNEPMTSDlyqGETALHIAV 97

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114326469 1705 RLAVEDLVEELIAARADV------GARDKRGKTAL-----H---WAAAVNNARAARSLLQAGADKDAQDSREQTPL 1766
Cdd:cd22192    98 VNQNLNLVRELIARGADVvspratGTFFRPGPKNLiyygeHplsFAACVGNEEIVRLLIEHGADIRAQDSLGNTVL 173
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1631-1769 8.16e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 50.83  E-value: 8.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1631 TPLHLAARfsRPTAAR---RLLEAGANPNQPDRAGRTPLHTAV--AADAREVCQLLlaSRQTTVDARTEDGTTPLMLAAR 1705
Cdd:PHA02876  275 TPLHHASQ--APSLSRlvpKLLERGADVNAKNIKGETPLYLMAknGYDTENIRTLI--MLGADVNAADRLYITPLHQAST 350

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 114326469 1706 L-AVEDLVEELIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLA 1769
Cdd:PHA02876  351 LdRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQKIGTALHFA 415
EGF_CA smart00179
Calcium-binding EGF-like domain;
191-229 9.21e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.16  E-value: 9.21e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 114326469    191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVG-QEGPQCK 229
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1606-1733 9.46e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 50.37  E-value: 9.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1606 GNLEPWEPLLDRGACPQAHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASR 1685
Cdd:PHA02875   79 GDVKAVEELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHK 158

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 114326469 1686 QTTvdaRTED--GTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTAL 1733
Cdd:PHA02875  159 ACL---DIEDccGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCVAA 205
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 587-622 1.57e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.57e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  587 VDECLS-DPCPVGASCLDLPGAFFCLCRPGFTGQLCE 622
Cdd:cd00054     2 IDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 191-229 1.70e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 1.70e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 114326469  191 DINECfLEPGPCPQGTSCHNTLGSYQCLCPVGQEGPQCK 229
Cdd:cd00054     1 DIDEC-ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1648-1703 2.13e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 43.87  E-value: 2.13e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 114326469  1648 LLEAG-ANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQtTVDARTEDGTTPLMLA 1703
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1571-1659 2.16e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469  1571 DVDTCGPDGVTPLMSAVFCGGVQSTtgaspqRLglgnlepwepLLDrgaCPQAHTVGTGETPLHLAARFSRPTAARRLLE 1650
Cdd:pfam12796   22 DANLQDKNGRTALHLAAKNGHLEIV------KL----------LLE---HADVNLKDNGRTALHYAARSGHLEIVKLLLE 82


                   ....*....
gi 114326469  1651 AGANPNQPD 1659
Cdd:pfam12796   83 KGADINVKD 91
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 1601-1839 2.26e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 49.68  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1601 QRLGLGNLEPWEPLLDRGACPQAHTVGTgETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADArevcql 1680
Cdd:PHA02876  151 ERIQQDELLIAEMLLEGGADVNAKDIYC-ITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKN------ 223

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1681 lLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARA--DVGARDKRGKTALHWAAAVNN-ARAARSLLQAGADKDA 1757
Cdd:PHA02876  224 -IDTIKAIIDNRSNINKNDLSLLKAIRNEDLETSLLLYDAgfSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNA 302

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1758 QDSREQTPLFLAAREG-AVEVAQLLLELGAARGLRDQAGLAPGDVAR--QRSHWDLLTLLE-GAgptTQEARAHARTTPG 1833
Cdd:PHA02876  303 KNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLElGA---NVNARDYCDKTPI 379


                  ....*.
gi 114326469 1834 GGAAPR 1839
Cdd:PHA02876  380 HYAAVR 385
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1748-1788 2.41e-05

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 44.72  E-value: 2.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 114326469  1748 LLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAAR 1788
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVN 56
PHA02946 PHA02946
ankyin-like protein; Provisional
 1612-1734 2.67e-05

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 48.90  E-value: 2.67e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1612 EPLLDRGACPQaHTVGTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAR--EVCQLLLASRQTTV 1689
Cdd:PHA02946   56 EELLHRGYSPN-ETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEviERINLLVQYGAKIN 134

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 114326469 1690 DARTEDGTTPLmLAARLAVEDLVEELIAARADVGARDKRGKTALH 1734
Cdd:PHA02946  135 NSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIH 178
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1634-1715 3.11e-05

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 49.13  E-value: 3.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1634 HLAARfSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLL--ASRQTTVDartEDGTTPLMLAARLAVEDL 1711
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLefGADPTLLD---KDGKTPLELAEENGFREV 163


                  ....
gi 114326469 1712 VEEL 1715
Cdd:PTZ00322  164 VQLL 167
EGF_CA smart00179
Calcium-binding EGF-like domain;
510-546 3.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    510 EVNECTS-NPCLNQAACHDLLNGFQCLCLPGFT-GARCE 546
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 472-508 3.66e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 3.66e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 114326469  472 DHNECLSQ-PCHPGSTCLDLLATFHCLCPPGLEGRLCE 508
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 765-800 3.92e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 3.92e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQGLHCE 800
Cdd:cd00054     2 IDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1681-1734 5.64e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 42.33  E-value: 5.64e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 114326469  1681 LLASRQTTVDARTEDGTTPLMLAARLAVEDLVEELIAARADVGARDKRGKTALH 1734
Cdd:pfam13857    1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 1605-1783 6.70e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 47.95  E-value: 6.70e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1605 LGNLEPWEPLLDRGACPQAHTVG-TGETPLHLAARFSRPT---AARRLLEAGANPNQPDR-----------AGRTPLHTA 1669
Cdd:cd21882     1 LEELLGLLECLRWYLTDSAYQRGaTGKTCLHKAALNLNDGvneAIMLLLEAAPDSGNPKElvnapctdefyQGQTALHIA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1670 VAADAREVCQLLLAsRQTTVDARTED-------------GTTPLMLAARLAVEDLVEELI---AARADVGARDKRGKTAL 1733
Cdd:cd21882    81 IENRNLNLVRLLVE-NGADVSARATGrffrkspgnlfyfGELPLSLAACTNQEEIVRLLLengAQPAALEAQDSLGNTVL 159

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 114326469 1734 HWAAAVNNARAARS---------LLQAGADKDAQDSREQ-------TPLFLAAREGAVEVAQLLLE 1783
Cdd:cd21882   160 HALVLQADNTPENSafvcqmynlLLSYGAHLDPTQQLEEipnhqglTPLKLAAVEGKIVMFQHILQ 225
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 1632-1798 7.65e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 47.57  E-value: 7.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1632 PLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLAS-------------------------RQ 1686
Cdd:PHA02878   40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSinkcsvfytlvaikdafnnrnveifKI 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1687 TTVDARTEDGTTPLMLAARLAVEDLVEE-----LIAARADVGARDK-RGKTALHWAAAVNNARAARSLLQAGADKDAQDS 1760
Cdd:PHA02878  120 ILTNRYKNIQTIDLVYIDKKSKDDIIEAeitklLLSYGADINMKDRhKGNTALHYATENKDQRLTELLLSYGANVNIPDK 199

                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 114326469 1761 REQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAP 1798
Cdd:PHA02878  200 TNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTP 237
EGF_CA smart00179
Calcium-binding EGF-like domain;
926-961 1.04e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.04e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 114326469    926 NVNPCE-PNPCHHGSTCVPQPSGYVCQCAPGYE-GQNC 961
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1629-1660 1.55e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 40.74  E-value: 1.55e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 114326469  1629 GETPLHLAA-RFSRPTAARRLLEAGANPNQPDR 1660
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 892-924 1.58e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 1.58e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 114326469  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGKLCQ 924
Cdd:cd00054     6 ASGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 968-998 2.49e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.06  E-value: 2.49e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   968 CQSQPCHNHGTCTSRPGGFHCACPPGFVGLR 998
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1630-1802 3.41e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 45.34  E-value: 3.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1630 ETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLaSRQTTVDARTEDGTTPLMLAARLAVE 1709
Cdd:PHA02874  125 KTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLL-EKGAYANVKDNNGESPLHNAAEYGDY 203

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1710 DLVEELIAARADVGARDKRGKTALHwaAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAR-EGAVEVAQLLLELGAAR 1788
Cdd:PHA02874  204 ACIKLLIDHGNHIMNKCKNGFTPLH--NAIIHNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILLYHKADI 281

                         170
                  ....*....|....
gi 114326469 1789 GLRDQAGLAPGDVA 1802
Cdd:PHA02874  282 SIKDNKGENPIDTA 295
EGF_CA smart00179
Calcium-binding EGF-like domain;
966-1000 3.67e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 3.67e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 114326469    966 DACQS-QPCHNHGTCTSRPGGFHCACPPGFV-GLRCE 1000
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
311-343 3.77e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 39.53  E-value: 3.77e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 114326469   311 DIDECeARGPPRCRNGGTCQNTAGSFHCVCVSG 343
Cdd:pfam07645    1 DVDEC-ATGTHNCPANTVCVNTIGSFECRCPDG 32
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 1715-1782 4.63e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 45.27  E-value: 4.63e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 114326469 1715 LIAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLL 1782
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 930-960 4.96e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 4.96e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   930 CEPNPCHHGSTCVPQPSGYVCQCAPGYEGQN 960
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1002-1040 5.40e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 5.40e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 114326469 1002 DVDECLDR-PCHPSGTaaCHSLANAFYCQCLPGHTGQRCE 1040
Cdd:cd00054     1 DIDECASGnPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
765-800 5.60e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 5.60e-04
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 114326469    765 VDHCVSAS-CLNGGTCVNKPGTFFCLCATGFQ-GLHCE 800
Cdd:smart00179    2 IDECASGNpCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
586-622 5.82e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 5.82e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    586 EVDECLS-DPCPVGASCLDLPGAFFCLCRPGFT-GQLCE 622
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1648-1786 6.80e-04

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 44.86  E-value: 6.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1648 LLEAGANPNQPDRAGRTPLHTAvAADAREVCQLLLASRQTTVDARTEDGTTPLMLA---------------ARLAVEDLV 1712
Cdd:PLN03192  544 LLKAKLDPDIGDSKGRTPLHIA-ASKGYEDCVLVLLKHACNVHIRDANGNTALWNAisakhhkifrilyhfASISDPHAA 622

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 114326469 1713 EELI---AARADVGArdkrgktalhwaaavnnaraARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGA 1786
Cdd:PLN03192  623 GDLLctaAKRNDLTA--------------------MKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGA 679
EGF_CA smart00179
Calcium-binding EGF-like domain;
472-508 7.02e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 7.02e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 114326469    472 DHNECLS-QPCHPGSTCLDLLATFHCLCPPGLE-GRLCE 508
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 696-723 7.04e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 7.04e-04
                          10        20
                  ....*....|....*....|....*...
gi 114326469  696 PCAHGGTCHPQPSGYNCTCPAGYMGLTC 723
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1629-1656 8.27e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.39  E-value: 8.27e-04
                           10        20
                   ....*....|....*....|....*...
gi 114326469  1629 GETPLHLAARFSRPTAARRLLEAGANPN 1656
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADIN 29
Ank_5 pfam13857
Ankyrin repeats (many copies);
1748-1802 9.48e-04

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 38.87  E-value: 9.48e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 114326469  1748 LLQAG-ADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAGLAPGDVA 1802
Cdd:pfam13857    1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1291-1340 1.19e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 38.65  E-value: 1.19e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 114326469  1291 PSLAL----LVVLRPPaldQQLLALA----RVLSLTLRVGLWVRKDSEGRNMVFPYPG 1340
Cdd:pfam06816    2 EKLAEgvlvIVVLMDP---EELLNNSvqflRELSTVLRTNVRFKKDENGNPMIYPWYG 56
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
1636-1866 1.24e-03

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 43.46  E-value: 1.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1636 AARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLASRQTTVDARTEDGTTPLMLAARLAVEDLVEEL 1715
Cdd:COG0515   252 EERYQSAAELAAALRAVLRSLAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAPAAAAAAAA 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1716 IAARADVGARDKRGKTALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLLELGAARGLRDQAG 1795
Cdd:COG0515   332 AAAALAAAAAAAAAAAAAALLAAAAALAAAAAAAAAAAAAAAAAAAAAAAAAALAAAAAAAAAAAAAALAAAAAAAAAAA 411

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326469 1796 LAPGDVARQRSHWDLLTLLEGAGPTTQEARAHARTTPGGGAAPRCRTLSAGARPRGGGACLQARTWSVDLG 1866
Cdd:COG0515   412 AAAAAAAALAAAAAAAAAAAAAAAAAAAAAARLLAAAAAAAAAAAAAPLLAALLAAAALAAAAAAAALALA 482
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 1606-1798 1.42e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 43.41  E-value: 1.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1606 GNLEPWEPLLDRGACPQAHTVgTGETPLHLAARFSRPTAARRLLEAGANPNQPDRAGRTPLHTAVAADAREVCQLLLaSR 1685
Cdd:PHA02874  135 GDLESIKMLFEYGADVNIEDD-NGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLI-DH 212

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1686 QTTVDARTEDGTTPL---MLAARLAVEDLVEEliaarADVGARDKRGKTALHWA-AAVNNARAARSLLQAGADKDAQDSR 1761
Cdd:PHA02874  213 GNHIMNKCKNGFTPLhnaIIHNRSAIELLINN-----ASINDQDIDGSTPLHHAiNPPCDIDIIDILLYHKADISIKDNK 287

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 114326469 1762 EQTPLFLAARegAVEVAQLLLELGAARGLRDQAGLAP 1798
Cdd:PHA02874  288 GENPIDTAFK--YINKDPVIKDIIANAVLIKEADKLK 322
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 1695-1727 1.44e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 38.04  E-value: 1.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 114326469  1695 DGTTPLMLAA-RLAVEDLVEELIAARADVGARDK 1727
Cdd:pfam00023    1 DGNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 440-468 1.54e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.84  E-value: 1.54e-03
                          10        20
                  ....*....|....*....|....*....
gi 114326469  440 PSPCEHGGSCINTPGSFNCLCLPGYTGSR 468
Cdd:cd00053     5 SNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 352-387 1.72e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 1.72e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 114326469  352 NLDDCAAAT-CAPGSTCIDRVGSFSCLCPPGRTGLLC 387
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
429-463 1.73e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.60  E-value: 1.73e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 114326469   429 DLDECQmaqQGPSPCEHGGSCINTPGSFNCLCLPG 463
Cdd:pfam07645    1 DVDECA---TGTHNCPANTVCVNTIGSFECRCPDG 32
PHA03095 PHA03095
ankyrin-like protein; Provisional
 1700-1786 1.76e-03

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 43.09  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326469 1700 LMLAARLAVEDlVEELIAARADVGARDKRGKTALHWAAAVNNARAA---RSLLQAGADKDAQDSREQTPLFLAAREGAVE 1776
Cdd:PHA03095   19 LLNASNVTVEE-VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKdivRLLLEAGADVNAPERCGFTPLHLYLYNATTL 97

                          90
                  ....*....|.
gi 114326469 1777 -VAQLLLELGA 1786
Cdd:PHA03095   98 dVIKLLIKAGA 108
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 514-544 1.81e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 1.81e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   514 CTSNPCLNQAACHDLLNGFQCLCLPGFTGAR 544
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 440-468 2.21e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.21e-03
                           10        20
                   ....*....|....*....|....*....
gi 114326469   440 PSPCEHGGSCINTPGSFNCLCLPGYTGSR 468
Cdd:pfam00008    3 PNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 969-998 2.24e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.24e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 114326469  969 QSQPCHNHGTCTSRPGGFHCACPPGFVGLR 998
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
892-924 2.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 2.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 114326469    892 EISGLCQNGGLCIDTGSSYFCRCPPGFQ-GKLCQ 924
Cdd:smart00179    6 ASGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 552-582 2.94e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 114326469   552 CSSTPCANGGRCRDQPGAFYCECLPGFEGPH 582
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 810-839 3.24e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 3.24e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 114326469  810 SPCRNKATCQDTPRGARCLCSPGYTGSSCQ 839
Cdd:cd00054     9 NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1731-1782 3.24e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 37.64  E-value: 3.24e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 114326469  1731 TALHWAAAVNNARAARSLLQAGADKDAQDSREQTPLFLAAREGAVEVAQLLL 1782
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
 1375-1415 3.62e-03

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 37.64  E-value: 3.62e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 114326469  1375 AGFVVVMGVDLSRCGPEHpaSRCPWDSGLLLRFLAAMAAVG 1415
Cdd:pfam07684    2 IGSVVYLEIDNRKCSQSS--DECFSTAQSAADFLAALAAKG 40
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 892-921 4.83e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 4.83e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 114326469  892 EISGLCQNGGLCIDTGSSYFCRCPPGFQGK 921
Cdd:cd00053     3 AASNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 931-960 6.56e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 6.56e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 114326469  931 EPNPCHHGSTCVPQPSGYVCQCAPGYEGQN 960
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
352-381 6.69e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.07  E-value: 6.69e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 114326469    352 NLDDCA-AATCAPGSTCIDRVGSFSCLCPPG 381
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 158-189 8.02e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 8.02e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 114326469  158 SANPCANGGVCLATYPQIQCRCPPGFEGHTCE 189
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 897-921 9.38e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 9.38e-03
                           10        20
                   ....*....|....*....|....*
gi 114326469   897 CQNGGLCIDTGSSYFCRCPPGFQGK 921
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTGK 30
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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