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Conserved domains on  [gi|6754474|ref|NP_034785|]
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importin subunit alpha-1 [Mus musculus]

Protein Classification

armadillo/beta-catenin-like repeat-containing protein( domain architecture ID 1000979)

armadillo/beta-catenin-like repeat-containing protein similar to Saccharomyces cerevisiae vacuolar protein 8 that functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SRP1 super family cl34886
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
9-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


The actual alignment was detected with superfamily member COG5064:

Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 532.16  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    9 LPAARLNRFKNKGKDST-EMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVEDIVKG 84
Cdd:COG5064   6 VPEARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474   85 INSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAI 164
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  165 PAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL--AVPDLSTLacgylRNLTWTLSNLCRNKNP 242
Cdd:COG5064 160 PLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHISML-----RNATWTLSNLCRGKNP 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  243 APPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT 322
Cdd:COG5064 235 PPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVT 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  323 GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAIT 402
Cdd:COG5064 315 GSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAIS 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  403 NYTSGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEA 475
Cdd:COG5064 395 NATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHG 474

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|...
gi 6754474  476 LQRHENESVYKASLNLIEKYFSvEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 528
Cdd:COG5064 475 LQDSVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
9-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 532.16  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    9 LPAARLNRFKNKGKDST-EMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVEDIVKG 84
Cdd:COG5064   6 VPEARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474   85 INSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAI 164
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  165 PAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL--AVPDLSTLacgylRNLTWTLSNLCRNKNP 242
Cdd:COG5064 160 PLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHISML-----RNATWTLSNLCRGKNP 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  243 APPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT 322
Cdd:COG5064 235 PPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVT 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  323 GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAIT 402
Cdd:COG5064 315 GSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAIS 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  403 NYTSGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEA 475
Cdd:COG5064 395 NATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHG 474

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|...
gi 6754474  476 LQRHENESVYKASLNLIEKYFSvEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 528
Cdd:COG5064 475 LQDSVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-98 3.07e-38

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 134.59  E-value: 3.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474     13 RLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATsplqenrNNQGTVNWSVEDIVKGINSNNLES 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSS-------SAESQLLESLPEMVQGVNSDDPEL 73


                  ....*.
gi 6754474     93 QLQATQ 98
Cdd:pfam01749  74 QLEATQ 79
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 1.54e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.51  E-value: 1.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6754474     151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 78-195 4.35e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474     78 VEDIVKGINSNNLESQLQATQAARKLLsREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKA 157
Cdd:PLN03200  191 VDILVKLLSSGNSDAQANAASLLARLM-MAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKEAKQA 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6754474    158 VVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAGDGSA 195
Cdd:PLN03200  270 IADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICGGMSA 316
Syo1_like cd13394
Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes ...
 144-448 9.27e-03

Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes Saccharomyces cerevisiae Ydl063c and Chaetomium thermophilum Syo1, which mediate the co-import of two ribosomal proteins, Rpl5 and Rpl11 (which both interact with 5S rRNA) into the nucleus. Import precedes their association with rRNA and subsequent ribosome assembly in the nucleolus. The primary structure of syo1 is a mixture of Armadillo- (ARM, N-terminal part of syo1) and HEAT-repeats (C-terminal part of syo1).


Pssm-ID: 240521 [Multi-domain]  Cd Length: 597  Bit Score: 38.83  E-value: 9.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  144 LTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH-ISEQAVWALGN----IAGDGSAFRDLVIKH-GAIDPLLALLAVPD 217
Cdd:cd13394 167 LWNLAEGSDEILSAVNKEDLLLFLLAILINFLTSkLPTSLFNAALQclytLSEDNPEFIDKLSSDpEILGNLLDIVSSDP 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  218 LS------TLACGYLRNLTwTLSNLCRNKNPAppldAVEQILPTLVRLLHHNDPEVLADSC---------WAI-SYLTDG 281
Cdd:cd13394 247 SSsnillkVLVCGILLNIL-EVLSWLAGKDAA----ADAILLPILSAILSILALEILANICkeldkkddeAMEdEQSDED 321

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  282 PNERIEMVVKKGVVPQLVKLLGATELPivtPALRaigNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEAT----- 356
Cdd:cd13394 322 EEEDEDDEASETLVPELSPLEISLDLL---TALL---ELIAPTPESVEPILPSSTIEELPPPLSKLLLSLHSRALeclnn 395

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  357 --WTM-SNITAGRQDQ--------IQQVVNHGLVPFLVGVLSKAdfktqKEAAWAIT------NYTSGGTVEQIVYLVH- 418
Cdd:cd13394 396 llWLFlSLELGGDWNNslqqlwdlLAQLIFKDVISADLELLEAA-----TSVLWALLkslggeILLQQNTHDFIQSLIEa 470

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  419 -------------CGII-----------------EPLMNLLSAKDTKIIQVILDAISNIF 448
Cdd:cd13394 471 sktdadlelrvrcVGVLgslaqvpgnievnkeigQFLLELLTKLPNTPPEVLVEALNAIF 530
 
Name Accession Description Interval E-value
SRP1 COG5064
Karyopherin (importin) alpha [Intracellular trafficking and secretion];
9-528 0e+00

Karyopherin (importin) alpha [Intracellular trafficking and secretion];


Pssm-ID: 227396 [Multi-domain]  Cd Length: 526  Bit Score: 532.16  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    9 LPAARLNRFKNKGKDST-EMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATS---PLQENRNNQgtvnwsVEDIVKG 84
Cdd:COG5064   6 VPEARRYNFKGKGRFSAdELRRRREEQQVELRKQKREELLNKRRNLADVSEEAESsfiPMEQQFYSE------LPQLTQQ 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474   85 INSNNLESQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAI 164
Cdd:COG5064  80 LFSDDIEQQLQAVYKFRKLLSKETSPPIQPVIDAGVVPRFVEFMDEIQRDMLQFEAAWALTNIASGTTQQTKVVVDAGAV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  165 PAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL--AVPDLSTLacgylRNLTWTLSNLCRNKNP 242
Cdd:COG5064 160 PLFIQLLSSTEDDVREQAVWALGNIAGDSEGCRDYVLQCGALEPLLGLLlsSAIHISML-----RNATWTLSNLCRGKNP 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  243 APPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT 322
Cdd:COG5064 235 PPDWSNISQALPILAKLIYSRDPEVLVDACWAISYLSDGPNEKIQAVLDVGIPGRLVELLSHESAKIQTPALRSVGNIVT 314

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  323 GTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAIT 402
Cdd:COG5064 315 GSDDQTQVIINCGALKAFRSLLSSPKENIRKEACWTISNITAGNTEQIQAVIDANLIPPLIHLLSSAEYKIKKEACWAIS 394

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  403 NYTSGGT--VEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAE--KLGETEKLSI---MIEECGGLDKIEA 475
Cdd:COG5064 395 NATSGGLnrPDIIRYLVSQGFIKPLCDLLDVVDNKIIEVALDAIENILKVGEqdRLRYGKNINIyavYVEKAGGMDAIHG 474

                       490       500       510       520       530
                ....*....|....*....|....*....|....*....|....*....|...
gi 6754474  476 LQRHENESVYKASLNLIEKYFSvEEEEDQNVVPETTSEGFAFQVQDGAPGTFN 528
Cdd:COG5064 475 LQDSVNRTIYDKAYSIIEKFFG-EEDAVDELAPETAGNTFTFGSNVNQQGNFN 526
IBB pfam01749
Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), ...
 13-98 3.07e-38

Importin beta binding domain; This family consists of the importin alpha (karyopherin alpha), importin beta (karyopherin beta) binding domain. The domain mediates formation of the importin alpha beta complex; required for classical NLS import of proteins into the nucleus, through the nuclear pore complex and across the nuclear envelope. Also in the alignment is the NLS of importin alpha which overlaps with the IBB domain.


Pssm-ID: 460311 [Multi-domain]  Cd Length: 79  Bit Score: 134.59  E-value: 3.07e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474     13 RLNRFKNKGKDSTEMRRRRIEVNVELRKAKKDEQMLKRRNVSSFPDDATsplqenrNNQGTVNWSVEDIVKGINSNNLES 92
Cdd:pfam01749   1 RRKSFKNKGKDADELRRRREEVQVELRKQKREEQLLKRRNVGAPSSSSS-------SAESQLLESLPEMVQGVNSDDPEL 73


                  ....*.
gi 6754474     93 QLQATQ 98
Cdd:pfam01749  74 QLEATQ 79
Arm_3 pfam16186
Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic ...
 462-509 1.51e-20

Atypical Arm repeat; This atypical Arm repeat appears at the very C-terminus of eukaryotic proteins such as importin subunit alpha-2, as the last of the repeating units.


Pssm-ID: 465050 [Multi-domain]  Cd Length: 49  Bit Score: 84.95  E-value: 1.51e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 6754474    462 IMIEECGGLDKIEALQRHENESVYKASLNLIEKYFSVEEE-EDQNVVPE 509
Cdd:pfam16186   1 LLIEEAGGLDKIEALQNHENEEIYKKAYKIIEKYFSDEEEeDDENLAPE 49
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 324-364 6.13e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 51.69  E-value: 6.13e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6754474    324 TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 9.81e-09

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 50.92  E-value: 9.81e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 6754474    151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLA 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 151-190 1.54e-08

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 50.51  E-value: 1.54e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6754474     151 TSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIA 190
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 135-189 1.26e-07

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 48.52  E-value: 1.26e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 6754474    135 PIQFESAWALTNIASGTSEQTKAVVDGgAIPAFISLLASPHAHISEQAVWALGNI 189
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVPE-LLPALLPLLNDDSDLVREAAAWALGRL 55
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 367-406 1.63e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 47.45  E-value: 1.63e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 6754474    367 QDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTS 406
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
HEAT COG1413
HEAT repeat [General function prediction only];
163-320 3.54e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.63  E-value: 3.54e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  163 AIPAFISLLASPHAHISEQAVWALGNIaGDGSafrdlvikhgAIDPLLALLAVPDLSTlacgyLRNLTWTLSNLcrnknp 242
Cdd:COG1413  17 AVPALIAALADEDPDVRAAAARALGRL-GDPR----------AVPALLEALKDPDPEV-----RAAAAEALGRI------ 74

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6754474  243 appldAVEQILPTLVRLLHHNDPEVLADSCWAISYLTDgpneriemvvkKGVVPQLVKLLGATELPIVTPALRAIGNI 320
Cdd:COG1413  75 -----GDPEAVPALIAALKDEDPEVRRAAAEALGRLGD-----------PAAVPALLEALKDPDWEVRRAAARALGRL 136
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 409-447 5.78e-07

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 45.91  E-value: 5.78e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 6754474    409 TVEQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNI 447
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 366-406 7.89e-07

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.50  E-value: 7.89e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 6754474     366 RQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTS 406
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 324-364 1.38e-06

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 45.11  E-value: 1.38e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 6754474     324 TDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITA 364
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 109-149 2.56e-06

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 44.37  E-value: 2.56e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6754474    109 QPPIDNIIRAGLIPKFVSFLGKTDCSpIQFESAWALTNIAS 149
Cdd:pfam00514   2 PENKQAVIEAGAVPPLVRLLSSPDEE-VQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 252-280 1.62e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 42.06  E-value: 1.62e-05
                          10        20
                  ....*....|....*....|....*....
gi 6754474    252 ILPTLVRLLHHNDPEVLADSCWAISYLTD 280
Cdd:pfam00514  13 AVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 282-322 2.36e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 2.36e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 6754474    282 PNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIVT 322
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWALSNLAA 41
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 197-238 2.84e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 41.29  E-value: 2.84e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 6754474    197 RDLVIKHGAIDPLLALLAVPDLSTlacgyLRNLTWTLSNLCR 238
Cdd:pfam00514   5 KQAVIEAGAVPPLVRLLSSPDEEV-----QEEAAWALSNLAA 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 282-321 7.65e-05

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 40.11  E-value: 7.65e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 6754474     282 PNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGNIV 321
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNLS 40
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 108-149 1.18e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.18e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 6754474     108 KQPPIDNIIRAGLIPKFVSFLGKTDcSPIQFESAWALTNIAS 149
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSED-EEVVKEAAWALSNLSS 41
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 411-447 1.25e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6754474     411 EQIVYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNI 447
Cdd:smart00185   3 ENKQAVVDAGGLPALVELLKSEDEEVVKEAAWALSNL 39
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 250-280 1.30e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 39.33  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 6754474     250 EQILPTLVRLLHHNDPEVLADSCWAISYLTD 280
Cdd:smart00185  11 AGGLPALVELLKSEDEEVVKEAAWALSNLSS 41
HEAT COG1413
HEAT repeat [General function prediction only];
121-267 1.99e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.54  E-value: 1.99e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  121 IPKFVSFLGKTDcSPIQFESAWALTNIAsgtseqtkavvDGGAIPAFISLLASPHAHISEQAVWALGNIAGDgsafrdlv 200
Cdd:COG1413  18 VPALIAALADED-PDVRAAAARALGRLG-----------DPRAVPALLEALKDPDPEVRAAAAEALGRIGDP-------- 77

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6754474  201 ikhGAIDPLLALLAVPDLS--TLACGYLRNLtwtlsnlcrnknpappldAVEQILPTLVRLLHHNDPEV 267
Cdd:COG1413  78 ---EAVPALIAALKDEDPEvrRAAAEALGRL------------------GDPAAVPALLEALKDPDWEV 125
HEAT COG1413
HEAT repeat [General function prediction only];
250-401 2.30e-04

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 41.15  E-value: 2.30e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  250 EQILPTLVRLLHHNDPEVLADSCWAISYLTDgpneriemvvkKGVVPQLVKLLGATELPIVTPALRAIGNIvtGTDEQTQ 329
Cdd:COG1413  15 PAAVPALIAALADEDPDVRAAAARALGRLGD-----------PRAVPALLEALKDPDPEVRAAAAEALGRI--GDPEAVP 81

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6754474  330 KVIDAgalavfpslLTNPKTNIQKEATWTMSNITAGRqdqiqqvvnhgLVPFLVGVLSKADFKTQKEAAWAI 401
Cdd:COG1413  82 ALIAA---------LKDEDPEVRRAAAEALGRLGDPA-----------AVPALLEALKDPDWEVRRAAARAL 133
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 231-278 2.46e-04

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 38.89  E-value: 2.46e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 6754474    231 WTLSNLCrNKNPAPPLDAVEQILPTLVRLLHHNDPEVLADSCWAISYL 278
Cdd:pfam13513   9 LALGSLA-EGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWALGRL 55
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 78-195 4.35e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 43.17  E-value: 4.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474     78 VEDIVKGINSNNLESQLQATQAARKLLsREKQPPIDNIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKA 157
Cdd:PLN03200  191 VDILVKLLSSGNSDAQANAASLLARLM-MAFESSISKVLDAGAVKQLLKLLGQGNEVSVRAEAAGALEALSSQSKEAKQA 269

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6754474    158 VVDGGAIPAFISLLASP--------HAH-ISEQAVWALGNIAGDGSA 195
Cdd:PLN03200  270 IADAGGIPALINATVAPskefmqgeFAQaLQENAMGALANICGGMSA 316
PLN03200 PLN03200
cellulose synthase-interactive protein; Provisional
 163-448 6.12e-04

cellulose synthase-interactive protein; Provisional


Pssm-ID: 215629 [Multi-domain]  Cd Length: 2102  Bit Score: 42.78  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    163 AIPAFISLLASPHAHISEQAVWALGNIAGDgSAFRDLVIKHGAIDPLLALL----------------------------- 213
Cdd:PLN03200   59 AMPLLVSLLRSGTLGAKVNAAAVLGVLCKE-EDLRVKVLLGGCIPPLLSLLksgsaeaqkaaaeaiyavssgglsdhvgs 137

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    214 -------AVPDLSTLacgyLRN-----------LTWTLSNLCRNKNP--APPLDA--VEqilpTLVRLLHHNDPEVLADS 271
Cdd:PLN03200  138 kifstegVVPSLWDQ----LQPgnkqdkvveglLTGALRNLCGSTDGfwSATLEAggVD----ILVKLLSSGNSDAQANA 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    272 CWAISYLTDGPNERIEMVVKKGVVPQLVKLLG-ATELPIVTPALRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNP-KT 349
Cdd:PLN03200  210 ASLLARLMMAFESSISKVLDAGAVKQLLKLLGqGNEVSVRAEAAGALEALSSQSKEAKQAIADAGGIPALINATVAPsKE 289

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474    350 NIQKE--------ATWTMSNITAGrqdqiqqvvnhglVPFLVGVLSKADFKTQKEA---------AWAITNYTSGGTVEQ 412
Cdd:PLN03200  290 FMQGEfaqalqenAMGALANICGG-------------MSALILYLGELSESPRSPApiadtlgalAYALMVFDSSAESTR 356

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 6754474    413 IVYLVHcgIIEPLMNLLSAKDTKIIQV-ILDAISNIF 448
Cdd:PLN03200  357 AFDPTV--IEQILVKLLKPRDTKLVQErIIEALASLY 391
Syo1_like cd13394
Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes ...
 144-448 9.27e-03

Fungal symportin 1 (syo1) and similar proteins; This family of eukaryotic proteins includes Saccharomyces cerevisiae Ydl063c and Chaetomium thermophilum Syo1, which mediate the co-import of two ribosomal proteins, Rpl5 and Rpl11 (which both interact with 5S rRNA) into the nucleus. Import precedes their association with rRNA and subsequent ribosome assembly in the nucleolus. The primary structure of syo1 is a mixture of Armadillo- (ARM, N-terminal part of syo1) and HEAT-repeats (C-terminal part of syo1).


Pssm-ID: 240521 [Multi-domain]  Cd Length: 597  Bit Score: 38.83  E-value: 9.27e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  144 LTNIASGTSEQTKAVVDGGAIPAFISLLASPHAH-ISEQAVWALGN----IAGDGSAFRDLVIKH-GAIDPLLALLAVPD 217
Cdd:cd13394 167 LWNLAEGSDEILSAVNKEDLLLFLLAILINFLTSkLPTSLFNAALQclytLSEDNPEFIDKLSSDpEILGNLLDIVSSDP 246

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  218 LS------TLACGYLRNLTwTLSNLCRNKNPAppldAVEQILPTLVRLLHHNDPEVLADSC---------WAI-SYLTDG 281
Cdd:cd13394 247 SSsnillkVLVCGILLNIL-EVLSWLAGKDAA----ADAILLPILSAILSILALEILANICkeldkkddeAMEdEQSDED 321

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  282 PNERIEMVVKKGVVPQLVKLLGATELPivtPALRaigNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEAT----- 356
Cdd:cd13394 322 EEEDEDDEASETLVPELSPLEISLDLL---TALL---ELIAPTPESVEPILPSSTIEELPPPLSKLLLSLHSRALeclnn 395

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  357 --WTM-SNITAGRQDQ--------IQQVVNHGLVPFLVGVLSKAdfktqKEAAWAIT------NYTSGGTVEQIVYLVH- 418
Cdd:cd13394 396 llWLFlSLELGGDWNNslqqlwdlLAQLIFKDVISADLELLEAA-----TSVLWALLkslggeILLQQNTHDFIQSLIEa 470

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6754474  419 -------------CGII-----------------EPLMNLLSAKDTKIIQVILDAISNIF 448
Cdd:cd13394 471 sktdadlelrvrcVGVLgslaqvpgnievnkeigQFLLELLTKLPNTPPEVLVEALNAIF 530
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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