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Conserved domains on  [gi|6753890|ref|NP_034361|]
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flavin-containing monooxygenase 1 isoform 1 [Mus musculus]

Protein Classification

flavin-binding monooxygenase-like family protein( domain architecture ID 1000557)

flavin-binding monooxygenase-like family protein; such as flavin-containing monooxygenases (FMOs) that catalyze the monooxygenation of a variety of substrates

EC:  1.14.13.-
Gene Ontology:  GO:0004497

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
FMO-like super family cl30939
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


The actual alignment was detected with superfamily member pfam00743:

Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 935.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890      3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFV 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFPG 162
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFPG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    163 ILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNM 242
Cdd:pfam00743 162 IEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTSF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    243 LRNLLPTPIVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKEEPI 322
Cdd:pfam00743 242 LRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEEDI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    323 DIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTGETQARWVVQVLKGATTLPPP 402
Cdd:pfam00743 322 DVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPSQ 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    403 SVMMEEVNERKKNKHSGFGLCYCKALQTDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWE 482
Cdd:pfam00743 402 SEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKWE 481

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 6753890    483 GARKAILTQWDRTVKVTKTRTIQESPSSFET-LLKLFSFLALLIAVFLIF 531
Cdd:pfam00743 482 GARNAILTQWDRILKPLKTRVVEKSSSPASSfTLKIFGLPVVLVAIFLIL 531
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 935.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890      3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFV 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFPG 162
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFPG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    163 ILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNM 242
Cdd:pfam00743 162 IEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTSF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    243 LRNLLPTPIVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKEEPI 322
Cdd:pfam00743 242 LRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEEDI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    323 DIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTGETQARWVVQVLKGATTLPPP 402
Cdd:pfam00743 322 DVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPSQ 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    403 SVMMEEVNERKKNKHSGFGLCYCKALQTDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWE 482
Cdd:pfam00743 402 SEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKWE 481

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 6753890    483 GARKAILTQWDRTVKVTKTRTIQESPSSFET-LLKLFSFLALLIAVFLIF 531
Cdd:pfam00743 482 GARNAILTQWDRILKPLKTRVVEKSSSPASSfTLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-394 2.30e-82

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 262.49  E-value: 2.30e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEhveegraslYKSVVSNSSREMSCYPDFPFPEDYPNFVP 83
Cdd:COG2072   8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   84 NSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDfavSGQWeVVTVTNGKQNSAifDAVMVCTGFLTNPHLPldSFPGI 163
Cdd:COG2072  79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRW-TVTTDDGETLTA--RFVVVATGPLSRPKIP--DIPGL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  164 LTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVfdsGYPWDmifMTRFQNML 243
Cdd:COG2072 151 EDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---NYDPE---RGRPANYL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  244 RNLLPTPI----VSWLISKKMNSWFNHVNYGVAPEDRTQLRE-PVLNDELPGRIITGKV-FIKPSIKEVKENSVVFNNtP 317
Cdd:COG2072 225 GLEAPPALnrrdARAWLRRLLRAQVKDPELGLLTPDYPPGCKrPLLSTDYYEALRRGNVeLVTGGIERITEDGVVFAD-G 303

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  318 KEEPIDIIVFATGYTFAFPFLDESVVKVEDGQAS--LYKYIFPAHLpkPTLAVIGLIKPLG--SMVPTGETQARWVVQVL 393
Cdd:COG2072 304 TEHEVDVIVWATGFRADLPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLI 381


                .
gi 6753890  394 K 394
Cdd:COG2072 382 A 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-411 4.05e-45

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 165.03  E-value: 4.05e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEG-----------RASLYKSVVSNSSREMSCYPD 71
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    72 FPF----------PEDYPNfvpNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITkrpdfAVSGQWEVVTVTNGK-QNSAIF 140
Cdd:PLN02172  91 FPFvprfddesrdSRRYPS---HREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGfSKDEIF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   141 DAVMVCTGFLTNPHLPldSFPGILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSttggawv 220
Cdd:PLN02172 163 DAVVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA------- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   221 iSRvfdsgypwdmifmtrfqnmlrnllptpivswliskkmnswfnhvnygvAPEDRTQLREPVLNDELpgriitgkvFIK 300
Cdd:PLN02172 234 -SR------------------------------------------------ASESDTYEKLPVPQNNL---------WMH 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   301 PSIKEVKEN-SVVFNNTpKEEPIDIIVFATGYTFAFPFLDES-VVKVEDGQAS-LYKYIFPAHLpKPTLAVIGLiKPLGS 377
Cdd:PLN02172 256 SEIDTAHEDgSIVFKNG-KVVYADTIVHCTGYKYHFPFLETNgYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGI 332

                        410       420       430
                 ....*....|....*....|....*....|....
gi 6753890   378 MVPTGETQARWVVQVLKGATTLPPPSVMMEEVNE 411
Cdd:PLN02172 333 QFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINA 366
 
Name Accession Description Interval E-value
FMO-like pfam00743
Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone ...
 3-531 0e+00

Flavin-binding monooxygenase-like; This family includes FMO proteins, cyclohexanone mono-oxygenase and a number of different mono-oxygenases.


Pssm-ID: 395602 [Multi-domain]  Cd Length: 531  Bit Score: 935.35  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890      3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEGRASLYKSVVSNSSREMSCYPDFPFPEDYPNFV 82
Cdd:pfam00743   2 KKVAVIGAGVSGLASIKCCLEEGLEPTCFERSDDIGGLWRFTENVEEGRASIYKSVITNTSKEMSCFSDFPFPEDYPNFM 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDFAVSGQWEVVTVTNGKQNSAIFDAVMVCTGFLTNPHLPLDSFPG 162
Cdd:pfam00743  82 HNSKFLEYFRMFAKEFDLLKYIQFKTTVCSVKKRPDFSTSGQWEVVTEHEGKQESAVFDAVMVCTGHHTNPHLPLESFPG 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    163 ILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVFDSGYPWDMIFMTRFQNM 242
Cdd:pfam00743 162 IEKFKGQYFHSRDYKHPEGFTGKRVLVIGIGNSGGDIAVELSHTAAQVFLSTRRGSWVLSRVSDHGYPWDMLFSTRFTSF 241

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    243 LRNLLPTPIVSWLISKKMNSWFNHVNYGVAPEDRTQLREPVLNDELPGRIITGKVFIKPSIKEVKENSVVFNNTPKEEPI 322
Cdd:pfam00743 242 LRNILPTSISNWLMEKQMNRRFNHENYGLKPKNRALSKEPVVNDDLPNRILCGAVKVKPNVKEFTETSAIFEDGTVEEDI 321

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    323 DIIVFATGYTFAFPFLDESVVKVEDGQASLYKYIFPAHLPKPTLAVIGLIKPLGSMVPTGETQARWVVQVLKGATTLPPP 402
Cdd:pfam00743 322 DVVIFATGYTFAFPFLEESLVKVENNKVSLYKYVFPPNLEKPTLAIIGLIQPLGSIIPTVELQARWATRVFKGLCTLPSQ 401

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    403 SVMMEEVNERKKNKHSGFGLCYCKALQTDYITYIDDLLTSINAKPDLRAMLLTDPRLALSIFFGPCTPYHFRLTGPGKWE 482
Cdd:pfam00743 402 SEMMAEINKRQEKKIKRFGDSQSHTIQTDYIDYMDELALFIGAKPNLLSLLLTDPKLALKLFFGPCTPYQYRLVGPGKWE 481

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|
gi 6753890    483 GARKAILTQWDRTVKVTKTRTIQESPSSFET-LLKLFSFLALLIAVFLIF 531
Cdd:pfam00743 482 GARNAILTQWDRILKPLKTRVVEKSSSPASSfTLKIFGLPVVLVAIFLIL 531
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 4-394 2.30e-82

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 262.49  E-value: 2.30e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEhveegraslYKSVVSNSSREMSCYPDFPFPEDYPNFVP 83
Cdd:COG2072   8 DVVVIGAGQAGLAAAYHLRRAGIDFVVLEKADDVGGTWRDNR---------YPGLRLDTPSHLYSLPFFPNWSDDPDFPT 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   84 NSLFLEYLKLYSTQFNLQRCIYFNTKVCSITKRPDfavSGQWeVVTVTNGKQNSAifDAVMVCTGFLTNPHLPldSFPGI 163
Cdd:COG2072  79 GDEILAYLEAYADKFGLRRPIRFGTEVTSARWDEA---DGRW-TVTTDDGETLTA--RFVVVATGPLSRPKIP--DIPGL 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  164 LTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSTTGGAWVISRVfdsGYPWDmifMTRFQNML 243
Cdd:COG2072 151 EDFAGEQLHSADWRNPVDLAGKRVLVVGTGASAVQIAPELARVAAHVTVFQRTPPWVLPRP---NYDPE---RGRPANYL 224

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  244 RNLLPTPI----VSWLISKKMNSWFNHVNYGVAPEDRTQLRE-PVLNDELPGRIITGKV-FIKPSIKEVKENSVVFNNtP 317
Cdd:COG2072 225 GLEAPPALnrrdARAWLRRLLRAQVKDPELGLLTPDYPPGCKrPLLSTDYYEALRRGNVeLVTGGIERITEDGVVFAD-G 303

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  318 KEEPIDIIVFATGYTFAFPFLDESVVKVEDGQAS--LYKYIFPAHLpkPTLAVIGLIKPLG--SMVPTGETQARWVVQVL 393
Cdd:COG2072 304 TEHEVDVIVWATGFRADLPWLAPLDVRGRDGRSGprAYLGVVVPGF--PNLFFLGPNSPSGhsSLTLGAERQARYIARLI 381


                .
gi 6753890  394 K 394
Cdd:COG2072 382 A 382
PLN02172 PLN02172
flavin-containing monooxygenase FMO GS-OX
 3-411 4.05e-45

flavin-containing monooxygenase FMO GS-OX


Pssm-ID: 215116 [Multi-domain]  Cd Length: 461  Bit Score: 165.03  E-value: 4.05e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRFTEHVEEG-----------RASLYKSVVSNSSREMSCYPD 71
Cdd:PLN02172  11 QHVAVIGAGAAGLVAARELRREGHTVVVFEREKQVGGLWVYTPKSESDplsldptrsivHSSVYESLRTNLPRECMGYRD 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    72 FPF----------PEDYPNfvpNSLFLEYLKLYSTQFNLQRCIYFNTKVCSITkrpdfAVSGQWEVVTVTNGK-QNSAIF 140
Cdd:PLN02172  91 FPFvprfddesrdSRRYPS---HREVLAYLQDFAREFKIEEMVRFETEVVRVE-----PVDGKWRVQSKNSGGfSKDEIF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   141 DAVMVCTGFLTNPHLPldSFPGILTFKGEYFHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEASHLAKKVFLSttggawv 220
Cdd:PLN02172 163 DAVVVCNGHYTEPNVA--HIPGIKSWPGKQIHSHNYRVPDPFKNEVVVVIGNFASGADISRDIAKVAKEVHIA------- 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   221 iSRvfdsgypwdmifmtrfqnmlrnllptpivswliskkmnswfnhvnygvAPEDRTQLREPVLNDELpgriitgkvFIK 300
Cdd:PLN02172 234 -SR------------------------------------------------ASESDTYEKLPVPQNNL---------WMH 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   301 PSIKEVKEN-SVVFNNTpKEEPIDIIVFATGYTFAFPFLDES-VVKVEDGQAS-LYKYIFPAHLpKPTLAVIGLiKPLGS 377
Cdd:PLN02172 256 SEIDTAHEDgSIVFKNG-KVVYADTIVHCTGYKYHFPFLETNgYMRIDENRVEpLYKHVFPPAL-APGLSFIGL-PAMGI 332

                        410       420       430
                 ....*....|....*....|....*....|....
gi 6753890   378 MVPTGETQARWVVQVLKGATTLPPPSVMMEEVNE 411
Cdd:PLN02172 333 QFVMFEIQSKWVAAVLSGRVTLPSEDKMMEDINA 366
Pyr_redox_3 pfam13738
Pyridine nucleotide-disulphide oxidoreductase;
70-352 6.18e-18

Pyridine nucleotide-disulphide oxidoreductase;


Pssm-ID: 404603 [Multi-domain]  Cd Length: 296  Bit Score: 84.20  E-value: 6.18e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     70 PDFPFPEDYPNfvpNSLFLEYLKLYSTQFNLQrcIYFNTKVCSITKrpdfaVSGQWEVVTvtngkqNSAIFDA--VMVCT 147
Cdd:pfam13738  63 PAFTFNREHPS---GNEYAEYLRRVADHFELP--INLFEEVTSVKK-----EDDGFVVTT------SKGTYQAryVIIAT 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    148 GFLTNPHLPLDSFPGIltfkgeyfHSRQYKHPDIFKDKRVLVVGMGNSGTDIAVEashLAKKvflsttgGAWVisRVFDS 227
Cdd:pfam13738 127 GEFDFPNKLGVPELPK--------HYSYVKDFHPYAGQKVVVIGGYNSAVDAALE---LVRK-------GARV--TVLYR 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    228 GYPWDmifmtrfqnmlrnllptpivswliskkmnSWFNHVNYGVAPEDRTQLREPVLNdelpGRIitgKVFIKPSIKEVK 307
Cdd:pfam13738 187 GSEWE-----------------------------DRDSDPSYSLSPDTLNRLEELVKN----GKI---KAHFNAEVKEIT 230

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 6753890    308 ENSVVFN-NTPKEEPI---DIIVFATGYTFAFPFLDESVVKV-EDGQASL 352
Cdd:pfam13738 231 EVDVSYKvHTEDGRKVtsnDDPILATGYHPDLSFLKKGLFELdEDGRPVL 280
YdhS COG4529
Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];
3-216 2.21e-08

Uncharacterized NAD(P)/FAD-binding protein YdhS [General function prediction only];


Pssm-ID: 443597 [Multi-domain]  Cd Length: 466  Bit Score: 56.50  E-value: 2.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    3 KRVAIVGAGVSG---LASIKCCLEEGLEPTCFERSSDLGglwrftehveEGRAslY----KSVVSN-SSREMSCYPDFP- 73
Cdd:COG4529   6 KRIAIIGGGASGtalAIHLLRRAPEPLRITLFEPRPELG----------RGVA--YstdsPEHLLNvPAGRMSAFPDDPd 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   74 --------------FPEDYPNFVPNSLFLEYLK-----LYSTQFNLQRCIYFNTKVCSITKRpdfavSGQWEVVTvTNGK 134
Cdd:COG4529  74 hflrwlrengaraaPAIDPDAFVPRRLFGEYLRerlaeALARAPAGVRLRHIRAEVVDLERD-----DGGYRVTL-ADGE 147

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890  135 qnSAIFDAVMVCTGfltnpHLPLDSFPGILTFKGEYFHS--RQYKHPDIFKDKRVLVVGMGNSGTDIAV---EASHLAKK 209
Cdd:COG4529 148 --TLRADAVVLATG-----HPPPAPPPGLAAGSPRYIADpwPPGALARIPPDARVLIIGTGLTAIDVVLslaARGHRGPI 220


                ....*..
gi 6753890  210 VFLSTTG 216
Cdd:COG4529 221 TALSRRG 227
PRK12770 PRK12770
putative glutamate synthase subunit beta; Provisional
 3-213 3.74e-06

putative glutamate synthase subunit beta; Provisional


Pssm-ID: 237197 [Multi-domain]  Cd Length: 352  Bit Score: 49.22  E-value: 3.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     3 KRVAIVGAGVSGLAS---IKCcleEGLEPTCFERSSDLGGLWRFT--------EHVEEGRASLYKSVVSNSSREMSCYPD 71
Cdd:PRK12770  19 KKVAIIGAGPAGLAAagyLAC---LGYEVHVYDKLPEPGGLMLFGipefripiERVREGVKELEEAGVVFHTRTKVCCGE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    72 FPFPEDYPNFVPNSLFLEYLklystqfnlqrciyfntkvcsITKrpdfavsgqwevvtvtngkqnsaiFDAVMVCTGFLT 151
Cdd:PRK12770  96 PLHEEEGDEFVERIVSLEEL---------------------VKK------------------------YDAVLIATGTWK 130

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6753890   152 N--PHLPLDSFPGIltFKG-EY-FHSRQYKH--------PDiFKDKRVLVVGMGNSGTDIAVEASHL-AKKVFLS 213
Cdd:PRK12770 131 SrkLGIPGEDLPGV--YSAlEYlFRIRAAKLgylpwekvPP-VEGKKVVVVGAGLTAVDAALEAVLLgAEKVYLA 202
TrxB COG0492
Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];
5-212 1.77e-05

Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440258 [Multi-domain]  Cd Length: 305  Bit Score: 46.65  E-value: 1.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    5 VAIVGAGVSGL-ASIKCCLEeGLEPTCFERSsDLGGLWRFTEHVEegraslyksvvsNssremscYPDFPF----PEdyp 79
Cdd:COG0492   3 VVIIGAGPAGLtAAIYAARA-GLKTLVIEGG-EPGGQLATTKEIE------------N-------YPGFPEgisgPE--- 58

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   80 nfvpnslFLEYLKLYSTQFNLQrciYFNTKVCSITKrpdfavSGQWEVVTVTNGKQNSAifDAVMVCTGFltNP-HLPLd 158
Cdd:COG0492  59 -------LAERLREQAERFGAE---ILLEEVTSVDK------DDGPFRVTTDDGTEYEA--KAVIIATGA--GPrKLGL- 117

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6753890  159 sfPGILTFKGE----------YFhsrqykhpdiFKDKRVLVVGMGNSGTDIAVEASHLAKKVFL 212
Cdd:COG0492 118 --PGEEEFEGRgvsycatcdgFF----------FRGKDVVVVGGGDSALEEALYLTKFASKVTL 169
Pyr_redox_2 pfam07992
Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II ...
 3-210 3.33e-05

Pyridine nucleotide-disulphide oxidoreductase; This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases. This domain is actually a small NADH binding domain within a larger FAD binding domain.


Pssm-ID: 400379 [Multi-domain]  Cd Length: 301  Bit Score: 45.77  E-value: 3.33e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890      3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFErssdLGGLWRFtehveeGRASLYKSVVSnssremscypdfpFPEDYPNFV 82
Cdd:pfam07992   1 YDVVVIGGGPAGLAAALTLAQLGGKVTLIE----DEGTCPY------GGCVLSKALLG-------------AAEAPEIAS 57

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     83 PNSLFLEYLKLYSTQFNLQRCIYFNTKVCSItkrpDFAvsgqWEVVTVTNGKQNSAI---FDAVMVCTGFLTNPhLPLDS 159
Cdd:pfam07992  58 LWADLYKRKEEVVKKLNNGIEVLLGTEVVSI----DPG----AKKVVLEELVDGDGEtitYDRLVIATGARPRL-PPIPG 128

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6753890    160 FPGILTFKGEYFHSRQYKHPDIfKDKRVLVVGMGNSGTDIAVEASHLAKKV 210
Cdd:pfam07992 129 VELNVGFLVRTLDSAEALRLKL-LPKRVVVVGGGYIGVELAAALAKLGKEV 178
NAD_binding_9 pfam13454
FAD-NAD(P)-binding;
6-150 3.55e-05

FAD-NAD(P)-binding;


Pssm-ID: 433222 [Multi-domain]  Cd Length: 155  Bit Score: 44.19  E-value: 3.55e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890      6 AIVGAGVSGLAS----IKCCLEEGLEPTCFERSSD-LGGLWRfTEHVEEGRAslyksvvsNS-SREMSCYPDFPF----- 74
Cdd:pfam13454   1 AIVGGGPSGLALlerlLARAPKRPLEITLFDPSPPgAGGVYR-TDQSPEHLL--------NVpASRMSLFPDDPPhflew 71

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890     75 ----------PEDYPN-FVPNSLFLEYLKLYSTQF-----NLQRCIYFNTKVCSITKRPDfavsGQWevVTVTNGkqNSA 138
Cdd:pfam13454  72 lrargaldeaPGLDPDdFPPRALYGRYLRDRFEEAlarapAGVTVRVHRARVTDLRPRGD----GYR--VLLADG--RTL 143

                         170
                  ....*....|..
gi 6753890    139 IFDAVMVCTGFL 150
Cdd:pfam13454 144 AADAVVLATGHG 155
HemY COG1232
Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen ...
 3-40 6.68e-05

Protoporphyrinogen oxidase HemY/PPOX [Coenzyme transport and metabolism]; Protoporphyrinogen oxidase HemY/PPOX is part of the Pathway/BioSystem: Heme biosynthesis


Pssm-ID: 440845 [Multi-domain]  Cd Length: 443  Bit Score: 45.21  E-value: 6.68e-05
                        10        20        30
                ....*....|....*....|....*....|....*...
gi 6753890    3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGL 40
Cdd:COG1232   2 KRVAVIGGGIAGLTAAYRLAKAGHEVTVLEASDRVGGL 39
NAD_binding_8 pfam13450
NAD(P)-binding Rossmann-like domain;
7-66 2.70e-04

NAD(P)-binding Rossmann-like domain;


Pssm-ID: 433218 [Multi-domain]  Cd Length: 67  Bit Score: 39.44  E-value: 2.70e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6753890      7 IVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGL---WRFTEHVEEGRASLYKSVVSNSSREM 66
Cdd:pfam13450   1 IVGAGLAGLVAAALLAKRGFRVLVLEKRDRLGGNaysYRVPGYVFDYGAHIFHGSDEPNVRDL 63
PRK07233 PRK07233
hypothetical protein; Provisional
 4-40 2.84e-04

hypothetical protein; Provisional


Pssm-ID: 235977 [Multi-domain]  Cd Length: 434  Bit Score: 43.34  E-value: 2.84e-04
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 6753890     4 RVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGL 40
Cdd:PRK07233   1 KIAIVGGGIAGLAAAYRLAKRGHEVTVFEADDQLGGL 37
COG3349 COG3349
Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function ...
 1-39 3.16e-04

Uncharacterized protein, contains NAD-binding domain and a Fe-S cluster [General function prediction only];


Pssm-ID: 442577 [Multi-domain]  Cd Length: 445  Bit Score: 43.30  E-value: 3.16e-04
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 6753890    1 MVKRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGG 39
Cdd:COG3349   2 MPPRVVVVGGGLAGLAAAVELAEAGFRVTLLEARPRLGG 40
gltD PRK12810
glutamate synthase subunit beta; Reviewed
 3-43 3.52e-04

glutamate synthase subunit beta; Reviewed


Pssm-ID: 237213 [Multi-domain]  Cd Length: 471  Bit Score: 43.23  E-value: 3.52e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 6753890     3 KRVAIVGAGVSGLAsikcCLEE----GLEPTCFERSSDLGGLWRF 43
Cdd:PRK12810 144 KKVAVVGSGPAGLA----AADQlaraGHKVTVFERADRIGGLLRY 184
PRK12769 PRK12769
putative oxidoreductase Fe-S binding subunit; Reviewed
 3-43 3.58e-04

putative oxidoreductase Fe-S binding subunit; Reviewed


Pssm-ID: 183733 [Multi-domain]  Cd Length: 654  Bit Score: 43.20  E-value: 3.58e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 6753890     3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSDLGGLWRF 43
Cdd:PRK12769 328 KRVAIIGAGPAGLACADVLARNGVAVTVYDRHPEIGGLLTF 368
GltD COG0493
NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport ...
 3-203 5.79e-04

NADPH-dependent glutamate synthase beta chain or related oxidoreductase [Amino acid transport and metabolism, General function prediction only]; NADPH-dependent glutamate synthase beta chain or related oxidoreductase is part of the Pathway/BioSystem: Glutamine biosynthesis


Pssm-ID: 440259 [Multi-domain]  Cd Length: 434  Bit Score: 42.43  E-value: 5.79e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890    3 KRVAIVGAGVSGLAsikcC----LEEGLEPTCFERSSDLGGLWRFtehveeGraslyksvvsnssremscYPDFPFPEDy 78
Cdd:COG0493 122 KKVAVVGSGPAGLA----AayqlARAGHEVTVFEALDKPGGLLRY------G------------------IPEFRLPKD- 172

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753890   79 pnFVpnSLFLEYLKLYSTQFnlqrciYFNTKVcsitkrpdfavsgqwevvtvtnGKQNS-----AIFDAVMVCTGFLTNP 153
Cdd:COG0493 173 --VL--DREIELIEALGVEF------RTNVEV----------------------GKDITldellEEFDAVFLATGAGKPR 220

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6753890  154 HLPLdsfPGIlTFKGEYF------HSRQYKHPD--IFKDKRVLVVGMGNSGTDIAVEA 203
Cdd:COG0493 221 DLGI---PGE-DLKGVHSamdfltAVNLGEAPDtiLAVGKRVVVIGGGNTAMDCARTA 274
MurD COG0771
UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; ...
 3-36 3.50e-03

UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell wall/membrane/envelope biogenesis]; UDP-N-acetylmuramoylalanine-D-glutamate ligase is part of the Pathway/BioSystem: Mureine biosynthesis


Pssm-ID: 440534 [Multi-domain]  Cd Length: 445  Bit Score: 40.06  E-value: 3.50e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 6753890    3 KRVAIVGAGVSGLASIKCCLEEGLEPTCFERSSD 36
Cdd:COG0771   5 KKVLVLGLGKSGLAAARLLAKLGAEVTVSDDRPA 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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