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Conserved domains on  [gi|183583542|ref|NP_034248|]
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E3 SUMO-protein ligase EGR2 isoform 1 [Mus musculus]

Protein Classification

DUF3446 and COG5048 domain-containing protein( domain architecture ID 12112558)

protein containing domains DUF3446, zf-C2H2, and COG5048

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 94-189 4.95e-13

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


:

Pssm-ID: 463400  Cd Length: 104  Bit Score: 65.24  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542   94 GKFSIDPQYP-GASCYPEGIINIVSaGILQGVTPPASTTASSSVTSASPNplATGPLGVCTMSQTQPELDHLYSPPPPPP 172
Cdd:pfam11928   1 GKFSIDPQYPgGGSLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSPN--SSGPLCTMSCSVQSSEMEHIYSAPPPYP 77

                          90
                  ....*....|....*..
gi 183583542  173 PySGCtGDLYQDPSAFL 189
Cdd:pfam11928  78 S-SGC-GDLYQDPSAFL 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-421 2.68e-08

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 183583542 365 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIHLRQK 421
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNP 90
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-361 2.07e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*
gi 183583542  337 YPCPaeGCDRRFSRSDELTRHIRIH 361
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 94-189 4.95e-13

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 65.24  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542   94 GKFSIDPQYP-GASCYPEGIINIVSaGILQGVTPPASTTASSSVTSASPNplATGPLGVCTMSQTQPELDHLYSPPPPPP 172
Cdd:pfam11928   1 GKFSIDPQYPgGGSLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSPN--SSGPLCTMSCSVQSSEMEHIYSAPPPYP 77

                          90
                  ....*....|....*..
gi 183583542  173 PySGCtGDLYQDPSAFL 189
Cdd:pfam11928  78 S-SGC-GDLYQDPSAFL 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-421 2.68e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 183583542 365 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIHLRQK 421
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNP 90
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 7.77e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 7.77e-07
                          10        20
                  ....*....|....*....|....*.
gi 183583542  381 HLTTHIRTHTGEKPFACDYCGRKFAR 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-361 2.07e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*
gi 183583542  337 YPCPaeGCDRRFSRSDELTRHIRIH 361
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
 366-413 2.86e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 2.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 183583542 366 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDYCGRKFARSDERKRH 413
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
 
Name Accession Description Interval E-value
DUF3446 pfam11928
Early growth response N-terminal domain; Proteins containing this domain include early growth ...
 94-189 4.95e-13

Early growth response N-terminal domain; Proteins containing this domain include early growth response protein 1/2/3 (EGR1/2/3). EGR1 is a transcriptional regulator that binds specifically to 9-bp target sequences containing two CpG sites that can potentially be methylated at four cytosine bases. EGR2, also known as Krox20, is an E3 ligase that sumoylates its Nab coregulators. This domain has a single completely conserved residue P that may be functionally important. Furthermore, it is found associated with pfam00096.


Pssm-ID: 463400  Cd Length: 104  Bit Score: 65.24  E-value: 4.95e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542   94 GKFSIDPQYP-GASCYPEGIINIVSaGILQGVTPPASTTASSSVTSASPNplATGPLGVCTMSQTQPELDHLYSPPPPPP 172
Cdd:pfam11928   1 GKFSIDPQYPgGGSLWPEGLISLVS-GLVGMANPPSSSSSSSPSSSSSPN--SSGPLCTMSCSVQSSEMEHIYSAPPPYP 77

                          90
                  ....*....|....*..
gi 183583542  173 PySGCtGDLYQDPSAFL 189
Cdd:pfam11928  78 S-SGC-GDLYQDPSAFL 92
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
365-421 2.68e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.86  E-value: 2.68e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 183583542 365 KPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSD--ERKRHTKIHLRQK 421
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHHNNP 90
zf-H2C2_2 pfam13465
Zinc-finger double domain;
381-406 7.77e-07

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 45.05  E-value: 7.77e-07
                          10        20
                  ....*....|....*....|....*.
gi 183583542  381 HLTTHIRTHTGEKPFACDYCGRKFAR 406
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
333-403 4.16e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.92  E-value: 4.16e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 183583542 333 HERPYPCPaeGCDRRFSRSDELTRHIRIHTGHKPFQCRICMR--NFSRSDHLTTHIRTHTGEKPFACDYCGRK 403
Cdd:COG5048   30 APRPDSCP--NCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDLNSKSLPL 100
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 322-415 1.79e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 47.02  E-value: 1.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542 322 KYPNRPSKTpVHERPYPCPAEGCDRRFSRSDELTRHiRIHtGHK-----PFQCRICMRNFSRSDhltthirthtgeKPFA 396
Cdd:COG5189  336 DTPSRMLKV-KDGKPYKCPVEGCNKKYKNQNGLKYH-MLH-GHQnqklhENPSPEKMNIFSAKD------------KPYR 400

                         90
                 ....*....|....*....
gi 183583542 397 CDYCGRKFARSDERKRHTK 415
Cdd:COG5189  401 CEVCDKRYKNLNGLKYHRK 419
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
243-421 2.43e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 2.43e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542 243 GPDRKPFPCPLDSLRVPPPLTPLSTIRNFTLGGPGAGVTGPGASGGGEGPRLPGSGSAavTATPYNPHHLPLRPILRPRK 322
Cdd:COG5048  195 SIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSD--SSSSASESPRSSLPTASSQS 272

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542 323 YPNRPSKTPVHERP-YPCPAEGCDRRFSRSDELTRHIR--IHTG--HKPFQCRI--CMRNFSRSDHLTTHIRTHTGEKPF 395
Cdd:COG5048  273 SSPNESDSSSEKGFsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSISPA 352

                        170       180
                 ....*....|....*....|....*...
gi 183583542 396 ACDY--CGRKFARSDERKRHTKIHLRQK 421
Cdd:COG5048  353 KEKLlnSSSKFSPLLNNEPPQSLQQYKD 380
zf-H2C2_2 pfam13465
Zinc-finger double domain;
353-378 3.41e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.43  E-value: 3.41e-05
                          10        20
                  ....*....|....*....|....*.
gi 183583542  353 ELTRHIRIHTGHKPFQCRICMRNFSR 378
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 337-361 2.07e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.44  E-value: 2.07e-04
                          10        20
                  ....*....|....*....|....*
gi 183583542  337 YPCPaeGCDRRFSRSDELTRHIRIH 361
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 367-389 7.33e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 7.33e-04
                          10        20
                  ....*....|....*....|...
gi 183583542  367 FQCRICMRNFSRSDHLTTHIRTH 389
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 395-417 1.69e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 1.69e-03
                          10        20
                  ....*....|....*....|...
gi 183583542  395 FACDYCGRKFARSDERKRHTKIH 417
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2_4 pfam13894
C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.
 367-389 2.64e-03

C2H2-type zinc finger; This family contains a number of divergent C2H2 type zinc fingers.


Pssm-ID: 464025  Cd Length: 24  Bit Score: 35.31  E-value: 2.64e-03
                          10        20
                  ....*....|....*....|...
gi 183583542  367 FQCRICMRNFSRSDHLTTHIRTH 389
Cdd:pfam13894   1 FKCPICGKSFSSKKSLKRHLKTH 23
PHA00733 PHA00733
hypothetical protein
 366-413 2.86e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.93  E-value: 2.86e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 183583542 366 PFQCRICMRNFSRSDHLTTHIRTHTGEKpfACDYCGRKFARSDERKRH 413
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQHIRYTEHSK--VCPVCGKEFRNTDSTLDH 118
COG5236 COG5236
Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];
339-418 2.95e-03

Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only];


Pssm-ID: 227561 [Multi-domain]  Cd Length: 493  Bit Score: 40.00  E-value: 2.95e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 183583542 339 CPAEGCDRRFSRSDELTRHIRIHtgHKPFQCRICMRN---------FSRSDHLTTHIRTHTGEKPFA----CDYCGRKFA 405
Cdd:COG5236  154 CPKSKCHRRCGSLKELKKHYKAQ--HGFVLCSECIGNkkdfwneirLFRSSTLRDHKNGGLEEEGFKghplCIFCKIYFY 231

                         90
                 ....*....|....*...
gi 183583542 406 RSDE-----RKRHTKIHL 418
Cdd:COG5236  232 DDDElrrhcRLRHEACHI 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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