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Conserved domains on  [gi|169234958|ref|NP_034209|]
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desmoglein-1-alpha preproprotein [Mus musculus]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-265 8.26e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 8.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  165 QIEENSNANTLVMKLNATDADEPNnlNSMIAFKIIrqEPSDSPMFIINRKTGEIRTmNNFLDREQYSQYSLVVRGSdrDG 244
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIV--SGNEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT--DG 77

                          90       100
                  ....*....|....*....|.
gi 169234958  245 GADGMSAESECSITILDVNDN 265
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-155 2.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 2.04e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958     73 IHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDIND 152
Cdd:smart00112    3 TDADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 169234958    153 NPP 155
Cdd:smart00112   79 NAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 7.51e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  273 SYDITIEENALHSQLV-QIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIemNERTnvGTLKVVKPLDYEAMKNLQLSIGV 351
Cdd:cd11304     1 SYEVSVPENAPPGTVVlTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*...
gi 169234958  352 RNVAEFHQSiisqyrlTATMVTVTVLNV 379
Cdd:cd11304    75 TDGGGPPLS-------STATVTITVLDV 95
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 724-779 9.96e-10

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 55.24  E-value: 9.96e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   724 ADEDEGRPSNDCLLIYDIEGVGSPAGSVgcCSF----IGEDLDESFLDTLGPKFKKLADI 779
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSL--SSLesstSDSDQDYDYLSDWGPRFKKLAEL 58
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-483 4.14e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  391 TFVVDSRMEANHRVGEFVATDLDTGRAStNVRYE-MGNNPENLLVVDSRTGIITLRNRVTMEQYQrlngEYKGTVLSID- 468
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREEQS----SYTLTVTATDg 77

                          90
                  ....*....|....*
gi 169234958  469 DSLQRTCTGTIVIEL 483
Cdd:cd11304    78 GGPPLSSTATVTITV 92
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-265 8.26e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 8.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  165 QIEENSNANTLVMKLNATDADEPNnlNSMIAFKIIrqEPSDSPMFIINRKTGEIRTmNNFLDREQYSQYSLVVRGSdrDG 244
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIV--SGNEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT--DG 77

                          90       100
                  ....*....|....*....|.
gi 169234958  245 GADGMSAESECSITILDVNDN 265
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-260 9.97e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 9.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   162 FLGQIEENSNANTLVMKLNATDADEPnnLNSMIAFKIIRQEPSDspMFIINRKTGEIRTMNNfLDREQYSQYSLVVRGSD 241
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 169234958   242 RDGGadGMSAESECSITIL 260
Cdd:pfam00028   76 SGGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-267 2.99e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.99e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958    180 NATDADEPNNlnSMIAFKIIRQEPSDspMFIINRKTGEIRTMNNfLDREQYSQYSLVVRgsDRDGGADGMSAESECSITI 259
Cdd:smart00112    1 SATDADSGEN--GKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVE--ATDGGGPPLSSTATVTITV 73


                    ....*...
gi 169234958    260 LDVNDNIP 267
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-155 2.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 2.04e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958     73 IHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDIND 152
Cdd:smart00112    3 TDADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 169234958    153 NPP 155
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
54-147 2.68e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958    54 FAAACREGE-DNSKRNPIAKIHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNA 132
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 169234958   133 QGQDLENPLELRVRV 147
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.25e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   62 EDNSKRNPIAKIH---SDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLE 138
Cdd:cd11304     8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 169234958  139 NPLELRVRVMDINDN 153
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 7.51e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  273 SYDITIEENALHSQLV-QIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIemNERTnvGTLKVVKPLDYEAMKNLQLSIGV 351
Cdd:cd11304     1 SYEVSVPENAPPGTVVlTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*...
gi 169234958  352 RNVAEFHQSiisqyrlTATMVTVTVLNV 379
Cdd:cd11304    75 TDGGGPPLS-------STATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
274-377 2.05e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 2.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   274 YDITIEENALHSQLV-QIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIEmnerTNVGTLKVVKPLDYEAMKNLQLSIGVR 352
Cdd:pfam00028    1 YSASVPENAPVGTEVlTVTATDPDLG--PNGRIFYSILGGGPGGNFRID----PDTGDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....*
gi 169234958   353 NVAEFHQSiisqyrlTATMVTVTVL 377
Cdd:pfam00028   75 DSGGPPLS-------STATVTITVL 92
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 724-779 9.96e-10

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 55.24  E-value: 9.96e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   724 ADEDEGRPSNDCLLIYDIEGVGSPAGSVgcCSF----IGEDLDESFLDTLGPKFKKLADI 779
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSL--SSLesstSDSDQDYDYLSDWGPRFKKLAEL 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-379 3.48e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 3.48e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958    291 RVIDLDEEfsDNWKAIIFFISGNEGNWFEIEmnerTNVGTLKVVKPLDYEAMKNLQLSIGVRNVAefhqsiiSQYRLTAT 370
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSID----PETGEITTTKPLDREEQPEYTLTVEATDGG-------GPPLSSTA 67


                    ....*....
gi 169234958    371 MVTVTVLNV 379
Cdd:smart00112   68 TVTITVLDV 76
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-483 4.14e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  391 TFVVDSRMEANHRVGEFVATDLDTGRAStNVRYE-MGNNPENLLVVDSRTGIITLRNRVTMEQYQrlngEYKGTVLSID- 468
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREEQS----SYTLTVTATDg 77

                          90
                  ....*....|....*
gi 169234958  469 DSLQRTCTGTIVIEL 483
Cdd:cd11304    78 GGPPLSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
391-483 1.34e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   391 TFVVDSRMEANHRVGEFVATDLDTGrASTNVRYEM-GNNPENLLVVDSRTGIITLRNRVTMEQYqrlnGEYKGTVLSIDD 469
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLG-PNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDS 76

                           90
                   ....*....|....*
gi 169234958   470 SLQ-RTCTGTIVIEL 483
Cdd:pfam00028   77 GGPpLSSTATVTITV 91
 
Name Accession Description Interval E-value
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 165-265 8.26e-23

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 93.92  E-value: 8.26e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  165 QIEENSNANTLVMKLNATDADEPNnlNSMIAFKIIrqEPSDSPMFIINRKTGEIRTmNNFLDREQYSQYSLVVRGSdrDG 244
Cdd:cd11304     5 SVPENAPPGTVVLTVSATDPDSGE--NGEVTYSIV--SGNEDGLFSIDPSTGEITT-AKPLDREEQSSYTLTVTAT--DG 77

                          90       100
                  ....*....|....*....|.
gi 169234958  245 GADGMSAESECSITILDVNDN 265
Cdd:cd11304    78 GGPPLSSTATVTITVLDVNDN 98
Cadherin pfam00028
Cadherin domain;
162-260 9.97e-21

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 87.74  E-value: 9.97e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   162 FLGQIEENSNANTLVMKLNATDADEPnnLNSMIAFKIIRQEPSDspMFIINRKTGEIRTMNNfLDREQYSQYSLVVRGSD 241
Cdd:pfam00028    1 YSASVPENAPVGTEVLTVTATDPDLG--PNGRIFYSILGGGPGG--NFRIDPDTGDISTTKP-LDRESIGEYELTVEATD 75

                           90
                   ....*....|....*....
gi 169234958   242 RDGGadGMSAESECSITIL 260
Cdd:pfam00028   76 SGGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 180-267 2.99e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 80.09  E-value: 2.99e-18
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958    180 NATDADEPNNlnSMIAFKIIRQEPSDspMFIINRKTGEIRTMNNfLDREQYSQYSLVVRgsDRDGGADGMSAESECSITI 259
Cdd:smart00112    1 SATDADSGEN--GKVTYSILSGNDDG--LFSIDPETGEITTTKP-LDREEQPEYTLTVE--ATDGGGPPLSSTATVTITV 73


                    ....*...
gi 169234958    260 LDVNDNIP 267
Cdd:smart00112   74 LDVNDNAP 81
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 73-155 2.04e-14

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 69.30  E-value: 2.04e-14
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958     73 IHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLENPLELRVRVMDIND 152
Cdd:smart00112    3 TDADSGENGKVTYSILS----GNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVND 78


                    ...
gi 169234958    153 NPP 155
Cdd:smart00112   79 NAP 81
Cadherin pfam00028
Cadherin domain;
54-147 2.68e-14

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 69.25  E-value: 2.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958    54 FAAACREGE-DNSKRNPIAKIHSDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNA 132
Cdd:pfam00028    1 YSASVPENApVGTEVLTVTATDPDLGPNGRIFYSILG----GGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDS 76

                           90
                   ....*....|....*
gi 169234958   133 QGQDLENPLELRVRV 147
Cdd:pfam00028   77 GGPPLSSTATVTITV 91
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 62-153 1.25e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 67.72  E-value: 1.25e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   62 EDNSKRNPIAKIH---SDCAANQPVTYRISGvgidQPPYGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQDLE 138
Cdd:cd11304     8 ENAPPGTVVLTVSatdPDSGENGEVTYSIVS----GNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGPPLS 83

                          90
                  ....*....|....*
gi 169234958  139 NPLELRVRVMDINDN 153
Cdd:cd11304    84 STATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-379 7.51e-13

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 65.41  E-value: 7.51e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  273 SYDITIEENALHSQLV-QIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIemNERTnvGTLKVVKPLDYEAMKNLQLSIGV 351
Cdd:cd11304     1 SYEVSVPENAPPGTVVlTVSATDPDSG--ENGEVTYSIVSGNEDGLFSI--DPST--GEITTAKPLDREEQSSYTLTVTA 74

                          90       100
                  ....*....|....*....|....*...
gi 169234958  352 RNVAEFHQSiisqyrlTATMVTVTVLNV 379
Cdd:cd11304    75 TDGGGPPLS-------STATVTITVLDV 95
Cadherin pfam00028
Cadherin domain;
274-377 2.05e-12

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 63.86  E-value: 2.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   274 YDITIEENALHSQLV-QIRVIDLDEEfsDNWKAIIFFISGNEGNWFEIEmnerTNVGTLKVVKPLDYEAMKNLQLSIGVR 352
Cdd:pfam00028    1 YSASVPENAPVGTEVlTVTATDPDLG--PNGRIFYSILGGGPGGNFRID----PDTGDISTTKPLDRESIGEYELTVEAT 74

                           90       100
                   ....*....|....*....|....*
gi 169234958   353 NVAEFHQSiisqyrlTATMVTVTVL 377
Cdd:pfam00028   75 DSGGPPLS-------STATVTITVL 92
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 724-779 9.96e-10

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 55.24  E-value: 9.96e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   724 ADEDEGRPSNDCLLIYDIEGVGSPAGSVgcCSF----IGEDLDESFLDTLGPKFKKLADI 779
Cdd:pfam01049    1 ADNDPSAPPYDSLQTYAYEGDGSSAGSL--SSLesstSDSDQDYDYLSDWGPRFKKLAEL 58
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 291-379 3.48e-08

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 51.58  E-value: 3.48e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958    291 RVIDLDEEfsDNWKAIIFFISGNEGNWFEIEmnerTNVGTLKVVKPLDYEAMKNLQLSIGVRNVAefhqsiiSQYRLTAT 370
Cdd:smart00112    1 SATDADSG--ENGKVTYSILSGNDDGLFSID----PETGEITTTKPLDREEQPEYTLTVEATDGG-------GPPLSSTA 67


                    ....*....
gi 169234958    371 MVTVTVLNV 379
Cdd:smart00112   68 TVTITVLDV 76
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 57-153 1.32e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 50.42  E-value: 1.32e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   57 ACREGEDNSKRnpIAKIHSDCAANQPVTYRISGVGIDQPPyGIFIINQKTGEINITSIVDREVTPFFIIYCRALNAQGQD 136
Cdd:cd00031     5 SAVEGRSRGSF--RVSIPTDLIASSGEIIKISAAGKEALP-SWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANV 81

                          90
                  ....*....|....*..
gi 169234958  137 LENPLELRVRVMDINDN 153
Cdd:cd00031    82 PQTSSVFSIEVYDENDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 391-483 4.14e-07

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 49.23  E-value: 4.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958  391 TFVVDSRMEANHRVGEFVATDLDTGRAStNVRYE-MGNNPENLLVVDSRTGIITLRNRVTMEQYQrlngEYKGTVLSID- 468
Cdd:cd11304     3 EVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSiVSGNEDGLFSIDPSTGEITTAKPLDREEQS----SYTLTVTATDg 77

                          90
                  ....*....|....*
gi 169234958  469 DSLQRTCTGTIVIEL 483
Cdd:cd11304    78 GGPPLSSTATVTITV 92
Cadherin pfam00028
Cadherin domain;
391-483 1.34e-05

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 44.60  E-value: 1.34e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 169234958   391 TFVVDSRMEANHRVGEFVATDLDTGrASTNVRYEM-GNNPENLLVVDSRTGIITLRNRVTMEQYqrlnGEYKGTVLSIDD 469
Cdd:pfam00028    2 SASVPENAPVGTEVLTVTATDPDLG-PNGRIFYSIlGGGPGGNFRIDPDTGDISTTKPLDRESI----GEYELTVEATDS 76

                           90
                   ....*....|....*
gi 169234958   470 SLQ-RTCTGTIVIEL 483
Cdd:pfam00028   77 GGPpLSSTATVTITV 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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