|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1836-2162 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
:
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 630.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1836 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYRSIGNIYKG 1915
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1916 LVQTGAWGCFDEFNRIAVEVLSVVAVQVKMIHDAIRNGRKRFVFLGETIPLKPSVGIFITLNPGYAGRTELPENLKALFR 1995
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1996 PCAMVAPDTELICEIMLVAEGFVDARSLARKFISLYTLCEELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2075
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2076 RALRDFNMPKIVTDDVPVFLGLVSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2155
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 393794754 2156 NAGTGKS 2162
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
221-792 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
:
Pssm-ID: 462457 Cd Length: 560 Bit Score: 627.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 221 LHAIESLVIKWSHQIQEIIEKDSAhpllsGLHPTPETELDFWTMRHDNLKCIYSQLQAPIVLKMVKILRTRQSSYLPALK 300
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDSQ-----GRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 301 GIFTTVENALLEAQDVELHLRPLRRHIHSLQEA-EFPQTRILIAPLLHTICLIWSHSKFYNTPARVIVLLQEFCNLFIDQ 379
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEELtDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 380 ARAYLSPEDLLKGEIEDALEKVQVAISVLKTFQNSFFKYRKGLTSyftrNTEQRSWDFQSHLVFGRFNKFLDRLVKIEDM 459
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEE----SPRERPWDFSERYIFGRFDAFLERLEKILEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 460 FVTILEFEKLERLefGGSKGAVLNAQIHSTSEEFIECCKVFQQSTYDPSDCDDMEFESDYFKFKSRTLDFDRRLGTLLCE 539
Cdd:pfam08385 232 FETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 540 GLSNCSGLESAFKLLTIFGNFLEKPVVMEMFSPHYSTLLNMFNAELDVCKQLYDEHMKQiehgHEILNKNMPFTSGNIKW 619
Cdd:pfam08385 310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIW 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 620 ARMLLERLQMFWSNFTSLHYLFpDSPDEAAVCQKYAEMTTLLDQFESHIYSEWRRNVDETCEFNLNQPL-VKFSPINGLL 698
Cdd:pfam08385 386 ARQLFRRIQEPMKRFKEELGLL-KHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLL 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 699 SVNFDPKLVAVLREVKYLLMLkKSDIPDSALGIFQKRNIILKYIGNLELLVQGYNKLKQTLLEVEYPLIEDELGAIDEQL 778
Cdd:pfam08385 465 SVNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKL 543
|
570
....*....|....
gi 393794754 779 RVAATWLTWQDDFW 792
Cdd:pfam08385 544 EPGLTTLTWNSLGI 557
|
|
| MT super family |
cl37598 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3069-3413 |
8.36e-171 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
The actual alignment was detected with superfamily member pfam12777:
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 530.03 E-value: 8.36e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3069 EHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQREC 3148
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3149 EADLLKAEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAAKIFMGKVDDFLQALI 3228
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3229 NYDKEHIPENCLKVVnEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLAAATEKLEA 3308
Cdd:pfam12777 161 KFDKEHIHEACLKAF-KPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3309 VRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAA 3388
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 393794754 3389 FVSYIGSFTRQYRQELVDCKWIPFL 3413
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1297-1702 |
2.39e-153 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
:
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 482.53 E-value: 2.39e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1297 MKQCRQEIRLLKGLWDVIIYVRRSIDNWTETQWRQINVEQMDLELRRFAKEIWSLDKAVRVWDAYSGLEGTVKDMTTSLR 1376
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1377 AIAELQNPALRDRHWQQLMKAIGVRF-SINDSTTLSDLLAVQLHRVEDDVRDIVDQAVKELGTEKVITDVSHTWEALEFS 1455
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFdPLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1456 YEAHHRTGTPLLKSDEQLFETLEHNQVQLQSLLQSKYVEYFIEQVLSWQNKLNVADAVIFTWMQVQRTWSHLESIFVcSE 1535
Cdd:pfam08393 161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1536 DIRVQLVEDARRFDKVDAEFKELMFETAKVKNVLEATCRPHLYEKLKDFQHRLSLCEKALAEYLETKRVTFPRFYFISSA 1615
Cdd:pfam08393 240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1616 DLLDILSKGAQPKQVTHHLVKLFDSISDLQFEDNLDVsthkaVGMFSKEKEYVPF-QAGCECIGHVESWLLQLEQTMKDT 1694
Cdd:pfam08393 320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394
|
....*...
gi 393794754 1695 VRLAITEA 1702
Cdd:pfam08393 395 LRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4191-4486 |
2.06e-122 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
:
Pssm-ID: 465677 Cd Length: 301 Bit Score: 389.29 E-value: 2.06e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4191 TVTSNTLFRTLLEMQPRNAVSQEELGQSTEDKVKNILDDILERLPEEFNMAEIMQKNP--NRSPYVLVCFQECERMNVLI 4268
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPvgYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4269 REIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4348
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4349 SGFFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKK-TKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTS 4427
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 393794754 4428 MMPVIFAKAVPVDRQEIKHA-YECPVYKTKARG-PTYVWTFRLRSKDRIAKWVLAGVALLL 4486
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDENtYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 super family |
cl34955 |
Dynein, heavy chain [Cytoskeleton]; |
1524-4138 |
8.60e-116 |
|
Dynein, heavy chain [Cytoskeleton];
The actual alignment was detected with superfamily member COG5245:
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 415.93 E-value: 8.60e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1524 WSHLESIFVCSEDIRVQLVEDARRFDKVDAEFKELMFETAKVKNVLEATCRPhLYEKLKDFQHRLSLCEKALAEYLETKR 1603
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1604 VTFPRFyfISSADLLDILSKGAQPKQVTHHLVKLFDSI-SDLQFEDNLdvsthKAVGMFSKEKE-YVPFQAGCECIgHVE 1681
Cdd:COG5245 706 REVERA--SEVEELMDRVRELENRVYSYRFFVKKIAKEeMKTVFSSRI-----QKKEPFSLDSEaYVGFFRLYEKS-IVI 777
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1682 SWLLQLEQTMKDTVRLAITEAItayEEKPRELWIFDFPAQVALTGSQIWwtTDVgiafsrLEEGYETALKDFHKkqisQL 1761
Cdd:COG5245 778 RGINRSMGRVLSQYLESVQEAL---EIEDGSFFVSRHRVRDGGLEKGRG--CDA------WENCFDPPLSEYFR----IL 842
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1762 NTLITLLLGELSPGDRQKVMTICTIDVHARDVVAKLISQKVVSPHAFTWLSqLRHEWEDSRKHCVVNICDAHFQYFYEYL 1841
Cdd:COG5245 843 EKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKN 921
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1842 GNSPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYRSigNIYKGLVQTGA 1921
Cdd:COG5245 922 TIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEE 989
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1922 WGcFDEFNRIAvEVLSVVAVQVKMIHDAIRNGRKRFVFLGETIPLKPSVGIFITLNPgyagRTELPENLKALFRPCAMVA 2001
Cdd:COG5245 990 RG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNI 1063
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2002 PdteliceimlvaEGFVDAR--SLARKFISLYTLCEELLSKQDHYDWglRAIKSVLVVAGSLKRgDKNRPEDQVLmralR 2079
Cdd:COG5245 1064 P------------FGAIKSRreSLDREIGAFNNEVDGIAREEDELMF--YPMFKSLKAKHRMLE-EKTEYLNKIL----S 1124
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2080 DFNMPKIvtDDVPVFLglvSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVrhsvfvVGNAGT 2159
Cdd:COG5245 1125 ITGLPLI--SDTLRER---IDTLDAEWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTGAFHAE------YFRVFL 1193
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2160 GKSKILRTL-------NRTYVnmkqkpvwsdlnpkavtTDELFgfihHATREWKdGLFSSILREQANLT-HDGPTWIVLD 2231
Cdd:COG5245 1194 CKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR-QFFLMFNREDMEARlADSKMEYEVE 1251
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2232 GdidplWIESLNTVMDDNKVLTLASNERvalkpsmRLLFEThhlRTATPATVSRAGILY----------VNPQDLG-WNP 2300
Cdd:COG5245 1252 R-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSN---LGSIGDKVGRCLVEYdsisrlstkgVFLDELGdTKR 1316
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2301 YVASWIDRRRHQSEKANLTILFDK-YIPVCLE---------KLRTSFKAITSVPES-SLVQTICTLLECLLTPENIppDS 2369
Cdd:COG5245 1317 YLDECLDFFSCFEEVQKEIDELSMvFCADALRfsadlyhivKERRFSGVLAGSDASeSLGGKSIELAAILEHKDLI--VE 1394
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2370 PKETYEVYFAFACvwtFGGTLLRDQLSDYQ---ADFSrwwhKEMKAVKFPSQGTIFDYYLDHKTKKFLPwtdkVPQFSMD 2446
Cdd:COG5245 1395 MKRGINDVLKLRI---FGDKCRESTPRFYLisdGDLI----KDLNERSDYEEMLIMMFNISAVITNNGS----IAGFELR 1463
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2447 ADAPL--KTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASlSENYIVSCVPFNYYTTSAALQRILE 2524
Cdd:COG5245 1464 GERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCTMTPSKLSVLE 1542
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2525 KPLEKKagRNYG-----PKGN-KKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDY-GHWYDRHKiMLKEIRNCQYVACMN 2597
Cdd:COG5245 1543 RETEYY--PNTGvvrlyPKPVvKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAV-SWVTICGIILYGACN 1619
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2598 P--MVGSFTVNPRLQRHfTVFAF-NFPSLDALTTIYgqifSFYLQQQAFC-PSVLRAGPSLIQATIAFHQMMAESFvPTA 2673
Cdd:COG5245 1620 PgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIY----EAVLMGSYLCfDEFNRLSEETMSASVELYLSSKDKT-KFF 1693
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2674 IKFHYNFNLRDLSNIFQGIL-FASPECLKSLEDLARLWLHETSRVYGDRLIDTNDFDLFQRKMLETAHKYFKGVDANALL 2752
Cdd:COG5245 1694 LQMNYGYKPRELTRSLRAIFgYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREMIAGHIG 1773
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2753 RQPLVYCHFASGGedpcyMPVKDWEGLKAVLMEMVDNYNELHSAMHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSG 2832
Cdd:COG5245 1774 EAEITFSMILFFG-----MACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRG 1848
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2833 KQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAKNMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFS 2912
Cdd:COG5245 1849 ACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFS 1928
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2913 DEDMDKIISGIRNEVRGLGL-VDSRENCWAFFLARVRQQLKMVFCFSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEAL 2991
Cdd:COG5245 1929 GNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEEM 2008
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2992 VSVSRRFI-EEIEGIEPQH--------KDSISLFMAHVHTSVKEVSAWYYQNERRYNYTTPRSFLEQISLFKSLLKKKRE 3062
Cdd:COG5245 2009 SQYANSVEtLSRDGGRVFFingelgvgKGALISEVFGDDAVVIEGRGFEISMIEGSLGESKIKFIGGLKVYDARCVIYIE 2088
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3063 EVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIgLQTEKVSREKAIADAEERKVAAIQTEAS 3142
Cdd:COG5245 2089 ELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSVFVEAPRDMLFLLEEEV 2167
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3143 QKQRECEADLLK-AEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLaprGRVPKDrsWKAAKIFMgKVD 3221
Cdd:COG5245 2168 RKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEAKI--WFGEQQSL-RRD 2241
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3222 DFLQALINYDKE-HIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLA 3300
Cdd:COG5245 2242 DFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAF 2321
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3301 AATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLC 3380
Cdd:COG5245 2322 LVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELD 2401
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3381 GDVLLTAAFVSYIGSFTRQYRQ-ELVDCKwiPFLQQKVSIP-------IAEGLDLIamlTDDATIATWNNEGLPSDRMST 3452
Cdd:COG5245 2402 GDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKI---EDFKEEACSTDYGLENSRIRK 2476
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3453 ENATILthcerwPLMIDPQQQGIKWIKNKYGPdlKVTHLG---QKGFLNTIETALAFGDVILIENlKETVDPVLGPLLGR 3529
Cdd:COG5245 2477 DLQDLT------AVLNDPSSKIVTSQRQMYDE--KKAILGsfrEMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKE 2547
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3530 NTTKKGKFIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVSIERPDLERLKLVL 3607
Cdd:COG5245 2548 EFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKAL 2627
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3608 TKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVTEARENERKINETRECYRPVAARASLL 3687
Cdd:COG5245 2628 NALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESI 2707
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3688 YFVISDLRRINPVYQFSLKAFNTLFHRaieqadkVEDTQERICALIESITHATFLYasqaLFERDKLTFlsqmafqillr 3767
Cdd:COG5245 2708 RVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHEDRSGF----------- 2765
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3768 rneIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVkavalmeeFRGLDRDVEGSAKQWRKWVESEcpekeklpqewKKK 3847
Cdd:COG5245 2766 ---IHRLDVSFLLRTKRFVSTLLEDKNYRQVLSSCS--------LYGNDVISHSCDRFDRDVYRAL-----------KHQ 2823
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3848 SLIQKLIILRAVRPDRMTYALRNFVEEKLGAKYVERT--RLDLGKAFEESSPST-PVFFILSPGVDALKDLEVLG--KRL 3922
Cdd:COG5245 2824 MDNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSgdLYKFEEGLLELIVGHaPLIYAHKKSLENERNVDRLGskENE 2903
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3923 GFTIDSGKFHNVSlgqgqelvaemamekaaagGHWVILQNVHLVAKWlgtLEKLLEKFSQGS-----HRDYRVFLSAETV 3997
Cdd:COG5245 2904 VYAVLNSLFSRKE-------------------KSWFEVYNISLSFGW---FKRYVEDVVYPIkasrvCGKVKNMWTSMVD 2961
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3998 PSQhepiIPQGLLENSIKITNEPPTGMLANLhAALYNFDQ---DTLEMCSKDqefksILFSLCYFHACVAGRLRFGPQGW 4074
Cdd:COG5245 2962 ADM----LPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRypfDYTLVIACD-----DAFYLSWEHAAVASVISAGPKEN 3031
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4075 SRSYPFSPGDLTICTNILYNYLEANP--NVPWEDLRYLFGEIMYGGHITDAWD----RKLCRVYLEEFMN 4138
Cdd:COG5245 3032 NEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1836-2162 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 630.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1836 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYRSIGNIYKG 1915
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1916 LVQTGAWGCFDEFNRIAVEVLSVVAVQVKMIHDAIRNGRKRFVFLGETIPLKPSVGIFITLNPGYAGRTELPENLKALFR 1995
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1996 PCAMVAPDTELICEIMLVAEGFVDARSLARKFISLYTLCEELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2075
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2076 RALRDFNMPKIVTDDVPVFLGLVSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2155
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 393794754 2156 NAGTGKS 2162
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
221-792 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 627.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 221 LHAIESLVIKWSHQIQEIIEKDSAhpllsGLHPTPETELDFWTMRHDNLKCIYSQLQAPIVLKMVKILRTRQSSYLPALK 300
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDSQ-----GRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 301 GIFTTVENALLEAQDVELHLRPLRRHIHSLQEA-EFPQTRILIAPLLHTICLIWSHSKFYNTPARVIVLLQEFCNLFIDQ 379
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEELtDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 380 ARAYLSPEDLLKGEIEDALEKVQVAISVLKTFQNSFFKYRKGLTSyftrNTEQRSWDFQSHLVFGRFNKFLDRLVKIEDM 459
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEE----SPRERPWDFSERYIFGRFDAFLERLEKILEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 460 FVTILEFEKLERLefGGSKGAVLNAQIHSTSEEFIECCKVFQQSTYDPSDCDDMEFESDYFKFKSRTLDFDRRLGTLLCE 539
Cdd:pfam08385 232 FETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 540 GLSNCSGLESAFKLLTIFGNFLEKPVVMEMFSPHYSTLLNMFNAELDVCKQLYDEHMKQiehgHEILNKNMPFTSGNIKW 619
Cdd:pfam08385 310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIW 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 620 ARMLLERLQMFWSNFTSLHYLFpDSPDEAAVCQKYAEMTTLLDQFESHIYSEWRRNVDETCEFNLNQPL-VKFSPINGLL 698
Cdd:pfam08385 386 ARQLFRRIQEPMKRFKEELGLL-KHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLL 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 699 SVNFDPKLVAVLREVKYLLMLkKSDIPDSALGIFQKRNIILKYIGNLELLVQGYNKLKQTLLEVEYPLIEDELGAIDEQL 778
Cdd:pfam08385 465 SVNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKL 543
|
570
....*....|....
gi 393794754 779 RVAATWLTWQDDFW 792
Cdd:pfam08385 544 EPGLTTLTWNSLGI 557
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3069-3413 |
8.36e-171 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 530.03 E-value: 8.36e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3069 EHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQREC 3148
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3149 EADLLKAEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAAKIFMGKVDDFLQALI 3228
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3229 NYDKEHIPENCLKVVnEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLAAATEKLEA 3308
Cdd:pfam12777 161 KFDKEHIHEACLKAF-KPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3309 VRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAA 3388
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 393794754 3389 FVSYIGSFTRQYRQELVDCKWIPFL 3413
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1297-1702 |
2.39e-153 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 482.53 E-value: 2.39e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1297 MKQCRQEIRLLKGLWDVIIYVRRSIDNWTETQWRQINVEQMDLELRRFAKEIWSLDKAVRVWDAYSGLEGTVKDMTTSLR 1376
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1377 AIAELQNPALRDRHWQQLMKAIGVRF-SINDSTTLSDLLAVQLHRVEDDVRDIVDQAVKELGTEKVITDVSHTWEALEFS 1455
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFdPLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1456 YEAHHRTGTPLLKSDEQLFETLEHNQVQLQSLLQSKYVEYFIEQVLSWQNKLNVADAVIFTWMQVQRTWSHLESIFVcSE 1535
Cdd:pfam08393 161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1536 DIRVQLVEDARRFDKVDAEFKELMFETAKVKNVLEATCRPHLYEKLKDFQHRLSLCEKALAEYLETKRVTFPRFYFISSA 1615
Cdd:pfam08393 240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1616 DLLDILSKGAQPKQVTHHLVKLFDSISDLQFEDNLDVsthkaVGMFSKEKEYVPF-QAGCECIGHVESWLLQLEQTMKDT 1694
Cdd:pfam08393 320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394
|
....*...
gi 393794754 1695 VRLAITEA 1702
Cdd:pfam08393 395 LRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4191-4486 |
2.06e-122 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 389.29 E-value: 2.06e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4191 TVTSNTLFRTLLEMQPRNAVSQEELGQSTEDKVKNILDDILERLPEEFNMAEIMQKNP--NRSPYVLVCFQECERMNVLI 4268
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPvgYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4269 REIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4348
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4349 SGFFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKK-TKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTS 4427
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 393794754 4428 MMPVIFAKAVPVDRQEIKHA-YECPVYKTKARG-PTYVWTFRLRSKDRIAKWVLAGVALLL 4486
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDENtYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1524-4138 |
8.60e-116 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 415.93 E-value: 8.60e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1524 WSHLESIFVCSEDIRVQLVEDARRFDKVDAEFKELMFETAKVKNVLEATCRPhLYEKLKDFQHRLSLCEKALAEYLETKR 1603
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1604 VTFPRFyfISSADLLDILSKGAQPKQVTHHLVKLFDSI-SDLQFEDNLdvsthKAVGMFSKEKE-YVPFQAGCECIgHVE 1681
Cdd:COG5245 706 REVERA--SEVEELMDRVRELENRVYSYRFFVKKIAKEeMKTVFSSRI-----QKKEPFSLDSEaYVGFFRLYEKS-IVI 777
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1682 SWLLQLEQTMKDTVRLAITEAItayEEKPRELWIFDFPAQVALTGSQIWwtTDVgiafsrLEEGYETALKDFHKkqisQL 1761
Cdd:COG5245 778 RGINRSMGRVLSQYLESVQEAL---EIEDGSFFVSRHRVRDGGLEKGRG--CDA------WENCFDPPLSEYFR----IL 842
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1762 NTLITLLLGELSPGDRQKVMTICTIDVHARDVVAKLISQKVVSPHAFTWLSqLRHEWEDSRKHCVVNICDAHFQYFYEYL 1841
Cdd:COG5245 843 EKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKN 921
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1842 GNSPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYRSigNIYKGLVQTGA 1921
Cdd:COG5245 922 TIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEE 989
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1922 WGcFDEFNRIAvEVLSVVAVQVKMIHDAIRNGRKRFVFLGETIPLKPSVGIFITLNPgyagRTELPENLKALFRPCAMVA 2001
Cdd:COG5245 990 RG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNI 1063
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2002 PdteliceimlvaEGFVDAR--SLARKFISLYTLCEELLSKQDHYDWglRAIKSVLVVAGSLKRgDKNRPEDQVLmralR 2079
Cdd:COG5245 1064 P------------FGAIKSRreSLDREIGAFNNEVDGIAREEDELMF--YPMFKSLKAKHRMLE-EKTEYLNKIL----S 1124
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2080 DFNMPKIvtDDVPVFLglvSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVrhsvfvVGNAGT 2159
Cdd:COG5245 1125 ITGLPLI--SDTLRER---IDTLDAEWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTGAFHAE------YFRVFL 1193
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2160 GKSKILRTL-------NRTYVnmkqkpvwsdlnpkavtTDELFgfihHATREWKdGLFSSILREQANLT-HDGPTWIVLD 2231
Cdd:COG5245 1194 CKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR-QFFLMFNREDMEARlADSKMEYEVE 1251
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2232 GdidplWIESLNTVMDDNKVLTLASNERvalkpsmRLLFEThhlRTATPATVSRAGILY----------VNPQDLG-WNP 2300
Cdd:COG5245 1252 R-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSN---LGSIGDKVGRCLVEYdsisrlstkgVFLDELGdTKR 1316
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2301 YVASWIDRRRHQSEKANLTILFDK-YIPVCLE---------KLRTSFKAITSVPES-SLVQTICTLLECLLTPENIppDS 2369
Cdd:COG5245 1317 YLDECLDFFSCFEEVQKEIDELSMvFCADALRfsadlyhivKERRFSGVLAGSDASeSLGGKSIELAAILEHKDLI--VE 1394
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2370 PKETYEVYFAFACvwtFGGTLLRDQLSDYQ---ADFSrwwhKEMKAVKFPSQGTIFDYYLDHKTKKFLPwtdkVPQFSMD 2446
Cdd:COG5245 1395 MKRGINDVLKLRI---FGDKCRESTPRFYLisdGDLI----KDLNERSDYEEMLIMMFNISAVITNNGS----IAGFELR 1463
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2447 ADAPL--KTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASlSENYIVSCVPFNYYTTSAALQRILE 2524
Cdd:COG5245 1464 GERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCTMTPSKLSVLE 1542
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2525 KPLEKKagRNYG-----PKGN-KKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDY-GHWYDRHKiMLKEIRNCQYVACMN 2597
Cdd:COG5245 1543 RETEYY--PNTGvvrlyPKPVvKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAV-SWVTICGIILYGACN 1619
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2598 P--MVGSFTVNPRLQRHfTVFAF-NFPSLDALTTIYgqifSFYLQQQAFC-PSVLRAGPSLIQATIAFHQMMAESFvPTA 2673
Cdd:COG5245 1620 PgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIY----EAVLMGSYLCfDEFNRLSEETMSASVELYLSSKDKT-KFF 1693
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2674 IKFHYNFNLRDLSNIFQGIL-FASPECLKSLEDLARLWLHETSRVYGDRLIDTNDFDLFQRKMLETAHKYFKGVDANALL 2752
Cdd:COG5245 1694 LQMNYGYKPRELTRSLRAIFgYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREMIAGHIG 1773
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2753 RQPLVYCHFASGGedpcyMPVKDWEGLKAVLMEMVDNYNELHSAMHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSG 2832
Cdd:COG5245 1774 EAEITFSMILFFG-----MACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRG 1848
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2833 KQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAKNMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFS 2912
Cdd:COG5245 1849 ACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFS 1928
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2913 DEDMDKIISGIRNEVRGLGL-VDSRENCWAFFLARVRQQLKMVFCFSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEAL 2991
Cdd:COG5245 1929 GNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEEM 2008
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2992 VSVSRRFI-EEIEGIEPQH--------KDSISLFMAHVHTSVKEVSAWYYQNERRYNYTTPRSFLEQISLFKSLLKKKRE 3062
Cdd:COG5245 2009 SQYANSVEtLSRDGGRVFFingelgvgKGALISEVFGDDAVVIEGRGFEISMIEGSLGESKIKFIGGLKVYDARCVIYIE 2088
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3063 EVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIgLQTEKVSREKAIADAEERKVAAIQTEAS 3142
Cdd:COG5245 2089 ELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSVFVEAPRDMLFLLEEEV 2167
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3143 QKQRECEADLLK-AEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLaprGRVPKDrsWKAAKIFMgKVD 3221
Cdd:COG5245 2168 RKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEAKI--WFGEQQSL-RRD 2241
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3222 DFLQALINYDKE-HIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLA 3300
Cdd:COG5245 2242 DFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAF 2321
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3301 AATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLC 3380
Cdd:COG5245 2322 LVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELD 2401
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3381 GDVLLTAAFVSYIGSFTRQYRQ-ELVDCKwiPFLQQKVSIP-------IAEGLDLIamlTDDATIATWNNEGLPSDRMST 3452
Cdd:COG5245 2402 GDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKI---EDFKEEACSTDYGLENSRIRK 2476
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3453 ENATILthcerwPLMIDPQQQGIKWIKNKYGPdlKVTHLG---QKGFLNTIETALAFGDVILIENlKETVDPVLGPLLGR 3529
Cdd:COG5245 2477 DLQDLT------AVLNDPSSKIVTSQRQMYDE--KKAILGsfrEMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKE 2547
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3530 NTTKKGKFIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVSIERPDLERLKLVL 3607
Cdd:COG5245 2548 EFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKAL 2627
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3608 TKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVTEARENERKINETRECYRPVAARASLL 3687
Cdd:COG5245 2628 NALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESI 2707
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3688 YFVISDLRRINPVYQFSLKAFNTLFHRaieqadkVEDTQERICALIESITHATFLYasqaLFERDKLTFlsqmafqillr 3767
Cdd:COG5245 2708 RVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHEDRSGF----------- 2765
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3768 rneIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVkavalmeeFRGLDRDVEGSAKQWRKWVESEcpekeklpqewKKK 3847
Cdd:COG5245 2766 ---IHRLDVSFLLRTKRFVSTLLEDKNYRQVLSSCS--------LYGNDVISHSCDRFDRDVYRAL-----------KHQ 2823
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3848 SLIQKLIILRAVRPDRMTYALRNFVEEKLGAKYVERT--RLDLGKAFEESSPST-PVFFILSPGVDALKDLEVLG--KRL 3922
Cdd:COG5245 2824 MDNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSgdLYKFEEGLLELIVGHaPLIYAHKKSLENERNVDRLGskENE 2903
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3923 GFTIDSGKFHNVSlgqgqelvaemamekaaagGHWVILQNVHLVAKWlgtLEKLLEKFSQGS-----HRDYRVFLSAETV 3997
Cdd:COG5245 2904 VYAVLNSLFSRKE-------------------KSWFEVYNISLSFGW---FKRYVEDVVYPIkasrvCGKVKNMWTSMVD 2961
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3998 PSQhepiIPQGLLENSIKITNEPPTGMLANLhAALYNFDQ---DTLEMCSKDqefksILFSLCYFHACVAGRLRFGPQGW 4074
Cdd:COG5245 2962 ADM----LPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRypfDYTLVIACD-----DAFYLSWEHAAVASVISAGPKEN 3031
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4075 SRSYPFSPGDLTICTNILYNYLEANP--NVPWEDLRYLFGEIMYGGHITDAWD----RKLCRVYLEEFMN 4138
Cdd:COG5245 3032 NEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3438-3656 |
6.09e-111 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 352.90 E-value: 6.09e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3438 ATWNNEGLPSDRMSTENATILTHCERWPLMIDPQQQGIKWIKNKYGP-DLKVTHLGQKGFLNTIETALAFGDVILIENLK 3516
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3517 ETVDPVLGPLLGRNTTKKG--KFIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVS 3594
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 393794754 3595 IERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEI 3656
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3047-3171 |
5.03e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.47 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3047 LEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAI 3126
Cdd:COG1196 255 LEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE 334
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 393794754 3127 ADAEERKVAAIQTEASQKQRECEADLLKAEPALVAAKDALNTLNR 3171
Cdd:COG1196 335 LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
3076-3170 |
1.15e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 44.72 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3076 QKLQTTASQVGNLKSRLASQEAEL-QLRNLDAEALITKIGLQTEKVSREKAIADAEErKVAAIQTEASQKQ----RECEA 3150
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQK-ELANAQAQALQTAqnnlATAQA 325
|
90 100
....*....|....*....|
gi 393794754 3151 DLLKAEPALVAAKDALNTLN 3170
Cdd:TIGR04320 326 ALANAEARLAKAKEALANLN 345
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| AAA_6 |
pfam12774 |
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic ... |
1836-2162 |
0e+00 |
|
Hydrolytic ATP binding site of dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities: AAA1-AAA6). This is the first site (out of four nucleotide binding sites in the dynein motor) where the movement depends on ATP hydrolysis. When this site is nucleotide free or bound to ADP, the microtubule binding domain (MTBD) binds to the microtubule and the linker adopts the straight post-power-stroke conformation. Upon ATP binding and hydrolysis, the MTBD detaches from the microtubule and the linker is primed into the pre-power-stroke conformation. Dynein's AAA+ domains are each divided into an alpha/beta large subdomain designated with an L and and alpha small subdomains designated with an S. This is the AAA1 large (AAA1L) subdomain with the accompanying small subdomain (AAA1S). AAA1L, AAA1S and AAA2L enclose ADP.vanadate (ADP.Vi, ATP-hydrolysis transition state analogue). The AAA1L sensor-I loop, which varies in position depending on dynein's nucleotide state, swings in to contact AAA2L forming the important AAA1 nucleotide-binding site.
Pssm-ID: 463697 [Multi-domain] Cd Length: 327 Bit Score: 630.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1836 YFYEYLGNSPRLVITPLTDRCYITLTQSLHLTMSGAPAGPAGTGKTETTKDLGRALGMMVYVFNCSEQMDYRSIGNIYKG 1915
Cdd:pfam12774 1 YGYEYLGNSGRLVITPLTDRCYLTLTQALHLHLGGAPAGPAGTGKTETVKDLAKALAKQVVVFNCSDGLDYKSMGRIFKG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1916 LVQTGAWGCFDEFNRIAVEVLSVVAVQVKMIHDAIRNGRKRFVFLGETIPLKPSVGIFITLNPGYAGRTELPENLKALFR 1995
Cdd:pfam12774 81 LAQCGAWGCFDEFNRIDIEVLSVVAQQILTIQQALAANLKTFVFEGSEIKLNPSCGIFITMNPGYAGRTELPDNLKALFR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1996 PCAMVAPDTELICEIMLVAEGFVDARSLARKFISLYTLCEELLSKQDHYDWGLRAIKSVLVVAGSLKRGDKNRPEDQVLM 2075
Cdd:pfam12774 161 PVAMMVPDYALIAEIMLFSEGFSDAKVLAKKLVTLYKLCSEQLSKQDHYDFGLRALKSVLVTAGSLKRSNPNLNEDVLLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2076 RALRDFNMPKIVTDDVPVFLGLVSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVRHSVFVVG 2155
Cdd:pfam12774 241 RALRDMNLPKLVADDVPLFLGLISDLFPGVELPPSDYGELEEAIEEVCKELGLQPHDAFILKVIQLYETMLVRHGVMLVG 320
|
....*..
gi 393794754 2156 NAGTGKS 2162
Cdd:pfam12774 321 PTGSGKT 327
|
|
| DHC_N1 |
pfam08385 |
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains ... |
221-792 |
0e+00 |
|
Dynein heavy chain, N-terminal region 1; Dynein heavy chains interact with other heavy chains to form dimers, and with intermediate chain-light chain complexes to form a basal cargo binding unit. The region featured in this family includes the sequences implicated in mediating these interactions. It is thought to be flexible and not to adopt a rigid conformation.
Pssm-ID: 462457 Cd Length: 560 Bit Score: 627.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 221 LHAIESLVIKWSHQIQEIIEKDSAhpllsGLHPTPETELDFWTMRHDNLKCIYSQLQAPIVLKMVKILRTRQSSYLPALK 300
Cdd:pfam08385 1 LHALESVVIKWTKQIQDVLKEDSQ-----GRNPGPLAEIEFWKSREANLSSIYEQLKSPEVKKVLEILEAAKSSYLPAFK 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 301 GIFTTVENALLEAQDVELHLRPLRRHIHSLQEA-EFPQTRILIAPLLHTICLIWSHSKFYNTPARVIVLLQEFCNLFIDQ 379
Cdd:pfam08385 76 ALDTELTDALNEAKDNVKYLKTLERPFEDLEELtDPPEIIEAIPPLMNTIRLIWSISRYYNTSERMTVLLEKISNQLIEQ 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 380 ARAYLSPEDLLKGEIEDALEKVQVAISVLKTFQNSFFKYRKGLTSyftrNTEQRSWDFQSHLVFGRFNKFLDRLVKIEDM 459
Cdd:pfam08385 156 CKKYLSPEGIFDGDVEEALEKLQECIELLEAWKEEYKKTREKLEE----SPRERPWDFSERYIFGRFDAFLERLEKILEL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 460 FVTILEFEKLERLefGGSKGAVLNAQIHSTSEEFIECCKVFQQSTYDPSDCDDMEFESDYFKFKSRTLDFDRRLGTLLCE 539
Cdd:pfam08385 232 FETIEQFSKLEKI--GGTKGPELEGVIEEILEEFQEAYKVFKSKTYDILDVSNEGFDDDYEEFKERIKDLERRLQAFIDQ 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 540 GLSNCSGLESAFKLLTIFGNFLEKPVVMEMFSPHYSTLLNMFNAELDVCKQLYDEHMKQiehgHEILNKNMPFTSGNIKW 619
Cdd:pfam08385 310 AFDDARSTESAFKLLRIFEFLLERPIIRGALEEKYTDLLQMFKKELDAVKKIFDKQKYN----PSPIAKNMPPVAGAIIW 385
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 620 ARMLLERLQMFWSNFTSLHYLFpDSPDEAAVCQKYAEMTTLLDQFESHIYSEWRRNVDETCEFNLNQPL-VKFSPINGLL 698
Cdd:pfam08385 386 ARQLFRRIQEPMKRFKEELGLL-KHAEGKKVIKKYNELAKKLDEYERLIYEAWLKEVEEASEGNLKRPLlVRHPETGKLL 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 699 SVNFDPKLVAVLREVKYLLMLkKSDIPDSALGIFQKRNIILKYIGNLELLVQGYNKLKQTLLEVEYPLIEDELGAIDEQL 778
Cdd:pfam08385 465 SVNFDPQLLALLREVKYLQKL-GFEIPESALNIALKEERLRPYAESLELLVRWYNKIRSTLLPVERPLLAPHLKDIDEKL 543
|
570
....*....|....
gi 393794754 779 RVAATWLTWQDDFW 792
Cdd:pfam08385 544 EPGLTTLTWNSLGI 557
|
|
| MT |
pfam12777 |
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ... |
3069-3413 |
8.36e-171 |
|
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.
Pssm-ID: 463699 [Multi-domain] Cd Length: 344 Bit Score: 530.03 E-value: 8.36e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3069 EHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAIADAEERKVAAIQTEASQKQREC 3148
Cdd:pfam12777 1 ERLENGLLKLHSTAAQVDDLKAKLAAQEAELKQKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKAC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3149 EADLLKAEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLAPRGRVPKDRSWKAAKIFMGKVDDFLQALI 3228
Cdd:pfam12777 81 EEDLAKAEPALLAAQAALDTLNKNNLTELKSFGSPPDAVSNVSAAVMILMAPGGKIPKDKSWKAAKIMMAKVDGFLDSLI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3229 NYDKEHIPENCLKVVnEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLAAATEKLEA 3308
Cdd:pfam12777 161 KFDKEHIHEACLKAF-KPYLGDPEFDPEFIASKSTAAAGLCSWCINIVRFYEVFCDVAPKRQALEEANADLAAAQEKLAA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3309 VRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLCGDVLLTAA 3388
Cdd:pfam12777 240 IKAKIAELNANLAKLTAAFEKATADKIKCQQEADATARTILLANRLVGGLASENIRWADAVENFKQQERTLCGDILLISA 319
|
330 340
....*....|....*....|....*
gi 393794754 3389 FVSYIGSFTRQYRQELVDCKWIPFL 3413
Cdd:pfam12777 320 FISYLGFFTKKYRNELLDKFWIPYI 344
|
|
| DHC_N2 |
pfam08393 |
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic ... |
1297-1702 |
2.39e-153 |
|
Dynein heavy chain, N-terminal region 2; Dyneins are described as motor proteins of eukaryotic cells, as they can convert energy derived from the hydrolysis of ATP to force and movement along cytoskeletal polymers, such as microtubules. This region is found C-terminal to the dynein heavy chain N-terminal region 1 (pfam08385) in many members of this family. No functions seem to have been attributed specifically to this region.
Pssm-ID: 462462 [Multi-domain] Cd Length: 402 Bit Score: 482.53 E-value: 2.39e-153
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1297 MKQCRQEIRLLKGLWDVIIYVRRSIDNWTETQWRQINVEQMDLELRRFAKEIWSLDKAVRVWDAYSGLEGTVKDMTTSLR 1376
Cdd:pfam08393 1 LEEIKKELEPLKKLWDLVSEWQESLEEWKNGPFSDLDVEELEEELEEFLKELKKLPKELRDWDVAEELKKKIDDFKKSLP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1377 AIAELQNPALRDRHWQQLMKAIGVRF-SINDSTTLSDLLAVQLHRVEDDVRDIVDQAVKELGTEKVITDVSHTWEALEFS 1455
Cdd:pfam08393 81 LIEDLRNPALRERHWKQLSEILGFDFdPLSEFFTLGDLLDLNLHKYEEEIEEISEQASKEYSIEKALKKIEEEWKTMEFE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1456 YEAHHRTGTPLLKSDEQLFETLEHNQVQLQSLLQSKYVEYFIEQVLSWQNKLNVADAVIFTWMQVQRTWSHLESIFVcSE 1535
Cdd:pfam08393 161 LVPYKDTGTFILKGWDEIQELLDDHLVKLQSMKSSPYVKPFEEEVSEWEKKLSLLQEILDEWLKVQRKWLYLEPIFS-SE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1536 DIRVQLVEDARRFDKVDAEFKELMFETAKVKNVLEATCRPHLYEKLKDFQHRLSLCEKALAEYLETKRVTFPRFYFISSA 1615
Cdd:pfam08393 240 DIRKQLPEEAKRFQNVDKEWKKIMKKAVKDPNVLEACNIPGLLEKLEELNELLEKIQKSLNEYLEKKRLAFPRFYFLSND 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1616 DLLDILSKGAQPKQVTHHLVKLFDSISDLQFEDNLDVsthkaVGMFSKEKEYVPF-QAGCECIGHVESWLLQLEQTMKDT 1694
Cdd:pfam08393 320 ELLEILSQTKDPTRVQPHLKKCFEGIASLEFDENKEI-----TGMISKEGEVVPFsKPPVEAKGNVEEWLNELEEEMRET 394
|
....*...
gi 393794754 1695 VRLAITEA 1702
Cdd:pfam08393 395 LRDLLKEA 402
|
|
| Dynein_C |
pfam18199 |
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein ... |
4191-4486 |
2.06e-122 |
|
Dynein heavy chain C-terminal domain; This family represents the C-terminal domain of dynein heavy chain. This domain is a complex structure comprising six alpha-helices and an incomplete six-stranded antiparallel beta-barrel. The shape of this domain is distinctively flat, spreading over the AAA1, AAA5 and AAA6 domain.
Pssm-ID: 465677 Cd Length: 301 Bit Score: 389.29 E-value: 2.06e-122
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4191 TVTSNTLFRTLLEMQPRNAVSQEELGQSTEDKVKNILDDILERLPEEFNMAEIMQKNP--NRSPYVLVCFQECERMNVLI 4268
Cdd:pfam18199 1 TNETNELLSTLLSLQPRSDSGGGGGGSSREEIVLELAKDILEKLPEPFDIEEAEEKYPvgYEDPLNTVLLQEIERFNKLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4269 REIRVSLQHLDLGLKGELTLSPDVETQLSALSYDRVPDTWNKLAYPSTYGLAQWFNDLLLRCRELDTWTQDLTLPAVVWL 4348
Cdd:pfam18199 81 KVIRRSLQDLQKAIKGLVVMSSELEELANSLLNGKVPESWAKKSYPSLKPLGSWIRDLLERLKQLQDWLDDEGPPKVFWL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4349 SGFFNPQSFLTAIMQTMARKNEWPLDRMCLTIDVTKK-TKEDYGHPPREGAYLHGLHLEGARWDIQSGALVDARLKELTS 4427
Cdd:pfam18199 161 SGFFFPQAFLTAVLQNYARKNGWPIDKLSFDFEVTKKvSPEEVTEPPEDGVYVHGLFLEGARWDRKNGCLVESEPKELFS 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 393794754 4428 MMPVIFAKAVPVDRQEIKHA-YECPVYKTKARG-PTYVWTFRLRSKDRIAKWVLAGVALLL 4486
Cdd:pfam18199 241 PLPVIHLKPVESDKKKLDENtYECPVYKTSERHsTNFVFSVDLPTDKPPDHWILRGVALLL 301
|
|
| DYN1 |
COG5245 |
Dynein, heavy chain [Cytoskeleton]; |
1524-4138 |
8.60e-116 |
|
Dynein, heavy chain [Cytoskeleton];
Pssm-ID: 227570 [Multi-domain] Cd Length: 3164 Bit Score: 415.93 E-value: 8.60e-116
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1524 WSHLESIFVCSEDIRVQLVEDARRFDKVDAEFKELMFETAKVKNVLEATCRPhLYEKLKDFQHRLSLCEKALAEYLETKR 1603
Cdd:COG5245 627 RLDEYLMMMSLEDLMPLIPHAVHRKMSLVSGVRGIYKRVVSGCEAINTILED-VGDDLDLFYKEMDQVFMSIEKVLGLRW 705
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1604 VTFPRFyfISSADLLDILSKGAQPKQVTHHLVKLFDSI-SDLQFEDNLdvsthKAVGMFSKEKE-YVPFQAGCECIgHVE 1681
Cdd:COG5245 706 REVERA--SEVEELMDRVRELENRVYSYRFFVKKIAKEeMKTVFSSRI-----QKKEPFSLDSEaYVGFFRLYEKS-IVI 777
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1682 SWLLQLEQTMKDTVRLAITEAItayEEKPRELWIFDFPAQVALTGSQIWwtTDVgiafsrLEEGYETALKDFHKkqisQL 1761
Cdd:COG5245 778 RGINRSMGRVLSQYLESVQEAL---EIEDGSFFVSRHRVRDGGLEKGRG--CDA------WENCFDPPLSEYFR----IL 842
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1762 NTLITLLLGELSPGDRQKVMTICTIDVHARDVVAKLISQKVVSPHAFTWLSqLRHEWEDSRKHCVVNICDAHFQYFYEYL 1841
Cdd:COG5245 843 EKIFPSEEGYFFDEVLKRLDPGHEIKSRIEEIIRMVTVKYDFCLEVLGSVS-ISELPQGLYKRFIKVRSSYRSAEMFAKN 921
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1842 GNSPRLVITPLTDRCYITLTQSLHLTMSGApagpAGTGKTETTKDLGRALGMMVyvfncsEQMDYRSigNIYKGLVQTGA 1921
Cdd:COG5245 922 TIPFFVFEHSMDTSQHQKLFEAVCDEVCRF----VDTENSRVYGMLVAGKGRIY------DGTEPRS--RIEAGPICEEE 989
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1922 WGcFDEFNRIAvEVLSVVAVQVKMIHDAIRNGRKRFVFLGETIPLKPSVGIFITLNPgyagRTELPENLKALFRPCAMVA 2001
Cdd:COG5245 990 RG-TEESALLD-EISRTILVDEYLNSDEFRMLEELNSAVVEHGLKSPSTPVEMIINE----RNIVLEIGRRALDMFLSNI 1063
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2002 PdteliceimlvaEGFVDAR--SLARKFISLYTLCEELLSKQDHYDWglRAIKSVLVVAGSLKRgDKNRPEDQVLmralR 2079
Cdd:COG5245 1064 P------------FGAIKSRreSLDREIGAFNNEVDGIAREEDELMF--YPMFKSLKAKHRMLE-EKTEYLNKIL----S 1124
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2080 DFNMPKIvtDDVPVFLglvSDLFPALDVPRQRKPHFEQMVKQSTLELRLQPEESFILKVVQLEELLAVrhsvfvVGNAGT 2159
Cdd:COG5245 1125 ITGLPLI--SDTLRER---IDTLDAEWDSFCRISESLKKYESQQVSGLDVAQFVSFLRSVDTGAFHAE------YFRVFL 1193
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2160 GKSKILRTL-------NRTYVnmkqkpvwsdlnpkavtTDELFgfihHATREWKdGLFSSILREQANLT-HDGPTWIVLD 2231
Cdd:COG5245 1194 CKIKHYTDAcdylwhvKSPYV-----------------KKKYF----DADMELR-QFFLMFNREDMEARlADSKMEYEVE 1251
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2232 GdidplWIESLNTVMDDNKVLTLASNERvalkpsmRLLFEThhlRTATPATVSRAGILY----------VNPQDLG-WNP 2300
Cdd:COG5245 1252 R-----YVEKTKAEVSSLKLELSSVGEG-------QVVVSN---LGSIGDKVGRCLVEYdsisrlstkgVFLDELGdTKR 1316
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2301 YVASWIDRRRHQSEKANLTILFDK-YIPVCLE---------KLRTSFKAITSVPES-SLVQTICTLLECLLTPENIppDS 2369
Cdd:COG5245 1317 YLDECLDFFSCFEEVQKEIDELSMvFCADALRfsadlyhivKERRFSGVLAGSDASeSLGGKSIELAAILEHKDLI--VE 1394
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2370 PKETYEVYFAFACvwtFGGTLLRDQLSDYQ---ADFSrwwhKEMKAVKFPSQGTIFDYYLDHKTKKFLPwtdkVPQFSMD 2446
Cdd:COG5245 1395 MKRGINDVLKLRI---FGDKCRESTPRFYLisdGDLI----KDLNERSDYEEMLIMMFNISAVITNNGS----IAGFELR 1463
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2447 ADAPL--KTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASlSENYIVSCVPFNYYTTSAALQRILE 2524
Cdd:COG5245 1464 GERVMlrKEVVIPTSDTGFVDSFSNEALNTLRSYIYCGPPGSGKEMLMCPSLRS-ELITEVKYFNFSTCTMTPSKLSVLE 1542
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2525 KPLEKKagRNYG-----PKGN-KKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDY-GHWYDRHKiMLKEIRNCQYVACMN 2597
Cdd:COG5245 1543 RETEYY--PNTGvvrlyPKPVvKDLVLFCDEINLPYGFEYYPPTVIVFLRPLVERqGFWSSIAV-SWVTICGIILYGACN 1619
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2598 P--MVGSFTVNPRLQRHfTVFAF-NFPSLDALTTIYgqifSFYLQQQAFC-PSVLRAGPSLIQATIAFHQMMAESFvPTA 2673
Cdd:COG5245 1620 PgtDEGRVKYYERFIRK-PVFVFcCYPELASLRNIY----EAVLMGSYLCfDEFNRLSEETMSASVELYLSSKDKT-KFF 1693
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2674 IKFHYNFNLRDLSNIFQGIL-FASPECLKSLEDLARLWLHETSRVYGDRLIDTNDFDLFQRKMLETAHKYFKGVDANALL 2752
Cdd:COG5245 1694 LQMNYGYKPRELTRSLRAIFgYAETRIDTPDVSLIIDWYCEAIREKIDRLVQQKESSTSRQDLYDFGLRAIREMIAGHIG 1773
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2753 RQPLVYCHFASGGedpcyMPVKDWEGLKAVLMEMVDNYNELHSAMHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSG 2832
Cdd:COG5245 1774 EAEITFSMILFFG-----MACLLKKDLAVFVEEVRKIFGSSHLDVEAVAYKDALLHILRSRRGLLVVGGHGVLKGVLIRG 1848
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2833 KQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAKNMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFS 2912
Cdd:COG5245 1849 ACDAREFVCWLNPRNMREIFGHRDELTGDFRDSLKVQDLRRNIHGGRECLFIFESIPVESSFLEDFNPLLDNNRFLCLFS 1928
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2913 DEDMDKIISGIRNEVRGLGL-VDSRENCWAFFLARVRQQLKMVFCFSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEAL 2991
Cdd:COG5245 1929 GNERIRIPENLRFVFESTSLeKDTEATLTRVFLVYMEENLPVVFSACCSQDTSVLAGIRSPALKNRCFIDFKKLWDTEEM 2008
|
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2992 VSVSRRFI-EEIEGIEPQH--------KDSISLFMAHVHTSVKEVSAWYYQNERRYNYTTPRSFLEQISLFKSLLKKKRE 3062
Cdd:COG5245 2009 SQYANSVEtLSRDGGRVFFingelgvgKGALISEVFGDDAVVIEGRGFEISMIEGSLGESKIKFIGGLKVYDARCVIYIE 2088
|
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3063 EVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIgLQTEKVSREKAIADAEERKVAAIQTEAS 3142
Cdd:COG5245 2089 ELDCTNVNLVEGVRKYNEYGRGMGELKEQLSNTVVILGVKEKNADDALSGT-PGERLEREVKSVFVEAPRDMLFLLEEEV 2167
|
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3143 QKQRECEADLLK-AEPALVAAKDALNTLNRVNLTELKTFPNPPNAVTNVTAAVMVLLaprGRVPKDrsWKAAKIFMgKVD 3221
Cdd:COG5245 2168 RKRKGSVMKFKSsKKPAVLEAVLFVYKIKKASLREIRSFIRPPGDLCIEMEDVCDLL---GFEAKI--WFGEQQSL-RRD 2241
|
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3222 DFLQALINYDKE-HIPENCLKVVNEQYLKDPEFNPNLIRTKSFAAAGLCAWVINIIRFYEVYCDVEPKRQALAQTNLDLA 3300
Cdd:COG5245 2242 DFIRIIGKYPDEiEFDLEARRFREARECSDPSFTGSILNRASKACGPLKRWLVRECNRSKVLEVKIPLREEEKRIDGEAF 2321
|
1850 1860 1870 1880 1890 1900 1910 1920
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3301 AATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELESEKIRWGQSIKSFETQEKTLC 3380
Cdd:COG5245 2322 LVEDRLTLGKGLSSDLMTFKLRRRSYYSLDILRVHGKIADMDTVHKDVLRSIFVSEILINEDSEWGGVFSEVPKLMVELD 2401
|
1930 1940 1950 1960 1970 1980 1990 2000
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3381 GDVLLTAAFVSYIGSFTRQYRQ-ELVDCKwiPFLQQKVSIP-------IAEGLDLIamlTDDATIATWNNEGLPSDRMST 3452
Cdd:COG5245 2402 GDGHPSSCLHPYIGTLGFLCRAiEFGMSF--IRISKEFRDKeirrrqfITEGVQKI---EDFKEEACSTDYGLENSRIRK 2476
|
2010 2020 2030 2040 2050 2060 2070 2080
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3453 ENATILthcerwPLMIDPQQQGIKWIKNKYGPdlKVTHLG---QKGFLNTIETALAFGDVILIENlKETVDPVLGPLLGR 3529
Cdd:COG5245 2477 DLQDLT------AVLNDPSSKIVTSQRQMYDE--KKAILGsfrEMEFAFGLSQARREGSDKIIGD-AEALDEEIGRLIKE 2547
|
2090 2100 2110 2120 2130 2140 2150 2160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3530 NTTKKGKFIR--IGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVSIERPDLERLKLVL 3607
Cdd:COG5245 2548 EFKSNLSEVKvmINPPEIVRSTVEAVFWLSEGRSGDMGSIEWKQLIQVMFVSKVLGCETEIPDALEKLVSGPLFVHEKAL 2627
|
2170 2180 2190 2200 2210 2220 2230 2240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3608 TKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEIEHKVTEARENERKINETRECYRPVAARASLL 3687
Cdd:COG5245 2628 NALKACGSLFLWVLARYLLAKLMLSISNMEQTDEIAVLLHNLKKSRKEIEEEESESMEIEDRIDALKSEYNASVKRLESI 2707
|
2250 2260 2270 2280 2290 2300 2310 2320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3688 YFVISDLRRINPVYQFSLKAFNTLFHRaieqadkVEDTQERICALIESITHATFLYasqaLFERDKLTFlsqmafqillr 3767
Cdd:COG5245 2708 RVEIAMFDEKALMYNKSICELSSEFEK-------WRRMKSKYLCAIRYMLMSSEWI----LDHEDRSGF----------- 2765
|
2330 2340 2350 2360 2370 2380 2390 2400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3768 rneIHPLELDFLLRFTVEHTYSSPVDFLTAQSWSAVkavalmeeFRGLDRDVEGSAKQWRKWVESEcpekeklpqewKKK 3847
Cdd:COG5245 2766 ---IHRLDVSFLLRTKRFVSTLLEDKNYRQVLSSCS--------LYGNDVISHSCDRFDRDVYRAL-----------KHQ 2823
|
2410 2420 2430 2440 2450 2460 2470 2480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3848 SLIQKLIILRAVRPDRMTYALRNFVEEKLGAKYVERT--RLDLGKAFEESSPST-PVFFILSPGVDALKDLEVLG--KRL 3922
Cdd:COG5245 2824 MDNRTHSTILTSNSKTNPYKEYTYNDSWAEAFEVEDSgdLYKFEEGLLELIVGHaPLIYAHKKSLENERNVDRLGskENE 2903
|
2490 2500 2510 2520 2530 2540 2550 2560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3923 GFTIDSGKFHNVSlgqgqelvaemamekaaagGHWVILQNVHLVAKWlgtLEKLLEKFSQGS-----HRDYRVFLSAETV 3997
Cdd:COG5245 2904 VYAVLNSLFSRKE-------------------KSWFEVYNISLSFGW---FKRYVEDVVYPIkasrvCGKVKNMWTSMVD 2961
|
2570 2580 2590 2600 2610 2620 2630 2640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3998 PSQhepiIPQGLLENSIKITNEPPTGMLANLhAALYNFDQ---DTLEMCSKDqefksILFSLCYFHACVAGRLRFGPQGW 4074
Cdd:COG5245 2962 ADM----LPIQLLIAIDSFVSSTYPETGCGY-ADLVEIDRypfDYTLVIACD-----DAFYLSWEHAAVASVISAGPKEN 3031
|
2650 2660 2670 2680 2690 2700 2710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4075 SRSYPFSPGDLTICTNILYNYLEANP--NVPWEDLRYLFGEIMYGGHITDAWD----RKLCRVYLEEFMN 4138
Cdd:COG5245 3032 NEEIYFGDKDFEFKTHLLKNILFLNHlnARKWGNNRDLIFTIVYGKKHSLMEDskvvDKYCRGYGAHETS 3101
|
|
| AAA_9 |
pfam12781 |
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. ... |
3438-3656 |
6.09e-111 |
|
ATP-binding dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the fifth AAA+ domain subdomain AAA5S. Structural analysis reveal that it is the coiled-coil buttress interface. The relative movement of AAA5S together with the stalk (AAA4S), is coupled to rearrangements in the AAA+ ring. Closure of the AAA1 site and the rigid body movement of AAA2-AAA4 force the AAA4/AAA5 interface to close and the AAA6L subdomain to rotate towards the ring centre. The AAA5S subdomain rotates as a unit together with AAA6L, and this movement pulls the buttress relative to the stalk.
Pssm-ID: 463702 [Multi-domain] Cd Length: 222 Bit Score: 352.90 E-value: 6.09e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3438 ATWNNEGLPSDRMSTENATILTHCERWPLMIDPQQQGIKWIKNKYGP-DLKVTHLGQKGFLNTIETALAFGDVILIENLK 3516
Cdd:pfam12781 1 REWNIQGLPNDELSIENAIIVTNSRRWPLLIDPQGQANKWIKNMEKDnGLKVTSFTDKNFLKTLENAIRFGKPLLIEDVG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3517 ETVDPVLGPLLGRNTTKKG--KFIRIGDKECEFNKNFRLILHTKLANPHYKPELQAQTTLLNFTVTEDGLEGQLLAEVVS 3594
Cdd:pfam12781 81 EELDPILDPVLLKEIFKGGgrKVIKLGDKEVDYNPNFRLYLTTKLPNPHYPPEVAAKVTLINFTVTRSGLEDQLLGIVVK 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 393794754 3595 IERPDLERLKLVLTKQQNDFKIELRQLEDDLLLRLSAAEGSFLDDTDLVERLETTKATAAEI 3656
Cdd:pfam12781 161 KERPDLEEQRNELIKEIAENKKQLKELEDKLLELLSSSEGNILDDEELIETLETSKKTSEEI 222
|
|
| AAA_8 |
pfam12780 |
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA ... |
2797-3056 |
4.76e-109 |
|
P-loop containing dynein motor region D4; The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This particular family is the D4 ATP-binding region of the motor.
Pssm-ID: 463701 [Multi-domain] Cd Length: 259 Bit Score: 349.21 E-value: 4.76e-109
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2797 MHLVLFEDAMQHVCRISRILRIPQGHALLIGVGGSGKQSLSRLAAYICSLEVFQITLTEGYGAQELRVDLANLYVRTGAK 2876
Cdd:pfam12780 1 MDLVLFRDALEHLCRICRILRQPRGHALLVGVGGSGRQSLTKLAAFIAGYELFQIEVTRNYDMNEFREDLKKVLKKAGIK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2877 NMPTVFLLTDAHVLDESFLVLINDLLASGDIPDLFSDEDMDKIISGIRNEVRGLGLVDSRENCWAFFLARVRQQLKMVFC 2956
Cdd:pfam12780 81 GKPTVFLLSDTQIIEESFLEDINNLLNSGEVPNLFTDEEKEEIIESVRDDAKAQNIEDSREAVYNYFVKRCRNNLHIVLC 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2957 FSPVGHTLRVRARKFPAIVNCTAIDWFHEWPQEALVSVSRRFIEEIEGIEpQHKDSISLFMAHVHTSVKEVSAWYYQNER 3036
Cdd:pfam12780 161 MSPVGEAFRNRLRMFPSLVNCCTIDWFNEWPEEALLAVAEKFLEDIEIPE-ELKSNVVKVFVYVHSSVEDMSKKFYEELK 239
|
250 260
....*....|....*....|
gi 393794754 3037 RYNYTTPRSFLEQISLFKSL 3056
Cdd:pfam12780 240 RKNYVTPKSYLELLRLYKNL 259
|
|
| AAA_7 |
pfam12775 |
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ... |
2446-2621 |
4.27e-87 |
|
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).
Pssm-ID: 463698 [Multi-domain] Cd Length: 179 Bit Score: 282.74 E-value: 4.27e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2446 DADAPLKTVLVHTPETTRLRYFTELLLCKGKPIMLVGNAGVGKTVFLSNTLASLS-ENYIVSCVPFNYYTTSAALQRILE 2524
Cdd:pfam12775 2 PPDVPFSEILVPTVDTVRYTYLLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDkEKYLPLFINFSAQTTSNQTQDIIE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2525 KPLEKKAGRNYGPKGNKKLVYFIDDLNMPEVDLYGTIQPHALLRQHIDYGHWYDRHKIMLKEIRNCQYVACMNPMVGS-F 2603
Cdd:pfam12775 82 SKLEKRRKGVYGPPGGKKLVVFIDDLNMPAVDTYGAQPPIELLRQWLDYGGWYDRKKLTFKEIVDVQFVAAMGPPGGGrN 161
|
170
....*....|....*...
gi 393794754 2604 TVNPRLQRHFTVFAFNFP 2621
Cdd:pfam12775 162 DITPRLLRHFNVFNITFP 179
|
|
| AAA_lid_11 |
pfam18198 |
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the ... |
4049-4185 |
2.13e-64 |
|
Dynein heavy chain AAA lid domain; This family represents the AAA lid domain found neat the C-terminal region of dynein heavy chain.
Pssm-ID: 465676 Cd Length: 139 Bit Score: 216.17 E-value: 2.13e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4049 FKSILFSLCYFHACVAGRLRFGPQGWSRSYPFSPGDLTICTNILYNYLEANP-NVPWEDLRYLFGEIMYGGHITDAWDRK 4127
Cdd:pfam18198 1 WKKLLFGLCFFHAVVQERRKFGPLGWNIPYEFNESDLRISVQQLQMYLDEYDeKIPWDALRYLIGEINYGGRVTDDWDRR 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 4128 LCRVYLEEFMNPSLIEDEVMLAPG-FAAPPYSDYSGYHQYIEdTLP-PESPALYGLHPNA 4185
Cdd:pfam18198 81 LLNTYLEEFFNPEVLEEDFKFSPSlYYIPPDGDLEDYLEYIE-SLPlVDSPEVFGLHPNA 139
|
|
| Dynein_heavy |
pfam03028 |
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of ... |
3896-4017 |
3.45e-42 |
|
Dynein heavy chain region D6 P-loop domain; This family represents the C-terminal region of dynein heavy chain. The chain also contains ATPase activity and microtubule binding ability and acts as a motor for the movement of organelles and vesicles along microtubules. Dynein is also involved in cilia and flagella movement. The dynein subunit consists of at least two heavy chains and a number of intermediate and light chains. The 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This C-terminal domain carries the D6 region of the dynein motor where the P-loop has been lost in evolution but the general structure of a potential ATP binding site appears to be retained.
Pssm-ID: 460782 Cd Length: 115 Bit Score: 151.44 E-value: 3.45e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3896 SPSTPVFFILSPGVDALKDLEVLGKRLGFTidsGKFHNVSLGQGQELVAEMAMEKAAAGGHWVILQNVHLVAKWLGTLEK 3975
Cdd:pfam03028 1 SPTTPLIFILSPGSDPTADLEKLAKKLGFG---GKLHSISLGQGQGPIAEKLIEEAAKEGGWVLLQNCHLALSWMPELEK 77
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 393794754 3976 LLEKF-SQGSHRDYRVFLSAEtvPSqhePIIPQGLLENSIKIT 4017
Cdd:pfam03028 78 ILEELpEETLHPDFRLWLTSE--PS---PKFPISILQNSIKIT 115
|
|
| AAA_lid_1 |
pfam17857 |
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3. |
2654-2743 |
3.14e-35 |
|
AAA+ lid domain; This domain represents the AAA lid domain from dynein heavy chain D3.
Pssm-ID: 465535 [Multi-domain] Cd Length: 100 Bit Score: 131.21 E-value: 3.14e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2654 LIQATIAFHQMMAESFVPTAIKFHYNFNLRDLSNIFQGILFASPECLKSLEDLARLWLHETSRVYGDRLIDTNDFDLFQR 2733
Cdd:pfam17857 1 LIAAALAFHQKIAATFLPTAIKFHYIFNLRDFANIFQGILFSSAECLKSPLDLIRLWLHESERVYGDKMVDEKDFDLFDK 80
|
90
....*....|
gi 393794754 2734 KMLETAHKYF 2743
Cdd:pfam17857 81 IQMASLKKFF 90
|
|
| Dynein_AAA_lid |
pfam17852 |
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA ... |
2321-2438 |
6.55e-29 |
|
Dynein heavy chain AAA lid domain; This entry corresponds to the extension domain of AAA domain 5 in the dynein heavy chain. This domain is composed of 8 alpha helices.
Pssm-ID: 465532 [Multi-domain] Cd Length: 126 Bit Score: 113.92 E-value: 6.55e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2321 LFDKYIPVCLEKLRTSFKAITSVPESSLVQTICTLLECLLTP-------ENIPPDSPKETYEVYFAFACVWTFGGTLLRD 2393
Cdd:pfam17852 4 LFEWLVPPALEFVRKNCKEIVPTSDLNLVQSLCRLLESLLDEvleyngvHPLSPDKLKEYLEKLFLFALVWSIGGTLDED 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 393794754 2394 QlsdyQADFSRWWHKEMKAVKFP--SQGTIFDYYLDHKTKKFLPWTD 2438
Cdd:pfam17852 84 S----RKKFDEFLRELFSGLDLPppEKGTVYDYFVDLEKGEWVPWSD 126
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2150-2285 |
3.29e-11 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 63.85 E-value: 3.29e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2150 SVFVVGNAGTGKSKILRTLNRTYVNmkqKPVWSDLNPKAVTTDELFGFIHHATR--EWKDGLFSSILREqanlthdgpTW 2227
Cdd:pfam07728 1 GVLLVGPPGTGKTELAERLAAALSN---RPVFYVQLTRDTTEEDLFGRRNIDPGgaSWVDGPLVRAARE---------GE 68
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 393794754 2228 IVLDGDID---PLWIESLNTVMDDNKVLTLASNERVALKP-SMRLLFETHHLRT----ATPATVSR 2285
Cdd:pfam07728 69 IAVLDEINranPDVLNSLLSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLDRglneLSPALRSR 134
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
2477-2613 |
1.27e-06 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 50.75 E-value: 1.27e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 2477 PIMLVGNAGVGKTvFLSNTLASLSENYIVSCVPFNYYTTSAALQRILEkPLEKKAGRNYGP---KGNKKLVYFIDDLNMP 2553
Cdd:pfam07728 1 GVLLVGPPGTGKT-ELAERLAAALSNRPVFYVQLTRDTTEEDLFGRRN-IDPGGASWVDGPlvrAAREGEIAVLDEINRA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 393794754 2554 EVDLYGTIQPhaLL---RQHIDYGHWYDRHKimlKEIRNCqyVACMNP-MVGSFTVNPRLQRHF 2613
Cdd:pfam07728 79 NPDVLNSLLS--LLderRLLLPDGGELVKAA---PDGFRL--IATMNPlDRGLNELSPALRSRF 135
|
|
| Smc |
COG1196 |
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ... |
3047-3171 |
5.03e-04 |
|
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];
Pssm-ID: 440809 [Multi-domain] Cd Length: 983 Bit Score: 46.47 E-value: 5.03e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3047 LEQISLFKSLLKKKREEVKQKQEHLGNGIQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTEKVSREKAI 3126
Cdd:COG1196 255 LEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEE 334
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 393794754 3127 ADAEERKVAAIQTEASQKQRECEADLLKAEPALVAAKDALNTLNR 3171
Cdd:COG1196 335 LEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEE 379
|
|
| Laminin_II |
pfam06009 |
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 ... |
3295-3359 |
8.38e-04 |
|
Laminin Domain II; It has been suggested that the domains I and II from laminin A, B1 and B2 may come together to form a triple helical coiled-coil structure.
Pssm-ID: 368703 [Multi-domain] Cd Length: 138 Bit Score: 42.47 E-value: 8.38e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 393794754 3295 TNLDLAAATEKLEAVRRKLVDLDHNLSRLTASFEKATAEKVRCQEEVNQTNKTIDLANKLVSELE 3359
Cdd:pfam06009 1 SKELAREANETAKEVLEQLAPLSQNLENTSEKLSGINRSLEETNELVNDANKALDDAGRSVKKLE 65
|
|
| Surf_Exclu_PgrA |
TIGR04320 |
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface ... |
3076-3170 |
1.15e-03 |
|
SEC10/PgrA surface exclusion domain; This model describes a conserved domain found in surface proteins of a number of Firmutes. Many members have LPXTG C-terminal anchoring motifs and a substantial number have the KxYKxGKxW putative sorting signal at the N-terminus. The tetracycline resistance plasmid pCF10 in Enterococcus faecalis promotes conjugal plasmid transfer in response to sex pheromones, but PgrA/Sec10 encoded by that plasmid, a member of this family, specifically inhibits the ability of cells to receive homologous plasmids. The phenomenon is called surface exclusion.
Pssm-ID: 275124 [Multi-domain] Cd Length: 356 Bit Score: 44.72 E-value: 1.15e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3076 QKLQTTASQVGNLKSRLASQEAEL-QLRNLDAEALITKIGLQTEKVSREKAIADAEErKVAAIQTEASQKQ----RECEA 3150
Cdd:TIGR04320 247 TPIPNPPNSLAALQAKLATAQADLaAAQTALNTAQAALTSAQTAYAAAQAALATAQK-ELANAQAQALQTAqnnlATAQA 325
|
90 100
....*....|....*....|
gi 393794754 3151 DLLKAEPALVAAKDALNTLN 3170
Cdd:TIGR04320 326 ALANAEARLAKAKEALANLN 345
|
|
| AAA_5 |
pfam07728 |
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not ... |
1874-1994 |
1.55e-03 |
|
AAA domain (dynein-related subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.
Pssm-ID: 400191 [Multi-domain] Cd Length: 135 Bit Score: 41.89 E-value: 1.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 1874 GPAGTGKTETTKDLGRAL-GMMVYVFNCSEQMDY------RSIGNIYKGLV--------QTGAWGCFDEFNRIAVEVLSV 1938
Cdd:pfam07728 6 GPPGTGKTELAERLAAALsNRPVFYVQLTRDTTEedlfgrRNIDPGGASWVdgplvraaREGEIAVLDEINRANPDVLNS 85
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 393794754 1939 VavqvkmiHDAIRNGRKRFVFLGETIPLKP-SVGIFITLNPGYAGRTELPENLKALF 1994
Cdd:pfam07728 86 L-------LSLLDERRLLLPDGGELVKAAPdGFRLIATMNPLDRGLNELSPALRSRF 135
|
|
| DUF4515 |
pfam14988 |
Domain of unknown function (DUF4515); This family of proteins is found in bacteria and ... |
3049-3159 |
1.91e-03 |
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Domain of unknown function (DUF4515); This family of proteins is found in bacteria and eukaryotes. Proteins in this family are typically between 198 and 469 amino acids in length. There are two completely conserved L residues that may be functionally important.
Pssm-ID: 405647 [Multi-domain] Cd Length: 206 Bit Score: 42.83 E-value: 1.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 393794754 3049 QISLFKSLLKKKREEVKQKQEHLGNG-IQKLQTTASQVGNLKSRLASQEAELQLRNLDAEALITKIGLQTE--------K 3119
Cdd:pfam14988 1 ENKFFLEYLAKKTEEKQKKIEKLWNQyVQECEEIERRRQELASRYTQQTAELQTQLLQKEKEQASLKKELQalrpfaklK 80
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90 100 110 120
....*....|....*....|....*....|....*....|
gi 393794754 3120 VSREKAIADAEERKvAAIQTEASQKQRECEADLLKAEPAL 3159
Cdd:pfam14988 81 ESQEREIQDLEEEK-EKVRAETAEKDREAHLQFLKEKALL 119
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