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Conserved domains on  [gi|114326522|ref|NP_034146|]
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complement decay-accelerating factor, GPI-anchored isoform 1 preproprotein [Mus musculus]

Protein Classification

beta-2-glycoprotein 1( domain architecture ID 12867676)

beta-2-glycoprotein 1 is a heavily glycosylated plasma membrane-adhesion protein, which plays a role in blood coagulation and removal of apoptotic bodies

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02927 super family cl33700
secreted complement-binding protein; Provisional
 98-292 1.10e-41

secreted complement-binding protein; Provisional


The actual alignment was detected with superfamily member PHA02927:

Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.49  E-value: 1.10e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  98 CVAPER---LSFASLKKEYLNMNFfPVGTIVEYECRPGFRKQPPLPGKATCLEDlVWSPVAQfCKKKSCPNPKDLDNGHI 174
Cdd:PHA02927  21 CTIPSRpinMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDIDNGQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 175 NIpTGILFGSEINFSCNPGYRLVGVSSTFCSV--TGNTVdWDDEFPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYS 252
Cdd:PHA02927  98 DI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYS 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 114326522 253 CDKGFILVGNASIYCTvsksdVGQWSSPPPRCIEKSKVPT 292
Cdd:PHA02927 176 CNSGYSLIGNSGVLCS-----GGEWSDPPTCQIVKCPHPT 210
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 36-95 9.77e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


:

Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 9.77e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  36 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 95
Cdd:cd00033    1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 98-292 1.10e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.49  E-value: 1.10e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  98 CVAPER---LSFASLKKEYLNMNFfPVGTIVEYECRPGFRKQPPLPGKATCLEDlVWSPVAQfCKKKSCPNPKDLDNGHI 174
Cdd:PHA02927  21 CTIPSRpinMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDIDNGQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 175 NIpTGILFGSEINFSCNPGYRLVGVSSTFCSV--TGNTVdWDDEFPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYS 252
Cdd:PHA02927  98 DI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYS 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 114326522 253 CDKGFILVGNASIYCTvsksdVGQWSSPPPRCIEKSKVPT 292
Cdd:PHA02927 176 CNSGYSLIGNSGVLCS-----GGEWSDPPTCQIVKCPHPT 210
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 225-285 2.22e-16

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 72.88  E-value: 2.22e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326522 225 CPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSksdvGQWSSPPPRCI 285
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 225-284 1.12e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 65.24  E-value: 1.12e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522   225 CPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSksdvGQWSSPPPRC 284
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
225-284 6.78e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 60.21  E-value: 6.78e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  225 CPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSksdvGQWSSPPPRC 284
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED----GTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 36-95 9.77e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 9.77e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  36 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 95
Cdd:cd00033    1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 36-94 3.42e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 3.42e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522    36 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 94
Cdd:smart00032   1 CPPPPDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
36-94 3.63e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 3.63e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522   36 CGPPPDIPNARPIlGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 94
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
 
Name Accession Description Interval E-value
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 98-292 1.10e-41

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 147.49  E-value: 1.10e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  98 CVAPER---LSFASLKKEYLNMNFfPVGTIVEYECRPGFRKQPPLPGKATCLEDlVWSPVAQfCKKKSCPNPKDLDNGHI 174
Cdd:PHA02927  21 CTIPSRpinMKFKNSVETDANANY-NIGDTIEYLCLPGYRKQKMGPIYAKCTGT-GWTLFNQ-CIKRRCPSPRDIDNGQL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 175 NIpTGILFGSEINFSCNPGYRLVGVSSTFCSV--TGNTVdWDDEFPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYS 252
Cdd:PHA02927  98 DI-GGVDFGSSITYSCNSGYQLIGESKSYCELgsTGSMV-WNPEAPICESVKCQSPPSISNGRHNGYEDFYTDGSVVTYS 175

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 114326522 253 CDKGFILVGNASIYCTvsksdVGQWSSPPPRCIEKSKVPT 292
Cdd:PHA02927 176 CNSGYSLIGNSGVLCS-----GGEWSDPPTCQIVKCPHPT 210
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 225-285 2.22e-16

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 72.88  E-value: 2.22e-16
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326522 225 CPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSksdvGQWSSPPPRCI 285
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSYSYGSTVTYSCNEGYTLVGSSTITCTEN----GGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 225-284 1.12e-13

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 65.24  E-value: 1.12e-13
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522   225 CPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSksdvGQWSSPPPRC 284
Cdd:smart00032   1 CPPPPDIENGTVTSSSGTYSYGDTVTYSCDPGYTLIGSSTITCLEN----GTWSPPPPTC 56
PHA02927 PHA02927
secreted complement-binding protein; Provisional
 32-285 1.44e-13

secreted complement-binding protein; Provisional


Pssm-ID: 222943 [Multi-domain]  Cd Length: 263  Bit Score: 70.07  E-value: 1.44e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  32 VRGDCGPPPDIPNARPILGrHSKFAeqSKVAYSCNNGFKQVpdksnivvclengqwSSHETFCEKSCVAperlsfaslkk 111
Cdd:PHA02927  82 IKRRCPSPRDIDNGQLDIG-GVDFG--SSITYSCNSGYQLI---------------GESKSYCELGSTG----------- 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 112 eylnmnffpvgtiveyecrpgfrkqpplpgkatcleDLVWSPVAQFCKKKSCPNPKDLDNG-HINIPTGILFGSEINFSC 190
Cdd:PHA02927 133 ------------------------------------SMVWNPEAPICESVKCQSPPSISNGrHNGYEDFYTDGSVVTYSC 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 191 NPGYRLVGVSSTFCSvtgnTVDWDDEfPVCTEIHCPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVS 270
Cdd:PHA02927 177 NSGYSLIGNSGVLCS----GGEWSDP-PTCQIVKCPHPTISNGYLSSGFKRSYSYNDNVDFKCKYGYKLSGSSSSTCSPG 251

                        250
                 ....*....|....*
gi 114326522 271 KSdvgqWSSPPPRCI 285
Cdd:PHA02927 252 NT----WQPELPKCV 262
PHA02639 PHA02639
EEV host range protein; Provisional
 116-290 2.85e-12

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 66.61  E-value: 2.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 116 MNFFPVGTIVEYECRPGFrkqpPLPGKA--TCLED---LVWSPVAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFS 189
Cdd:PHA02639  37 MEKYEIGKLIEYTCNTDY----ALIGDRfrTCIKDknnAIWSNKAPFCMLKECNDPPSIINGKIyNKREMYKVGDEIYYV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 190 CNP----GYRLVGVSSTFCSvtgNTVDWDDEFPVCTEIHCpEPPKINNGIMRG--ESDSYTYSQVVTYSCDKGFILVGNA 263
Cdd:PHA02639 113 CNEhkgvQYSLVGNEKITCI---QDKSWKPDPPICKMINC-RFPALQNGYINGipSNKKFYYKTRVGFSCKSGFDLVGEK 188

                        170       180
                 ....*....|....*....|....*..
gi 114326522 264 SIYCTVSKSdvgqWSSPPPRCIEKSKV 290
Cdd:PHA02639 189 YSTCNINAT----WFPSIPTCVRNKPI 211
Sushi pfam00084
Sushi repeat (SCR repeat);
225-284 6.78e-12

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 60.21  E-value: 6.78e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  225 CPEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSksdvGQWSSPPPRC 284
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEYNYGASVSYECDPGYRLVGSPTITCQED----GTWSPPFPEC 56
PHA02639 PHA02639
EEV host range protein; Provisional
 159-284 8.97e-12

EEV host range protein; Provisional


Pssm-ID: 165022 [Multi-domain]  Cd Length: 295  Bit Score: 65.46  E-value: 8.97e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 159 KKKSCPNPKDLDNGHIN-IPTGILFGSEINFSCNPGYRLVGVSSTFCSVTGNTVDWDDEFPVCTEIHCPEPPKINNGIMR 237
Cdd:PHA02639  18 KSIYCDKPDDISNGFITeLMEKYEIGKLIEYTCNTDYALIGDRFRTCIKDKNNAIWSNKAPFCMLKECNDPPSIINGKIY 97

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 114326522 238 GESDSYTYSQVVTYSCD--KG--FILVGNASIYCTVSKSdvgqWSSPPPRC 284
Cdd:PHA02639  98 NKREMYKVGDEIYYVCNehKGvqYSLVGNEKITCIQDKS----WKPDPPIC 144
PHA02817 PHA02817
EEV Host range protein; Provisional
 154-289 4.17e-11

EEV Host range protein; Provisional


Pssm-ID: 165167 [Multi-domain]  Cd Length: 225  Bit Score: 62.27  E-value: 4.17e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 154 VAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFSCNPG-----YRLVGVSSTFCSVTGNtvdWDDEFPVCTEIHCpE 227
Cdd:PHA02817  15 VYSLCDLNKCCYPPSIKNGYIyNKKTEYNIGSNVTFFCGNNtrgvrYTLVGEKNIICEKDGK---WNKEFPVCKIIRC-R 90

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 114326522 228 PPKINNGIMRGESDS--YTYSQVVTYSCDKGFILVGNASIYCTVSKSdvgqWSSPPPRCIEKSK 289
Cdd:PHA02817  91 FPALQNGFVNGIPDSkkFYYESEVSFSCKPGFVLIGTKYSVCGINSS----WIPKVPICSRDNI 150
PHA02831 PHA02831
EEV host range protein; Provisional
 125-288 8.33e-11

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 61.93  E-value: 8.33e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 125 VEYECRPGFRKQpplpgKATClEDLVWSPVAQFCKKKSCPNPKDLDNGHI-NIPTGILFGSEINFSCNPG----YRLVGV 199
Cdd:PHA02831  46 LEYKCNNNFDKV-----FVTC-NNGSWSTKNMCIGKRNCKDPVTILNGYIkNKKDQYSFGDSVTYACKVNklekYSIVGN 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 200 SSTFCsVTGNtvdWDDEFPVCTEIHCpEPPKINNGIMRGESDSYTYSQVVTYSCDKGFILVGNASIYCTVSKSdvgqWSS 279
Cdd:PHA02831 120 ETVKC-INKQ---WVPKYPVCKLIRC-KYPALQNGFLNVFEKKFYYGDIVNFKCKKGFILLGSSVSTCDINSI----WYP 190


                 ....*....
gi 114326522 280 PPPRCIEKS 288
Cdd:PHA02831 191 GIPKCVKDK 199
PHA02831 PHA02831
EEV host range protein; Provisional
 55-222 5.62e-10

EEV host range protein; Provisional


Pssm-ID: 165176 [Multi-domain]  Cd Length: 268  Bit Score: 59.62  E-value: 5.62e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  55 FAEQSKVAYSCNNGFKQVpdksnIVVClENGQWSShETFC--EKSCVAPERLSFASLKKEylnMNFFPVGTIVEYECRPG 132
Cdd:PHA02831  40 YEENENLEYKCNNNFDKV-----FVTC-NNGSWST-KNMCigKRNCKDPVTILNGYIKNK---KDQYSFGDSVTYACKVN 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 133 FRKQPPLPGKAT--CLeDLVWSPVAQFCKKKSCPNPKdLDNGHINI-PTGILFGSEINFSCNPGYRLVGVSSTFCSVtgN 209
Cdd:PHA02831 110 KLEKYSIVGNETvkCI-NKQWVPKYPVCKLIRCKYPA-LQNGFLNVfEKKFYYGDIVNFKCKKGFILLGSSVSTCDI--N 185

                        170
                 ....*....|...
gi 114326522 210 TVdWDDEFPVCTE 222
Cdd:PHA02831 186 SI-WYPGIPKCVK 197
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 36-95 9.77e-10

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 54.01  E-value: 9.77e-10
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  36 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFCE 95
Cdd:cd00033    1 CPPPPVPENGT-VTGSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 163-220 2.38e-09

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 52.85  E-value: 2.38e-09
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522 163 CPNPKDLDNGHINIPTGI-LFGSEINFSCNPGYRLVGVSSTFCSVTGNtvdWDDEFPVC 220
Cdd:cd00033    1 CPPPPVPENGTVTGSKGSySYGSTVTYSCNEGYTLVGSSTITCTENGG---WSPPPPTC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 163-220 5.93e-09

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 51.76  E-value: 5.93e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522   163 CPNPKDLDNGHIN-IPTGILFGSEINFSCNPGYRLVGVSSTFCSVTGNtvdWDDEFPVC 220
Cdd:smart00032   1 CPPPPDIENGTVTsSSGTYSYGDTVTYSCDPGYTLIGSSTITCLENGT---WSPPPPTC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
163-220 2.31e-08

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 50.19  E-value: 2.31e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522  163 CPNPKDLDNGHINIPTGI-LFGSEINFSCNPGYRLVGVSSTFCSVTGNtvdWDDEFPVC 220
Cdd:pfam00084   1 CPPPPDIPNGKVSATKNEyNYGASVSYECDPGYRLVGSPTITCQEDGT---WSPPFPEC 56
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 36-94 3.42e-08

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 49.45  E-value: 3.42e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522    36 CGPPPDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 94
Cdd:smart00032   1 CPPPPDIENGT-VTSSSGTYSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
PHA02954 PHA02954
EEV membrane glycoprotein; Provisional
 40-289 3.49e-08

EEV membrane glycoprotein; Provisional


Pssm-ID: 165263 [Multi-domain]  Cd Length: 317  Bit Score: 54.71  E-value: 3.49e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522  40 PDIPNARpILGRHSKFAEQSKVAYSCNNGFKQVPDKSnivVClENGQWSsHETFCEKSCVAPERLSfaslkkEYLNMNFF 119
Cdd:PHA02954  24 PTMNNAK-LTSTETSFNDKQKVTFTCDSGYYSLDPNA---VC-ETDKWK-YENPCKKMCTVSDYVS------ELYDKPLY 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 120 PVGTIVEYECRPG---FRKQPPlpGKATCLEDLVWSPVAQfCKkkscpnPKDLDNGHIN-IPTGILFGSEINFSCNPGYR 195
Cdd:PHA02954  92 EVNSTITLICKDEtkyFRCEEK--NGNTSWNDTVTCPNAE-CQ------PLQLEHGSCQpVKEKYSFGEHITINCDVGYE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 114326522 196 LVGVSSTFCSVTGNTVdwddeFPVCTEiHCpEPPKINNGIMRGEsdSYTYSQVVTYSCDKGFILVGNASIYCTvsksdVG 275
Cdd:PHA02954 163 VIGASYISCTANSWNV-----IPSCQQ-KC-DIPSLSNGLISGS--TFSIGGVIHLSCKSGFTLTGSPSSTCI-----DG 228

                        250
                 ....*....|....
gi 114326522 276 QWSSPPPRCIEKSK 289
Cdd:PHA02954 229 KWNPVLPICVRSNE 242
Sushi pfam00084
Sushi repeat (SCR repeat);
98-158 3.26e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 3.26e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326522   98 CVAPERLSFASLkkeYLNMNFFPVGTIVEYECRPGFRKQPPLpgKATCLEDLVWSPVAQFC 158
Cdd:pfam00084   1 CPPPPDIPNGKV---SATKNEYNYGASVSYECDPGYRLVGSP--TITCQEDGTWSPPFPEC 56
Sushi pfam00084
Sushi repeat (SCR repeat);
36-94 3.63e-07

Sushi repeat (SCR repeat);


Pssm-ID: 459664 [Multi-domain]  Cd Length: 56  Bit Score: 46.72  E-value: 3.63e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 114326522   36 CGPPPDIPNARPIlGRHSKFAEQSKVAYSCNNGFKQVPdkSNIVVCLENGQWSSHETFC 94
Cdd:pfam00084   1 CPPPPDIPNGKVS-ATKNEYNYGASVSYECDPGYRLVG--SPTITCQEDGTWSPPFPEC 56
CCP cd00033
Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) ...
 98-159 6.19e-06

Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system; SUSHI repeats (short complement-like repeat, SCR) are abundant in complement control proteins. The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. Typically, 2 to 4 modules contribute to a binding site, implying that the orientation of the modules to each other is critical for function.


Pssm-ID: 153056 [Multi-domain]  Cd Length: 57  Bit Score: 43.22  E-value: 6.19e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 114326522  98 CVAPERLSFASLKkeyLNMNFFPVGTIVEYECRPGFRKQPplPGKATCLEDLVWSPVAQFCK 159
Cdd:cd00033    1 CPPPPVPENGTVT---GSKGSYSYGSTVTYSCNEGYTLVG--SSTITCTENGGWSPPPPTCE 57
CCP smart00032
Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat ...
 98-158 3.16e-04

Domain abundant in complement control proteins; SUSHI repeat; short complement-like repeat (SCR); The complement control protein (CCP) modules (also known as short consensus repeats SCRs or SUSHI repeats) contain approximately 60 amino acid residues and have been identified in several proteins of the complement system. A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII.


Pssm-ID: 214478 [Multi-domain]  Cd Length: 56  Bit Score: 38.28  E-value: 3.16e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 114326522    98 CVAPERLSFASLKKEYLNmnfFPVGTIVEYECRPGFRKQPplPGKATCLEDLVWSPVAQFC 158
Cdd:smart00032   1 CPPPPDIENGTVTSSSGT---YSYGDTVTYSCDPGYTLIG--SSTITCLENGTWSPPPPTC 56
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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