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Conserved domains on  [gi|6753176|ref|NP_033876|]
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B-cell CLL/lymphoma 7 protein family member C isoform 2 [Mus musculus]

Protein Classification

BCL_N domain-containing protein( domain architecture ID 10520246)

BCL_N domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BCL_N pfam04714
BCL7, N-terminal conserver region; Members of the BCL family have significant sequence ...
 4-50 6.54e-29

BCL7, N-terminal conserver region; Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.


:

Pssm-ID: 461406  Cd Length: 48  Bit Score: 102.56  E-value: 6.54e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 6753176      4 RTVRAETRSRAKDDIKKVMATIEKVRRWEKRWVTVGDTSLRIFKWVP 50
Cdd:pfam04714   2 RSLRAETRSRAKDDVKRVILSIEKVRKWEKKWVTIGDTSMRIYKWVP 48
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
111-217 3.30e-03

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK07994:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 647  Bit Score: 37.92  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753176   111 AEPSPGGTPQPSRPGSPTGPPEVITEDTQPPQLG---QERDPGGTPAGGTDEPPKLTKEEPVPELLE--AEAPEAYPVFE 185
Cdd:PRK07994 391 VAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAarqQLQRAQGATKAKKSEPAAASRARPVNSALErlASVRPAPSALE 470

                         90       100       110
                 ....*....|....*....|....*....|..
gi 6753176   186 PVPSVPEAAQGDTEDSEGAPPLKRICPNAPDP 217
Cdd:PRK07994 471 KAPAKKEAYRWKATNPVEVKKEPVATPKALKK 502
 
Name Accession Description Interval E-value
BCL_N pfam04714
BCL7, N-terminal conserver region; Members of the BCL family have significant sequence ...
 4-50 6.54e-29

BCL7, N-terminal conserver region; Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.


Pssm-ID: 461406  Cd Length: 48  Bit Score: 102.56  E-value: 6.54e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 6753176      4 RTVRAETRSRAKDDIKKVMATIEKVRRWEKRWVTVGDTSLRIFKWVP 50
Cdd:pfam04714   2 RSLRAETRSRAKDDVKRVILSIEKVRKWEKKWVTIGDTSMRIYKWVP 48
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 111-217 3.30e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 37.92  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753176   111 AEPSPGGTPQPSRPGSPTGPPEVITEDTQPPQLG---QERDPGGTPAGGTDEPPKLTKEEPVPELLE--AEAPEAYPVFE 185
Cdd:PRK07994 391 VAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAarqQLQRAQGATKAKKSEPAAASRARPVNSALErlASVRPAPSALE 470

                         90       100       110
                 ....*....|....*....|....*....|..
gi 6753176   186 PVPSVPEAAQGDTEDSEGAPPLKRICPNAPDP 217
Cdd:PRK07994 471 KAPAKKEAYRWKATNPVEVKKEPVATPKALKK 502
 
Name Accession Description Interval E-value
BCL_N pfam04714
BCL7, N-terminal conserver region; Members of the BCL family have significant sequence ...
 4-50 6.54e-29

BCL7, N-terminal conserver region; Members of the BCL family have significant sequence similarity at their N-terminus, represented in this family. The function of BCL7 proteins is unknown. They may be involved in early development. In addition, BCL7B is commonly hemizygously deleted in patients with Williams syndrome.


Pssm-ID: 461406  Cd Length: 48  Bit Score: 102.56  E-value: 6.54e-29
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 6753176      4 RTVRAETRSRAKDDIKKVMATIEKVRRWEKRWVTVGDTSLRIFKWVP 50
Cdd:pfam04714   2 RSLRAETRSRAKDDVKRVILSIEKVRKWEKKWVTIGDTSMRIYKWVP 48
PRK07994 PRK07994
DNA polymerase III subunits gamma and tau; Validated
 111-217 3.30e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236138 [Multi-domain]  Cd Length: 647  Bit Score: 37.92  E-value: 3.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6753176   111 AEPSPGGTPQPSRPGSPTGPPEVITEDTQPPQLG---QERDPGGTPAGGTDEPPKLTKEEPVPELLE--AEAPEAYPVFE 185
Cdd:PRK07994 391 VAPPQAPAVPPPPASAPQQAPAVPLPETTSQLLAarqQLQRAQGATKAKKSEPAAASRARPVNSALErlASVRPAPSALE 470

                         90       100       110
                 ....*....|....*....|....*....|..
gi 6753176   186 PVPSVPEAAQGDTEDSEGAPPLKRICPNAPDP 217
Cdd:PRK07994 471 KAPAKKEAYRWKATNPVEVKKEPVATPKALKK 502
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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