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Conserved domains on  [gi|6857757|ref|NP_033831|]
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aquaporin-5 [Mus musculus]

Protein Classification

MIP/aquaporin family protein( domain architecture ID 11088534)

MIP (Major Intrinsic Protein)/aquaporin family protein similar to aquaporin that permits osmotically driven movement of water in both directions, and glycerol uptake facilitator protein that mediates glycerol diffusion across the cytoplasmic membrane via a pore-type mechanism

CATH:  1.20.1080.10
Gene Ontology:  GO:0055085|GO:0015267
PubMed:  11473620|8849412|11964478
SCOP:  3000508
TCDB:  1.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 5.52e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


:

Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 248.00  E-value: 5.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757      4 EVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLI 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     79 GNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6857757    159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPSHWVFWVGPIVGAVLAAILY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHWVYWVGPFIGAALGALVY 223
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 5.52e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 248.00  E-value: 5.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757      4 EVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLI 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     79 GNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6857757    159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPSHWVFWVGPIVGAVLAAILY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-224 4.92e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 217.89  E-value: 4.92e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   12 KAVFAEFLATLIFVFFGLGSALKW---PSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAI 88
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   89 FYVAAQLVGAIAGAGILYWLAPGNARGNLAVNA---------LSNNTTPGKAVVVELILTFQLALCIFSSTD-SRRTSPV 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6857757  159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS--PSHWVFWVGPIVGAVLAAILYFYL 224
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-221 4.40e-66

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.84  E-value: 4.40e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     16 AEFLATLIFVFFGLGSAL-------KWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAI 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     89 FYVAAQLVGAIAGAGILYWLAPGNARGNLAVNAL-SNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6857757    167 LSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-PSHWVFWVGPIVGAVLAAILY 221
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-225 1.10e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 181.09  E-value: 1.10e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   10 FFKAVFAEFLATLIFVFFGLGSA--LKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRA 87
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   88 IFYVAAQLVGAIAGAGILYWLAPGNARG---NLAVNAL-----SNNTTPGKAVVVELILTFQLALCIFSSTDSRRTsPVG 159
Cdd:COG0580  82 LPYIIAQLLGAFLGAALVYLIYGGHFDAtedGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6857757  160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-----PSHWVFWVGPIVGAVLAAILYFYLL 225
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwGYLWVPIVAPILGAALAALLYRALF 231
PRK05420 PRK05420
aquaporin Z; Provisional
 11-225 9.75e-46

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 153.20  E-value: 9.75e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    11 FKAVFAEFLATLIFVFFGLGSALkWPSALPTI----LQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    87 AIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNN----TTPGK-----AVVVELILTFQLALCIFSSTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFASNgygeHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6857757   158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSH-WVFWVGPIVGAVLAAILYFYLL 225
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlWLFWVAPIVGAIIGGLIYRLLL 227
 
Name Accession Description Interval E-value
MIP pfam00230
Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two ...
 4-221 5.52e-83

Major intrinsic protein; MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators.


Pssm-ID: 395174 [Multi-domain]  Cd Length: 223  Bit Score: 248.00  E-value: 5.52e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757      4 EVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALP-----TILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLI 78
Cdd:pfam00230   1 ELRSVSFLRAVIAEFLATLLFVFFGVGSALGVKKLVSslavsGLLAVALAFGLALATLVYCAGHISGAHLNPAVTLALLV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     79 GNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPV 158
Cdd:pfam00230  81 GRRFSLLRAIFYIVAQLLGAIAGAALLYGVTVGLQRAGLFANTLAPGVNAGQAFVVEIILTFQLVYCVFATTDDRRNGSL 160

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6857757    159 GS-PALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFsPSHWVFWVGPIVGAVLAAILY 221
Cdd:pfam00230 161 GTvAPLAIGFAVFLNHLAGGPYTGASMNPARSFGPAVVLWKW-DDHWVYWVGPFIGAALGALVY 223
MIP cd00333
Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane ...
 12-224 4.92e-71

Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal cytosolic portion followed by six transmembrane helices, which might have arisen through gene duplication. On the basis of sequence similarity and functional characteristics, the superfamily can be subdivided into two major groups: water-selective channels called aquaporins (AQPs) and glycerol uptake facilitators (GlpFs). AQPs are found in all three kingdoms of life, while GlpFs have been characterized only within microorganisms.


Pssm-ID: 238204  Cd Length: 228  Bit Score: 217.89  E-value: 4.92e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   12 KAVFAEFLATLIFVFFGLGSALKW---PSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAI 88
Cdd:cd00333   1 RKYLAEFLGTFLLVFFGCGSVLAVklaGGASGGLLGIALAWGFAIFVLVYAVGHISGGHINPAVTLALAVGGRFPLIRVI 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   89 FYVAAQLVGAIAGAGILYWLAPGNARGNLAVNA---------LSNNTTPGKAVVVELILTFQLALCIFSSTD-SRRTSPV 158
Cdd:cd00333  81 PYIIAQLLGAILGAALLYGLYYGLYLEFLGANNivagifgtyPSPGVSNGNAFFVEFIGTFILVLVVFATTDdPNGPPPG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6857757  159 GSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS--PSHWVFWVGPIVGAVLAAILYFYL 224
Cdd:cd00333 161 GLAPLAIGLLVAAIGLAGGPITGASMNPARSLGPALFTGLARhwHYFWVYWVGPLIGAIAGALVYDYV 228
MIP TIGR00861
MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is ...
 16-221 4.40e-66

MIP family channel proteins; 1.A.8 The Major Intrinsic Protein (MIP) FamilyThe MIP family is large and diverse, possessing over 100 members that all form transmembrane channels. These channel proteins function in water, smallcarbohydrate (e.g., glycerol), urea, NH3, CO2 and possibly ion transport by an energy independent mechanism. They are found ubiquitously in bacteria, archaeaand eukaryotes. The MIP family contains two major groups of channels: aquaporins and glycerol facilitators.The known aquaporins cluster loosely together as do the known glycerol facilitators. MIP family proteins are believed to form aqueous pores that selectively allow passive transport of their solute(s) across the membrane with minimal apparent recognition. Aquaporins selectively transport water (but not glycerol) while glycerol facilitators selectively transport glycerol but not water. Some aquaporins can transport NH3 and CO2. Glycerol facilitators function as solute nonspecific channels, and may transport glycerol, dihydroxyacetone, propanediol, urea and other small neutral molecules in physiologically importantprocesses. Some members of the family, including the yeast FPS protein (TC #1.A.8.5.1) and tobacco NtTIPA may transport both water and small solutes. [Transport and binding proteins, Unknown substrate]


Pssm-ID: 273306 [Multi-domain]  Cd Length: 216  Bit Score: 204.84  E-value: 4.40e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     16 AEFLATLIFVFFGLGSAL-------KWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAI 88
Cdd:TIGR00861   1 AEFLGTFLLVFFGVGSALgvnvagaYGAVGGGQFLGVALAFGLAVATLVYCVGGISGAHLNPAVTIALLLGRRFPLKRVP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     89 FYVAAQLVGAIAGAGILYWLAPGNARGNLAVNAL-SNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVG-SPALSIG 166
Cdd:TIGR00861  81 VYIVAQLIGAILGAALLYGLTSGLFPGNLAVNGSaSAGVSSGQAFFVEFIGTAILVLVIFATTDDRNRVPRGgFAPLAIG 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 6857757    167 LSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-PSHWVFWVGPIVGAVLAAILY 221
Cdd:TIGR00861 161 LLVFLIHLSMGPYTGTGMNPARSLGPALFAGLAGwGNHWVYWVGPIIGAILGALVY 216
GlpF COG0580
Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) ...
 10-225 1.10e-56

Glycerol uptake facilitator or related aquaporin (Major Intrinsic protein Family) [Carbohydrate transport and metabolism];


Pssm-ID: 440345 [Multi-domain]  Cd Length: 232  Bit Score: 181.09  E-value: 1.10e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   10 FFKAVFAEFLATLIFVFFGLGSA--LKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRA 87
Cdd:COG0580   2 LMKRLLAEFLGTFILVLLGCGVVavLAGTKGGIGWLGIALAWGLAVLAGVYAFGHISGAHLNPAVTLALAVAGRFPWKDV 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   88 IFYVAAQLVGAIAGAGILYWLAPGNARG---NLAVNAL-----SNNTTPGKAVVVELILTFQLALCIFSSTDSRRTsPVG 159
Cdd:COG0580  82 LPYIIAQLLGAFLGAALVYLIYGGHFDAtedGGAKLGVfatspAIGYSLGAAFLTEIIGTFVLVFVILGITDKRAA-PGG 160

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6857757  160 SPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFS-----PSHWVFWVGPIVGAVLAAILYFYLL 225
Cdd:COG0580 161 LAPLAIGLLVAAIGLSLGPLTGYAINPARDLGPRLFHALGKggsdwGYLWVPIVAPILGAALAALLYRALF 231
PRK05420 PRK05420
aquaporin Z; Provisional
 11-225 9.75e-46

aquaporin Z; Provisional


Pssm-ID: 235453 [Multi-domain]  Cd Length: 231  Bit Score: 153.20  E-value: 9.75e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    11 FKAVFAEFLATLIFVFFGLGSALkWPSALPTI----LQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLR 86
Cdd:PRK05420   2 FKKLAAEFFGTFWLVFGGCGSAV-LAAAFPELgigfLGVALAFGLTVLTMAYAVGHISGGHFNPAVSVGLWAGGRFPAKE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    87 AIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNN----TTPGK-----AVVVELILTFQLALCIFSSTDSRrtSP 157
Cdd:PRK05420  81 LVPYIIAQVVGGIAAAAVLYLIASGKAGFDLAGSGFASNgygeHSPGGysllaALVCEVVLTAFFLLVILGATDKR--AP 158

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6857757   158 VGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSPSH-WVFWVGPIVGAVLAAILYFYLL 225
Cdd:PRK05420 159 AGFAPIAIGLALTLIHLISIPVTNTSVNPARSTGVALFVGGWALEQlWLFWVAPIVGAIIGGLIYRLLL 227
PLN00166 PLN00166
aquaporin TIP2; Provisional
 7-221 3.91e-37

aquaporin TIP2; Provisional


Pssm-ID: 165733  Cd Length: 250  Bit Score: 131.60  E-value: 3.91e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     7 SVAFFKAVFAEFLATLIFVFFGLGSALKWP-----SAL--PTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIG 79
Cdd:PLN00166  14 SVASLKAYLSEFIATLLFVFAGVGSAIAFAkltsdAALdpAGLVAVAVAHAFALFVGVSIAANISGGHLNPAVTLGLAIG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    80 NQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNArgnLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVG 159
Cdd:PLN00166  94 GNITIITGFFYWIAQCLGSIVACLLLVFVTNGES---VPTHGVAAGLGAIEGVVMEIVVTFALVYTVYATAADPKKGSLG 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6857757   160 SPA-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00166 171 TIApIAIGFIVGANILAAGPFSGGSMNPARSFGPAVVSGDFS-QIWIYWVGPLVGGALAGLIY 232
PLN00027 PLN00027
aquaporin TIP; Provisional
 11-221 3.88e-36

aquaporin TIP; Provisional


Pssm-ID: 177664  Cd Length: 252  Bit Score: 128.75  E-value: 3.88e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    11 FKAVFAEFLATLIFVFFGLGSALKW-------PSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQIS 83
Cdd:PLN00027  20 LKAALAEFISTLIFVFAGEGSGMAFnkltdngSTTPAGLVAAALAHAFALFVAVSVGANISGGHVNPAVTFGAFIGGNIT 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    84 LLRAIFYVAAQLVGAIAGAGILYWlapgnARGNLAVNA--LSNNTTPGKAVVVELILTFQLALCIFSSTDSRRTSPVGSP 161
Cdd:PLN00027 100 LLRGILYWIAQLLGSVVACLLLKF-----STGGLETSAfsLSSGVGVWNAFVFEIVMTFGLVYTVYATAVDPKKGDLGII 174

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6857757   162 A-LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00027 175 ApIAIGFIVGANILAGGAFDGASMNPAVSFGPAVVSWTWT-NHWVYWAGPLIGGGIAGLVY 234
PLN00167 PLN00167
aquaporin TIP5; Provisional
 3-227 7.37e-33

aquaporin TIP5; Provisional


Pssm-ID: 215085  Cd Length: 256  Bit Score: 120.39  E-value: 7.37e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     3 KEVCSVAFFKAVFAEFLATLIFVFFGLGSALKWPSALP-------TILQISIAFGLAIGTLAQALGPVSGGHINPAITLA 75
Cdd:PLN00167  14 QQSVTRNALRSYLAEFISTFFFVFAAVGSAMSSRKLMPdaasdpsSLLIVAIANAFALSSAVYIAANISGGHVNPAVTFG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    76 LLIGNQISLLRAIFYVAAQLVGAIAGAGILYWLAPGNargNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDSRRT 155
Cdd:PLN00167  94 MAVGGHISVPTAMFYWISQMLASVMACLFLKVTTVGQ---HVPTYKIAEEMTGFGASVLEGVLTFGLVYTVYAAGDPRRG 170

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6857757   156 SPVGSPALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILYFYLLFP 227
Cdd:PLN00167 171 LLGAIGPLAIGLVAGANVLAAGPFSGGSMNPACAFGSAVVAGSFK-NQAVYWVGPLLGGAVAGLLYDNVVFP 241
PTZ00016 PTZ00016
aquaglyceroporin; Provisional
 16-229 3.32e-25

aquaglyceroporin; Provisional


Pssm-ID: 240230 [Multi-domain]  Cd Length: 294  Bit Score: 100.97  E-value: 3.32e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    16 AEFLATLIFVFFGLG---------SALKWPSalptiLQISIAFGLAIGTLAQAlgPVSGGHINPAITLALLIGNQISLLR 86
Cdd:PTZ00016  55 AEFLGTFVLLFFGEGvvatthtvgNNGDYLA-----ITIGWGLGVTFGLLVSA--GISGGHLNPAVTLGNAVFGKFPWKK 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    87 AIFYVAAQLVGAIAGAGILYWL--------------APGNARGNLAVNALSNNTTPGKAVVVELILTFQLALCIFSSTDS 152
Cdd:PTZ00016 128 LPGYFVAQLLGAFVGAACVYGLyygffkdhgipelpWETMANGFAGVFATYPREGNFYAIFSELILTAILLLVILAITDP 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757   153 RRTSPVGSPALSIGLSVTlghLVGIYF---TGCSMNPARSFGPAVVM------NRFSPSHWVFW---VGPIVGAVLAAIL 220
Cdd:PTZ00016 208 NNCPAFNYLPVAVGLLVF---VIGISFggnTGYALNPARDLGPRLFSailwgsEVFTKDNYYFWvplVAPFVGAVLGMFL 284


                 ....*....
gi 6857757   221 YFYLLFPSS 229
Cdd:PTZ00016 285 YDKFIPPLI 293
PLN00182 PLN00182
putative aquaporin NIP4; Provisional
 1-226 2.10e-24

putative aquaporin NIP4; Provisional


Pssm-ID: 165748  Cd Length: 283  Bit Score: 98.83  E-value: 2.10e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     1 MKKEVCS----VAFFKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITL 74
Cdd:PLN00182  28 IETAICTspsiVCLTQKLIAEMIGTYFIIFSGCGVVVvnVLYGGTITFPGICVTWGLIVMVMIYSTGHISGAHFNPAVTV 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    75 ALLIGNQISLLRAIFYVAAQLVGAIAGAGIL---YWLAPGNARGNLAVNalsnntTPGKAVVVELILTFQLALCIFS-ST 150
Cdd:PLN00182 108 TFAIFRRFPWYQVPLYIGAQLTGSLLASLTLrlmFNVTPEAFFGTTPTD------SSGQALVAEIIISFLLMFVISGvAT 181

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6857757   151 DSRRTSPVGspALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILYFYLLF 226
Cdd:PLN00182 182 DSRAVGELA--GIAVGMTIILNVFVAGPISGASMNPARSLGPAIVMGRYK-GIWVYIVGPFVGIIAGGFVYNLIRF 254
PLN00184 PLN00184
aquaporin NIP1; Provisional
 7-221 1.76e-23

aquaporin NIP1; Provisional


Pssm-ID: 177778  Cd Length: 296  Bit Score: 96.63  E-value: 1.76e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     7 SVAFFKAVFAEFLATLIFVFFGLGSAL--KWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISL 84
Cdd:PLN00184  50 SVPFLQKLIAEVLGTYFLVFTGCASVVvnMQNDNVVTLPGIAIVWGLTIMVLIYSLGHISGAHINPAVTIAFASCGRFPL 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    85 LRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNNTTPG----KAVVVELILTFQLALCIFS-STDSRRTSPVG 159
Cdd:PLN00184 130 KQVPAYVISQVIGSTLAAATLRLLFGLDHDVCSGKHDVFIGSSPVgsdlQAFVMEFIVTFYLMFIISGvATDNRAIGELA 209

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 6857757   160 spALSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00184 210 --GLAIGSTVLLNVLIAAPVSSASMNPGRSLGPAMVYGCYK-GIWIYIVAPTLGAIAGAWVY 268
PLN00026 PLN00026
aquaporin NIP; Provisional
 8-221 2.32e-20

aquaporin NIP; Provisional


Pssm-ID: 177663 [Multi-domain]  Cd Length: 298  Bit Score: 88.00  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757     8 VAFFKAVFAEFLATLIFVFFGLGSAL---KWPSAlPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISL 84
Cdd:PLN00026  68 VSLTRKLGAEFVGTFILIFAATAGPIvnqKYDGA-ETLIGNAACAGLAVMIVILSTGHISGAHLNPSLTIAFAALRHFPW 146

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    85 LRAIFYVAAQLVGAIAGAGILYWLAPGNARGNLAVNALSNnttpGKAVVVELILTFQLALCIFS-STDSRrtsPVGSPA- 162
Cdd:PLN00026 147 KHVPAYIAAQVSASICASFALKGVFHPFMSGGVTVPSVST----GQAFALEFIITFNLLFVVTAvATDTR---AVGELAg 219

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 6857757   163 LSIGLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00026 220 IAVGATVMLNILVAGPSTGGSMNPVRTLGPAVAAGNYR-AIWIYLVAPTLGALAGAGTY 277
PLN00183 PLN00183
putative aquaporin NIP7; Provisional
 12-221 3.86e-19

putative aquaporin NIP7; Provisional


Pssm-ID: 215092  Cd Length: 274  Bit Score: 84.14  E-value: 3.86e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    12 KAVFAEFLATLIFVF--FGLGSALKWPSALPTILQISIAFGLAIGTLAQALGPVSGGHINPAITLALLIGNQISLLRAIF 89
Cdd:PLN00183  46 RMVLAEMVGTFILMFcvCGIIASTQLSGGEVGLLEYAATAGLTVVVVVFSIGSISGAHVNPSVTIAFATFGHFPWSKVPL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6857757    90 YVAAQLVGAIAGAGIlywlapgnARGNLAVNALSNNTTPG----KAVVVELILTFqLALCIFSSTDSRRTSPVGSPALSI 165
Cdd:PLN00183 126 YITAQTVGSVLATYV--------GVSVYGVKADLMTTKPAqgcsSAFWVEFIATF-IVMFLAASLTSQPQSLGHLSGFVI 196

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 6857757   166 GLSVTLGHLVGIYFTGCSMNPARSFGPAVVMNRFSpSHWVFWVGPIVGAVLAAILY 221
Cdd:PLN00183 197 GIAIGLAVLITGPVSGGSMNPARSLGPAIVSWDFK-DIWIYITAPTIGAVAGALMF 251
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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