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Conserved domains on  [gi|6678393|ref|NP_033432|]
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troponin I, cardiac muscle [Mus musculus]

Protein Classification

Troponin-I_N and Troponin domain-containing protein( domain architecture ID 12110577)

Troponin-I_N and Troponin domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 47-178 2.83e-44

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


:

Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 144.24  E-value: 2.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678393     47 KLQLKTLMLQIAKQEMEREAEERRGEKGRVLRTRCQPLELDGLGFEELQDLCRQLHARVDKVDEERYDVEAKVTKNITEI 126
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGLSAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6678393    127 ADLTQKIYDLRGKFKRPTLRRVRISADAMMQALLGTRAKESLDLRAHLKQVK 178
Cdd:pfam00992  81 NDLKKKVNDLRGKFKKPLLKKVRKTADAMLKALLGSKHKVSMDFRANLKQVK 132
Troponin-I_N pfam11636
Troponin I residues 1-32; This family of proteins represents the cardiac N-extension of ...
 1-32 2.52e-16

Troponin I residues 1-32; This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity.


:

Pssm-ID: 463315  Cd Length: 32  Bit Score: 69.51  E-value: 2.52e-16
                          10        20        30
                  ....*....|....*....|....*....|..
gi 6678393      1 MADESSDAAGEPQPAPAPVRRRSSANYRAYAT 32
Cdd:pfam11636   1 MADPSSDAAGEPRPAPAPVRRRSSANYRAYAT 32
 
Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 47-178 2.83e-44

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 144.24  E-value: 2.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678393     47 KLQLKTLMLQIAKQEMEREAEERRGEKGRVLRTRCQPLELDGLGFEELQDLCRQLHARVDKVDEERYDVEAKVTKNITEI 126
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGLSAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6678393    127 ADLTQKIYDLRGKFKRPTLRRVRISADAMMQALLGTRAKESLDLRAHLKQVK 178
Cdd:pfam00992  81 NDLKKKVNDLRGKFKKPLLKKVRKTADAMLKALLGSKHKVSMDFRANLKQVK 132
Troponin-I_N pfam11636
Troponin I residues 1-32; This family of proteins represents the cardiac N-extension of ...
 1-32 2.52e-16

Troponin I residues 1-32; This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity.


Pssm-ID: 463315  Cd Length: 32  Bit Score: 69.51  E-value: 2.52e-16
                          10        20        30
                  ....*....|....*....|....*....|..
gi 6678393      1 MADESSDAAGEPQPAPAPVRRRSSANYRAYAT 32
Cdd:pfam11636   1 MADPSSDAAGEPRPAPAPVRRRSSANYRAYAT 32
 
Name Accession Description Interval E-value
Troponin pfam00992
Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and ...
 47-178 2.83e-44

Troponin; Troponin (Tn) contains three subunits, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). this Pfam contains members of the TnT subunit. Troponin is a complex of three proteins, Ca2+ binding (TnC), inhibitory (TnI), and tropomyosin binding (TnT). The troponin complex regulates Ca++ induced muscle contraction. This family includes troponin T and troponin I. Troponin I binds to actin and troponin T binds to tropomyosin.


Pssm-ID: 460018 [Multi-domain]  Cd Length: 132  Bit Score: 144.24  E-value: 2.83e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6678393     47 KLQLKTLMLQIAKQEMEREAEERRGEKGRVLRTRCQPLELDGLGFEELQDLCRQLHARVDKVDEERYDVEAKVTKNITEI 126
Cdd:pfam00992   1 KRLLKSLLLQKAAEELEFEQEKKEEEKLRYLAERIPPLRLRGLSAEQLQELCEELHERIDKLEEERYDIEEKVAKKDKEI 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6678393    127 ADLTQKIYDLRGKFKRPTLRRVRISADAMMQALLGTRAKESLDLRAHLKQVK 178
Cdd:pfam00992  81 NDLKKKVNDLRGKFKKPLLKKVRKTADAMLKALLGSKHKVSMDFRANLKQVK 132
Troponin-I_N pfam11636
Troponin I residues 1-32; This family of proteins represents the cardiac N-extension of ...
 1-32 2.52e-16

Troponin I residues 1-32; This family of proteins represents the cardiac N-extension of troponin I. This region of the protein (1-32) interacts with the N-lobe of cTnC and modulates myofilament calcium(2) sensitivity.


Pssm-ID: 463315  Cd Length: 32  Bit Score: 69.51  E-value: 2.52e-16
                          10        20        30
                  ....*....|....*....|....*....|..
gi 6678393      1 MADESSDAAGEPQPAPAPVRRRSSANYRAYAT 32
Cdd:pfam11636   1 MADPSSDAAGEPRPAPAPVRRRSSANYRAYAT 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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