hepatocyte nuclear factor 1-alpha [Mus musculus]
HNF-1_N and HNF-1B_C domain-containing protein( domain architecture ID 11153346)
protein containing domains HNF-1_N, homeodomain, HNF-1B_C, and HNF-1A_C
List of domain hits
Name | Accession | Description | Interval | E-value | |||||
HNF-1B_C | pfam04812 | Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ... |
282-538 | 3.62e-103 | |||||
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). : Pssm-ID: 461438 Cd Length: 258 Bit Score: 313.47 E-value: 3.62e-103
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HNF-1_N | pfam04814 | Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ... |
8-168 | 1.82e-66 | |||||
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). : Pssm-ID: 461440 Cd Length: 178 Bit Score: 215.07 E-value: 1.82e-66
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HNF-1A_C | pfam04813 | Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ... |
540-627 | 1.72e-21 | |||||
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). : Pssm-ID: 461439 Cd Length: 85 Bit Score: 89.06 E-value: 1.72e-21
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
200-273 | 2.64e-08 | |||||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. : Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 50.70 E-value: 2.64e-08
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Name | Accession | Description | Interval | E-value | |||||
HNF-1B_C | pfam04812 | Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ... |
282-538 | 3.62e-103 | |||||
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). Pssm-ID: 461438 Cd Length: 258 Bit Score: 313.47 E-value: 3.62e-103
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HNF-1_N | pfam04814 | Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ... |
8-168 | 1.82e-66 | |||||
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). Pssm-ID: 461440 Cd Length: 178 Bit Score: 215.07 E-value: 1.82e-66
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HNF-1A_C | pfam04813 | Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ... |
540-627 | 1.72e-21 | |||||
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). Pssm-ID: 461439 Cd Length: 85 Bit Score: 89.06 E-value: 1.72e-21
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
200-273 | 2.64e-08 | |||||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 50.70 E-value: 2.64e-08
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
199-273 | 2.55e-07 | |||||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 47.63 E-value: 2.55e-07
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Homeodomain | pfam00046 | Homeodomain; |
200-272 | 1.69e-04 | |||||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 39.79 E-value: 1.69e-04
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Name | Accession | Description | Interval | E-value | |||||
HNF-1B_C | pfam04812 | Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region ... |
282-538 | 3.62e-103 | |||||
Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus; This family consists of a region found within the alpha isoform and at the C terminus of the beta isoform of the homeobox-containing transcription factor of HNF-1. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). Pssm-ID: 461438 Cd Length: 258 Bit Score: 313.47 E-value: 3.62e-103
|
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HNF-1_N | pfam04814 | Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of ... |
8-168 | 1.82e-66 | |||||
Hepatocyte nuclear factor 1 (HNF-1), N terminus; This family consists of the N terminus of homeobox-containing transcription factor HNF-1. This region contains a dimerization sequence and an acidic region that may be involved in transcription activation. Mutations and the common Ala/Val 98 polymorphism in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). Pssm-ID: 461440 Cd Length: 178 Bit Score: 215.07 E-value: 1.82e-66
|
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HNF-1A_C | pfam04813 | Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an ... |
540-627 | 1.72e-21 | |||||
Hepatocyte nuclear factor 1 (HNF-1), alpha isoform C terminus; This family consists of an alternative C terminus of homeobox-containing transcription factor HNF-1, found in the HNF-1A isoform. Different isoforms of HNF-1 are generated by the differential use of polyadenylation sites and by alternative splicing. The C-terminal region of HNF-1 is responsible for the activation of transcription, and HNF-1A, which has this C-terminal extension, transactivates less well than the B and C isoforms. Mutations and polymorphisms in HNF-1 cause the type 3 form of maturity-onset diabetes of the young (MODY3). Pssm-ID: 461439 Cd Length: 85 Bit Score: 89.06 E-value: 1.72e-21
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homeodomain | cd00086 | Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ... |
200-273 | 2.64e-08 | |||||
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. Pssm-ID: 238039 [Multi-domain] Cd Length: 59 Bit Score: 50.70 E-value: 2.64e-08
|
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HOX | smart00389 | Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ... |
199-273 | 2.55e-07 | |||||
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes Pssm-ID: 197696 [Multi-domain] Cd Length: 57 Bit Score: 47.63 E-value: 2.55e-07
|
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Homeodomain | pfam00046 | Homeodomain; |
200-272 | 1.69e-04 | |||||
Homeodomain; Pssm-ID: 459649 [Multi-domain] Cd Length: 57 Bit Score: 39.79 E-value: 1.69e-04
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Blast search parameters | ||||
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