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Conserved domains on  [gi|33667036|ref|NP_032845|]
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phosphatidylethanolamine N-methyltransferase isoform b [Mus musculus]

Protein Classification

PEMT/PEM2 family methyltransferase( domain architecture ID 10514660)

PEMT/PEM2 family methyltransferase is involved in the methylation pathway of phosphatidylcholine biosynthesis, such as phosphatidylethanolamine N-methyltransferase (PEMT) that catalyzes the first step of the pathway, the SAM-dependent methylation of\n phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME)

EC:  2.1.1.-
Gene Ontology:  GO:0008757|GO:0032259|GO:0006656|GO:1904047
PubMed:  2445736

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
 89-191 6.13e-39

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


:

Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 129.22  E-value: 6.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667036    89 TYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVL 168
Cdd:pfam04191   2 RLILGLLLIALGLWLVLSSYRALGIFGTFYGDFFGILMDKLVTGGPYRYLNNPMYVGGTLGFLGLALITGSPAGLLLALL 81

                          90       100
                  ....*....|....*....|....
gi 33667036   169 VAIVYVVALLY-EEPFTAEIYRQK 191
Cdd:pfam04191  82 VLLVYFIALKFvEEPHMAKIYGKR 105
 
Name Accession Description Interval E-value
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
 89-191 6.13e-39

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 129.22  E-value: 6.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667036    89 TYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVL 168
Cdd:pfam04191   2 RLILGLLLIALGLWLVLSSYRALGIFGTFYGDFFGILMDKLVTGGPYRYLNNPMYVGGTLGFLGLALITGSPAGLLLALL 81

                          90       100
                  ....*....|....*....|....
gi 33667036   169 VAIVYVVALLY-EEPFTAEIYRQK 191
Cdd:pfam04191  82 VLLVYFIALKFvEEPHMAKIYGKR 105
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 93-188 8.89e-10

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 54.01  E-value: 8.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667036  93 GLAFLGWGFVFVLSSFYALGFTGTFLGDyfgILKESR-VTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVAI 171
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLVP---PRKAHRlVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLL 78

                        90
                ....*....|....*..
gi 33667036 172 VYVVALLYEEPFTAEIY 188
Cdd:COG2020  79 LYVLRIRREERRLRARF 95
 
Name Accession Description Interval E-value
PEMT pfam04191
Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) ...
 89-191 6.13e-39

Phospholipid methyltransferase; The S. cerevisiae phospholipid methyltransferase (EC:2.1.1.16) has a broad substrate specificity of unsaturated phospholipids.


Pssm-ID: 461218 [Multi-domain]  Cd Length: 105  Bit Score: 129.22  E-value: 6.13e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667036    89 TYFLGLAFLGWGFVFVLSSFYALGFTGTFLGDYFGILKESRVTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVL 168
Cdd:pfam04191   2 RLILGLLLIALGLWLVLSSYRALGIFGTFYGDFFGILMDKLVTGGPYRYLNNPMYVGGTLGFLGLALITGSPAGLLLALL 81

                          90       100
                  ....*....|....*....|....
gi 33667036   169 VAIVYVVALLY-EEPFTAEIYRQK 191
Cdd:pfam04191  82 VLLVYFIALKFvEEPHMAKIYGKR 105
STE14 COG2020
Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein ...
 93-188 8.89e-10

Protein-S-isoprenylcysteine O-methyltransferase Ste14 [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 441623 [Multi-domain]  Cd Length: 113  Bit Score: 54.01  E-value: 8.89e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 33667036  93 GLAFLGWGFVFVLSSFYALGFTGTFLGDyfgILKESR-VTTFPFSVLDNPMYWGSTANYLGWALMHASPTGLLLTVLVAI 171
Cdd:COG2020   2 GLVLILLGLLLRLWAVLTLGRSWTTLVP---PRKAHRlVTTGPYRYVRHPMYLGFLLLLLGLALLLGSLLALLLALLLLL 78

                        90
                ....*....|....*..
gi 33667036 172 VYVVALLYEEPFTAEIY 188
Cdd:COG2020  79 LYVLRIRREERRLRARF 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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