NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|6679166|ref|NP_032786|]
View 

mimecan precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-250 2.23e-13

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 2.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  123 YLYARFNKIKKLTAkDFADMPNLRRLDFTGNLIEDIEDgTFSKLSLLEELTLAENQLLRLPV-LP--PKLTLLNAKHNKI 199
Cdd:COG4886 163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEpLAnlTNLETLDLSNNQL 240

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6679166  200 KSkgikANTFKKLNKLSFLYLDHNDLESVPPNLP-ESLRVIHLQFNSISSLT 250
Cdd:COG4886 241 TD----LPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK 288
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-250 2.23e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 2.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  123 YLYARFNKIKKLTAkDFADMPNLRRLDFTGNLIEDIEDgTFSKLSLLEELTLAENQLLRLPV-LP--PKLTLLNAKHNKI 199
Cdd:COG4886 163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEpLAnlTNLETLDLSNNQL 240

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6679166  200 KSkgikANTFKKLNKLSFLYLDHNDLESVPPNLP-ESLRVIHLQFNSISSLT 250
Cdd:COG4886 241 TD----LPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK 288
LRR_8 pfam13855
Leucine rich repeat;
143-225 4.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 4.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166    143 PNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLlrlpvlppkltllnakhnkiksKGIKANTFKKLNKLSFLYLDH 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSG 58


                  ...
gi 6679166    223 NDL 225
Cdd:pfam13855  59 NRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-251 1.53e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166    90 EMPTCLLCVCLSGSVYCEEvdIDAVPP-LPKESAYLYARFNKIKKLTAKdfadMPN-LRRLDFTGNLIediedgTFSKLS 167
Cdd:PRK15370 255 ELPERLPSALQSLDLFHNK--ISCLPEnLPEELRYLSVYDNSIRTLPAH----LPSgITHLNVQSNSL------TALPET 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166   168 L---LEELTLAENQLLRLPV-LPPKLTLLNAKHNKIKskgIKANTFKKlnKLSFLYLDHNDLESVPPNLPESLRVIHLQF 243
Cdd:PRK15370 323 LppgLKTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASR 397


                 ....*...
gi 6679166   244 NSISSLTD 251
Cdd:PRK15370 398 NNLVRLPE 405
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-275 4.70e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 4.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  143 PNLRRLDFTGNLIED--IED--GTFSKLSLLEELTLAENQLLR------LPVLP--PKLTLLNAKHNKIKSKGIK--ANT 208
Cdd:cd00116 137 PALEKLVLGRNRLEGasCEAlaKALRANRDLKELNLANNGIGDagiralAEGLKanCNLEVLDLNNNGLTDEGASalAET 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6679166  209 FKKLNKLSFLYLDHNDLESVP--------PNLPESLRVIHLQFNSISSLTDDTFCkandtRYIRE--RIEEIRLEGN 275
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCNDITDDGAKDLA-----EVLAEkeSLLELDLRGN 288
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-250 2.23e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 69.96  E-value: 2.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  123 YLYARFNKIKKLTAkDFADMPNLRRLDFTGNLIEDIEDgTFSKLSLLEELTLAENQLLRLPV-LP--PKLTLLNAKHNKI 199
Cdd:COG4886 163 SLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTDLPEpLAnlTNLETLDLSNNQL 240

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6679166  200 KSkgikANTFKKLNKLSFLYLDHNDLESVPPNLP-ESLRVIHLQFNSISSLT 250
Cdd:COG4886 241 TD----LPELGNLTNLEELDLSNNQLTDLPPLANlTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-249 8.90e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 8.90e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  123 YLYARFNKIKKLtAKDFADMPNLRRLDFTGNLIEDIEDgTFSKLSLLEELTLAENQLLRLPVLP---PKLTLLNAKHNKI 199
Cdd:COG4886 117 SLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPEELgnlTNLKELDLSNNQI 194

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6679166  200 KSKGikaNTFKKLNKLSFLYLDHNDLESVPPNLPE--SLRVIHLQFNSISSL 249
Cdd:COG4886 195 TDLP---EPLGNLTNLEELDLSGNQLTDLPEPLANltNLETLDLSNNQLTDL 243
LRR_8 pfam13855
Leucine rich repeat;
143-225 4.36e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 4.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166    143 PNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLlrlpvlppkltllnakhnkiksKGIKANTFKKLNKLSFLYLDH 222
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL----------------------TTLSPGAFSGLPSLRYLDLSG 58


                  ...
gi 6679166    223 NDL 225
Cdd:pfam13855  59 NRL 61
LRR_8 pfam13855
Leucine rich repeat;
123-179 1.00e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.00e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 6679166    123 YLYARFNKIKKLTAKDFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQL 179
Cdd:pfam13855   5 SLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-251 1.53e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 52.39  E-value: 1.53e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166    90 EMPTCLLCVCLSGSVYCEEvdIDAVPP-LPKESAYLYARFNKIKKLTAKdfadMPN-LRRLDFTGNLIediedgTFSKLS 167
Cdd:PRK15370 255 ELPERLPSALQSLDLFHNK--ISCLPEnLPEELRYLSVYDNSIRTLPAH----LPSgITHLNVQSNSL------TALPET 322

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166   168 L---LEELTLAENQLLRLPV-LPPKLTLLNAKHNKIKskgIKANTFKKlnKLSFLYLDHNDLESVPPNLPESLRVIHLQF 243
Cdd:PRK15370 323 LppgLKTLEAGENALTSLPAsLPPELQVLDVSKNQIT---VLPETLPP--TITTLDVSRNALTNLPENLPAALQIMQASR 397


                 ....*...
gi 6679166   244 NSISSLTD 251
Cdd:PRK15370 398 NNLVRLPE 405
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 143-275 4.70e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 4.70e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  143 PNLRRLDFTGNLIED--IED--GTFSKLSLLEELTLAENQLLR------LPVLP--PKLTLLNAKHNKIKSKGIK--ANT 208
Cdd:cd00116 137 PALEKLVLGRNRLEGasCEAlaKALRANRDLKELNLANNGIGDagiralAEGLKanCNLEVLDLNNNGLTDEGASalAET 216

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6679166  209 FKKLNKLSFLYLDHNDLESVP--------PNLPESLRVIHLQFNSISSLTDDTFCkandtRYIRE--RIEEIRLEGN 275
Cdd:cd00116 217 LASLKSLEVLNLGDNNLTDAGaaalasalLSPNISLLTLSLSCNDITDDGAKDLA-----EVLAEkeSLLELDLRGN 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
129-251 1.53e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.00  E-value: 1.53e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  129 NKIKKLTAKDFADMPNLRRLDFTGNLiediedgTFSKLSLLEELTLAENQLLRLPvlppkltllnakhnkikskgikaNT 208
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLP-----------------------EE 131

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6679166  209 FKKLNKLSFLYLDHNDLESVPPNLPE--SLRVIHLQFNSISSLTD 251
Cdd:COG4886 132 LANLTNLKELDLSNNQLTDLPEPLGNltNLKSLDLSNNQLTDLPE 176
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
169-249 1.70e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 43.15  E-value: 1.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166   169 LEELTLAENQLLRLP-VLPPKLTLLNAKHNKIkskgikANTFKKL-NKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSI 246
Cdd:PRK15370 222 IKTLYANSNQLTSIPaTLPDTIQEMELSINRI------TELPERLpSALQSLDLFHNKISCLPENLPEELRYLSVYDNSI 295


                 ...
gi 6679166   247 SSL 249
Cdd:PRK15370 296 RTL 298
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
123-254 2.76e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 2.76e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166  123 YLYARFNKIKKLtaKDFADMPNLRRLDFTGNLIEDIEDgtFSKLSLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSK 202
Cdd:COG4886 232 TLDLSNNQLTDL--PELGNLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLL 307

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 6679166  203 GIKANTFKKLNKLSFLYLDHNDLESVPPNLPESLRVIHLQFNSISSLTDDTF 254
Cdd:COG4886 308 LNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLL 359
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
167-278 3.86e-04

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 42.07  E-value: 3.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166   167 SLLEELTLAENQLLRLPVLPPKLTLLNAKHNKIKSKGIKANTFKKL--------------NKLSFLYLDHNDLESVpPNL 232
Cdd:PRK15387 342 SGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELivsgnrltslpvlpSELKELMVSGNRLTSL-PML 420

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 6679166   233 PESLRVIHLQFNSISSLTDDTFCKANDTryirerieEIRLEGNPIA 278
Cdd:PRK15387 421 PSGLLSLSVYRNQLTRLPESLIHLSSET--------TVNLEGNPLS 458
LRR_8 pfam13855
Leucine rich repeat;
187-246 2.67e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.67e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6679166    187 PKLTLLNAKHNKIKSkgIKANTFKKLNKLSFLYLDHNDLESVPPN----LPeSLRVIHLQFNSI 246
Cdd:pfam13855   1 PNLRSLDLSNNRLTS--LDDGAFKGLSNLKVLDLSNNLLTTLSPGafsgLP-SLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 137-195 3.54e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.84  E-value: 3.54e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6679166  137 KDFADMPNLRRLDFTGNLIEDIED--GTFSKLSLLEELTLAENQLLRLP-------VLPPKLTLLNAK 195
Cdd:cd21340 136 EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPkyrdkiiLASKSLEVLDGK 203
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 138-244 4.45e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 38.68  E-value: 4.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679166   138 DFADMPNLRRLDFTGNLIEDIEDGTFSKLSLLEELTLAENQLlrLPVLP------PKLTLLNAKHNKIksKGIKANTFKK 211
Cdd:PLN00113 470 DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKL--SGEIPdelsscKKLVSLDLSHNQL--SGQIPASFSE 545

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 6679166   212 LNKLSFLYLDHNDLE-SVPPNLP--ESLRVIHLQFN 244
Cdd:PLN00113 546 MPVLSQLDLSQNQLSgEIPKNLGnvESLVQVNISHN 581
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH