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Conserved domains on  [gi|224967065|ref|NP_032740|]
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neurogenic locus notch homolog protein 1 precursor [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1710-1789 6.71e-47

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


:

Pssm-ID: 411985  Cd Length: 80  Bit Score: 163.04  E-value: 6.71e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1710 AVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN 1789
Cdd:cd21702     1 AVKSETVEPPPPSQLYPMYVVLAALVLLAFVGVGVLVSRKRRREHGQLWFPEGFKVSEPSKKKRREPVGEDSVGLKPLKN 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1894-2108 2.85e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 2.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1894 EDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRN 1973
Cdd:COG0666    63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1974 RAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEET 2053
Cdd:COG0666   143 GA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2054 PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNL 2108
Cdd:COG0666   222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1566-1621 6.29e-29

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


:

Pssm-ID: 462014  Cd Length: 56  Bit Score: 110.68  E-value: 6.29e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 224967065  1566 PERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYG 1621
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1661-1719 2.34e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


:

Pssm-ID: 462229  Cd Length: 59  Bit Score: 97.73  E-value: 2.34e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224967065  1661 IRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPP 1719
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1487-1522 1.88e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 54.84  E-value: 1.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224967065  1487 WKNCTQSlQCWKYFSDGHCDSQCNSAGCLFDGFDCQ 1522
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
869-905 2.16e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 2.16e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  869 DINECV-KSPCRHGASCQNTNGSYRCLCQAGYTGRNCE 905
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1442-1479 2.36e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


:

Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.36e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 224967065   1442 PPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDC 1479
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
412-450 7.96e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224967065  412 DVDECALGaNPCEHAGKCLNTLGSFECQCLQGYTGPRCE 450
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1525-1561 1.02e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


:

Pssm-ID: 459658  Cd Length: 35  Bit Score: 49.83  E-value: 1.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 224967065  1525 EGQCNPlydQYCKDHFSDGHCDQGCNSAECEWDGLDC 1561
Cdd:pfam00066    1 WPNCPY---PYCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
528-564 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  528 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYTGTHCE 564
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1021-1057 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065 1021 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYTGLNCQ 1057
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
295-332 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.47e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  295 DVDECQlMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
945-981 2.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  945 DINECAS-NPCQNGANCTDCVDSYTCTCPVGFNGIHCE 981
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
2183-2492 2.67e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2183 SSSMLSPVDSLESPHgyLSDVASPPLLPSPFQ-QSPSMPLS--------HLPGMPDTHlgiSHLNVAAKPemaalaggsr 2253
Cdd:pfam03154  191 TTQAATAGPTPSAPS--VPPQGSPATSQPPNQtQSTAAPHTliqqtptlHPQRLPSPH---PPLQPMTQP---------- 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2254 lafePPPPRLSHLPVAssastvlstngtgamnftvgaPASLNGQCEWLPR-LQNGM------VPSQYNPLRP----GVTP 2322
Cdd:pfam03154  256 ----PPPSQVSPQPLP---------------------QPSLHGQMPPMPHsLQTGPshmqhpVPPQPFPLTPqssqSQVP 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2323 GTLSTQAAGLQHSMMGPLHSSLSTNTLSPIIYQGLPNTRLAtQPHLvqtQQVQPQNLQLQPQNLQPPSQPHLSVSSAAng 2402
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLS-MPHI---KPPPTTPIPQLPNPQSHKHPPHLSGPSPF-- 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2403 hlgrSFLSGEPSQADVQPLgpSSLPVH----------TILPQeSQALPTslPSSMVPPMTTTQFLTPPSQHSYSSSPVDN 2472
Cdd:pfam03154  385 ----QMNSNLPPPPALKPL--SSLSTHhppsahppplQLMPQ-SQQLPP--PPAQPPVLTQSQSLPPPAASHPPTSGLHQ 455
                          330       340
                   ....*....|....*....|
gi 224967065  2473 TPShQLQVPEHPFLTPSPES 2492
Cdd:pfam03154  456 VPS-QSPFPQHPFVPGGPPP 474
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1184-1219 4.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065 1184 INECLSQ-PCQNGGTCIDLTNSYKCSCPRGTQGVHCE 1219
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1146-1180 6.05e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065 1146 VDEC-SPNPCQNGATCTDYLGGFSCKCVAGYHGSNC 1180
Cdd:cd00054     2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
791-827 6.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.48e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  791 NINECAS-NPCLNQGTCIDDVAGYKCNCPLPYTGATCE 827
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
678-713 8.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  678 NIDECA-GSPCHNGGTCEDGIAGFTCRCPEGYHDPTC 713
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
178-216 8.95e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224967065  178 DVNECSQNpGLCRHGGTCHNEIGSYRCACRATHTGPHCE 216
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
452-488 1.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  452 DVNEC-ISNPCQNDATCLDQIGEFQCICMPGYEGVYCE 488
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1221-1265 5.77e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 224967065 1221 NVDDChppldpASRSPkCFNNGTCVDQVGGYTCTCPPGFVGERCE 1265
Cdd:cd00054     1 DIDEC------ASGNP-CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
907-943 9.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 9.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  907 DIDDCR-PNPCHNGGSCTDGINTAFCDCLPGFQGAFCE 943
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
755-789 1.06e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065  755 NECES-NPCVNGGTCKDMTSGYVCTCREGFSGPNCQ 789
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
988-1019 1.23e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.23e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 224967065  988 TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ 1019
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
603-639 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  603 NINECHSQ-PCRHGGTCQDRDNSYLCLCLKGTTGPNCE 639
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
142-175 3.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224967065  142 DPCAS-NPCANGGQCLPFESSYICRCPPGFHGPTC 175
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1267-1305 4.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224967065 1267 DVNECLS-NPCDPRGTqnCVQRVNDFHCECRAGHTGRRCE 1305
Cdd:cd00054     1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
566-601 4.90e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  566 DIDECD-PDPCHY-GSCKDGVATFTCLCQPGYTGHHCE 601
Cdd:cd00054     1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
257-293 5.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  257 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 293
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
490-526 2.93e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  490 NTDECAS-SPCLHNGHCMDKINEFQCQCPKGFNGHLCQ 526
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
717-750 4.17e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065  717 VNECNS-NPCIHGA-CRDGLNGYKCDCAPGWSGTNC 750
Cdd:cd00054     2 IDECASgNPCQNGGtCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
335-370 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  335 NIDDCASAA-CFQGATCHDRVASFYCECPHGRTGLLC 370
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
641-675 5.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  641 NLDDCAS-NPCD-SGTCLDKIDGYECACEPGYTGSMC 675
Cdd:cd00054     1 DIDECASgNPCQnGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1067-1094 6.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.44e-03
                          10        20
                  ....*....|....*....|....*...
gi 224967065 1067 PCKNGGRCWQTNTQYHCECRSGWTGVNC 1094
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1710-1789 6.71e-47

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 163.04  E-value: 6.71e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1710 AVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN 1789
Cdd:cd21702     1 AVKSETVEPPPPSQLYPMYVVLAALVLLAFVGVGVLVSRKRRREHGQLWFPEGFKVSEPSKKKRREPVGEDSVGLKPLKN 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1894-2108 2.85e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 2.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1894 EDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRN 1973
Cdd:COG0666    63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1974 RAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEET 2053
Cdd:COG0666   143 GA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2054 PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNL 2108
Cdd:COG0666   222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1566-1621 6.29e-29

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 110.68  E-value: 6.29e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 224967065  1566 PERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYG 1621
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1661-1719 2.34e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 97.73  E-value: 2.34e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224967065  1661 IRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPP 1719
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1922-2015 8.39e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 8.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  1922 LHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDarmHDGTTPLILAARLAVEGML 2001
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77
                           90
                   ....*....|....
gi 224967065  2002 EDLINSHADVNAVD 2015
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1907-2079 2.35e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1907 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATdLDARMHDGT 1986
Cdd:PHA02878  157 GADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS-TDARDKCGN 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1987 TPL-ILAARLAVEGMLEDLINSHADVNAVDD-LGKSALHwaAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGS- 2063
Cdd:PHA02878  236 TPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLc 313
                         170       180
                  ....*....|....*....|.
gi 224967065 2064 YETAKVLLDH-----FANRDI 2079
Cdd:PHA02878  314 INIGRILISNicllkRIKPDI 334
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1487-1522 1.88e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 54.84  E-value: 1.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224967065  1487 WKNCTQSlQCWKYFSDGHCDSQCNSAGCLFDGFDCQ 1522
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1918-2062 5.44e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 61.57  E-value: 5.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1918 GETALHLAARYSRSDAAKRLLEASADAnIQDNM------GRTPLHAAVSADAQGVFQILLRNRATDLDAR---------- 1981
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAAPEL-VNEPMtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgp 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1982 ---MHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVV----LLKNGANKD------MQN 2048
Cdd:cd22192   130 knlIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDlqpldlVPN 209
                         170
                  ....*....|....
gi 224967065 2049 NKEETPLFLAAREG 2062
Cdd:cd22192   210 NQGLTPFKLAAKEG 223
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
869-905 2.16e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 2.16e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  869 DINECV-KSPCRHGASCQNTNGSYRCLCQAGYTGRNCE 905
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1442-1479 2.36e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.36e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 224967065   1442 PPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDC 1479
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1485-1521 4.59e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.17  E-value: 4.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 224967065   1485 DPWKNCtQSLQCWKYFSDGHCDSQCNSAGCLFDGFDC 1521
Cdd:smart00004    3 DPWSRC-EDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
869-905 6.64e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 6.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    869 DINECV-KSPCRHGASCQNTNGSYRCLCQAGYT-GRNCE 905
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
412-450 7.96e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224967065  412 DVDECALGaNPCEHAGKCLNTLGSFECQCLQGYTGPRCE 450
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1525-1561 1.02e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 49.83  E-value: 1.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 224967065  1525 EGQCNPlydQYCKDHFSDGHCDQGCNSAECEWDGLDC 1561
Cdd:pfam00066    1 WPNCPY---PYCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
528-564 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  528 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYTGTHCE 564
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1021-1057 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065 1021 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYTGLNCQ 1057
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
295-332 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.47e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  295 DVDECQlMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1446-1480 2.39e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 48.68  E-value: 2.39e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 224967065  1446 EEACELPECQVDAGNKVCNLQCNNHACGWDGGDCS 1480
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
945-981 2.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  945 DINECAS-NPCQNGANCTDCVDSYTCTCPVGFNGIHCE 981
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
2183-2492 2.67e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2183 SSSMLSPVDSLESPHgyLSDVASPPLLPSPFQ-QSPSMPLS--------HLPGMPDTHlgiSHLNVAAKPemaalaggsr 2253
Cdd:pfam03154  191 TTQAATAGPTPSAPS--VPPQGSPATSQPPNQtQSTAAPHTliqqtptlHPQRLPSPH---PPLQPMTQP---------- 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2254 lafePPPPRLSHLPVAssastvlstngtgamnftvgaPASLNGQCEWLPR-LQNGM------VPSQYNPLRP----GVTP 2322
Cdd:pfam03154  256 ----PPPSQVSPQPLP---------------------QPSLHGQMPPMPHsLQTGPshmqhpVPPQPFPLTPqssqSQVP 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2323 GTLSTQAAGLQHSMMGPLHSSLSTNTLSPIIYQGLPNTRLAtQPHLvqtQQVQPQNLQLQPQNLQPPSQPHLSVSSAAng 2402
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLS-MPHI---KPPPTTPIPQLPNPQSHKHPPHLSGPSPF-- 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2403 hlgrSFLSGEPSQADVQPLgpSSLPVH----------TILPQeSQALPTslPSSMVPPMTTTQFLTPPSQHSYSSSPVDN 2472
Cdd:pfam03154  385 ----QMNSNLPPPPALKPL--SSLSTHhppsahppplQLMPQ-SQQLPP--PPAQPPVLTQSQSLPPPAASHPPTSGLHQ 455
                          330       340
                   ....*....|....*....|
gi 224967065  2473 TPShQLQVPEHPFLTPSPES 2492
Cdd:pfam03154  456 VPS-QSPFPQHPFVPGGPPP 474
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1533-1561 3.52e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.52e-07
                            10        20
                    ....*....|....*....|....*....
gi 224967065   1533 DQYCKDHFSDGHCDQGCNSAECEWDGLDC 1561
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1184-1219 4.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065 1184 INECLSQ-PCQNGGTCIDLTNSYKCSCPRGTQGVHCE 1219
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
412-450 5.46e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 5.46e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224967065    412 DVDECALGaNPCEHAGKCLNTLGSFECQCLQGYT-GPRCE 450
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1146-1180 6.05e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065 1146 VDEC-SPNPCQNGATCTDYLGGFSCKCVAGYHGSNC 1180
Cdd:cd00054     2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
791-827 6.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.48e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  791 NINECAS-NPCLNQGTCIDDVAGYKCNCPLPYTGATCE 827
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
678-713 8.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  678 NIDECA-GSPCHNGGTCEDGIAGFTCRCPEGYHDPTC 713
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
945-981 8.57e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.57e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    945 DINECAS-NPCQNGANCTDCVDSYTCTCPVGF-NGIHCE 981
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
178-216 8.95e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224967065  178 DVNECSQNpGLCRHGGTCHNEIGSYRCACRATHTGPHCE 216
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
412-443 1.22e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 1.22e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224967065   412 DVDECALGANPCEHAGKCLNTLGSFECQCLQG 443
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
452-488 1.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  452 DVNEC-ISNPCQNDATCLDQIGEFQCICMPGYEGVYCE 488
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
295-332 2.65e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.65e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    295 DVDECQlMPNACQNGGTCHNTHGGYNCVCVNGWT-GEDC 332
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
678-710 3.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.25e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 224967065    678 NIDECA-GSPCHNGGTCEDGIAGFTCRCPEGYHD 710
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-564 3.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.41e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    528 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYT-GTHCE 564
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1021-1057 3.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.69e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065   1021 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYT-GLNCQ 1057
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1183-1219 3.84e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.84e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065   1183 EINECLS-QPCQNGGTCIDLTNSYKCSCPRG-TQGVHCE 1219
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1221-1265 5.77e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 224967065 1221 NVDDChppldpASRSPkCFNNGTCVDQVGGYTCTCPPGFVGERCE 1265
Cdd:cd00054     1 DIDEC------ASGNP-CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1180 7.78e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.78e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 224967065   1145 EVDEC-SPNPCQNGATCTDYLGGFSCKCVAGYH-GSNC 1180
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
907-943 9.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 9.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  907 DIDDCR-PNPCHNGGSCTDGINTAFCDCLPGFQGAFCE 943
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
178-216 9.38e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 9.38e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224967065    178 DVNECSQnPGLCRHGGTCHNEIGSYRCACRA-THTGPHCE 216
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPgYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
755-789 1.06e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065  755 NECES-NPCVNGGTCKDMTSGYVCTCREGFSGPNCQ 789
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
988-1019 1.23e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.23e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 224967065  988 TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ 1019
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
603-639 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  603 NINECHSQ-PCRHGGTCQDRDNSYLCLCLKGTTGPNCE 639
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
452-488 1.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    452 DVNECIS-NPCQNDATCLDQIGEFQCICMPGYE-GVYCE 488
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
2111-2493 2.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2111 SPQLHGTALGGTPTLSPtlcSPNGYLGNLKSATQGKKARKPSTKGLACGSkEAKDLKARRKKSQDGKGCLLDSSSMLSPV 2190
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTV---PPPERPRDDPAPGRVSRPRRARRLGRAAQA-SSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2191 DSLES-PHGYLSDVASPPLLPSPFQQSPSMPLSHLP----GMPDTHLGISHLNVAAKPEMAALAGGSRLAFEPPPPRLSH 2265
Cdd:PHA03247 2706 PTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPpavpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2266 LPVASSAStvlSTNGTGAMNFTVGAPASLNGQCEWLPRLQNgmvPSqynplrPGVTPGTLSTQAAGLQHSmmGPLHSSLS 2345
Cdd:PHA03247 2786 PAVASLSE---SRESLPSPWDPADPPAAVLAPAAALPPAAS---PA------GPLPPPTSAQPTAPPPPP--GPPPPSLP 2851
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2346 T-NTLSPiiyqGLPNTRLATqphlvqtqqvqpqnlqLQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLGPS 2424
Cdd:PHA03247 2852 LgGSVAP----GGDVRRRPP----------------SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP 2911
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2425 SLPVHTILPQESQALPTSLPSSMVPPMTTTQfLTPPSQHSYSSSPVDNTPSHQL------QVPEHPFLTPSPESP 2493
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP-LAPTTDPAGAGEPSGAVPQPWLgalvpgRVAVPRFRVPQPAPS 2985
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
142-175 3.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224967065  142 DPCAS-NPCANGGQCLPFESSYICRCPPGFHGPTC 175
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
791-827 3.97e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.97e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    791 NINECAS-NPCLNQGTCIDDVAGYKCNCPLPYT-GATCE 827
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1267-1305 4.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224967065 1267 DVNECLS-NPCDPRGTqnCVQRVNDFHCECRAGHTGRRCE 1305
Cdd:cd00054     1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
566-601 4.90e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  566 DIDECD-PDPCHY-GSCKDGVATFTCLCQPGYTGHHCE 601
Cdd:cd00054     1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
257-293 5.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  257 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 293
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-639 6.24e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 6.24e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    603 NINECHS-QPCRHGGTCQDRDNSYLCLCLKG-TTGPNCE 639
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1025-1055 6.87e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 6.87e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065  1025 CDSRPCLHGGTCQDSYGTYKCTCPQGYTGLN 1055
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
295-326 7.81e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.84  E-value: 7.81e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224967065   295 DVDECQLMPNACQNGGTCHNTHGGYNCVCVNG 326
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
532-560 1.35e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....*....
gi 224967065   532 CASTPCKNGAKCLDGPNTYTCVCTEGYTG 560
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1149-1179 1.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 1.68e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065  1149 CSPNPCQNGATCTDYLGGFSCKCVAGYHGSN 1179
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-943 2.81e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.81e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    907 DIDDC-RPNPCHNGGSCTDGINTAFCDCLPGFQ-GAFCE 943
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
490-526 2.93e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  490 NTDECAS-SPCLHNGHCMDKINEFQCQCPKGFNGHLCQ 526
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1221-1265 3.28e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.28e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 224967065   1221 NVDDChppldpASRSPkCFNNGTCVDQVGGYTCTCPPGFV-GERCE 1265
Cdd:smart00179    1 DIDEC------ASGNP-CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
755-789 3.59e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.59e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 224967065    755 NECES-NPCVNGGTCKDMTSGYVCTCREGFS-GPNCQ 789
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
144-174 4.14e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.14e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   144 CASNPCANGGQCLPFESSYICRCPPGFHGPT 174
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
717-750 4.17e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065  717 VNECNS-NPCIHGA-CRDGLNGYKCDCAPGWSGTNC 750
Cdd:cd00054     2 IDECASgNPCQNGGtCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
992-1019 5.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.26e-04
                            10        20
                    ....*....|....*....|....*....
gi 224967065    992 CFNGGTCVDGINSFTCLCPPGFT-GSYCQ 1019
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
795-825 5.40e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.40e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   795 CASNPCLNQGTCIDDVAGYKCNCPLPYTGAT 825
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
566-601 9.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 9.50e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    566 DIDEC-DPDPCHYGS-CKDGVATFTCLCQPGYT-GHHCE 601
Cdd:smart00179    1 DIDECaSGNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
178-208 9.85e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.85e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   178 DVNECSQNPGLCRHGGTCHNEIGSYRCACRA 208
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPD 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-175 1.31e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.31e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 224967065    142 DPCAS-NPCANGGQCLPFESSYICRCPPGFH-GPTC 175
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
987-1017 1.67e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   987 CTESSCFNGGTCVDGINSFTCLCPPGFTGSY 1017
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
261-291 1.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.84e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   261 CPGNNCKNGGACVDGVNTYNCRCPPEWTGQY 291
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
335-370 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  335 NIDDCASAA-CFQGATCHDRVASFYCECPHGRTGLLC 370
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
490-526 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    490 NTDECAS-SPCLHNGHCMDKINEFQCQCPKGF-NGHLCQ 526
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
494-522 2.29e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*....
gi 224967065   494 CASSPCLHNGHCMDKINEFQCQCPKGFNG 522
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
1267-1305 2.37e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224967065   1267 DVNECLS-NPCDPRGTqnCVQRVNDFHCECRAGHT-GRRCE 1305
Cdd:smart00179    1 DIDECASgNPCQNGGT--CVNTVGSYRCECPPGYTdGRNCE 39
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
1238-1259 2.70e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.31  E-value: 2.70e-03
                           10        20
                   ....*....|....*....|..
gi 224967065  1238 CFNNGTCVDQVGGYTCTCPPGF 1259
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
682-712 2.76e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   682 CAGSPCHNGGTCEDGIAGFTCRCPEGYHDPT 712
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
949-979 3.56e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.56e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   949 CASNPCQNGANCTDCVDSYTCTCPVGFNGIH 979
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
257-293 4.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.45e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    257 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWT-GQYCT 293
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
716-751 4.50e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.50e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    716 EVNECNS-NPCIHGA-CRDGLNGYKCDCAPGWS-GTNCD 751
Cdd:smart00179    1 DIDECASgNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
641-675 5.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  641 NLDDCAS-NPCD-SGTCLDKIDGYECACEPGYTGSMC 675
Cdd:cd00054     1 DIDECASgNPCQnGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA pfam07645
Calcium-binding EGF domain;
452-481 5.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224967065   452 DVNECIS--NPCQNDATCLDQIGEFQCICMPG 481
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1067-1094 6.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.44e-03
                          10        20
                  ....*....|....*....|....*...
gi 224967065 1067 PCKNGGRCWQTNTQYHCECRSGWTGVNC 1094
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-364 6.67e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 6.67e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 224967065    335 NIDDCASAA-CFQGATCHDRVASFYCECPHG 364
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
911-939 7.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.24e-03
                           10        20
                   ....*....|....*....|....*....
gi 224967065   911 CRPNPCHNGGSCTDGINTAFCDCLPGFQG 939
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
 
Name Accession Description Interval E-value
JMTM_Notch1 cd21702
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1710-1789 6.71e-47

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 1 (Notch1) and similar proteins; Neurogenic locus notch homolog protein 1 (Notch1), also called translocation-associated notch protein TAN-1, functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. It affects the implementation of differentiation, proliferation and apoptotic programs. It is also involved in angiogenesis, and also negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch1, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411985  Cd Length: 80  Bit Score: 163.04  E-value: 6.71e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1710 AVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKN 1789
Cdd:cd21702     1 AVKSETVEPPPPSQLYPMYVVLAALVLLAFVGVGVLVSRKRRREHGQLWFPEGFKVSEPSKKKRREPVGEDSVGLKPLKN 80
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1894-2108 2.85e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 143.17  E-value: 2.85e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1894 EDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRN 1973
Cdd:COG0666    63 LAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEA 142
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1974 RAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEET 2053
Cdd:COG0666   143 GA-DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKT 221
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2054 PLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNL 2108
Cdd:COG0666   222 ALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALL 276
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1907-2108 5.11e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 142.79  E-value: 5.11e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1907 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtDLDARMHDGT 1986
Cdd:COG0666    43 ALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGA-DVNARDKDGE 121
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1987 TPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYET 2066
Cdd:COG0666   122 TPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEI 201
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|..
gi 224967065 2067 AKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNL 2108
Cdd:COG0666   202 VKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGA 243
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1863-2082 1.05e-35

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 138.93  E-value: 1.05e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1863 DVNVRGPDGFTPLMIASCSGggletgnseeeedAPAVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASA 1942
Cdd:COG0666    79 DINAKDDGGNTLLHAAARNG-------------DLEIVKLLLEAGADV-NARDKDGETPLHLAAYNGNLEIVKLLLEAGA 144
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1943 DANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSAL 2022
Cdd:COG0666   145 DVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGA-DVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2023 HWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDH 2082
Cdd:COG0666   224 DLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALL 283
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1863-2055 7.99e-31

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 124.68  E-value: 7.99e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1863 DVNVRGPDGFTPLMIASCSGggletgnseeeedAPAVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASA 1942
Cdd:COG0666   112 DVNARDKDGETPLHLAAYNG-------------NLEIVKLLLEAGADV-NAQDNDGNTPLHLAAANGNLEIVKLLLEAGA 177
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1943 DANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSAL 2022
Cdd:COG0666   178 DVNARDNDGETPLHLAAENGHLEIVKLLLEAGA-DVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTAL 256
                         170       180       190
                  ....*....|....*....|....*....|...
gi 224967065 2023 HWAAAVNNVDAAVVLLKNGANKDMQNNKEETPL 2055
Cdd:COG0666   257 LLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
NOD pfam06816
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1566-1621 6.29e-29

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. Role of NOD domain remains to be elucidated.


Pssm-ID: 462014  Cd Length: 56  Bit Score: 110.68  E-value: 6.29e-29
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 224967065  1566 PERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYG 1621
Cdd:pfam06816    1 PEKLAEGVLVIVVLMDPEELLNNSVQFLRELSTVLRTNVRFKKDENGNPMIYPWYG 56
JMTM_Notch cd21701
juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus ...
1705-1787 1.43e-27

juxtamembrane and transmembrane (JMTM) domain found in Notch protein family; Neurogenic locus notch homolog (Notch) proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch proteins, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411984  Cd Length: 85  Bit Score: 107.85  E-value: 1.43e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1705 PYKIEAVKSE--PVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRqHGQLWFPEGFKVSEASK-KKRREPLGEDS 1781
Cdd:cd21701     1 PYPIYSVRSEpgPATKTTPPAQLSPLVVAAVCVLLVLVVLGVLVARKRRR-HGTLWFPEGFPRTRASRrSRRRDPVGQDS 79

                  ....*.
gi 224967065 1782 VGLKPL 1787
Cdd:cd21701    80 VGLKNL 85
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
1898-2103 4.71e-27

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 4.71e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1898 AVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtD 1977
Cdd:COG0666     1 LLLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGA-D 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1978 LDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFL 2057
Cdd:COG0666    80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 224967065 2058 AAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLL 2103
Cdd:COG0666   160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLL 205
NODP pfam07684
NOTCH protein; NOTCH signalling plays a fundamental role during a great number of ...
1661-1719 2.34e-24

NOTCH protein; NOTCH signalling plays a fundamental role during a great number of developmental processes in multicellular animals. NOD and NODP represent a region present in many NOTCH proteins and NOTCH homologs in multiple species such as NOTCH2 and NOTCH3, LIN12, SC1 and TAN1. The role of the NOD and NODP domains remains to be elucidated.


Pssm-ID: 462229  Cd Length: 59  Bit Score: 97.73  E-value: 2.34e-24
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 224967065  1661 IRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPP 1719
Cdd:pfam07684    1 VIGSVVYLEIDNRKCSQSSDECFSTAQSAADFLAALAAKGGLDLPYPIKEVRSEPPPPP 59
JMTM_Notch2 cd21703
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1704-1787 1.72e-22

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 2 (Notch2) and similar proteins; Neurogenic locus notch homolog protein 2 (Notch2) functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Notch2 is involved in bone remodeling and homeostasis. In collaboration with RELA/p65, it enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation. Notch2 positively regulates self-renewal of liver cancer cells. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch2, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411986  Cd Length: 82  Bit Score: 93.29  E-value: 1.72e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1704 IPYKIEAVKSEPVEPPLPSQLHLMYVAAAafVLLFFVGCGVLLSrKRRRQHGQLWFPEGFKVS-EASKKKRREPLGEDSV 1782
Cdd:cd21703     1 LPYPLVSVTSEPLKETKFNLLYLLAVAVA--IILLILLLGVLVA-KRKRKHGPLWFPEGFILNkENSNRKRREPVGQDAV 77

                  ....*
gi 224967065 1783 GLKPL 1787
Cdd:cd21703    78 GMKNL 82
JMTM_Notch3 cd21704
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1702-1785 3.22e-21

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 3 (Notch3) and similar proteins; Neurogenic locus notch homolog protein 3 (Notch3) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch3, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411987  Cd Length: 90  Bit Score: 90.19  E-value: 3.22e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1702 LNIPYKIEAVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRkRRRQHGQLWFPEGFKV-SEASKKKRREPLGED 1780
Cdd:cd21704     3 LEFPYPIKEVRGEKLEPPPPPVRLLPLLGVAAVILLVILVLGVLVAR-RKREHSTLWFPEGFFLkKESSNKNRREPVGQD 81

                  ....*
gi 224967065 1781 SVGLK 1785
Cdd:cd21704    82 ALGMK 86
JMTM_Notch4 cd21705
juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein ...
1704-1788 6.04e-18

juxtamembrane and transmembrane (JMTM) domain found in neurogenic locus notch homolog protein 4 (Notch4) and similar proteins; Neurogenic locus notch homolog protein 4 (Notch4) functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. It affects the implementation of differentiation, proliferation and apoptotic programs. This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of Notch4, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411988  Cd Length: 92  Bit Score: 80.90  E-value: 6.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1704 IPYKIEAVKSE--PVEPPLPSQL---HLMYVAAAAFVLLFF-VGCGVLLSRKRRRQHGQLWFPEGFKVSEASK-KKRREP 1776
Cdd:cd21705     1 LPFPLLAVTVEeaEKDPQLVAAQlpwPLVCSSVAGVLALVLgALLGVQLIRRRQREHGALWLPPGFARHRDPNpHRRREP 80
                          90
                  ....*....|..
gi 224967065 1777 LGEDSVGLKPLK 1788
Cdd:cd21705    81 VGEDAIGLKPLK 92
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1922-2015 8.39e-16

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 74.77  E-value: 8.39e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  1922 LHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDarmHDGTTPLILAARLAVEGML 2001
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLK---DNGRTALHYAARSGHLEIV 77
                           90
                   ....*....|....
gi 224967065  2002 EDLINSHADVNAVD 2015
Cdd:pfam12796   78 KLLLEKGADINVKD 91
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1907-2079 2.35e-11

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 68.75  E-value: 2.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1907 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATdLDARMHDGT 1986
Cdd:PHA02878  157 GADINMKDRHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGAS-TDARDKCGN 235
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1987 TPL-ILAARLAVEGMLEDLINSHADVNAVDD-LGKSALHwaAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGS- 2063
Cdd:PHA02878  236 TPLhISVGYCKDYDILKLLLEHGVDVNAKSYiLGLTALH--SSIKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQYLc 313
                         170       180
                  ....*....|....*....|.
gi 224967065 2064 YETAKVLLDH-----FANRDI 2079
Cdd:PHA02878  314 INIGRILISNicllkRIKPDI 334
JMTM_dNotch cd21706
juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic ...
1706-1774 6.09e-11

juxtamembrane and transmembrane (JMTM) domain found in Drosophila melanogaster neurogenic locus Notch protein (dNotch) and similar proteins; Drosophila melanogaster neurogenic locus Notch protein (dNotch) is an essential signaling protein which has a major role in many developmental processes. It functions as a receptor for membrane-bound ligands Delta and Serrate to regulate cell-fate determination. It regulates oogenesis, the differentiation of the ectoderm and the development of the central and peripheral nervous system, eye, wing disk, muscles and segmental appendages such as antennae and legs, through lateral inhibition or induction. It also regulates neuroblast self-renewal, identity and proliferation through the regulation of bHLH-O proteins; in larval brains, it is involved in the maintenance of type II neuroblast self-renewal and identity by suppressing erm expression together with pnt. It might also regulate dpn expression through the activation of the transcriptional regulator Su(H). This model corresponds to the juxtamembrane and transmembrane (JMTM) domain of dNotch, which comprises an extended coil, a transmembrane helix (TM), and a beta-strand.


Pssm-ID: 411989  Cd Length: 90  Bit Score: 60.74  E-value: 6.09e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1706 YKIEAVkSEPVEPPLPSQLHLMYVAAAAFVLLFFVGC-GVLLSRKRRRQHGQLWFPEGFKVSEASKKKRR 1774
Cdd:cd21706     5 YQVRGE-DPPDPPPEPPPSNLTYVVIGVVVVLLIGLLlGVLVTTQRKRARGITWFPEGFFTTSSSQRRRR 73
PHA03095 PHA03095
ankyrin-like protein; Provisional
1863-2071 7.13e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 67.36  E-value: 7.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1863 DVNVRGPDGFTPLMIASCsggGLETgnseeeedAPAVISDFIYQGASLhNQTDRTGETALHLAARYSRSDAA--KRLLEA 1940
Cdd:PHA03095  109 DVNAKDKVGRTPLHVYLS---GFNI--------NPKVIRLLLRKGADV-NALDLYGMTPLAVLLKSRNANVEllRLLIDA 176
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1941 SADANIQDNMGRTPLHA-AVSADA-QGVFQILLRnRATDLDARMHDGTTPLILAARLAV--EGMLEDLINSHADVNAVDD 2016
Cdd:PHA03095  177 GADVYAVDDRFRSLLHHhLQSFKPrARIVRELIR-AGCDPAATDMLGNTPLHSMATGSSckRSLVLPLLIAGISINARNR 255
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2017 LGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLL 2071
Cdd:PHA03095  256 YGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
PHA03095 PHA03095
ankyrin-like protein; Provisional
1863-2023 1.45e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 66.20  E-value: 1.45e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1863 DVNVRGPDGFTPL-MIASCSGggletgnseeeEDAPAVISDFIYQGASLhNQTDRTGETALHLAARYS-RSDAAKRLLEA 1940
Cdd:PHA03095   39 DVNFRGEYGKTPLhLYLHYSS-----------EKVKDIVRLLLEAGADV-NAPERCGFTPLHLYLYNAtTLDVIKLLIKA 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1941 SADANIQDNMGRTPLHAAVSADA--QGVFQILLRNRAtDLDARMHDGTTPL---ILAARLAVEgMLEDLINSHADVNAVD 2015
Cdd:PHA03095  107 GADVNAKDKVGRTPLHVYLSGFNinPKVIRLLLRKGA-DVNALDLYGMTPLavlLKSRNANVE-LLRLLIDAGADVYAVD 184

                  ....*...
gi 224967065 2016 DLGKSALH 2023
Cdd:PHA03095  185 DRFRSLLH 192
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1989-2081 1.93e-10

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 59.36  E-value: 1.93e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  1989 LILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNgANKDMQNNKeETPLFLAAREGSYETAK 2068
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNG-RTALHYAARSGHLEIVK 78
                           90
                   ....*....|...
gi 224967065  2069 VLLDHFANRDITD 2081
Cdd:pfam12796   79 LLLEKGADINVKD 91
PHA02875 PHA02875
ankyrin repeat protein; Provisional
1912-2103 6.29e-10

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 63.86  E-value: 6.29e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1912 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAV-SADAQGVFQILLRNRATDlDARMHDGTTPLI 1990
Cdd:PHA02875   29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVeEGDVKAVEELLDLGKFAD-DVFYKDGMTPLH 107
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1991 LAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVL 2070
Cdd:PHA02875  108 LATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKML 187
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 224967065 2071 LDHFANrdiTDHMDRLPrDI-----AQERMHHDIVRLL 2103
Cdd:PHA02875  188 LDSGAN---IDYFGKNG-CVaalcyAIENNKIDIVRLF 221
PHA03095 PHA03095
ankyrin-like protein; Provisional
1935-2076 9.43e-10

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.51  E-value: 9.43e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1935 KRLLEASADANIQDNMGRTPLHAAV---SADAQGVFQILLRNRAtDLDARMHDGTTPLILAARLA-VEGMLEDLINSHAD 2010
Cdd:PHA03095   31 RRLLAAGADVNFRGEYGKTPLHLYLhysSEKVKDIVRLLLEAGA-DVNAPERCGFTPLHLYLYNAtTLDVIKLLIKAGAD 109
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2011 VNAVDDLGKSALHWAAAVNNVDAA--VVLLKNGANKDMQNNKEETPL--FLAAREGSYETAKVLLDHFAN 2076
Cdd:PHA03095  110 VNAKDKVGRTPLHVYLSGFNINPKviRLLLRKGADVNALDLYGMTPLavLLKSRNANVELLRLLIDAGAD 179
PHA03095 PHA03095
ankyrin-like protein; Provisional
1904-2076 1.54e-09

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 63.12  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1904 IYQGASLhNQTDRTGETALHLAARYS---RSDAAKRLLEASADANIQDNMGRTPLHAAV-SADAQGVFQILLRNRAtDLD 1979
Cdd:PHA03095   34 LAAGADV-NFRGEYGKTPLHLYLHYSsekVKDIVRLLLEAGADVNAPERCGFTPLHLYLyNATTLDVIKLLIKAGA-DVN 111
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1980 ARMHDGTTPL--ILAARLAVEGMLEDLINSHADVNAVDDLGKSALHwaaavnnvdaavVLLKN-GANKDMQNnkeetpLF 2056
Cdd:PHA03095  112 AKDKVGRTPLhvYLSGFNINPKVIRLLLRKGADVNALDLYGMTPLA------------VLLKSrNANVELLR------LL 173
                         170       180
                  ....*....|....*....|....*
gi 224967065 2057 LAAreGSYETAK-----VLLDHFAN 2076
Cdd:PHA03095  174 IDA--GADVYAVddrfrSLLHHHLQ 196
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1912-2106 1.59e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 63.54  E-value: 1.59e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1912 NQTDRTGETALHLAARYS-RSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDARMHDGTTPLI 1990
Cdd:PHA02876  301 NAKNIKGETPLYLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQASTLDRNKDIVITLLELGANVNARDYCDKTPIH 380
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1991 LAARLAVEGMLEDLINSHADVNAVDDLGKSALHWA-AAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREG-SYETAK 2068
Cdd:PHA02876  381 YAAVRNNVVIINTLLDYGADIEALSQKIGTALHFAlCGTNPYMSVKTLIDRGANVNSKNKDLSTPLHYACKKNcKLDVIE 460
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 224967065 2069 VLLDHFANRDITDHMDRLPRDIAQErmHHDIVRLLDEY 2106
Cdd:PHA02876  461 MLLDNGADVNAINIQNQYPLLIALE--YHGIVNILLHY 496
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1487-1522 1.88e-09

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 54.84  E-value: 1.88e-09
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 224967065  1487 WKNCTQSlQCWKYFSDGHCDSQCNSAGCLFDGFDCQ 1522
Cdd:pfam00066    1 WPNCPYP-YCWDKFGNGVCDEECNNAECLWDGGDCS 35
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1918-2062 5.44e-09

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 61.57  E-value: 5.44e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1918 GETALHLAARYSRSDAAKRLLEASADAnIQDNM------GRTPLHAAVSADAQGVFQILLRNRATDLDAR---------- 1981
Cdd:cd22192    51 GETALHVAALYDNLEAAVVLMEAAPEL-VNEPMtsdlyqGETALHIAVVNQNLNLVRELIARGADVVSPRatgtffrpgp 129
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1982 ---MHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVV----LLKNGANKD------MQN 2048
Cdd:cd22192   130 knlIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILVLQPNKTFACQmydlILSYDKEDDlqpldlVPN 209
                         170
                  ....*....|....
gi 224967065 2049 NKEETPLFLAAREG 2062
Cdd:cd22192   210 NQGLTPFKLAAKEG 223
Ank_5 pfam13857
Ankyrin repeats (many copies);
1907-1958 7.01e-09

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 53.89  E-value: 7.01e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224967065  1907 GASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAA 1958
Cdd:pfam13857    5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2037-2103 1.80e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 53.97  E-value: 1.80e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224967065  2037 LLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHfANRDITDHmDRLPRDIAQERMHHDIVRLL 2103
Cdd:pfam12796   16 LLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTALHYAARSGHLEIVKLL 80
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
869-905 2.16e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 51.87  E-value: 2.16e-08
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  869 DINECV-KSPCRHGASCQNTNGSYRCLCQAGYTGRNCE 905
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1442-1479 2.36e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.94  E-value: 2.36e-08
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 224967065   1442 PPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDC 1479
Cdd:smart00004    1 PQDPWSRCEDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1922-2103 3.37e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 58.52  E-value: 3.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1922 LHLAARYSRSDAAKRLLEASADANIQDNMGRTPLH-----AAVSADAQGVFQILLRNRAtDLDARMHDGTTPLILAARLA 1996
Cdd:PHA03100   39 LYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHylsniKYNLTDVKEIVKLLLEYGA-NVNAPDNNGITPLLYAISKK 117
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1997 VEG--MLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAA------------------VVLLKNGANKDMQNNKEETPLF 2056
Cdd:PHA03100  118 SNSysIVEYLLDNGANVNIKNSDGENLLHLYLESNKIDLKilkllidkgvdinaknrvNYLLSYGVPINIKDVYGFTPLH 197
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 224967065 2057 LAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLL 2103
Cdd:PHA03100  198 YAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLL 244
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1485-1521 4.59e-08

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 51.17  E-value: 4.59e-08
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 224967065   1485 DPWKNCtQSLQCWKYFSDGHCDSQCNSAGCLFDGFDC 1521
Cdd:smart00004    3 DPWSRC-EDAQCWDKFGDGVCDEECNNAECLWDGGDC 38
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
1914-2052 4.67e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 58.73  E-value: 4.67e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1914 TDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLR-NRATDldarMHDGTTPLILA 1992
Cdd:PLN03192  554 GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHfASISD----PHAAGDLLCTA 629
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1993 ARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEE 2052
Cdd:PLN03192  630 AKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANTDDD 689
EGF_CA smart00179
Calcium-binding EGF-like domain;
869-905 6.64e-08

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 50.71  E-value: 6.64e-08
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    869 DINECV-KSPCRHGASCQNTNGSYRCLCQAGYT-GRNCE 905
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
Ank_2 pfam12796
Ankyrin repeats (3 copies);
1863-1948 6.98e-08

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 52.04  E-value: 6.98e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  1863 DVNVRGPDGFTPLMIAsCSGGGLEtgnseeeedapavISDFIYQGASLHNQTDrtGETALHLAARYSRSDAAKRLLEASA 1942
Cdd:pfam12796   22 DANLQDKNGRTALHLA-AKNGHLE-------------IVKLLLEHADVNLKDN--GRTALHYAARSGHLEIVKLLLEKGA 85

                   ....*.
gi 224967065  1943 DANIQD 1948
Cdd:pfam12796   86 DINVKD 91
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
412-450 7.96e-08

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 50.33  E-value: 7.96e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224967065  412 DVDECALGaNPCEHAGKCLNTLGSFECQCLQGYTGPRCE 450
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1525-1561 1.02e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 49.83  E-value: 1.02e-07
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 224967065  1525 EGQCNPlydQYCKDHFSDGHCDQGCNSAECEWDGLDC 1561
Cdd:pfam00066    1 WPNCPY---PYCWDKFGNGVCDEECNNAECLWDGGDC 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
528-564 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  528 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYTGTHCE 564
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1021-1057 1.06e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.94  E-value: 1.06e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065 1021 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYTGLNCQ 1057
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
295-332 1.47e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 49.56  E-value: 1.47e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  295 DVDECQlMPNACQNGGTCHNTHGGYNCVCVNGWTGEDC 332
Cdd:cd00054     1 DIDECA-SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
Notch pfam00066
LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch ...
1446-1480 2.39e-07

LNR domain; The LNR (Lin-12/Notch repeat) domain is found in three tandem copies in Notch related proteins. The structure of the domain has been determined by NMR and was shown to contain three disulphide bonds and coordinate a calcium ion. Three repeats are also found in the PAPP-A peptidase.


Pssm-ID: 459658  Cd Length: 35  Bit Score: 48.68  E-value: 2.39e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 224967065  1446 EEACELPECQVDAGNKVCNLQCNNHACGWDGGDCS 1480
Cdd:pfam00066    1 WPNCPYPYCWDKFGNGVCDEECNNAECLWDGGDCS 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
945-981 2.65e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.79  E-value: 2.65e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  945 DINECAS-NPCQNGANCTDCVDSYTCTCPVGFNGIHCE 981
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
2183-2492 2.67e-07

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 56.31  E-value: 2.67e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2183 SSSMLSPVDSLESPHgyLSDVASPPLLPSPFQ-QSPSMPLS--------HLPGMPDTHlgiSHLNVAAKPemaalaggsr 2253
Cdd:pfam03154  191 TTQAATAGPTPSAPS--VPPQGSPATSQPPNQtQSTAAPHTliqqtptlHPQRLPSPH---PPLQPMTQP---------- 255
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2254 lafePPPPRLSHLPVAssastvlstngtgamnftvgaPASLNGQCEWLPR-LQNGM------VPSQYNPLRP----GVTP 2322
Cdd:pfam03154  256 ----PPPSQVSPQPLP---------------------QPSLHGQMPPMPHsLQTGPshmqhpVPPQPFPLTPqssqSQVP 310
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2323 GTLSTQAAGLQHSMMGPLHSSLSTNTLSPIIYQGLPNTRLAtQPHLvqtQQVQPQNLQLQPQNLQPPSQPHLSVSSAAng 2402
Cdd:pfam03154  311 PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPLS-MPHI---KPPPTTPIPQLPNPQSHKHPPHLSGPSPF-- 384
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065  2403 hlgrSFLSGEPSQADVQPLgpSSLPVH----------TILPQeSQALPTslPSSMVPPMTTTQFLTPPSQHSYSSSPVDN 2472
Cdd:pfam03154  385 ----QMNSNLPPPPALKPL--SSLSTHhppsahppplQLMPQ-SQQLPP--PPAQPPVLTQSQSLPPPAASHPPTSGLHQ 455
                          330       340
                   ....*....|....*....|
gi 224967065  2473 TPShQLQVPEHPFLTPSPES 2492
Cdd:pfam03154  456 VPS-QSPFPQHPFVPGGPPP 474
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1912-2100 2.77e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 55.74  E-value: 2.77e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1912 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATdLDARMHDGTTPLIL 1991
Cdd:PHA02874  118 NIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAY-ANVKDNNGESPLHN 196
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1992 AARLAVEGMLEDLINSHADVNAVDDLGKSALHwaAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAR-EGSYETAKVL 2070
Cdd:PHA02874  197 AAEYGDYACIKLLIDHGNHIMNKCKNGFTPLH--NAIIHNRSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDIL 274
                         170       180       190
                  ....*....|....*....|....*....|
gi 224967065 2071 LDHFANRDITDHMDRLPRDIAQERMHHDIV 2100
Cdd:PHA02874  275 LYHKADISIKDNKGENPIDTAFKYINKDPV 304
NL smart00004
Domain found in Notch and Lin-12; The Notch protein is essential for the proper ...
1533-1561 3.52e-07

Domain found in Notch and Lin-12; The Notch protein is essential for the proper differentiation of the Drosophila ectoderm. This protein contains 3 NL domains.


Pssm-ID: 197463  Cd Length: 38  Bit Score: 48.48  E-value: 3.52e-07
                            10        20
                    ....*....|....*....|....*....
gi 224967065   1533 DQYCKDHFSDGHCDQGCNSAECEWDGLDC 1561
Cdd:smart00004   10 DAQCWDKFGDGVCDEECNNAECLWDGGDC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1184-1219 4.73e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 48.02  E-value: 4.73e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065 1184 INECLSQ-PCQNGGTCIDLTNSYKCSCPRGTQGVHCE 1219
Cdd:cd00054     2 IDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
412-450 5.46e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 48.01  E-value: 5.46e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224967065    412 DVDECALGaNPCEHAGKCLNTLGSFECQCLQGYT-GPRCE 450
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1146-1180 6.05e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.05e-07
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065 1146 VDEC-SPNPCQNGATCTDYLGGFSCKCVAGYHGSNC 1180
Cdd:cd00054     2 IDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
791-827 6.48e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.63  E-value: 6.48e-07
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  791 NINECAS-NPCLNQGTCIDDVAGYKCNCPLPYTGATCE 827
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_4 pfam13637
Ankyrin repeats (many copies);
1920-1971 6.65e-07

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 48.04  E-value: 6.65e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 224967065  1920 TALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILL 1971
Cdd:pfam13637    3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
678-713 8.27e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.27e-07
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  678 NIDECA-GSPCHNGGTCEDGIAGFTCRCPEGYHDPTC 713
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
945-981 8.57e-07

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 47.24  E-value: 8.57e-07
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    945 DINECAS-NPCQNGANCTDCVDSYTCTCPVGF-NGIHCE 981
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1937-2076 8.58e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 8.58e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1937 LLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGM-LEDLINSHADVNAVD 2015
Cdd:PHA02876  259 LYDAGFSVNSIDDCKNTPLHHASQAPSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDTEnIRTLIMLGADVNAAD 338
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224967065 2016 DLGKSALHWAAAVNNVDAAV-VLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFAN 2076
Cdd:PHA02876  339 RLYITPLHQASTLDRNKDIViTLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGAD 400
PHA02876 PHA02876
ankyrin repeat protein; Provisional
1900-2104 8.72e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 54.68  E-value: 8.72e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1900 ISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATdld 1979
Cdd:PHA02876  160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSN--- 236
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1980 arMHDGTTPLILAAR---LAVEGMLEDlinSHADVNAVDDLGKSALHWAAAVNN-VDAAVVLLKNGANKDMQNNKEETPL 2055
Cdd:PHA02876  237 --INKNDLSLLKAIRnedLETSLLLYD---AGFSVNSIDDCKNTPLHHASQAPSlSRLVPKLLERGADVNAKNIKGETPL 311
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 224967065 2056 FLAAREG-SYETAKVLLDHFANRDITDHMDRLPRDIAQ--ERMHHDIVRLLD 2104
Cdd:PHA02876  312 YLMAKNGyDTENIRTLIMLGADVNAADRLYITPLHQAStlDRNKDIVITLLE 363
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
178-216 8.95e-07

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 47.25  E-value: 8.95e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 224967065  178 DVNECSQNpGLCRHGGTCHNEIGSYRCACRATHTGPHCE 216
Cdd:cd00054     1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
412-443 1.22e-06

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 46.85  E-value: 1.22e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224967065   412 DVDECALGANPCEHAGKCLNTLGSFECQCLQG 443
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
452-488 1.24e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 46.86  E-value: 1.24e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  452 DVNEC-ISNPCQNDATCLDQIGEFQCICMPGYEGVYCE 488
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
295-332 2.65e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 46.09  E-value: 2.65e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    295 DVDECQlMPNACQNGGTCHNTHGGYNCVCVNGWT-GEDC 332
Cdd:smart00179    1 DIDECA-SGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
678-710 3.25e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.25e-06
                            10        20        30
                    ....*....|....*....|....*....|....
gi 224967065    678 NIDECA-GSPCHNGGTCEDGIAGFTCRCPEGYHD 710
Cdd:smart00179    1 DIDECAsGNPCQNGGTCVNTVGSYRCECPPGYTD 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
528-564 3.41e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.41e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    528 DVDECAST-PCKNGAKCLDGPNTYTCVCTEGYT-GTHCE 564
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1021-1057 3.69e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.69e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065   1021 DVNECDSR-PCLHGGTCQDSYGTYKCTCPQGYT-GLNCQ 1057
Cdd:smart00179    1 DIDECASGnPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1183-1219 3.84e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 45.70  E-value: 3.84e-06
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065   1183 EINECLS-QPCQNGGTCIDLTNSYKCSCPRG-TQGVHCE 1219
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1912-1976 4.14e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.97  E-value: 4.14e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 1912 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRAT 1976
Cdd:PHA03100  186 NIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS 250
PHA03100 PHA03100
ankyrin repeat protein; Provisional
1904-2085 5.10e-06

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 51.59  E-value: 5.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1904 IYQGASLhNQTDRTGETALHLAARYSRS-----DAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQI-LLRNRATD 1977
Cdd:PHA03100   55 LDNGADI-NSSTKNNSTPLHYLSNIKYNltdvkEIVKLLLEYGANVNAPDNNGITPLLYAISKKSNSYSIVeYLLDNGAN 133
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1978 LDARMHDGTTPLilaaRLAVEG------MLEDLINSHADVNA----------------VDDLGKSALHWAAAVNNVDAAV 2035
Cdd:PHA03100  134 VNIKNSDGENLL----HLYLESnkidlkILKLLIDKGVDINAknrvnyllsygvpiniKDVYGFTPLHYAVYNNNPEFVK 209
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 224967065 2036 VLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANrdiTDHMDR 2085
Cdd:PHA03100  210 YLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPS---IKTIIE 256
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1221-1265 5.77e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.94  E-value: 5.77e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 224967065 1221 NVDDChppldpASRSPkCFNNGTCVDQVGGYTCTCPPGFVGERCE 1265
Cdd:cd00054     1 DIDEC------ASGNP-CQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1145-1180 7.78e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 7.78e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 224967065   1145 EVDEC-SPNPCQNGATCTDYLGGFSCKCVAGYH-GSNC 1180
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
907-943 9.15e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.55  E-value: 9.15e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  907 DIDDCR-PNPCHNGGSCTDGINTAFCDCLPGFQGAFCE 943
Cdd:cd00054     1 DIDECAsGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
178-216 9.38e-06

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 44.55  E-value: 9.38e-06
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 224967065    178 DVNECSQnPGLCRHGGTCHNEIGSYRCACRA-THTGPHCE 216
Cdd:smart00179    1 DIDECAS-GNPCQNGGTCVNTVGSYRCECPPgYTDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
755-789 1.06e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.06e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065  755 NECES-NPCVNGGTCKDMTSGYVCTCREGFSGPNCQ 789
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
Ank_5 pfam13857
Ankyrin repeats (many copies);
1937-1992 1.10e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 44.64  E-value: 1.10e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 224967065  1937 LLEA-SADANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtDLDARMHDGTTPLILA 1992
Cdd:pfam13857    1 LLEHgPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGV-DLNLKDEEGLTALDLA 56
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1932-2076 1.21e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 50.35  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1932 DAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtdldarmhdgttplilaarlavegmledlinshaDV 2011
Cdd:PHA02874  105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGA----------------------------------DV 150
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2012 NAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFAN 2076
Cdd:PHA02874  151 NIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
988-1019 1.23e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.23e-05
                          10        20        30
                  ....*....|....*....|....*....|..
gi 224967065  988 TESSCFNGGTCVDGINSFTCLCPPGFTGSYCQ 1019
Cdd:cd00054     7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
603-639 1.35e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 44.16  E-value: 1.35e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  603 NINECHSQ-PCRHGGTCQDRDNSYLCLCLKGTTGPNCE 639
Cdd:cd00054     1 DIDECASGnPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
452-488 1.64e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.77  E-value: 1.64e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    452 DVNECIS-NPCQNDATCLDQIGEFQCICMPGYE-GVYCE 488
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
PHA03247 PHA03247
large tegument protein UL36; Provisional
2111-2493 2.01e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 50.32  E-value: 2.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2111 SPQLHGTALGGTPTLSPtlcSPNGYLGNLKSATQGKKARKPSTKGLACGSkEAKDLKARRKKSQDGKGCLLDSSSMLSPV 2190
Cdd:PHA03247 2630 SPSPAANEPDPHPPPTV---PPPERPRDDPAPGRVSRPRRARRLGRAAQA-SSPPQRPRRRAARPTVGSLTSLADPPPPP 2705
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2191 DSLES-PHGYLSDVASPPLLPSPFQQSPSMPLSHLP----GMPDTHLGISHLNVAAKPEMAALAGGSRLAFEPPPPRLSH 2265
Cdd:PHA03247 2706 PTPEPaPHALVSATPLPPGPAAARQASPALPAAPAPpavpAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2266 LPVASSAStvlSTNGTGAMNFTVGAPASLNGQCEWLPRLQNgmvPSqynplrPGVTPGTLSTQAAGLQHSmmGPLHSSLS 2345
Cdd:PHA03247 2786 PAVASLSE---SRESLPSPWDPADPPAAVLAPAAALPPAAS---PA------GPLPPPTSAQPTAPPPPP--GPPPPSLP 2851
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2346 T-NTLSPiiyqGLPNTRLATqphlvqtqqvqpqnlqLQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLGPS 2424
Cdd:PHA03247 2852 LgGSVAP----GGDVRRRPP----------------SRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQP 2911
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224967065 2425 SLPVHTILPQESQALPTSLPSSMVPPMTTTQfLTPPSQHSYSSSPVDNTPSHQL------QVPEHPFLTPSPESP 2493
Cdd:PHA03247 2912 QAPPPPQPQPQPPPPPQPQPPPPPPPRPQPP-LAPTTDPAGAGEPSGAVPQPWLgalvpgRVAVPRFRVPQPAPS 2985
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
142-175 3.00e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.01  E-value: 3.00e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 224967065  142 DPCAS-NPCANGGQCLPFESSYICRCPPGFHGPTC 175
Cdd:cd00054     3 DECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
TRPV3 cd22194
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a ...
1918-2085 3.24e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), type 3; TRPV3 is a temperature-sensitive Transient Receptor Potential (TRP) ion channel that is activated by warm temperatures, synthetic small-molecule chemicals, and natural compounds from plants. TRPV3 function is regulated by physiological factors such as extracellular divalent cations and acidic pH, intracellular adenosine triphosphate, membrane voltage, and arachidonic acid. It is expressed in both neuronal and non-neuronal tissues including epidermal keratinocytes, epithelial cells in the gut, endothelial cells in blood vessels, and neurons in dorsal root ganglia and CNS. TRPV3 null mice have abnormal hair morphogenesis and compromised skin barrier function. It may play roles in inflammatory skin disorders, such as itch and pain sensation. TRPV3 is also expressed by many neuronal and non-neuronal tissues, showing that TRPV3 might play roles in other unknown cellular and physiological functions. TRPV3 belongs to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411978 [Multi-domain]  Cd Length: 680  Bit Score: 49.37  E-value: 3.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1918 GETALHLAARYSRSDAAKRLLEASADANIQdnmgrtplhaavsadAQGVFqillrNRATDLDARMHDGTTPLILAA---R 1994
Cdd:cd22194   141 GQTALNIAIERRQGDIVKLLIAKGADVNAH---------------AKGVF-----FNPKYKHEGFYFGETPLALAActnQ 200
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1995 LAVEGMLEDliNSHADVNAVDDLGKSALHWAAAVNNVDAAVV---------LLKNGANKD---MQNNKEETPLFLAAREG 2062
Cdd:cd22194   201 PEIVQLLME--KESTDITSQDSRGNTVLHALVTVAEDSKTQNdfvkrmydmILLKSENKNletIRNNEGLTPLQLAAKMG 278
                         170       180
                  ....*....|....*....|...
gi 224967065 2063 SYEtakvLLDHFANRDITDHMDR 2085
Cdd:cd22194   279 KAE----ILKYILSREIKEKPNR 297
EGF_CA smart00179
Calcium-binding EGF-like domain;
791-827 3.97e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.62  E-value: 3.97e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    791 NINECAS-NPCLNQGTCIDDVAGYKCNCPLPYT-GATCE 827
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1267-1305 4.19e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.62  E-value: 4.19e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 224967065 1267 DVNECLS-NPCDPRGTqnCVQRVNDFHCECRAGHTGRRCE 1305
Cdd:cd00054     1 DIDECASgNPCQNGGT--CVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
566-601 4.90e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 4.90e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  566 DIDECD-PDPCHY-GSCKDGVATFTCLCQPGYTGHHCE 601
Cdd:cd00054     1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRNCE 38
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
1917-2092 4.95e-05

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 48.72  E-value: 4.95e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1917 TGETALHLAARY---SRSDAAKRLLEASADANIQDNM-----------GRTPLHAAVSADAQGVFQILLRNRAtDLDAR- 1981
Cdd:cd21882    25 TGKTCLHKAALNlndGVNEAIMLLLEAAPDSGNPKELvnapctdefyqGQTALHIAIENRNLNLVRLLVENGA-DVSARa 103
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1982 ------------MHDGTTPLILAARLAVEGMLEDLI-NSH--ADVNAVDDLGKSALH---------WAAAVNNVDAAVVL 2037
Cdd:cd21882   104 tgrffrkspgnlFYFGELPLSLAACTNQEEIVRLLLeNGAqpAALEAQDSLGNTVLHalvlqadntPENSAFVCQMYNLL 183
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224967065 2038 LKNGANKD-------MQNNKEETPLFLAAREGSYetakVLLDHFANRDITDHMDRLPRDIAQ 2092
Cdd:cd21882   184 LSYGAHLDptqqleeIPNHQGLTPLKLAAVEGKI----VMFQHILQREFSGPYQPLSRKFTE 241
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
257-293 5.79e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 42.24  E-value: 5.79e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  257 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWTGQYCT 293
Cdd:cd00054     1 DIDECaSGNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
603-639 6.24e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 42.23  E-value: 6.24e-05
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    603 NINECHS-QPCRHGGTCQDRDNSYLCLCLKG-TTGPNCE 639
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGyTDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1025-1055 6.87e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.98  E-value: 6.87e-05
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065  1025 CDSRPCLHGGTCQDSYGTYKCTCPQGYTGLN 1055
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA pfam07645
Calcium-binding EGF domain;
295-326 7.81e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 41.84  E-value: 7.81e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224967065   295 DVDECQLMPNACQNGGTCHNTHGGYNCVCVNG 326
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1960-2105 9.30e-05

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 47.65  E-value: 9.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1960 SADAQGVfQILLRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLK 2039
Cdd:PHA02874   11 SGDIEAI-EKIIKNKGNCINISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLID 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2040 NGA----------NKDM-------------QNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMH 2096
Cdd:PHA02874   90 NGVdtsilpipciEKDMiktildcgidvniKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNF 169

                  ....*....
gi 224967065 2097 HDIVRLLDE 2105
Cdd:PHA02874  170 FDIIKLLLE 178
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
532-560 1.35e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.21  E-value: 1.35e-04
                           10        20
                   ....*....|....*....|....*....
gi 224967065   532 CASTPCKNGAKCLDGPNTYTCVCTEGYTG 560
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
1149-1179 1.68e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 40.83  E-value: 1.68e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065  1149 CSPNPCQNGATCTDYLGGFSCKCVAGYHGSN 1179
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
1913-2011 1.70e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 46.93  E-value: 1.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1913 QTDRTGETALHLAARYSRSDAAKRLLE-ASADANIQDNMGRTPLHAAVSADAQGVFQILLRNrATDL-----DARMHDGT 1986
Cdd:cd22192    12 QQKRISESPLLLAAKENDVQAIKKLLKcPSCDLFQRGALGETALHVAALYDNLEAAVVLMEA-APELvnepmTSDLYQGE 90
                          90       100
                  ....*....|....*....|....*
gi 224967065 1987 TPLILAARLAVEGMLEDLINSHADV 2011
Cdd:cd22192    91 TALHIAVVNQNLNLVRELIARGADV 115
PHA02878 PHA02878
ankyrin repeat protein; Provisional
1899-2106 1.71e-04

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 46.80  E-value: 1.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1899 VISDFIYQGASLhNQTDRTGETALHLAARYSRSDAAKRLLEASadanIQDNMGRT--PLHAAVSADAQGVFQILLRNRAT 1976
Cdd:PHA02878   52 VVKSLLTRGHNV-NQPDHRDLTPLHIICKEPNKLGMKEMIRSI----NKCSVFYTlvAIKDAFNNRNVEIFKIILTNRYK 126
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1977 DLdaRMHDGTTPLILAARLAVEGMLEDLINSH-ADVNAVD-DLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETP 2054
Cdd:PHA02878  127 NI--QTIDLVYIDKKSKDDIIEAEITKLLLSYgADINMKDrHKGNTALHYATENKDQRLTELLLSYGANVNIPDKTNNSP 204
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 224967065 2055 LFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQER-MHHDIVRLLDEY 2106
Cdd:PHA02878  205 LHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISVGYcKDYDILKLLLEH 257
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1912-1980 1.76e-04

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 46.82  E-value: 1.76e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 224967065 1912 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDA 1980
Cdd:PTZ00322  109 NCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQCHFEL 177
TRPV1-4 cd22193
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are ...
1918-2091 2.06e-04

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 1-4; TRPV1-4 are thermo-sensing channels that function directly in temperature-sensing and nociception; they share substantial structural and functional properties. Transient Receptor Potential (TRP) ion channels activated by temperature (thermo TRPs) are important molecular players in acute, inflammatory, and chronic pain states. So far, 11 TRP channels in mammalian cells have been identified as thermosensitive TRP (thermo-TRP) channels. TRPV1-4 channels are activated by different heat temperatures, for example, TRPV1 and TRPV2 are activated by high temperatures (>43C and >55C, respectively). TRPV1-4 belong to the vanilloid TRP subfamily (TRPV), named after the founding member vanilloid receptor 1 (TRPV1). The structure of TRPV shows the typical topology features of all TRP ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains.


Pssm-ID: 411977 [Multi-domain]  Cd Length: 607  Bit Score: 46.71  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1918 GETALHLAARYSRSDAAKRLLEASADANIQDN--------------MGRTPLHAAVSADAQGVFQILLRNRATDLDARMH 1983
Cdd:cd22193    76 GQTALHIAIERRQGDIVALLVENGADVHAHAKgrffqpkyqgegfyFGELPLSLAACTNQPDIVQYLLENEHQPADIEAQ 155
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1984 DGTTPLILAARLAVEgmlEDLINSHADVNAVDDLgksalhwaaavnnvdaavvLLKNGAN-------KDMQNNKEETPLF 2056
Cdd:cd22193   156 DSRGNTVLHALVTVA---DNTKENTKFVTRMYDM-------------------ILIRGAKlcptvelEEIRNNDGLTPLQ 213
                         170       180       190
                  ....*....|....*....|....*....|....*....
gi 224967065 2057 LAAREGSYEtakvLLDHFANRDITD----HMDRLPRDIA 2091
Cdd:cd22193   214 LAAKMGKIE----ILKYILQREIKEpelrHLSRKFTDWA 248
Ank_2 pfam12796
Ankyrin repeats (3 copies);
2055-2119 2.27e-04

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 42.41  E-value: 2.27e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 224967065  2055 LFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGTAL 2119
Cdd:pfam12796    1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNGRTAL 65
EGF_CA smart00179
Calcium-binding EGF-like domain;
907-943 2.81e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 2.81e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    907 DIDDC-RPNPCHNGGSCTDGINTAFCDCLPGFQ-GAFCE 943
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
490-526 2.93e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.93e-04
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 224967065  490 NTDECAS-SPCLHNGHCMDKINEFQCQCPKGFNGHLCQ 526
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1221-1265 3.28e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.28e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*.
gi 224967065   1221 NVDDChppldpASRSPkCFNNGTCVDQVGGYTCTCPPGFV-GERCE 1265
Cdd:smart00179    1 DIDEC------ASGNP-CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
755-789 3.59e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.59e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 224967065    755 NECES-NPCVNGGTCKDMTSGYVCTCREGFS-GPNCQ 789
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
144-174 4.14e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.67  E-value: 4.14e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   144 CASNPCANGGQCLPFESSYICRCPPGFHGPT 174
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
717-750 4.17e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.17e-04
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 224967065  717 VNECNS-NPCIHGA-CRDGLNGYKCDCAPGWSGTNC 750
Cdd:cd00054     2 IDECASgNPCQNGGtCVNTVGSYRCSCPPGYTGRNC 37
JMTM_Notch_APP cd21700
juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins; The ...
1711-1750 4.24e-04

juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins; The substrates of gamma-secretase include amyloid precursor protein (APP) and the Notch receptor. APP, also called APPI, or Alzheimer disease amyloid protein (ABPP), or amyloid precursor protein, or amyloid-beta A4 protein, or cerebral vascular amyloid peptide (CVAP), or PreA4, or protease nexin-II (PN-II), functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Notch proteins are a family of type-1 transmembrane proteins that form a core component of the Notch signaling pathway. They operate in a variety of different tissues and play a role in a variety of developmental processes by controlling cell fate decisions. Successive cleavage of the APP carboxyl-terminal fragment generates amyloid-beta (Abeta) peptides of varying lengths. Accumulation of Abeta peptides such as Abeta42 and Abeta43 leads to formation of amyloid plaques in the brain, a hallmark of Alzheimer's disease. Notch cleavage is involved in cell-fate determination during development and neurogenesis. The model corresponds to the juxtamembrane and transmembrane (JMTM) domain found in Notch and APP family proteins. It comprises a transmembrane helix (TM) with adjacent juxtamembrane (JM) regions. The JMTM domain is likely to be recognized by gamma-secretase in a similar fashion to both Notch and APP family proteins.


Pssm-ID: 411983  Cd Length: 41  Bit Score: 40.07  E-value: 4.24e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 224967065 1711 VKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCG-VLLSRKR 1750
Cdd:cd21700     1 LPFFALDDGSGKGAIIGLLVGAVVILLVFVITGgLVAARKK 41
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1918-1949 4.77e-04

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.58  E-value: 4.77e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 224967065  1918 GETALHLAA-RYSRSDAAKRLLEASADANIQDN 1949
Cdd:pfam00023    2 GNTPLHLAAgRRGNLEIVKLLLSKGADVNARDK 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
992-1019 5.26e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.26e-04
                            10        20
                    ....*....|....*....|....*....
gi 224967065    992 CFNGGTCVDGINSFTCLCPPGFT-GSYCQ 1019
Cdd:smart00179   11 CQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
795-825 5.40e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 5.40e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   795 CASNPCLNQGTCIDDVAGYKCNCPLPYTGAT 825
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
566-601 9.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 9.50e-04
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    566 DIDEC-DPDPCHYGS-CKDGVATFTCLCQPGYT-GHHCE 601
Cdd:smart00179    1 DIDECaSGNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
178-208 9.85e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.85e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   178 DVNECSQNPGLCRHGGTCHNEIGSYRCACRA 208
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPD 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
142-175 1.31e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.31e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 224967065    142 DPCAS-NPCANGGQCLPFESSYICRCPPGFH-GPTC 175
Cdd:smart00179    3 DECASgNPCQNGGTCVNTVGSYRCECPPGYTdGRNC 38
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
2037-2106 1.35e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 44.12  E-value: 1.35e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2037 LLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEY 2106
Cdd:PTZ00322  101 LLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRH 170
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
1918-1946 1.52e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 38.01  E-value: 1.52e-03
                           10        20
                   ....*....|....*....|....*....
gi 224967065  1918 GETALHLAARYSRSDAAKRLLEASADANI 1946
Cdd:pfam13606    2 GNTPLHLAARNGRLEIVKLLLENGADINA 30
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
987-1017 1.67e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.67e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   987 CTESSCFNGGTCVDGINSFTCLCPPGFTGSY 1017
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
261-291 1.84e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 1.84e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   261 CPGNNCKNGGACVDGVNTYNCRCPPEWTGQY 291
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
335-370 1.92e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.92e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  335 NIDDCASAA-CFQGATCHDRVASFYCECPHGRTGLLC 370
Cdd:cd00054     1 DIDECASGNpCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
992-1013 2.01e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.70  E-value: 2.01e-03
                           10        20
                   ....*....|....*....|..
gi 224967065   992 CFNGGTCVDGINSFTCLCPPGF 1013
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF_CA smart00179
Calcium-binding EGF-like domain;
490-526 2.17e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 2.17e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    490 NTDECAS-SPCLHNGHCMDKINEFQCQCPKGF-NGHLCQ 526
Cdd:smart00179    1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYtDGRNCE 39
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
494-522 2.29e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.75  E-value: 2.29e-03
                           10        20
                   ....*....|....*....|....*....
gi 224967065   494 CASSPCLHNGHCMDKINEFQCQCPKGFNG 522
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF_CA smart00179
Calcium-binding EGF-like domain;
1267-1305 2.37e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 2.37e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 224967065   1267 DVNECLS-NPCDPRGTqnCVQRVNDFHCECRAGHT-GRRCE 1305
Cdd:smart00179    1 DIDECASgNPCQNGGT--CVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
298-330 2.54e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.54e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224967065  298 ECQLmPNACQNGGTCHNTHGGYNCVCVNGWTGE 330
Cdd:cd00053     1 ECAA-SNPCSNGGTCVNTPGSYRCVCPPGYTGD 32
hEGF pfam12661
Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six ...
1238-1259 2.70e-03

Human growth factor-like EGF; hEGF, or human growth factor-like EGF, domains have six conserved residues disulfide-bonded into the characteriztic 'ababcc' pattern. They are involved in growth and proliferation of cells, in proteins of the Notch/Delta pathway, neurogulin and selectins. hEGFs are also found in mosaic proteins with four-disulfide laminin EGFs such as aggrecan and perlecan. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal Cys residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In hEGFs the C-terminal thiol resides in the beta-turn, resulting in shorter loop-lengths between the Cys residues of disulfide 'c', typically C[8-9]XC. These shorter loop-lengths are also typical of the four-disulfide EGF domains, laminin ad integrin. Tandem hEGF domains have six linking residues between terminal cysteines of adjacent domains. hEGF domains may or may not bind calcium in the linker region. hEGF domains with the consensus motif CXD4X[F,Y]XCXC are hydroxylated exclusively in the Asp residue.


Pssm-ID: 463660  Cd Length: 22  Bit Score: 37.31  E-value: 2.70e-03
                           10        20
                   ....*....|....*....|..
gi 224967065  1238 CFNNGTCVDQVGGYTCTCPPGF 1259
Cdd:pfam12661    1 CQNGGTCVDGVNGYKCQCPPGY 22
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
682-712 2.76e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 37.36  E-value: 2.76e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   682 CAGSPCHNGGTCEDGIAGFTCRCPEGYHDPT 712
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1233-1263 2.89e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 37.46  E-value: 2.89e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 224967065 1233 SRSPKCFNNGTCVDQVGGYTCTCPPGFVGER 1263
Cdd:cd00053     3 AASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
1923-1994 3.41e-03

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 42.58  E-value: 3.41e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 224967065 1923 HLAARySRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRAtDLDARMHDGTTPLILAAR 1994
Cdd:PTZ00322   88 QLAAS-GDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGA-DPTLLDKDGKTPLELAEE 157
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
949-979 3.56e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 3.56e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 224967065   949 CASNPCQNGANCTDCVDSYTCTCPVGFNGIH 979
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
257-293 4.45e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.45e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    257 NVDDC-PGNNCKNGGACVDGVNTYNCRCPPEWT-GQYCT 293
Cdd:smart00179    1 DIDECaSGNPCQNGGTCVNTVGSYRCECPPGYTdGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
716-751 4.50e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 4.50e-03
                            10        20        30
                    ....*....|....*....|....*....|....*....
gi 224967065    716 EVNECNS-NPCIHGA-CRDGLNGYKCDCAPGWS-GTNCD 751
Cdd:smart00179    1 DIDECASgNPCQNGGtCVNTVGSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
876-905 4.59e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 4.59e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 224967065  876 SPCRHGASCQNTNGSYRCLCQAGYTG-RNCE 905
Cdd:cd00053     6 NPCSNGGTCVNTPGSYRCVCPPGYTGdRSCE 36
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1148-1179 4.68e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 4.68e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224967065 1148 ECS-PNPCQNGATCTDYLGGFSCKCVAGYHGSN 1179
Cdd:cd00053     1 ECAaSNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
641-675 5.08e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.08e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 224967065  641 NLDDCAS-NPCD-SGTCLDKIDGYECACEPGYTGSMC 675
Cdd:cd00054     1 DIDECASgNPCQnGGTCVNTVGSYRCSCPPGYTGRNC 37
PHA02874 PHA02874
ankyrin repeat protein; Provisional
1920-2103 5.32e-03

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 41.87  E-value: 5.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1920 TALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNratdldarmhdGTTPLILAARLAVEG 1999
Cdd:PHA02874   37 TPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGAHDIIKLLIDN-----------GVDTSILPIPCIEKD 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 2000 MLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDI 2079
Cdd:PHA02874  106 MIKTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV 185
                         170       180
                  ....*....|....*....|....
gi 224967065 2080 TDHMDRLPRDIAQERMHHDIVRLL 2103
Cdd:PHA02874  186 KDNNGESPLHNAAEYGDYACIKLL 209
PHA02946 PHA02946
ankyin-like protein; Provisional
1869-2023 5.53e-03

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 41.96  E-value: 5.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1869 PDGFTPLMIASCSGGGLETGNSEEeedapavisdFIYQGASlHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQD 1948
Cdd:PHA02946   34 PSGNYHILHAYCGIKGLDERFVEE----------LLHRGYS-PNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACD 102
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 224967065 1949 NMGRTPLHAAVSADAQGVFQI--LLRNRATDLDARMHDGTTPLiLAARLAVEGMLEDLINSHADVNAVDDLGKSALH 2023
Cdd:PHA02946  103 KQHKTPLYYLSGTDDEVIERInlLVQYGAKINNSVDEEGCGPL-LACTDPSERVFKKIMSIGFEARIVDKFGKNHIH 178
EGF_CA pfam07645
Calcium-binding EGF domain;
452-481 5.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 224967065   452 DVNECIS--NPCQNDATCLDQIGEFQCICMPG 481
Cdd:pfam07645    1 DVDECATgtHNCPANTVCVNTIGSFECRCPDG 32
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
415-448 6.23e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.23e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 224967065  415 ECALGaNPCEHAGKCLNTLGSFECQCLQGYTGPR 448
Cdd:cd00053     1 ECAAS-NPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
1067-1094 6.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.44e-03
                          10        20
                  ....*....|....*....|....*...
gi 224967065 1067 PCKNGGRCWQTNTQYHCECRSGWTGVNC 1094
Cdd:cd00054    10 PCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
992-1016 6.48e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 6.48e-03
                          10        20
                  ....*....|....*....|....*
gi 224967065  992 CFNGGTCVDGINSFTCLCPPGFTGS 1016
Cdd:cd00053     8 CSNGGTCVNTPGSYRCVCPPGYTGD 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
335-364 6.67e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 6.67e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 224967065    335 NIDDCASAA-CFQGATCHDRVASFYCECPHG 364
Cdd:smart00179    1 DIDECASGNpCQNGGTCVNTVGSYRCECPPG 31
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
1026-1053 7.08e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 7.08e-03
                          10        20
                  ....*....|....*....|....*...
gi 224967065 1026 DSRPCLHGGTCQDSYGTYKCTCPQGYTG 1053
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTG 31
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
911-939 7.24e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.21  E-value: 7.24e-03
                           10        20
                   ....*....|....*....|....*....
gi 224967065   911 CRPNPCHNGGSCTDGINTAFCDCLPGFQG 939
Cdd:pfam00008    1 CAPNPCSNGGTCVDTPGGYTCICPEGYTG 29
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
145-174 7.44e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.30  E-value: 7.44e-03
                          10        20        30
                  ....*....|....*....|....*....|
gi 224967065  145 ASNPCANGGQCLPFESSYICRCPPGFHGPT 174
Cdd:cd00053     4 ASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
PHA02917 PHA02917
ankyrin-like protein; Provisional
1912-1960 8.44e-03

ankyrin-like protein; Provisional


Pssm-ID: 165231 [Multi-domain]  Cd Length: 661  Bit Score: 41.52  E-value: 8.44e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 224967065 1912 NQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVS 1960
Cdd:PHA02917  446 NMIDKRGETLLHKAVRYNKQSLVSLLLESGSDVNIRSNNGYTCIAIAIN 494
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
681-712 8.45e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 35.92  E-value: 8.45e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 224967065  681 ECAGS-PCHNGGTCEDGIAGFTCRCPEGYHDPT 712
Cdd:cd00053     1 ECAASnPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
421-448 8.99e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.99e-03
                           10        20
                   ....*....|....*....|....*...
gi 224967065   421 NPCEHAGKCLNTLGSFECQCLQGYTGPR 448
Cdd:pfam00008    4 NPCSNGGTCVDTPGGYTCICPEGYTGKR 31
PHA02743 PHA02743
Viral ankyrin protein; Provisional
1903-2020 9.49e-03

Viral ankyrin protein; Provisional


Pssm-ID: 222925 [Multi-domain]  Cd Length: 166  Bit Score: 39.41  E-value: 9.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 224967065 1903 FIYQGASLHNQTDRTGETALHLAARYSRSDAAKR---LLEASADANIQD-NMGRTPLHAAVSADAQGVFQILLRNRATDL 1978
Cdd:PHA02743   42 FISGDGHLLHRYDHHGRQCTHMVAWYDRANAVMKielLVNMGADINARElGTGNTLLHIAASTKNYELAEWLCRQLGVNL 121
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 224967065 1979 DARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKS 2020
Cdd:PHA02743  122 GAINYQHETAYHIAYKMRDRRMMEILRANGAVCDDPLSIGLS 163
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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