NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|164519050|ref|NP_032720|]
View 

neutrophilic granule protein precursor [Mus musculus]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Cathelicidins super family cl29764
Cathelicidin; A novel protein family, showing a conserved proregion and a variable ...
 23-121 4.68e-33

Cathelicidin; A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.


The actual alignment was detected with superfamily member pfam00666:

Pssm-ID: 453055  Cd Length: 101  Bit Score: 112.98  E-value: 4.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050   23 RQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPP--SSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTG 100
Cdd:pfam00666   1 QRLSYREAVLRAVDQFNEQSSEANLYRLLELDPPpqDDEDPDTPKPVSFRVKETVCPRTTQQPPEQCDFKENGLVKRCVG 80

                          90       100
                  ....*....|....*....|.
gi 164519050  101 KFFRRRQSTSLTLTCDRDCSR 121
Cdd:pfam00666  81 TVTLNQARDSFDIRCNEDQSR 101
 
Name Accession Description Interval E-value
Cathelicidins pfam00666
Cathelicidin; A novel protein family, showing a conserved proregion and a variable ...
 23-121 4.68e-33

Cathelicidin; A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.


Pssm-ID: 395539  Cd Length: 101  Bit Score: 112.98  E-value: 4.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050   23 RQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPP--SSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTG 100
Cdd:pfam00666   1 QRLSYREAVLRAVDQFNEQSSEANLYRLLELDPPpqDDEDPDTPKPVSFRVKETVCPRTTQQPPEQCDFKENGLVKRCVG 80

                          90       100
                  ....*....|....*....|.
gi 164519050  101 KFFRRRQSTSLTLTCDRDCSR 121
Cdd:pfam00666  81 TVTLNQARDSFDIRCNEDQSR 101
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-116 1.88e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 57.44  E-value: 1.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050    26 RYEEIVDRAIEAYNQGRQGRPLFRLLSATPPSSQNPA-TNIPLQFRIKETECTSTQErQPKDCDFLEDGEErNCTGKFFR 104
Cdd:smart00043  15 EVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAgTNYYLKVEVGETNCKKLSV-DLENCPFLDQGEK-FCTAKVWE 92

                           90
                   ....*....|....*
gi 164519050   105 RR---QSTSLTLTCD 116
Cdd:smart00043  93 KPwenKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-115 2.02e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 52.09  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050  26 RYEEIVDRAIEAYNQGRQGR--PLFRLLSATPPSSQNpaTNIPLQFRIKETECTSTQ-ERQPKDCDFLEDGEERNCTGKF 102
Cdd:cd00042   12 EVQELADFAVAEYNKKSNDKylEFFKVLSAKSQVVAG--TNYYITVEAGDTNCKKSSvPLDCPDCKLLEEGKKKFCTAKV 89

                         90
                 ....*....|....*.
gi 164519050 103 FRR---RQSTSLTLTC 115
Cdd:cd00042   90 WEKpweNFKELLSFKC 105
 
Name Accession Description Interval E-value
Cathelicidins pfam00666
Cathelicidin; A novel protein family, showing a conserved proregion and a variable ...
 23-121 4.68e-33

Cathelicidin; A novel protein family, showing a conserved proregion and a variable carboxyl-terminal antimicrobial domain. This region shows similarity to cystatins.


Pssm-ID: 395539  Cd Length: 101  Bit Score: 112.98  E-value: 4.68e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050   23 RQLRYEEIVDRAIEAYNQGRQGRPLFRLLSATPP--SSQNPATNIPLQFRIKETECTSTQERQPKDCDFLEDGEERNCTG 100
Cdd:pfam00666   1 QRLSYREAVLRAVDQFNEQSSEANLYRLLELDPPpqDDEDPDTPKPVSFRVKETVCPRTTQQPPEQCDFKENGLVKRCVG 80

                          90       100
                  ....*....|....*....|.
gi 164519050  101 KFFRRRQSTSLTLTCDRDCSR 121
Cdd:pfam00666  81 TVTLNQARDSFDIRCNEDQSR 101
CY smart00043
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-116 1.88e-11

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 214484  Cd Length: 107  Bit Score: 57.44  E-value: 1.88e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050    26 RYEEIVDRAIEAYNQGRQGRPLFRLLSATPPSSQNPA-TNIPLQFRIKETECTSTQErQPKDCDFLEDGEErNCTGKFFR 104
Cdd:smart00043  15 EVQEAADFAVAEYNKKSNDKYELRVIKVVSAKSQVVAgTNYYLKVEVGETNCKKLSV-DLENCPFLDQGEK-FCTAKVWE 92

                           90
                   ....*....|....*
gi 164519050   105 RR---QSTSLTLTCD 116
Cdd:smart00043  93 KPwenKIKLVEFKCT 107
CY cd00042
Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly ...
 26-115 2.02e-09

Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.


Pssm-ID: 238002 [Multi-domain]  Cd Length: 105  Bit Score: 52.09  E-value: 2.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 164519050  26 RYEEIVDRAIEAYNQGRQGR--PLFRLLSATPPSSQNpaTNIPLQFRIKETECTSTQ-ERQPKDCDFLEDGEERNCTGKF 102
Cdd:cd00042   12 EVQELADFAVAEYNKKSNDKylEFFKVLSAKSQVVAG--TNYYITVEAGDTNCKKSSvPLDCPDCKLLEEGKKKFCTAKV 89

                         90
                 ....*....|....*.
gi 164519050 103 FRR---RQSTSLTLTC 115
Cdd:cd00042   90 WEKpweNFKELLSFKC 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH