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Conserved domains on  [gi|117320545|ref|NP_032559|]
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CD180 antigen isoform 1 precursor [Mus musculus]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
194-559 3.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 194 SSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCE 273
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 274 MSvesiNLQKHYFFNISSNT-FHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQiSASNFPSLTHLSI 352
Cdd:COG4886   92 LG----DLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 353 KGNtkRLELGTGCLENLENLRELDLSHDDIETSDCcnlQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRL 432
Cdd:COG4886  167 SNN--QLTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 433 KVKDAqspFQNLHLLKVLNLSHSLL-DISSEQlfdGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSI 511
Cdd:COG4886  241 TDLPE---LGNLTNLEELDLSNNQLtDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 117320545 512 DQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIL 559
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 549-623 1.22e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 1.22e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320545   549 NLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTL 623
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
194-559 3.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 194 SSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCE 273
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 274 MSvesiNLQKHYFFNISSNT-FHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQiSASNFPSLTHLSI 352
Cdd:COG4886   92 LG----DLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 353 KGNtkRLELGTGCLENLENLRELDLSHDDIETSDCcnlQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRL 432
Cdd:COG4886  167 SNN--QLTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 433 KVKDAqspFQNLHLLKVLNLSHSLL-DISSEQlfdGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSI 511
Cdd:COG4886  241 TDLPE---LGNLTNLEELDLSNNQLtDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 117320545 512 DQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIL 559
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 221-249 2.23e-10

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 55.93  E-value: 2.23e-10
                          10        20
                  ....*....|....*....|....*....
gi 117320545  221 SAVFQSLNFGGTQNLLVIFKGLKNSTIQS 249
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-481 5.61e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545  41 NLGLNEIPGTLPNST----ECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPL--- 113
Cdd:PLN00113 124 NLSNNNFTGSIPRGSipnlETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgq 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 114 -------------IFMAETALSG--PK------ALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPT 172
Cdd:PLN00113 204 iprelgqmkslkwIYLGYNNLSGeiPYeiggltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSL 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 173 EKLKVLDFQNNaihYLSKEDMSSLQQATNLS-LNLNGNDIAGIELGAFDS----AVFQ--SLNFGG--TQNLlvifkGLK 243
Cdd:PLN00113 284 QKLISLDLSDN---SLSGEIPELVIQLQNLEiLHLFSNNFTGKIPVALTSlprlQVLQlwSNKFSGeiPKNL-----GKH 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 244 NSTiqslwlgTFEDMDDEDISPAVFEGLCemsvESINLQKHYFFN------ISSNTFHCFSgLQELDLTATHLS-ELPSG 316
Cdd:PLN00113 356 NNL-------TVLDLSTNNLTGEIPEGLC----SSGNLFKLILFSnslegeIPKSLGACRS-LRRVRLQDNSFSgELPSE 423

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 317 LVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTgcLENLENLRELDLSHDDIetSDCCNLQLRNLS 396
Cdd:PLN00113 424 FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD--SFGSKRLENLDLSRNQF--SGAVPRKLGSLS 499

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 397 HLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSpFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNL 476
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPAS-FSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNI 578


                 ....*
gi 117320545 477 QGNHF 481
Cdd:PLN00113 579 SHNHL 583
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 549-623 1.22e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 1.22e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320545   549 NLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTL 623
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 323-481 2.31e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 323 LKKLVLSANKFENLCQISasNFPSLTHLSIKGNT-KRLElgtgCLENLENLRELDLSHDDIETSDccnlQLRNLSHLQSL 401
Cdd:cd21340   26 LKVLYLYDNKITKIENLE--FLTNLTHLYLQNNQiEKIE----NLENLVNLKKLYLGGNRISVVE----GLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 402 NLSYN----------EPLSLKTEAfkecPQLELLDLAFTRLkvkDAQSPFQNLHLLKVLNLSHSLLDISSE--QLFDGLP 469
Cdd:cd21340   96 HIENQrlppgekltfDPRSLAALS----NSLRVLNISGNNI---DSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                        170
                 ....*....|..
gi 117320545 470 ALQHLNLQGNHF 481
Cdd:cd21340  169 SLRELDLTGNPV 180
LRRCT smart00082
Leucine rich repeat C-terminal domain;
577-626 1.85e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 1.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 117320545   577 NPLDCTCSNIYFLEWyKENMQKLEDTEDTLCENPPLLRG--VRLSDVTLSCS 626
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASPSSLRGplLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
194-559 3.80e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.80e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 194 SSLQQATNLSLNLNGNDIAGIELGAFDSAVFQSLNFGGTQNLLVIFKGLKNSTIQSLWLGTFEDMDDEDISPAVFEGLCE 273
Cdd:COG4886   12 LLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 274 MSvesiNLQKHYFFNISSNT-FHCFSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQiSASNFPSLTHLSI 352
Cdd:COG4886   92 LG----DLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDL 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 353 KGNtkRLELGTGCLENLENLRELDLSHDDIETSDCcnlQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRL 432
Cdd:COG4886  167 SNN--QLTDLPEELGNLTNLKELDLSNNQITDLPE---PLGNLTNLEELDLSGNQ-LTDLPEPLANLTNLETLDLSNNQL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 433 KVKDAqspFQNLHLLKVLNLSHSLL-DISSEQlfdGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSI 511
Cdd:COG4886  241 TDLPE---LGNLTNLEELDLSNNQLtDLPPLA---NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELL 314

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*...
gi 117320545 512 DQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGIYLNLASNRISIIL 559
Cdd:COG4886  315 ILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
303-574 2.74e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 75.36  E-value: 2.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 303 LDLTATHLSELPSGLVGLSTLKKLVLSANKfenlcqiSASNFPSLTHLSIKGNtkRLELGTGCLENLENLRELDLSHDDI 382
Cdd:COG4886   78 SLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGN--QLTDLPEELANLTNLKELDLSNNQL 148

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 383 ETSDccnLQLRNLSHLQSLNLSYNEpLSLKTEAFKECPQLELLDLAFTRLKvkDAQSPFQNLHLLKVLNLSHSLL-DISS 461
Cdd:COG4886  149 TDLP---EPLGNLTNLKSLDLSNNQ-LTDLPEELGNLTNLKELDLSNNQIT--DLPEPLGNLTNLEELDLSGNQLtDLPE 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 462 EqlFDGLPALQHLNLQGNhfpkgNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAftSLKMMNHVDLSHNRLTSSSIEALS 541
Cdd:COG4886  223 P--LANLTNLETLDLSNN-----QLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELE 293

                        250       260       270
                 ....*....|....*....|....*....|...
gi 117320545 542 HLKGIYLNLASNRISIILPSLLPILSQQRTINL 574
Cdd:COG4886  294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 221-249 2.23e-10

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 55.93  E-value: 2.23e-10
                          10        20
                  ....*....|....*....|....*....
gi 117320545  221 SAVFQSLNFGGTQNLLVIFKGLKNSTIQS 249
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
33-508 5.54e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 5.54e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545  33 VNKTYNCENLGLNEIPGTLPNSTECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANP 112
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 113 LIFMAETALSGPKALKHLffiqTGISSIDFIPLHNQKTLESLYLGSNHISSikLPKGFPT-EKLKVLDFQNNAIHYLSke 191
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNL----TELDLSGNEELSNLTNLESLDLSGNQLTD--LPEELANlTNLKELDLSNNQLTDLP-- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 192 dmSSLQQATNL-SLNLNGNDIAGIELGAFDSAVFQSLNFGGTQnllvifkglknstIQSLwlgtfedmddedisPAVFEG 270
Cdd:COG4886  153 --EPLGNLTNLkSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ-------------ITDL--------------PEPLGN 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 271 LcemsvesinlqkhyffnissntfhcfSGLQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLCQIsaSNFPSLTHL 350
Cdd:COG4886  204 L--------------------------TNLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPEL--GNLTNLEEL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 351 SIKGNTKRlelGTGCLENLENLRELDLSHDDIETSDCCNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFT 430
Cdd:COG4886  256 DLSNNQLT---DLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKG 332

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 117320545 431 RLKVKDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDL 508
Cdd:COG4886  333 LLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDA 410
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 41-481 5.61e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 62.56  E-value: 5.61e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545  41 NLGLNEIPGTLPNST----ECLEFSFNVLPTIQNTTFSRLINLTFLDLTRCQIYWIHEDTFQSQHRLDTLVLTANPL--- 113
Cdd:PLN00113 124 NLSNNNFTGSIPRGSipnlETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgq 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 114 -------------IFMAETALSG--PK------ALKHLFFIQTGISSIDFIPLHNQKTLESLYLGSNHISSIKLPKGFPT 172
Cdd:PLN00113 204 iprelgqmkslkwIYLGYNNLSGeiPYeiggltSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSL 283

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 173 EKLKVLDFQNNaihYLSKEDMSSLQQATNLS-LNLNGNDIAGIELGAFDS----AVFQ--SLNFGG--TQNLlvifkGLK 243
Cdd:PLN00113 284 QKLISLDLSDN---SLSGEIPELVIQLQNLEiLHLFSNNFTGKIPVALTSlprlQVLQlwSNKFSGeiPKNL-----GKH 355

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 244 NSTiqslwlgTFEDMDDEDISPAVFEGLCemsvESINLQKHYFFN------ISSNTFHCFSgLQELDLTATHLS-ELPSG 316
Cdd:PLN00113 356 NNL-------TVLDLSTNNLTGEIPEGLC----SSGNLFKLILFSnslegeIPKSLGACRS-LRRVRLQDNSFSgELPSE 423

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 317 LVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLELGTgcLENLENLRELDLSHDDIetSDCCNLQLRNLS 396
Cdd:PLN00113 424 FTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPD--SFGSKRLENLDLSRNQF--SGAVPRKLGSLS 499

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 397 HLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSpFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNL 476
Cdd:PLN00113 500 ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPAS-FSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNI 578


                 ....*
gi 117320545 477 QGNHF 481
Cdd:PLN00113 579 SHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
420-481 1.13e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 1.13e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320545  420 PQLELLDLAFTRLKVkDAQSPFQNLHLLKVLNLSHSLLDISSEQLFDGLPALQHLNLQGNHF 481
Cdd:pfam13855   1 PNLRSLDLSNNRLTS-LDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
300-519 1.89e-08

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 1.89e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 300 LQELDLTATHLSELPSGLVGLSTLKKLVLSANKFENLcQISASNFPSLTHLSIKGNT-KRLElgtgCLENLENLRELDLS 378
Cdd:COG4886  184 LKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQlTDLP----ELGNLTNLEELDLS 258

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 379 HDDIETSDccnlQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRLKVKDAQSPFQNLHLLKVLNLSHSLLD 458
Cdd:COG4886  259 NNQLTDLP----PLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLL 334

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 117320545 459 ISSEQLFDGLPALQHLNLQGNHFPKGNIQKTNSLQTLGRLEILVLSFCDLSSIDQHAFTSL 519
Cdd:COG4886  335 VTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLT 395
LRR_8 pfam13855
Leucine rich repeat;
497-555 3.21e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 3.21e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545  497 RLEILVLSFCDLSSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRI 555
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLrYLDLSGNRL 61
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 549-623 1.22e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.01  E-value: 1.22e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 117320545   549 NLASNRISIILPSLLPILSQQRTINLRQNPLDCTCSNIYFLEWYKENMQKLEDTEDTLCENPPLLRGVRLSDVTL 623
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPL 75
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 323-481 2.31e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 49.01  E-value: 2.31e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 323 LKKLVLSANKFENLCQISasNFPSLTHLSIKGNT-KRLElgtgCLENLENLRELDLSHDDIETSDccnlQLRNLSHLQSL 401
Cdd:cd21340   26 LKVLYLYDNKITKIENLE--FLTNLTHLYLQNNQiEKIE----NLENLVNLKKLYLGGNRISVVE----GLENLTNLEEL 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 402 NLSYN----------EPLSLKTEAfkecPQLELLDLAFTRLkvkDAQSPFQNLHLLKVLNLSHSLLDISSE--QLFDGLP 469
Cdd:cd21340   96 HIENQrlppgekltfDPRSLAALS----NSLRVLNISGNNI---DSLEPLAPLRNLEQLDASNNQISDLEEllDLLSSWP 168

                        170
                 ....*....|..
gi 117320545 470 ALQHLNLQGNHF 481
Cdd:cd21340  169 SLRELDLTGNPV 180
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 346-534 3.50e-06

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 48.63  E-value: 3.50e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 346 SLTHLSIkgNTKRLElGTGCLENLENLRELDLSHDDIETsdCCNLQlrNLSHLQSLNLSYNEpLSlKTEAFKECPQLELL 425
Cdd:cd21340    3 RITHLYL--NDKNIT-KIDNLSLCKNLKVLYLYDNKITK--IENLE--FLTNLTHLYLQNNQ-IE-KIENLENLVNLKKL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 426 DLAFTRLKVKDAqspFQNLHLLKVLNLSHSLLDISSEQLFDG------LPALQHLNLQGNhfpkgNIQKTNSLQTLGRLE 499
Cdd:cd21340   74 YLGGNRISVVEG---LENLTNLEELHIENQRLPPGEKLTFDPrslaalSNSLRVLNISGN-----NIDSLEPLAPLRNLE 145

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 117320545 500 ILVLSFCDLSSIDQ--HAFTSLKMMNHVDLSHNRLTS 534
Cdd:cd21340  146 QLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCK 182
LRRCT smart00082
Leucine rich repeat C-terminal domain;
577-626 1.85e-05

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 42.42  E-value: 1.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 117320545   577 NPLDCTCSNIYFLEWyKENMQKLEDTEDTLCENPPLLRG--VRLSDVTLSCS 626
Cdd:smart00082   1 NPFICDCELRWLLRW-LQANEHLQDPVDLRCASPSSLRGplLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
321-382 3.23e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.23e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320545  321 STLKKLVLSANKFENLCQISASNFPSLTHLSIKGNTKRLeLGTGCLENLENLRELDLSHDDI 382
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT-LSPGAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 345-541 1.97e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 43.88  E-value: 1.97e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 345 PSLTHLSIKGN-TKRLELGTGC----LENLENLRELDLSHDDIETSDCCNLQ-LRNLSHLQSLNLSYNE----PLSLKTE 414
Cdd:cd00116   51 PSLKELCLSLNeTGRIPRGLQSllqgLTKGCGLQELDLSDNALGPDGCGVLEsLLRSSSLQELKLNNNGlgdrGLRLLAK 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 415 AFKEC-PQLELLDLAFTRLKV---KDAQSPFQNLHLLKVLNLS-HSLLDISSEQLFDGLPA---LQHLNLQGNhfpkgni 486
Cdd:cd00116  131 GLKDLpPALEKLVLGRNRLEGascEALAKALRANRDLKELNLAnNGIGDAGIRALAEGLKAncnLEVLDLNNN------- 203

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 117320545 487 qktnslqTLGRLEILVLSfcdlssidqHAFTSLKMMNHVDLSHNRLTSSSIEALS 541
Cdd:cd00116  204 -------GLTDEGASALA---------ETLASLKSLEVLNLGDNNLTDAGAAALA 242
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 295-461 7.92e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 41.96  E-value: 7.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 295 HCFSGLQELDLTATHLS-----ELPSGLVGLSTLKKLVLSANK-----FENLCQISASNfPSLTHLSIKGNTKRLELG-- 362
Cdd:cd00116  134 DLPPALEKLVLGRNRLEgasceALAKALRANRDLKELNLANNGigdagIRALAEGLKAN-CNLEVLDLNNNGLTDEGAsa 212

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 363 -TGCLENLENLRELDLSHDDIETSDCCNL--QLRNLSH-LQSLNLSYNE--PLSLKT--EAFKECPQLELLDLAFTRLKV 434
Cdd:cd00116  213 lAETLASLKSLEVLNLGDNNLTDAGAAALasALLSPNIsLLTLSLSCNDitDDGAKDlaEVLAEKESLLELDLRGNKFGE 292

                        170       180
                 ....*....|....*....|....*..
gi 117320545 435 KDAQSPFQNLHLLKVLNLSHSLLDISS 461
Cdd:cd00116  293 EGAQLLAESLLEPGNELESLWVKDDSF 319
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 300-579 2.03e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.37  E-value: 2.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 300 LQELDLTATHLS-ELPSGLVGLSTLKKLVLSANKFENLCQISASNFPSLTHLSIKGNtkrlELGTGCLENL---ENLREL 375
Cdd:PLN00113 286 LISLDLSDNSLSgEIPELVIQLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSN----KFSGEIPKNLgkhNNLTVL 361

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 376 DLSHDD----IETSDCCNLQLRNLShLQSLNLSYNEPLSLKTeafkeCPQLELLDLAFTRLKvKDAQSPFQNLHLLKVLN 451
Cdd:PLN00113 362 DLSTNNltgeIPEGLCSSGNLFKLI-LFSNSLEGEIPKSLGA-----CRSLRRVRLQDNSFS-GELPSEFTKLPLVYFLD 434

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 452 LSHS-----------------LLDISSEQLFDGLP------ALQHLNLQGNHFpKGNIqkTNSLQTLGRLEILVLSFCDL 508
Cdd:PLN00113 435 ISNNnlqgrinsrkwdmpslqMLSLARNKFFGGLPdsfgskRLENLDLSRNQF-SGAV--PRKLGSLSELMQLKLSENKL 511

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320545 509 SSIDQHAFTSLKMMNHVDLSHNRLTSSSIEALSHLKGI-YLNLASNRISIILPSLLPILSQQRTINLRQNPL 579
Cdd:PLN00113 512 SGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLsQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
LRR_8 pfam13855
Leucine rich repeat;
371-432 6.24e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.24e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 117320545  371 NLRELDLSHDDIETSDccNLQLRNLSHLQSLNLSYNEPLSLKTEAFKECPQLELLDLAFTRL 432
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 129-355 6.67e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 6.67e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 129 HLFFIQTGISSIDFipLHNQKTLESLYLGSNHISSIKLPKGFPteKLKVLDFQNNAIhylskEDMSSLQQATNLS-LNLN 207
Cdd:cd21340    6 HLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIENLEFLT--NLTHLYLQNNQI-----EKIENLENLVNLKkLYLG 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117320545 208 GNDIAGIElgafdsavfqslNFGGTQNL--LVIFKglknstiQSLWLGtfedmddedispavfEGLC--EMSVESInlqk 283
Cdd:cd21340   77 GNRISVVE------------GLENLTNLeeLHIEN-------QRLPPG---------------EKLTfdPRSLAAL---- 118

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117320545 284 hyffnisSNTfhcfsgLQELDLTATHLSELpSGLVGLSTLKKLVLSANKFENLCQISA--SNFPSLTHLSIKGN 355
Cdd:cd21340  119 -------SNS------LRVLNISGNNIDSL-EPLAPLRNLEQLDASNNQISDLEELLDllSSWPSLRELDLTGN 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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