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Conserved domains on  [gi|168693654|ref|NP_032370|]
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insulin-like growth factor-binding protein 6 precursor [Mus musculus]

Protein Classification

insulin-like growth factor-binding protein( domain architecture ID 11254546)

insulin-like growth factor-binding protein (IGFBP) controls the bioavailability, activity, and distribution of insulin-like growth factor (IGF) through high-affinity IGFBP/IGF complexes

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-106 4.29e-18

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


:

Pssm-ID: 197525  Cd Length: 75  Bit Score: 75.97  E-value: 4.29e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 168693654    28 AGCPGCGAGMQTGCRGGCVEeedaGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQCQPRENEEAPLRALLIGQGRCQ 106
Cdd:smart00121   1 ARCPPCDPARCPPCPPGCAE----LVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 160-232 4.72e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


:

Pssm-ID: 459665  Cd Length: 66  Bit Score: 72.72  E-value: 4.72e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168693654  160 CRRHLDSVLQQLQTevfRGGARGLYVPNCDLRGFYRKQQCRSSqgnrRGPCWCVDPMGQPLPVSPDGQGSTQC 232
Cdd:pfam00086   1 CERERARALEQAAS---GRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGGDPDC 66
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-106 4.29e-18

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 75.97  E-value: 4.29e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 168693654    28 AGCPGCGAGMQTGCRGGCVEeedaGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQCQPRENEEAPLRALLIGQGRCQ 106
Cdd:smart00121   1 ARCPPCDPARCPPCPPGCAE----LVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 160-232 4.72e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 72.72  E-value: 4.72e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168693654  160 CRRHLDSVLQQLQTevfRGGARGLYVPNCDLRGFYRKQQCRSSqgnrRGPCWCVDPMGQPLPVSPDGQGSTQC 232
Cdd:pfam00086   1 CERERARALEQAAS---GRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 159-232 4.93e-15

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 67.49  E-value: 4.93e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168693654 159 PCRRHLDSVLQQLQTEVFRGgargLYVPNCDLRGFYRKQQCRSSQgnrrGPCWCVDPMGQPLPVSPDGQGSTQC 232
Cdd:cd00191    1 PCERERASALESLAGPKLSG----LYVPQCDEDGNYEPVQCHGST----GYCWCVDPDGEEIPGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 185-233 3.51e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 48.53  E-value: 3.51e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 168693654   185 VPNCDLRGFYRKQQCRSSqgnrRGPCWCVDPMGQPLPVSPDGQGSTQCS 233
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDATGREIPGTRTEGGDPDCP 45
IGFBP pfam00219
Insulin-like growth factor binding protein;
51-85 1.63e-05

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 41.16  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 168693654   51 AGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQC 85
Cdd:pfam00219  19 AGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
 
Name Accession Description Interval E-value
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 28-106 4.29e-18

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 75.97  E-value: 4.29e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 168693654    28 AGCPGCGAGMQTGCRGGCVEeedaGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQCQPRENEEAPLRALLIGQGRCQ 106
Cdd:smart00121   1 ARCPPCDPARCPPCPPGCAE----LVRLDGCGCCPVCARQEGEPCGVYTPRCAPGLRCQPPPGEERPLRALLHGQGVCM 75
Thyroglobulin_1 pfam00086
Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the ...
 160-232 4.72e-17

Thyroglobulin type-1 repeat; Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.


Pssm-ID: 459665  Cd Length: 66  Bit Score: 72.72  E-value: 4.72e-17
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 168693654  160 CRRHLDSVLQQLQTevfRGGARGLYVPNCDLRGFYRKQQCRSSqgnrRGPCWCVDPMGQPLPVSPDGQGSTQC 232
Cdd:pfam00086   1 CERERARALEQAAS---GRPASGLYIPNCDEDGFYKPVQCHGS----TGYCWCVDPEGQEIPGTRTRGGDPDC 66
TY cd00191
Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 159-232 4.93e-15

Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases


Pssm-ID: 238114  Cd Length: 66  Bit Score: 67.49  E-value: 4.93e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 168693654 159 PCRRHLDSVLQQLQTEVFRGgargLYVPNCDLRGFYRKQQCRSSQgnrrGPCWCVDPMGQPLPVSPDGQGSTQC 232
Cdd:cd00191    1 PCERERASALESLAGPKLSG----LYVPQCDEDGNYEPVQCHGST----GYCWCVDPDGEEIPGTRTRGGPPNC 66
TY smart00211
Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 ...
 185-233 3.51e-08

Thyroglobulin type I repeats; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases and binding partners of heparin.


Pssm-ID: 214561  Cd Length: 46  Bit Score: 48.53  E-value: 3.51e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 168693654   185 VPNCDLRGFYRKQQCRSSqgnrRGPCWCVDPMGQPLPVSPDGQGSTQCS 233
Cdd:smart00211   1 IPQCDEDGNYEPVQCDGS----SGQCWCVDATGREIPGTRTEGGDPDCP 45
IGFBP pfam00219
Insulin-like growth factor binding protein;
51-85 1.63e-05

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 41.16  E-value: 1.63e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 168693654   51 AGSPADGCTEAGGCLRREGQPCGVYSPKCAPGLQC 85
Cdd:pfam00219  19 AGVVLDGCGCCKVCARQEGEPCGVYTPPCGKGLRC 53
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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