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Conserved domains on  [gi|6680225|ref|NP_032276|]
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H2.0-like homeobox protein [Mus musculus]

Protein Classification

homeobox domain-containing protein( domain architecture ID 10441114)

homeobox domain-containing protein may be involved in the transcriptional regulation of key eukaryotic developmental processes

CATH:  1.10.10.60
Gene Ontology:  GO:0003677
PubMed:  21557080|26464018|27768937|1357790
SCOP:  4000291

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
270-330 1.12e-23

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 93.72  E-value: 1.12e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680225    270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH 330
Cdd:pfam00046   1 RRKRT----TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
270-330 1.12e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 93.72  E-value: 1.12e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680225    270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH 330
Cdd:pfam00046   1 RRKRT----TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 270-329 2.66e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 86.92  E-value: 2.66e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680225     270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWR 329
Cdd:smart00389   2 RRKRT----SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 270-332 4.34e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.53  E-value: 4.34e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6680225  270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSK 332
Cdd:cd00086   1 RRKRT----RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
224-341 1.44e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 1.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680225  224 LDPISEASAILSPLS---SNPRNSVQHQFQDTFPGPYAVLTKDTmPQTYKRKRSwsravfSNLQRKGLEKRFEIQKYVTK 300
Cdd:COG5576   6 MQPLSALESQRMPQIrtiKTTKNKREVEAADSEMKLERKQDGSS-PPKSKRRRT------TDEQLMVLEREFEINPYPSS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6680225  301 PDRKQLAAMLGLTDAQVKVWFQNRRMKWRhsKEAQAQKDKD 341
Cdd:COG5576  79 ITRIKLSLLLNMPPKSVQIWFQNKRAKEK--KKRSGKVEQR 117
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
270-330 1.12e-23

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 93.72  E-value: 1.12e-23
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680225    270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH 330
Cdd:pfam00046   1 RRKRT----TFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 270-329 2.66e-21

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 86.92  E-value: 2.66e-21
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680225     270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWR 329
Cdd:smart00389   2 RRKRT----SFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 270-332 4.34e-21

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 86.53  E-value: 4.34e-21
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6680225  270 KRKRSwsraVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSK 332
Cdd:cd00086   1 RRKRT----RFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
224-341 1.44e-07

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 50.90  E-value: 1.44e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680225  224 LDPISEASAILSPLS---SNPRNSVQHQFQDTFPGPYAVLTKDTmPQTYKRKRSwsravfSNLQRKGLEKRFEIQKYVTK 300
Cdd:COG5576   6 MQPLSALESQRMPQIrtiKTTKNKREVEAADSEMKLERKQDGSS-PPKSKRRRT------TDEQLMVLEREFEINPYPSS 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6680225  301 PDRKQLAAMLGLTDAQVKVWFQNRRMKWRhsKEAQAQKDKD 341
Cdd:COG5576  79 ITRIKLSLLLNMPPKSVQIWFQNKRAKEK--KKRSGKVEQR 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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