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Conserved domains on  [gi|33468853|ref|NP_032126|]
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pro-glucagon preproprotein [Mus musculus]

Protein Classification

glucagon family hormone( domain architecture ID 10443965)

glucagon family hormone similar to glucagon, somatoliberin and VIP peptides

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 53-80 8.35e-12

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


:

Pssm-ID: 459681  Cd Length: 28  Bit Score: 56.68  E-value: 8.35e-12
                          10        20
                  ....*....|....*....|....*...
gi 33468853    53 HSQGTFTSDYSKYLDSRRAQDFVQWLMN 80
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 146-173 1.31e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


:

Pssm-ID: 459681  Cd Length: 28  Bit Score: 50.91  E-value: 1.31e-09
                          10        20
                  ....*....|....*....|....*...
gi 33468853   146 HADGSFSDEMSTILDNLATRDFINWLIQ 173
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 98-125 1.02e-08

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


:

Pssm-ID: 459681  Cd Length: 28  Bit Score: 48.59  E-value: 1.02e-08
                          10        20
                  ....*....|....*....|....*...
gi 33468853    98 HAEGTFTSDVSSYLEGQAAKEFIAWLVK 125
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
 
Name Accession Description Interval E-value
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 53-80 8.35e-12

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 56.68  E-value: 8.35e-12
                          10        20
                  ....*....|....*....|....*...
gi 33468853    53 HSQGTFTSDYSKYLDSRRAQDFVQWLMN 80
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
53-79 4.65e-11

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 54.83  E-value: 4.65e-11
                           10        20
                   ....*....|....*....|....*..
gi 33468853     53 HSQGTFTSDYSKYLDSRRAQDFVQWLM 79
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 146-173 1.31e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 50.91  E-value: 1.31e-09
                          10        20
                  ....*....|....*....|....*...
gi 33468853   146 HADGSFSDEMSTILDNLATRDFINWLIQ 173
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 98-125 1.02e-08

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 48.59  E-value: 1.02e-08
                          10        20
                  ....*....|....*....|....*...
gi 33468853    98 HAEGTFTSDVSSYLEGQAAKEFIAWLVK 125
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
98-124 1.76e-08

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 47.89  E-value: 1.76e-08
                           10        20
                   ....*....|....*....|....*..
gi 33468853     98 HAEGTFTSDVSSYLEGQAAKEFIAWLV 124
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
GLUCA smart00070
Glucagon like hormones;
146-172 4.78e-07

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 44.04  E-value: 4.78e-07
                           10        20
                   ....*....|....*....|....*..
gi 33468853    146 HADGSFSDEMSTILDNLATRDFINWLI 172
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
 
Name Accession Description Interval E-value
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 53-80 8.35e-12

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 56.68  E-value: 8.35e-12
                          10        20
                  ....*....|....*....|....*...
gi 33468853    53 HSQGTFTSDYSKYLDSRRAQDFVQWLMN 80
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
53-79 4.65e-11

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 54.83  E-value: 4.65e-11
                           10        20
                   ....*....|....*....|....*..
gi 33468853     53 HSQGTFTSDYSKYLDSRRAQDFVQWLM 79
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 146-173 1.31e-09

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 50.91  E-value: 1.31e-09
                          10        20
                  ....*....|....*....|....*...
gi 33468853   146 HADGSFSDEMSTILDNLATRDFINWLIQ 173
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
Hormone_2 pfam00123
Peptide hormone; This family contains glucagon, GIP, secretin and VIP.
 98-125 1.02e-08

Peptide hormone; This family contains glucagon, GIP, secretin and VIP.


Pssm-ID: 459681  Cd Length: 28  Bit Score: 48.59  E-value: 1.02e-08
                          10        20
                  ....*....|....*....|....*...
gi 33468853    98 HAEGTFTSDVSSYLEGQAAKEFIAWLVK 125
Cdd:pfam00123   1 HADGTFTSDYSKVLDQLAAKKFLQWLMN 28
GLUCA smart00070
Glucagon like hormones;
98-124 1.76e-08

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 47.89  E-value: 1.76e-08
                           10        20
                   ....*....|....*....|....*..
gi 33468853     98 HAEGTFTSDVSSYLEGQAAKEFIAWLV 124
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
GLUCA smart00070
Glucagon like hormones;
146-172 4.78e-07

Glucagon like hormones;


Pssm-ID: 128384  Cd Length: 27  Bit Score: 44.04  E-value: 4.78e-07
                           10        20
                   ....*....|....*....|....*..
gi 33468853    146 HADGSFSDEMSTILDNLATRDFINWLI 172
Cdd:smart00070   1 HADGTFTSDYSKYLDQLAAKKFLQWLM 27
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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