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Conserved domains on  [gi|6679931|ref|NP_032107|]
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beta-1,4 N-acetylgalactosaminyltransferase 2 [Mus musculus]

Protein Classification

glycosyltransferase family 2 protein( domain architecture ID 10455355)

glycosyltransferase family 2 protein catalyzes the transfer of saccharide moieties from a donor to an acceptor to form glycosidic bonds

CATH:  3.90.550.10
CAZY:  GT2
EC:  2.4.-.-
Gene Ontology:  GO:0016757|GO:0006486
SCOP:  3000077

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
268-412 4.30e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


:

Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 75.89  E-value: 4.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931    268 TIATKTFLRPHKLKILLQSIRK-YYPDITVIVADDS--KEPLEINDDY------VEYYTMPFGKGWFAGRNLAISQVTTK 338
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstDGTVEIAEEYakkdprVRVIRLPENRGKAGARNAGLRAATGD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6679931    339 YVLWVDDDFLFSDKtKIEVLVDVLEKTELDVVGGSV---QGNTYQFRLLYEQTKNGSC--LHQRWGSFQALDGFPGCTL 412
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRyviFGETGEYRRASRITLSRLPffLGLRLLGLNLPFLIGGFAL 158
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
268-412 4.30e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 75.89  E-value: 4.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931    268 TIATKTFLRPHKLKILLQSIRK-YYPDITVIVADDS--KEPLEINDDY------VEYYTMPFGKGWFAGRNLAISQVTTK 338
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstDGTVEIAEEYakkdprVRVIRLPENRGKAGARNAGLRAATGD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6679931    339 YVLWVDDDFLFSDKtKIEVLVDVLEKTELDVVGGSV---QGNTYQFRLLYEQTKNGSC--LHQRWGSFQALDGFPGCTL 412
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRyviFGETGEYRRASRITLSRLPffLGLRLLGLNLPFLIGGFAL 158
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
266-434 3.34e-10

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 59.72  E-value: 3.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  266 LVTIATKTFLRPHKLKILLQSIRKY-YPDITVIVADD-SK-------EPLEINDDYVEYYTMPFGKGWFAGRNLAISQVT 336
Cdd:COG0463   3 LVSVVIPTYNEEEYLEEALESLLAQtYPDFEIIVVDDgSTdgtaeilRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  337 TKYVLWVDDDFLFsDKTKIEVLVDVLEKTELDVVGGSvqgntyqfrllyEQTKNGSCLHQRWGSFQALDGFPGCTLTSGV 416
Cdd:COG0463  83 GDYIAFLDADDQL-DPEKLEELVAALEEGPADLVYGS------------RLIREGESDLRRLGSRLFNLVRLLTNLPDST 149
                       170
                ....*....|....*...
gi 6679931  417 VNFFLAHTEQLRRVGFDP 434
Cdd:COG0463 150 SGFRLFRREVLEELGFDE 167
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
280-372 8.68e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 51.74  E-value: 8.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  280 LKILLQSIRKY-YPDITVIVADD--SKEPLEI------NDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFs 350
Cdd:cd00761  12 LERCLESLLAQtYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLL- 90
                        90       100
                ....*....|....*....|...
gi 6679931  351 DKTKIEVLVDVLEK-TELDVVGG 372
Cdd:cd00761  91 LPDWLERLVAELLAdPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
267-381 2.09e-07

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 51.53  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931    267 VTIATKTFLRPHKLKILLQSIRKYYPDITVIVADDSKEPLEINDDY---------VEYYTMPFGKGWFAGRNL-AISQVT 336
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKFNENNLKvfknysnpnITYLHYPDLGVPFYEKLLdALEQVE 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6679931    337 TKYVLWV-DDDFLfsDKTKIEVLVDVLEKtELDVVggSVQGNTYQF 381
Cdd:TIGR04440  82 TPYVVICaDDDFI--IPSGLTECLSFLEA-NPDYS--AAQGRYVYF 122
 
Name Accession Description Interval E-value
Glycos_transf_2 pfam00535
Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, ...
268-412 4.30e-16

Glycosyl transferase family 2; Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.


Pssm-ID: 425738 [Multi-domain]  Cd Length: 166  Bit Score: 75.89  E-value: 4.30e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931    268 TIATKTFLRPHKLKILLQSIRK-YYPDITVIVADDS--KEPLEINDDY------VEYYTMPFGKGWFAGRNLAISQVTTK 338
Cdd:pfam00535   1 SVIIPTYNEEKYLLETLESLLNqTYPNFEIIVVDDGstDGTVEIAEEYakkdprVRVIRLPENRGKAGARNAGLRAATGD 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6679931    339 YVLWVDDDFLFSDKtKIEVLVDVLEKTELDVVGGSV---QGNTYQFRLLYEQTKNGSC--LHQRWGSFQALDGFPGCTL 412
Cdd:pfam00535  81 YIAFLDADDEVPPD-WLEKLVEALEEDGADVVVGSRyviFGETGEYRRASRITLSRLPffLGLRLLGLNLPFLIGGFAL 158
WcaA COG0463
Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis]; ...
266-434 3.34e-10

Glycosyltransferase involved in cell wall bisynthesis [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440231 [Multi-domain]  Cd Length: 208  Bit Score: 59.72  E-value: 3.34e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  266 LVTIATKTFLRPHKLKILLQSIRKY-YPDITVIVADD-SK-------EPLEINDDYVEYYTMPFGKGWFAGRNLAISQVT 336
Cdd:COG0463   3 LVSVVIPTYNEEEYLEEALESLLAQtYPDFEIIVVDDgSTdgtaeilRELAAKDPRIRVIRLERNRGKGAARNAGLAAAR 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  337 TKYVLWVDDDFLFsDKTKIEVLVDVLEKTELDVVGGSvqgntyqfrllyEQTKNGSCLHQRWGSFQALDGFPGCTLTSGV 416
Cdd:COG0463  83 GDYIAFLDADDQL-DPEKLEELVAALEEGPADLVYGS------------RLIREGESDLRRLGSRLFNLVRLLTNLPDST 149
                       170
                ....*....|....*...
gi 6679931  417 VNFFLAHTEQLRRVGFDP 434
Cdd:COG0463 150 SGFRLFRREVLEELGFDE 167
WcaE COG1216
Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];
267-346 2.06e-08

Glycosyltransferase, GT2 family [Carbohydrate transport and metabolism];


Pssm-ID: 440829 [Multi-domain]  Cd Length: 202  Bit Score: 54.23  E-value: 2.06e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  267 VTIATKTFLRPHKLKILLQSIRKY-YPDITVIVADD-----SKEPL-EINDDYVEYYTMPFGKGWFAGRNLAISQVTTKY 339
Cdd:COG1216   5 VSVVIPTYNRPELLRRCLESLLAQtYPPFEVIVVDNgstdgTAELLaALAFPRVRVIRNPENLGFAAARNLGLRAAGGDY 84

                ....*..
gi 6679931  340 VLWVDDD 346
Cdd:COG1216  85 LLFLDDD 91
Glyco_tranf_GTA_type cd00761
Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a ...
280-372 8.68e-08

Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Glycosyltransferases (GTs) are enzymes that synthesize oligosaccharides, polysaccharides, and glycoconjugates by transferring the sugar moiety from an activated nucleotide-sugar donor to an acceptor molecule, which may be a growing oligosaccharide, a lipid, or a protein. Based on the stereochemistry of the donor and acceptor molecules, GTs are classified as either retaining or inverting enzymes. To date, all GT structures adopt one of two possible folds, termed GT-A fold and GT-B fold. This hierarchy includes diverse families of glycosyl transferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. The majority of the proteins in this superfamily are Glycosyltransferase family 2 (GT-2) proteins. But it also includes families GT-43, GT-6, GT-8, GT13 and GT-7; which are evolutionarily related to GT-2 and share structure similarities.


Pssm-ID: 132997 [Multi-domain]  Cd Length: 156  Bit Score: 51.74  E-value: 8.68e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  280 LKILLQSIRKY-YPDITVIVADD--SKEPLEI------NDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLFs 350
Cdd:cd00761  12 LERCLESLLAQtYPNFEVIVVDDgsTDGTLEIleeyakKDPRVIRVINEENQGLAAARNAGLKAARGEYILFLDADDLL- 90
                        90       100
                ....*....|....*....|...
gi 6679931  351 DKTKIEVLVDVLEK-TELDVVGG 372
Cdd:cd00761  91 LPDWLERLVAELLAdPEADAVGG 113
glyco_TIGR04440 TIGR04440
glycosyltransferase domain; This model describes a putative glycotransferase domain, related ...
267-381 2.09e-07

glycosyltransferase domain; This model describes a putative glycotransferase domain, related to the group 2 family glycosyltransferases of pfam00535.


Pssm-ID: 275233  Cd Length: 215  Bit Score: 51.53  E-value: 2.09e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931    267 VTIATKTFLRPHKLKILLQSIRKYYPDITVIVADDSKEPLEINDDY---------VEYYTMPFGKGWFAGRNL-AISQVT 336
Cdd:TIGR04440   2 LTIIIPTYNRPEYLKRWLRYYSDFGCDYRIIIADSSDEKFNENNLKvfknysnpnITYLHYPDLGVPFYEKLLdALEQVE 81
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6679931    337 TKYVLWV-DDDFLfsDKTKIEVLVDVLEKtELDVVggSVQGNTYQF 381
Cdd:TIGR04440  82 TPYVVICaDDDFI--IPSGLTECLSFLEA-NPDYS--AAQGRYVYF 122
GT_2_like_c cd04186
Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse ...
276-407 4.77e-04

Subfamily of Glycosyltransferase Family GT2 of unknown function; GT-2 includes diverse families of glycosyltransferases with a common GT-A type structural fold, which has two tightly associated beta/alpha/beta domains that tend to form a continuous central sheet of at least eight beta-strands. These are enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. Glycosyltransferases have been classified into more than 90 distinct sequence based families.


Pssm-ID: 133029 [Multi-domain]  Cd Length: 166  Bit Score: 41.01  E-value: 4.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  276 RPHKLKILLQSIRKY-YPDITVIV-----ADDSKEPLEINDDYVEYYTMPFGKGWFAGRNLAISQVTTKYVLWVDDDFLF 349
Cdd:cd04186   8 SLEYLKACLDSLLAQtYPDFEVIVvdnasTDGSVELLRELFPEVRLIRNGENLGFGAGNNQGIREAKGDYVLLLNPDTVV 87
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 6679931  350 SDKTkIEVLVDVLEKtELDVvgGSVQGNTyqfrllyeqtkNGSCLHQRWGSFQALDGF 407
Cdd:cd04186  88 EPGA-LLELLDAAEQ-DPDV--GIVGPKV-----------SGAFLLVRREVFEEVGGF 130
BcsA COG1215
Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1, ...
280-413 8.94e-04

Glycosyltransferase, catalytic subunit of cellulose synthase and poly-beta-1,6-N-acetylglucosamine synthase [Cell motility];


Pssm-ID: 440828 [Multi-domain]  Cd Length: 303  Bit Score: 41.27  E-value: 8.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6679931  280 LKILLQSIRK-YYP--DITVIVADDSKEP--------LEINDDYVEYYTMPF--GKGWfaGRNLAISQVTTKYVLWVDDD 346
Cdd:COG1215  44 IEETLRSLLAqDYPkeKLEVIVVDDGSTDetaeiareLAAEYPRVRVIERPEngGKAA--ALNAGLKAARGDIVVFLDAD 121
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6679931  347 FLFsDKTKIEVLVDVLEKTELDVvggsvqgntyqfrllyeqtkNGSCLHQRWGSFQALDGFPGCTLT 413
Cdd:COG1215 122 TVL-DPDWLRRLVAAFADPGVGA--------------------SGANLAFRREALEEVGGFDEDTLG 167
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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