Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain; BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. It has also been implicated as the master regulator of breast cancer bone metastasis. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680764  554 TPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC 624
Cdd:cd14719   1 TPEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIKKLVCEKEKLLGERNQLKASMGELRENFSCLC 71

Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain; BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. It has also been implicated as the master regulator of breast cancer bone metastasis. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680764  554 TPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC 624
Cdd:cd14719   1 TPEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIKKLVCEKEKLLGERNQLKASMGELRENFSCLC 71

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764      35 DVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQT--DAELTVTLPeEVTVKGFEPLIQFAYTAKLILSKDNVDEVCRCVEF 112
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*
gi 6680764     113 LSVHNIEESCFQFLK 127
Cdd:smart00225  80 LQIPGLVELCEEFLL 94

bZIP Maf transcription factor; Maf transcription factors contain a conserved basic region leucine zipper (bZIP) domain, which mediates their dimerization and DNA binding property. Thus, this family is probably related to pfam00170. This family also includes the DNA_binding domain of Skn-1, this domain lacks the leucine zipper found in other bZip domains, and binds DNA is a monomer.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6680764    531 FNAQRIISLSRNDFQSLLKmhKLTPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERD 607
Cdd:pfam03131   1 LSDEELLSMSVREFNRFLR--GLTEEEVIRLKQRRRRLKNRGYAQSCRKRRLQQKESLEKERSELREQLERLVQELS 75

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 2 (BACH2); BACH2, also called BTB-basic leucine zipper transcription factor 2, belongs to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). It is also a potent general repressor of effector differentiation in naive T cells. Moreover, BACH2 is required for pulmonary surfactant homeostasis and alveolar macrophage function. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764    4 SESAVFAYESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTVKG 83
Cdd:cd18278   2 TESPMYVYESTVHCTNILLCLNDQRKQDILCDVTLIVEGKEFRAHRAVLAACSEYFLQALVGQTENDLVVSLPEEVTARG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6680764   84 FEPLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18278  82 FGPLLQFAYTAKLLLSRENIQEVIRCAEFLRMHNLEDSCFRFL 124

Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain; BACH proteins are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. In addition, they contain a BTB domain (Broad complex-Tramtrack-Bric-a-brac domain, also known as the POZ [poxvirus and zinc finger] domain) that is absent in other CNC proteins. Veterbrates contain two members, BACH1 and BACH2. BACH1 forms heterodimers with small Mafs such as MafK to function as a repressor of heme oxygenase-1 (HO-1) gene (Hmox-1) enhancers. It has also been implicated as the master regulator of breast cancer bone metastasis. The BACH1 bZIP transcription factor should not be confused with the protein originally named as BRCA1-Associated C-terminal Helicase1 (BACH1), which has been renamed BRIP1 (BRCA1 Interacting Protein C-terminal Helicase1) and also called FANCJ. BACH2 is a B-cell specific transcription factor that plays a critical role in oxidative stress-mediated apoptosis. It plays an important role in class switching and somatic hypermutation of immunoglobulin genes. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6680764  554 TPEQLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC 624
Cdd:cd14719   1 TPEQLEFIHDVRRRSKNRIAAQRCRKRKLDCIQNLECEIKKLVCEKEKLLGERNQLKASMGELRENFSCLC 71

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764     24 LNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLP-EEVTVKGFEPLIQFAYTAKLIlSKDN 102
Cdd:pfam00651   1 LNELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVSEITlDDVSPEDFEALLEFMYTGKLI-SEEN 79

                          90       100
                  ....*....|....*....|....*
gi 6680764    103 VDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:pfam00651  80 VDDLLAAADKLQIPSLVDKCEEFLI 104

Basic leucine zipper (bZIP) domain of Nuclear Factor, Erythroid-derived 2 (NFE2) and similar proteins: a DNA-binding and dimerization domain; This subfamily is composed of NFE2 and NFE2-like proteins including NFE2-like 1 or NFE2-related factor 1 (NFE2L1 or Nrf1), NFE2L2 (or Nrf2), and NFE2L3 (or Nrf3). These are Cap'n'Collar (CNC) Basic leucine zipper (bZIP) transcription factors that are defined by a conserved 43-amino acid region (called the CNC domain) located N-terminal to the bZIP DNA-binding domain. NFE2 functions in development; it is required for the proper development of platelets. The three Nrfs function in stress responses. Nrf2, the most extensively studied member of this subfamily, acts as a xenobiotic-activated receptor that regulates the adaptive response to oxidants and electrophiles. As the master regulator of the antioxidant defense pathway, it plays roles in the biology of inflammation, obesity, and cancer. Nrf1 is an essential protein that binds to the antioxidant response element (ARE) and is also involved in regulating oxidative stress. In addition, it also regulates genes involved in cell and tissue differentiation, inflammation, and hepatocyte homeostasis. bZIP factors act in networks of homo and heterodimers in the regulation of a diverse set of cellular processes. The bZIP structural motif contains a basic region and a leucine zipper, composed of alpha helices with leucine residues 7 amino acids apart, which stabilize dimerization with a parallel leucine zipper domain. Dimerization of leucine zippers creates a pair of the adjacent basic regions that bind DNA and undergo conformational change. Dimerization occurs in a specific and predictable manner resulting in hundreds of dimers having unique effects on transcription.

                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6680764  557 QLDCIHDIRRRSKNRIAAQRCRKRKLDCIQNLESEIEKLQSEKESLLKERDHILSTLGETKQNLTGLC 624
Cdd:cd14720   1 QLALIRDIRRRGKNKVAAQNCRKRKLDNIVGLEDEVEQLQRQREKLLREKAENAKSLREMKQKLNDLY 68

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 26 (KLHL26); KLHL26 is encoded by the klhl26 gene, which is regulated by p53 via fuzzy tandem repeats. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVG------QTDAELtvtlpEEVTVKGFEPLIQ 89
Cdd:cd18255   1 HSVTLLQGLNALRAKGQLLDVTLIADGQRFQAHKVVLASCSDYFRAMFTGgmressQDEIEL-----KGVSAKGLKHILD 75

                        90       100       110
                ....*....|....*....|....*....|....*...
gi 6680764   90 FAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:cd18255  76 FAYTSELTLDLDCIQDVLGAAVHLQMLPVVELCEEFLK 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 proteins, BCL-6 and BCL-6B; This family includes B-cell lymphoma 6 proteins, BCL-6 and BCL-6B. BCL-6 is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. BCL-6B is a sequence-specific transcriptional repressor in association with BCL-6. It may function in a narrow stage or be related to some events in the early B-cell development. Family members contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTV-TLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18215   2 HASDVLLNLNRLRSRDILTDVVLVVGREQFRAHKTVLMACSGLFYSIFTDQLKNNVSViNLDPEIEPEGFRILLDFMYTS 81

                        90       100       110
                ....*....|....*....|....*....|.
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQF 125
Cdd:cd18215  82 RLNLREGNIMAVMATAMYLQMEHVVDTCRKF 112

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764      35 DVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQT--DAELTVTLPeEVTVKGFEPLIQFAYTAKLILSKDNVDEVCRCVEF 112
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFkeSDKSEIYLD-DVSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|....*
gi 6680764     113 LSVHNIEESCFQFLK 127
Cdd:smart00225  80 LQIPGLVELCEEFLL 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in B-cell lymphoma 6 protein (BCL-6); BCL-6 is also called B-cell lymphoma 5 protein (BCL-5), zinc finger and BTB domain-containing protein 27 (ZBTB27), protein LAZ-3, or zinc finger protein 51 (ZNF51). It is a transcriptional repressor mainly required for germinal center (GC) formation and antibody affinity maturation, which have different mechanisms of action specific to the lineage and biological functions. It represses its target genes by binding directly to the DNA sequence 5'-TTCCTAGAA-3' or indirectly by repressing the transcriptional activity of transcription factors. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTV-TLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18331   7 HASDVLLNLNRLRSRDILTDVVIVVSREQFRAHKTVLMACSGLFYSIFTDQLKCNLSViNLDPEINPEGFNILLDFMYTS 86

                        90       100       110
                ....*....|....*....|....*....|..
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18331  87 RLNLREGNIMAVMATAMYLQMEHVVDTCRKFI 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7A (ZBTB7A); ZBTB7A is also called factor binding IST protein 1 (FBI-1), factor that binds to inducer of short transcripts protein 1, HIV-1 1st-binding protein 1, Leukemia/lymphoma-related factor (LRF), POZ and Krueppel erythroid myeloid ontogenic factor, POK erythroid myeloid ontogenic factor, Pokemon, TTF-I-interacting peptide 21 (TIP21), or zinc finger protein 857A (ZNF857A). It is a transcription repressor of key glycolytic genes, including GLUT3, PFKP, and PKM, and its downregulation in human cancer contributes to tumor metabolism. It has been implicated in carcinogenesis and cell differentiation and development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIV-GQTDAELTVTLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18326   8 HSSDILSSLNEQRTQGLLCDVVILVEGREFPTHRSVLAACSQYFKKLFTsGAVVDQQNVYEIDFVSAEALTALLDFAYTA 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18326  88 TLTVSTSNVGDILSAARLLEIPAVSHVCADLL 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18, ZBTB42 and similar proteins; The family includes zinc finger and BTB domain-containing proteins, ZBTB3, ZBTB18 and ZBTB42. ZBTB3 is a transcription factor essential for cancer cell growth via the regulation of the reactive oxygen species (ROS) detoxification pathway. ZBTB18 is a sequence-specific transrepressor associated with heterochromatin. ZBTB42 is a transcriptional repressor that specifically binds DNA and probably acts by recruiting chromatin remodeling multiprotein complexes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEE-VTVKGFEPLIQFAYTA 94
Cdd:cd18194   6 HSRQLLQCLREQRSQGFLCDCTVLVGSAQFPAHRAVLASCSMYFHLFYRDRLDKRDLVRLNSDiVTAPAFGLLLDFMYEG 85

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFLDS 133
Cdd:cd18194  86 RLALRDLPVEDVLAAASYLHMYDIVKVCKGRLQEKALAE 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18.2 and similar proteins; This subfamily is composed of Xenopus laevis zinc finger and BTB domain-containing protein 18.2, encoded by the znf238.2.L gene, and similar proteins. Many proteins in this group are annotated as zinc finger and BTB domain-containing protein 42 (ZBTB42). However, characterized mammalian ZBTB42 does not belong to this subfamily. ZBTB18.2, like ZBTB18, functions as a transcriptional repressor that plays a role in various developmental processes. Members of this family contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEE-VTVKGFEPLIQFAYTA 94
Cdd:cd18325   6 HSRQLLQCLSQQRHQGFLCDCTVLVGEAQFRAHRAVLASCSMYFHLFYRDQLDKRDIVHLNSDiVTAPAFSLLLEFMYEG 85

                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFLDSTSEQ 137
Cdd:cd18325  86 KLEFSSLPVEDVLAAASYLHMYDIVKVCKGKLKDKELCSEEKI 128

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7C (ZBTB7C); ZBTB7C is also called affected by papillomavirus DNA integration in ME180 cells protein 1 (APM-1), zinc finger and BTB domain-containing protein 36 (ZBTB36), zinc finger protein 857C (ZNF857C), or kidney cancer-related POZ domain and Kruppel-like protein (Kr-POK). It is a transcriptional repressor with a pro-oncogenic role that relies upon binding to p53 and inhibition of its transactivation function. It may act as an important regulator of fatty acid synthesis and may induce rapid cancer cell proliferation by increasing palmitate synthesis. The ZBTB7C gene has been identified as a susceptibility gene to ischemic injury. ZBTB7C contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAEL-TVTLPEEVTVKGFEPLIQFAYTA 94
Cdd:cd18328   8 HSSEVLCSLNEQRHDGLLCDVVLIVQDQEYRTHRSVLAACSKYFKKLFTAGTLADQpYVYEIDFVTPEALSAILEFAYTS 87

                        90       100       110
                ....*....|....*....|....*....|..
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18328  88 TLTITTSNVKHILNAAQMLEIQCIINVCLEIM 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGqtdaELTVTLPEEVTVKGFEP-----LIQF 90
Cdd:cd18237   4 LLADFMGVMNNMRKQKTLCDVILIVEGREIKAHRVVLAAASHFFHLMFTS----NMTESKSSEVELKDAEPdiielLVEF 79

                        90       100       110
                ....*....|....*....|....*....|....*..
gi 6680764   91 AYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:cd18237  80 AYTARISVNSNNVQSLLDAANQYQIEPVKKMCVDFLK 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 18 (ZBTB18); ZBTB18 is also called 58 kDa repressor protein (RP58), transcriptional repressor RP58, translin-associated zinc finger protein 1 (TAZ-1), zinc finger protein 238 (ZNF238), or zinc finger protein C2H2-171. It is a sequence-specific transrepressor associated with heterochromatin. It plays a role in various developmental processes such as myogenesis and brain development. It specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. ZBTB18 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEE-VTVKGFEPLIQFAYTA 94
Cdd:cd18324   6 HSRHLLQCLSEQRHQGFLCDCTVLVGDAQFRAHRAVLASCSMYFHLFYKDQLDKRDIVHLNSDiVTAPAFALLLEFMYEG 85

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 6680764   95 KLILSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKFL---DSTSEQQECARKKC 145
Cdd:cd18324  86 KLQFKDLPIEDVLAAASYLHMYDIVKVCKKKLKEKATteaDSTKKEEDASSCSD 139

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 7B (ZBTB7B); ZBTB7B is also called Krueppel-related zinc finger protein cKrox, T-helper-inducing POZ/Krueppel-like factor, zinc finger and BTB domain-containing protein 15 (ZBTB15), zinc finger protein 67 (ZNF67), Zfp67, zinc finger protein 857B (ZNF857B), or zinc finger protein Th-POK. It is a transcriptional regulator of extracellular matrix gene expression. It plays widespread and critical roles in T-cell development, particularly as the master regulator of CD4 commitment. It also plays a role as a potent driver of brown fat development and thermogenesis, as well as cold-induced beige fat formation. ZBTB7B contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDA-------------ELTVTLPEEVTVk 82
Cdd:cd18327   8 HSSELLSCLNEQRRAGLLCDLTIKTRGLEYRTHRAVLAACSLYFRKLFTGGGGGsgdlgagggqdvcELDFVGPEALGA- 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 6680764   83 gfepLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:cd18327  87 ----LLEFAYTATLTISSSNMREVLRAARLLEIPCVADACADILQ 127

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger protein 131 (ZNF131); ZNF131, also called zinc finger and BTB domain-containing protein 35 (ZBTB35), is a transcriptional activator implicated as a regulator of Kaiso-mediated biological processes. It regulates cell growth of developing and mature T cells. It inhibits estrogen signaling by suppressing estrogen receptor alpha homo-dimerization, and plays a role in breast cancer cell proliferation. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTlpEEVTVKGFEPLIQFAYTAK 95
Cdd:cd18221   1 HYKVMLDRLNEQRELDQFTDITLIVDGHQFKAHKAVLAACSQFFYKFFQDFTQEPLVEI--EGVSNMAFRHLIEFTYTAK 78

                        90       100
                ....*....|....*....|.
gi 6680764   96 LIL-SKDNVDEVCRCVEFLSV 115
Cdd:cd18221  79 LMVqGEEEANDVWKAAEYLQM 99

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8A (ZBTB8A); ZBTB8A, also called BTB/POZ and zinc-finger domain-containing factor or BTB/POZ and zinc-finger domains factor on chromosome 1 (BOZ-F1), is a novel proto-oncoprotein that stimulates cell proliferation. It binds to all the proximal GC boxes to repress transcription, and it inhibits p53 acetylation without affecting p53 stability. It may be involved in gastric adenocarcinoma cell differentiation, cancer invasion, and metastasis. ZBTB8A contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   13 SSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYF------HSRIVGQ-TDAELTVTLPEEVTVkgfe 85
Cdd:cd18329   1 ISSHQSRLLQQLDEQRKQELFCDCSILVEGQVFKAHRNVLFASSGYFkmllsqNAKETGQpTVATFDVFSPDTFTI---- 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 6680764   86 pLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18329  77 -ILDFVYSGKLSLTSQNVIEVMSAASYLQMTDVISVCKTFI 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 11 (ZBTB11); ZBTB11 is a transcriptional repressor of TP53. It is critical for basal and emergency granulopoiesis. It regulates neutrophil development through its integrase-like zinc finger domain. ZBTB11 contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIV--GQTDAELTVTLPEEVTVKGFEPLIQFAYT 93
Cdd:cd18202   2 HGQTVLDQLNQQRLNNQFCDVTLLIEGEEYKAHKSVLAANSEYFRELFIekGAVSSHEAVVDLSGFCKSSFLPLLEFAYT 81

                        90       100
                ....*....|....*....|....*....
gi 6680764   94 AKLILSKDNVDEVCRCVEFLSVHNIEESC 122
Cdd:cd18202  82 SELTFDFCSMAEVAMLARHLFMNEVLEIC 110

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1); PATZ1 is also called zinc finger and BTB domain-containing protein 19 (ZBTB19), BTB/POZ domain zinc finger transcription factor, protein kinase A RI subunit alpha-associated protein, zinc finger protein 278, or zinc finger sarcoma gene protein. It is an important transcriptional regulatory factor that regulates divergent pathways depending on the cellular context. For instance, it acts as a transcriptional suppressor that functions in T lymphocytes. It is also a DNA damage-responsive transcription factor that inhibits p53 function. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764    9 FAYESSVHSTNVLLSLNDQRKKD-VLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGQTDAELTVTLPEEVTV--KGFE 85
Cdd:cd18207   2 YTYQVSQHSADMLHNLNQQRKSGgRFCDVLLRVGEESFPAHRAVLAACSEYFESVFSAQEGDGGTPRELEMHTIssKVFG 81

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6680764   86 PLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:cd18207  82 DILDFAYTSRIVVRLESFPELMTAAKFLLMRSVIDICQEVIK 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 8 (ZBTB8); There are two ZBTB8 isoforms: ZBTB8A and ZBTB8B. ZBTB8A is a novel proto-oncoprotein that stimulates cell proliferation. ZBTB8B may be involved in transcriptional regulation. They both contain a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIV--GQTDAELTVTLPEEVTVKGFEPLIQFAYT 93
Cdd:cd18199   1 HQSRLLGQLNEQRKQDFFCDCSIIVEGRIFKAHRNVLFASSGYFRMLLShyIQDTGRPSTASFDVFSSDAFSIILDFVYS 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 6680764   94 AKLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18199  81 GKLSLTSQNVIEVMSAASYLQMTDVINVCKTFI 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   23 SLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGqtdaELTVTLPEEVTVKGF-----EPLIQFAYTAKLI 97
Cdd:cd18238   5 VLHQFYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTS----EMAESKQDSITIKDIdeeavELLVDFAYTGKLT 80

                        90       100       110
                ....*....|....*....|....*....|...
gi 6680764   98 LSKDNVDEVCRCVEFLSVHNIEESCFQFLKFKF 130
Cdd:cd18238  81 LTVDNVQSLLYAASLLQVEEVAKACCEFMKDHL 113

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in gigaxonin; Gigaxonin, also called Kelch-like protein 16 (KLHL16), may be a cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It may also act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, including tubulin folding cofactor B (TBCB), microtubule-associated protein MAP1B, and glial fibrillary acidic protein (GFAP). Gigaxonin is mutated in giant axonal neuropathy. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   21 LLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRI---VGQTDAELTVTLPEEVTVKGFEPLIQFAYTAKLI 97
Cdd:cd18245   2 LRALNSFREEPHLCDATLVVGGEEIPVQKNVLAAASPYFRAKLnynPPKDDGSTYKIELEGISVEVMEEILDYIYTGQIK 81

                        90       100       110
                ....*....|....*....|....*....|
gi 6680764   98 LSKDNVDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:cd18245  82 LSEDNIQDIVQAADLLLMTDLKDLCCEFLE 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 20 (KLHL20); KLHL20, also called Kelch-like ECT2-interacting protein (KLEIP) or Kelch-like protein X, is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. KLHL20 plays a role in actin assembly at cell-cell contact sites of Madin-Darby canine kidney cells. It also controls endothelial migration and sprouting angiogenesis. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   11 YESSVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGqtdaELTVTLPEEVTV-----KGFE 85
Cdd:cd18249   1 YTSDKHPRQTLEAINLLRKHRELCDVVLVVGAKKIYAHRVILSACSPYFRAMFTG----ELAESRQTEVTIrdideRAME 76

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6680764   86 PLIQFAYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFLK 127
Cdd:cd18249  77 LLIDFAYTSQITVEEGNVQTLLPAACLLQLAEIQEVCCEFLK 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins, KLHL2 and KLHL3; The family includes Kelch-like proteins, KLHL2 and KLHL3. KLHL2 is a novel actin-binding protein predominantly expressed in brain. It plays a role in the reorganization of the actin cytoskeleton, and promotes growth of cell projections in oligodendrocyte precursors. KLHL2 and KLHL3 each functions as a component of an E3 ubiquitin ligase complex that mediates the ubiquitination of target proteins. They contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   14 SVHSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVG---QTDAElTVTLpEEVTVKGFEPLIQF 90
Cdd:cd18235   2 PQHTQKAFDVMNELRKQNLLCDVILVADGVEIPAHRVVLASCSPYFHAMFTGdlsESRAN-RVTL-QDVDGKALLLLIDY 79

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 6680764   91 AYTAKLILSKDNVDEVCRCVEFLSVHNIEESCFQFL 126
Cdd:cd18235  80 VYTAEIQVTEENVQVLLPAANLLQLTDVRDACCDFL 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6680764   16 HSTNVLLSLNDQRKKDVLCDVTVLVEGQRFRAHRSVLAACSSYFHSRIVGqtdaELTVTLPEEVTVKGFEP-----LIQF 90
Cdd:cd18250   4 HALHLLRGLSELRAERKFFDVTLCAGGREFPCHRTVLAAASSYFRAMFAG----ELRESRADRVVLHGVSAeilglLLDF 79