|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
106-510 |
1.86e-99 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 304.48 E-value: 1.86e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIESHLQDNqlSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFH 185
Cdd:cd17352 1 GWVVVFASFLVNFFTDGILNSFGVLFVELLEE--FGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLA 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 186 VAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSmksdtd 265
Cdd:cd17352 79 ALGLLLSSFATSLWQLYLTYGVLGGLGLGLIYSPAIVIVGQYFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLD------ 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 266 pTYGFVWGIRTLGFLDLALLTLSIILvkerlphvienskdgesrwryilrvyilqcfdaKAFLDMKYLFCVLGTVFSELS 345
Cdd:cd17352 153 -NYGWRGALLILGGLCLNLCVCGLLL---------------------------------RLLKDPTFVLLALGVSFAMLG 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 346 INSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDK--FGRFNVAIATLLTLFIVMFVGWLPfgTNLTNM 423
Cdd:cd17352 199 FFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLADKprIGRLYLYIFTLLILGLSLLAFPLA--TTYVGL 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 424 YVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIktTADYQHYIIFCGLATFVSA 503
Cdd:cd17352 277 IVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDY--TGDYDAAFYFCGACLLLSG 354
|
....*..
gi 398366189 504 VCYIISR 510
Cdd:cd17352 355 VLLFLLP 361
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
105-505 |
6.06e-34 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 132.31 E-value: 6.06e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 105 KAWVVTFGCFLGLIACFGLLNSTGVIESHLQDN-QLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTV 183
Cdd:COG2223 2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEfGLSA---AQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 184 FHVAGLFATANSTKYWHFILsFAIVCGFGNGIVLSPLVSVPAHYFFK-RRGTALAMATIGGSVGGVVFPIMLRSFFSmks 262
Cdd:COG2223 79 LLGIGLLLLALAVSYWLLLL-LGLLLGIGGGGSFAVGIALVSKWFPPdRRGLALGLAAGGGNLGAAVAAFLAPLLIA--- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 263 dtdpTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILqcfdakafldmkYLFCVL--GTV 340
Cdd:COG2223 155 ----AFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEALRDPRF------------WLLSLLyfGTF 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 341 FSELSINSALTYYgsYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLtLFIVMFVGWLPFGTNL 420
Cdd:COG2223 219 GSFIGFSSWLPPY--LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFA-LMALGLLLLALALGSL 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 421 TNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISikTTADYQHYIIFCGLATF 500
Cdd:COG2223 296 WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLD--ATGSYTAAFLVFAVLAL 373
|
....*
gi 398366189 501 VSAVC 505
Cdd:COG2223 374 VALVL 378
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
106-508 |
1.21e-31 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 125.37 E-value: 1.21e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIESHLQ-DNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVF 184
Cdd:COG2271 8 RWRILALLFLAYFLNYLDRSNLSVAAPPLQaDLGLSA---AQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 185 HVAGLFATANSTKYWHFILSFAIVcGFGNGIVLSPLVSVPAHYFF-KRRGTALAMATIGGSVGGVVFPIMLRSFFSmksd 263
Cdd:COG2271 85 WGLATLLFGFATSFWQLLLLRFLL-GLGEAGFFPAALKLIAEWFPpKERGRALGIFNAGGPLGGALAPPLLGWLLA---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 264 tdptygfVWGIRTLgFLDLALLTLSIILVKerlphvienskdgesrwryilrvyilqcfdakafldmkYLFCVLGTVFSE 343
Cdd:COG2271 160 -------AFGWRAA-FLILGLPGLLLALLR--------------------------------------FWLLALAYFLVY 193
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 344 LSINSALTYYGSYATS-HGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTN 422
Cdd:COG2271 194 FALYGFLTWLPTYLVEvRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALLLLALLPSPAL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 423 MYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIIsikTTADYQHYIIFCGLATFVS 502
Cdd:COG2271 274 AIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL---DATGYQAAFLLLAALALLA 350
|
....*.
gi 398366189 503 AVCYII 508
Cdd:COG2271 351 ALLALL 356
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
106-504 |
6.70e-28 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 115.06 E-value: 6.70e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGV-IESHLQDNQLSSESVSTIgwlFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVF 184
Cdd:cd17355 1 GWVVLAVTFLILILSWGIRYYFGVfIIPIIAEFGWSRAVISLA---FTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 185 HVAGLFATANSTKYWHFILSFAIVCGFGNG-IVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSmksd 263
Cdd:cd17355 78 LAAGLVLLALATSLWQLYLLWGLLGGGGAGtLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIE---- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 264 tdpTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDG--ESRWRYILRVyilqcfdakAFLDMKYLFCVLGTVF 341
Cdd:cd17355 154 ---AFGWRTALLVLALLALLVLVPVLLLLRRRPADLALRAYDDasPASPGSTLKE---------ALRSASFWLLALAFFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 342 SELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIA----TLLTLFIVMFVGWLPFG 417
Cdd:cd17355 222 CGFAVVGLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAAsyalRALGLALLLLLPFPPLA 301
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 418 tnltnMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIktTADYQHYIIFCGL 497
Cdd:cd17355 302 -----LLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDR--TGSYTAAWALAVA 374
|
....*..
gi 398366189 498 ATFVSAV 504
Cdd:cd17355 375 LGLIAAL 381
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
143-468 |
4.93e-27 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 111.99 E-value: 4.93e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILsFAIVCGFGNGIVLSPLVS 222
Cdd:COG2814 43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLA-ARFLQGLGAGALFPAALA 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYF-FKRRGTALAMATIGGSVGGVVFPIMLRSFFSmksdtdptygfVWGIRTLGFLDLALLTLSIILVKERLPhviE 301
Cdd:COG2814 122 LIADLVpPERRGRALGLLGAGLGLGPALGPLLGGLLAD-----------LFGWRWVFLVNAVLALLALLLLLRLLP---E 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 302 NSKDGESRWRYILRVYilqcfdakaFLDMKYLFCVLGTVFSELSINSALTYYGSYATS-HGISANDAYTLIMIINVCGIP 380
Cdd:COG2814 188 SRPAARARLRGSLREL---------LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEvLGLSASAAGLLLALFGLGGVL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 381 GRWVPGYLSDKFGRFNVAIATLLTLFIVMFVgwLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYST 460
Cdd:COG2814 259 GALLAGRLADRFGRRRLLLIGLLLLALGLLL--LALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336
|
....*...
gi 398366189 461 MYFVVGFG 468
Cdd:COG2814 337 YNSAFFLG 344
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
105-505 |
1.12e-26 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 111.55 E-value: 1.12e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 105 KAWVVTFGcFLGLIACFGLLNSTGVIESHLQDNQlsSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVF 184
Cdd:cd17353 1 RRWLVLLG-AVLMHLILGYQYAWSVFNPPLSSAL--GWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 185 HVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVF-PIMLRsffSMKSD 263
Cdd:cd17353 78 FGLGFILSAFAISLPLLFLGYGVLGGIGAGIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFsPLIAY---LINTV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 264 TDPTYGFVWGIrtlGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILQCFDAKAFLDMkYLFCVLGTVfse 343
Cdd:cd17353 155 GVPTTFLILGI---IFLIIIVIGAFLIRDPPKGWVPPGVDPLANNAENSPRDYTPREMLRTPTFWLL-WLMFFLNAT--- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 344 lSINSALTYYGSYATS-HGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFvGWLPFGTNLTN 422
Cdd:cd17353 228 -AGLMLIGQAKPIGQEfAGLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMF-LLPFIGSVAVL 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 423 MYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISiktTADYQHYIIFCGLATFVS 502
Cdd:cd17353 306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY---TGGYNAAFIIAAALSLVA 382
|
...
gi 398366189 503 AVC 505
Cdd:cd17353 383 LAL 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
113-472 |
3.74e-24 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 103.65 E-value: 3.74e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 113 CFLGLIACFGLLNSTGVIESHLQDNQlsSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFAT 192
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLLLAEDL--GISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 193 ANSTKYWHFILsFAIVCGFGNGIVLSPLVSVPAHYF-FKRRGTALAMATIGGSVGGVVFPIMLRSFFSmksdtdptygfV 271
Cdd:pfam07690 80 LFASSLWLLLV-LRVLQGLGAGALFPAALALIADWFpPEERGRALGLVSAGFGLGAALGPLLGGLLAS-----------L 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 272 WGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYIlqcfdaKAFLDMKYLFCVLGTVFSELSINSALT 351
Cdd:pfam07690 148 FGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW------KALLRDPVLWLLLALLLFGFAFFGLLT 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 352 YYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFN-VAIATLLTLFIVMFVGWLPFGTNLTNMYVISALY 430
Cdd:pfam07690 222 YLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRrLLLALLLLILAALGLLLLSLTLSSLWLLLALLLL 301
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 398366189 431 GFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVG 472
Cdd:pfam07690 302 GFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
113-507 |
9.02e-21 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 94.03 E-value: 9.02e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 113 CFLGLIACFGLLNSTGVIESHLQDNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFAT 192
Cdd:cd06174 2 LLGFFLTGLARGLISPLLPALLQSFGLSA---SQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 193 ANSTKYWHFILsFAIVCGFGNGIVLSPLVSVPAHYF-FKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSdtdptYGFV 271
Cdd:cd06174 79 AFAPSFWLLLL-GRFLLGLGSGLIDPAVLALIADLFpERERGRALGLLQAFGSVGGILGPLLGGILASSLG-----FGWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 272 WGIRTLGFLdLALLTLSIILVKERLPHVIENSKDGESRWRYILRVyilqcfdAKAFLDMKYLFCVLGTVFSELSINSALT 351
Cdd:cd06174 153 AVFLIAAAL-ALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------KRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 352 YYGSYATSHGISANDAYTLIMIIN-VCGIPGRWVPGYLSDK-FGRFNVAIATLltLFIVMFVGWLPFGTNLTNMYVISAL 429
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFgLAGALGSLLLGLLSDRlIGRKPLLLIGL--LLMALGLALLLLAPSLLLLLLLLLL 302
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398366189 430 YGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIktTADYQHYIIFCGLATFVSAVCYI 507
Cdd:cd06174 303 LGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAA--TFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
143-512 |
1.21e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 88.01 E-value: 1.21e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSfAIVCGFGNGIVLSPLVS 222
Cdd:COG2807 51 SATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAG-TALIGAGIAVGNVLLPG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFFKRRGTALAMATIGGSVGGVVFP---IMLRSFFSMKsdtdPTYGfVWGIrtlgfldLALLTLSIILVKERLPHV 299
Cdd:COG2807 130 LIKRWFPDRVGLMTGLYTAAMGLGAALAAgltVPLAAALGWR----GALA-VWAL-------LALLALLLWLPLLRRRPA 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 300 IENSKDGESRWRYILRVYILqcfdakafldmkYLFCVLGTVFSelsinsaLTYYG------SYATSHGISANDAYTLIMI 373
Cdd:COG2807 198 AAAAAPAAASLRSLWRSPLA------------WLLTLFFGLQS-------LLYYAvvawlpPILRDAGLSAATAGLLLSL 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 374 INVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTnmYVISALYGFCSGSVFSLLPVCCGQISKT-E 452
Cdd:COG2807 259 FQLAGIPGSLLVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLP--WLWAVLLGLGQGGLFPLALTLIGLRARTpA 336
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 398366189 453 EFGKRYSTMYFVVGFGTLVGIPITGAIISIktTADYQHYIIFCGLATFVSAVC-YIISRAY 512
Cdd:COG2807 337 EAAALSGMAQSVGYLLAALGPLLVGALHDA--TGSWTAALLLLAALAVLMLVAgLLAGRPY 395
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
114-480 |
2.03e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 84.14 E-value: 2.03e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 114 FLGLIACFGLL----NSTGVIESHLQDN-QLSSESVSTIGWLFSLFLFVCSascIISGTYFDRNGFRTIMIVGTVFHVAG 188
Cdd:COG0738 10 LIAIYLLFFLWgfatALWGPLIPALKDAfGLSDAQAGLLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 189 LFATANSTKYWHFILSFAIVcGFGNGIV---LSPLVsvpAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTD 265
Cdd:COG0738 87 LLLFALAPSYPLLLLALFLL-GLGLGLLdvaANPYV---AALGPETAASRLNLLHAFFSLGALLGPLLGGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 266 PTYGFVWGIrtlgfldLALLTLSIILVKERLPHVIENSKDGESRWRYILRVyilqcFDAKAFLDMkyLFCVLGTVFSELS 345
Cdd:COG0738 163 WHLPYLILA-------VLLLLLALLFLRSKLPEIEEEEEEAAGSAASLKSL-----LKNPRLLLG--GLAIFLYVGAEGA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 346 INSALTYYGSyaTSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWlpFGTNLTNMYV 425
Cdd:COG0738 229 IGDWLPLYLK--DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLAL--LAPGPWLALI 304
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 398366189 426 ISALYGFCSG----SVFSLLPVCCGQISkteefGKRYSTMYFVVGFGTLVGIPITGAII 480
Cdd:COG0738 305 GLALVGLGLSlmfpTIFSLALDGLGKRT-----AAAVSAVLIMGIVGGAIGPPLIGFLA 358
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
143-510 |
4.04e-17 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 83.01 E-value: 4.04e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSfAIVCGFGNGIVLSPLVS 222
Cdd:cd17325 29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLA-RFLQGLASAAVWPAAMA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYF-FKRRGTALAMATIGGSVGGVVFPImLRSFFSmksdtdPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIE 301
Cdd:cd17325 108 LIADIApPEERGRAMGIFSSAIGLGFLIGPL-LGGLLA------DALGYRAPFLVCAALALLALVLALLLLPEPRPPPNK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 302 NSKDGESRWRYILRVyilqcfdakaFLDMKYLFCVLGTVFSELSINSALTYYGSYATSH-GISANDAYTLIMIINVCGIP 380
Cdd:cd17325 181 RAVSAARLRSGLRLL----------LRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELgGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 381 GRWVPGYLSDKFGRFNVAIATLltLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYST 460
Cdd:cd17325 251 SQPPAGKLSDRIGRKPLILIGL--LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 398366189 461 MYFVVGFGTLVGIPITGAIIsikTTADYQHYIIFCGLATFVSAVCYIISR 510
Cdd:cd17325 329 FNTAFSLGMVLGPLLGGFLY---DAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
143-509 |
9.42e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 79.56 E-value: 9.42e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNG-----FRTIMIVGTVFHVAGLFATANS------TKYWHFILSFaIVCGF 211
Cdd:COG2211 44 SAALVGLILLVARLWDAITDPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLLFTApdlsptGKLIYALVTY-LLLGL 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 212 GNGIVLSPLVSVPAHYF--FKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDtDPTYGFVWGIRTLGFLDLALLTLSI 289
Cdd:COG2211 123 AYTLVNIPYSALGAELTpdYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGG-DAALGYRLTALIFAVLGLLAFLLTF 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 290 ILVKERLPHVIENSKDGESrWRYILRVyilqcfdaKAFldMKYLFCVLGTVFSELSINSALTYYGSYATshGISANDAYT 369
Cdd:COG2211 202 FGTKERPVPEEEKVSLKES-LKALLKN--------RPF--LLLLLAYLLFFLALALVAALLLYYFKYVL--GLSAALVGL 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 370 LIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQIS 449
Cdd:COG2211 269 LLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVV 348
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366189 450 KTEE--FGKR-----YSTMYFVVGFGTLVGIPITGAIISI-------KTTADYQHYIIFcgLATFVSAVCYIIS 509
Cdd:COG2211 349 DYDEwkTGRRreglyFGIFTFAIKLGQALAGALAGLLLALfgyvagaAQSPSALTGIRL--LFFLLPAVLLLLA 420
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
143-507 |
1.00e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 78.75 E-value: 1.00e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSfAIVCGFGNGIVLSPLVS 222
Cdd:cd17324 32 SVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLA-RALAGLAHGGFWAIAAA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYF-FKRRGTALAMAtIGGSVGGVVFPIMLRSFFSMksdtdptygfVWGIRTLgFLDLALLTL-SIILVKERLPHvi 300
Cdd:cd17324 111 YAADLVpPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLGQ----------LLGWRAA-FLAIAVLALlAALLLWRLLPS-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 301 enSKDGESRWRYILRVYILQCFDAKAFLDMKYLFCVLGTVFselsinSALTYYGSYATS-HGISANDAYTLIMIINVCGI 379
Cdd:cd17324 177 --LPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFF------ALYTYLAPFLTDvPGFSSSAIIGLLLLFGVAGV 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 380 PGRWVPGYLSDKFGRFNVAIATLLtLFIVMFVGWLpFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISK--TEEFGKR 457
Cdd:cd17324 249 VGSPLAGRLADRGGRRALLIALLL-LAAALLLLTL-LGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPeaRGLASSL 326
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 398366189 458 YSTMYFV-VGFGTLVGipitGAIIsikTTADYQHYIIFCGLATFVSAVCYI 507
Cdd:cd17324 327 YLAAYNLgGALGAALG----GLVL---DHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
107-442 |
1.13e-15 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 78.59 E-value: 1.13e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQdnQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17423 2 WVVVLAAFLQNALVFGVLRSFGVFFVEFV--EYFEESAQRVSWITSIGLAVQQLASPVGSALSTRYGARPVVMLGGLLSS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSmksdtdp 266
Cdd:cd17423 80 LGFLLASFATSLLHLYLCIGLLSGLGWALVFAPTMATVSRYFSRRRSLATGLALTGVGLSSFALSPLFQLLLD------- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 267 TYGFVWGIRTLGFLDLALLTLSIILVKERLPhviensKDGESRWRYILRVYILQCFDAKAFLdmkyLFCvLGTVFSELSI 346
Cdd:cd17423 153 TYAWRGALLLLSALSLHLVPCGALLRPLALP------GDPPAPPRSLSAAFGLSLLTHRAFL----RYA-LATTLINTGY 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 347 NSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVI 426
Cdd:cd17423 222 FIPYVHLVAHARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADLGPLRLLHLLVLWTALTGLSLLLLPLAKVYGSLLAL 301
|
330 340
....*....|....*....|
gi 398366189 427 SALYGFCSGS----VFSLLP 442
Cdd:cd17423 302 AVAYGFCAGAlaplVFSVLP 321
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
143-443 |
3.06e-14 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 74.13 E-value: 3.06e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWhFILSFAIVCGFGNGIvLSPLVS 222
Cdd:cd17478 29 SYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW-LLLLLVALAGIGSAA-FHPEGA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFF-KRRGTALAMATIGGSVGGVVFPIM----LRSFFSMKSdtdptygFVWGIrtLGFLDLALLTLSIILVKERLP 297
Cdd:cd17478 107 RLASQAAgGRRGLAMSIFSVGGNLGFALGPLIaaalVALFGGLGL-------LILLI--IPGLAVALLLLRLRPLKKPEA 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 298 HVIENSKDGESRWRYILRVYILqcfdakafldmkylfcVLGTVFSE-LSINSALTYYGSYATSHGISANDAYTLIMIINV 376
Cdd:cd17478 178 KKAAAKSSARSTLKGVWRALLL----------------LLIIVFLRsWVLSSLTTFLPFYLVQRGYSLVFAGLLLSLFLF 241
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 398366189 377 CGIPGRWVPGYLSDKFGRFNVAIATLLTLFIvmFVGWLPFgTNLTNMYVISALYGFCSGSVFSLLPV 443
Cdd:cd17478 242 AGAIGTLIGGPLSDRFGRRRVIIASLLLAAP--FLLLFLL-TPGIWSYILLVLAGFLLFASFPVTVV 305
|
|
| MFS_MCT14 |
cd17429 |
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; ... |
106-508 |
1.08e-13 |
|
Monocarboxylate transporter 14 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 14 (MCT14) is also called Solute carrier family 16 member 14 (SLC16A14). It is an orphan transporter expressed in the brain, heart, muscle, ovary, prostate, breast, lung, pancreas, liver, spleen, and thymus. It may function as a neuronal aromatic-amino-acid transporter. MCT14 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340987 [Multi-domain] Cd Length: 361 Bit Score: 72.56 E-value: 1.08e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIesHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFH 185
Cdd:cd17429 1 AWMVVLSSFIVHILVMGSQMALGIL--NMEWLEEFQQSRGLTAWISSLSMGITLIVGPFIGLFINTCGCRKTAIIGGILT 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 186 VAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMksdtd 265
Cdd:cd17429 79 SLGWVLSAYATNVHYLFISFGVTAGIGSGMAYLPAVVMVGQYFQKRRALAQGLSTTGTGFGTFLMTILLKYLCAE----- 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 266 ptygfvWGIRTLGFLDLAL-LTLSIILVKERLphvienskdgesrwrYILRVYILQCFDAkafldmkyLFCVLGTVFSEL 344
Cdd:cd17429 154 ------FGWRNAMFIQGAVsLNLCVCGALMRL---------------FTNKVFVAFIFWA--------LFAYCSFVIPFI 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 345 SINSALTYYGSyatshgISANDAYTLIMIINVCGIPGRWVPGYLSDK--FGRFNVAIATLLTLFIVMFVgwLPFGTNLTN 422
Cdd:cd17429 205 HLPEIVKLYGL------SEQNDKFPLTSIIAIVHIFGKVILGIICDLpcISVWNVFILANFTLGVCILI--LPLMHTYTG 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 423 MYVISALYGFCSGsVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYIifCGLATFVS 502
Cdd:cd17429 277 LAIVCALIGFSSG-YFSLMPVVTEDLVGIKNLANAYGIIICANGISALLGPPFAGWIYDITQKYDFSFYV--CGLLYMVG 353
|
....*.
gi 398366189 503 AVCYII 508
Cdd:cd17429 354 IICLLL 359
|
|
| MFS_MCT7 |
cd17422 |
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; ... |
107-510 |
2.43e-13 |
|
Monocarboxylate transporter 7 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 7 (MCT7) is also called Solute carrier family 16 member 6 (SLC16A6). Zebrafish MCT7 is required for hepatocyte secretion of ketone bodies during fasting; it has been shown to be a selective transporter of the major ketone body beta-hydroxybutyrate, whose abundance is increased during fasting. MCT7 is expressed in the brain, pancreas, muscle, and prostate. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340980 [Multi-domain] Cd Length: 363 Bit Score: 71.32 E-value: 2.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQDNqlSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17422 2 WAVAVAFFFVEVFTYGVIKSFGVFFNDLMSY--FNETNSRVSWIISICVFVMTFTAPLSTVLSNRFGHRPVVMVGGLLIS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPimlRSFFSMKSdtdp 266
Cdd:cd17422 80 LGMITASFASSIVEMYLTIGIISGLGYCFTFLPTVTILSQYFKKRRSLVTAIASTGECFAVFAFA---PAFTALKE---- 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 267 TYGFVWGIRTLGFLDLalltlsIILVKERLPHVIENSKdgesrwryilrvyilqcfdakafldmkYLFCVLGTVFSELSI 346
Cdd:cd17422 153 SIGWRYCLLVVGALQL------NIVVCGALLRVLKEPG---------------------------FICYALFGLFATLGF 199
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 347 NSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVI 426
Cdd:cd17422 200 FAPQLYIIPLSLSLGIDQDWAAYMLSAMAIAELFGRISAGWVLNKCPIRKIYIELICVILLCVVLLLFPFAYGFWSLLVC 279
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 427 SALYGFCSGSVFSL-LPVCC-GQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISikTTADYQHYIIFCGLATFVSAV 504
Cdd:cd17422 280 SIFYGFMFGTVAGThIPLLAeDDVVGIEKMSSALGVYVFIQSIAGLAGPPLGGVLVD--WTQNYGSAFYSCAAGMALGAV 357
|
....*.
gi 398366189 505 CYIISR 510
Cdd:cd17422 358 FLALVR 363
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
107-504 |
2.68e-13 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 71.29 E-value: 2.68e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQDNqlSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17314 2 WFVLYVSFLLSAMSTGFILSWSLFYQPWQDA--FGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMksdtdp 266
Cdd:cd17314 80 AGYTYLSYVFNSFPLSYACFVFIGAGTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVF------ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 267 tYGFVwgiRTLGFLDLALLTLSIILVKERLPHVIENSKDgesrwryiLRVYILQCFDAKAFLDMKyLFCVLGTVFseLSI 346
Cdd:cd17314 154 -YGLA---LVYTILGILAAIVLSVVSLLGFKEPPDNQAR--------LHVQKKKTQTMGEIFRDK-VFWILFIAI--FLV 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 347 NSALTYYGSYATSHGISANDAYT-----LIMIINVCGIPGRWVPGYLSDKFGRfnvAIATLLTLFIVMFVGWLPFGTNLT 421
Cdd:cd17314 219 LIGGFLFIANMASLVRSLQLDAPsfvtkLMSIYGLFNAFGRLLWGIVADFFGG---RLSTLSILLTILGLGLCAFLFLLK 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 422 NMYV----ISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISikTTADYQHYIIFCGL 497
Cdd:cd17314 296 MTPVglvlTGSLLGFSYGGLFTVYPATVSTVFGTESFATLYGILLFAPAIGSILGPMLGAKFYD--RTPSYISAVYIYAV 373
|
....*..
gi 398366189 498 ATFVSAV 504
Cdd:cd17314 374 IVFLASA 380
|
|
| 2A0113 |
TIGR00892 |
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic ... |
100-513 |
4.33e-13 |
|
monocarboxylate transporter 1; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273325 [Multi-domain] Cd Length: 455 Bit Score: 71.31 E-value: 4.33e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 100 PEGGFkAWVVTFGCFLGLIACFGLLNSTGVIESHLQdnQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMI 179
Cdd:TIGR00892 12 PDGGW-GWVVLGATFVSIGFSYAFPKAVTVFFKELQ--QIFQATYSETAWISSIMLAVLYAGGPISSILVNRFGCRPVVI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 180 VGTVFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFS 259
Cdd:TIGR00892 89 AGGLLASLGMILASFSSNVIELYLTAGFITGLGLAFNFQPSLTMLGKYFYRRRPLANGLAMAGSPVFLSTLAPLNQYLFE 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 260 mksdtdpTYGFVWGIRTLGFLDLALLTLSIIL-------VKERLPHVIENSKDGESRWRYILRVY--ILQCFDAKAFLDM 330
Cdd:TIGR00892 169 -------SFGWRGSFLILGGLLLHCCVCGALMrpvgpsqRVSKSKSKEGLPPDGSTKKLSKKSTAekINRFLDFSLFTHR 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 331 KYLFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKfGRFNVAIATLLTlFIVMF 410
Cdd:TIGR00892 242 GFLVYLSGNVIMFLGFFAPIIFLVPYAKDKGVDEYEAAFLLSIIGFVDIFARPSCGLIAGL-KWIRPHVQYLFS-FALLF 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 411 VGWL----PFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIktTA 486
Cdd:TIGR00892 320 NGLThllcALAGDYTGLVIYCIFFGLSFGSVGALLFEVLMDLVGAQRFSSAVGLVTIVECCAVLIGPPLAGRLVDA--TK 397
|
410 420
....*....|....*....|....*..
gi 398366189 487 DYQHYIIFCGLATFVSAVCYIISRAYC 513
Cdd:TIGR00892 398 NYKYIFYASGSIVVSAGLFLAIGNYIN 424
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
107-510 |
5.99e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 70.32 E-value: 5.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGliacFGLLNSTGVIesHLQDNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17489 2 LLANFFFFLS----FYLLLPVLPL--YAHDLGGSE---AVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILsFAIVCGFGNGIVL---SPLVS--VPAhyffKRRGTALAMATIGGSVGGVVFPiMLRSFFSMk 261
Cdd:cd17489 73 LATLLYLLATSVALLLV-LRLIHGIGWGAFTtaaATLVAdiIPP----SRRGEGIGYYGLATTLAMALGP-ALGLFLYQ- 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 262 sdtdpTYGFvWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILqcfdakafldmkyLFCVLGTVF 341
Cdd:cd17489 146 -----HLGF-AVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVL-------------PPALILFLA 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 342 SeLSINSALTYYGSYATSHGISAndaYTLIMIINVCGIPG-RWVPGYLSDKFGRFNVAIATLLTLFIVMFVgwLPFGTNL 420
Cdd:cd17489 207 S-IAYGAISTFLPLYAAERGISN---AGLFFTVYAIALLLsRPFSGKLSDRKGPKTVIIPGLLLLALGLLL--LSFAGSP 280
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 421 TNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIkttADYQHYIIFCGLATF 500
Cdd:cd17489 281 WMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAEL---FGYRAMFLLAAVVVL 357
|
410
....*....|
gi 398366189 501 VSAVCYIISR 510
Cdd:cd17489 358 LALVLYIFLL 367
|
|
| MFS_MCT8_10 |
cd17420 |
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator ... |
106-504 |
9.54e-13 |
|
Monocarboxylate transporters 8 and 10, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 8 (MCT8) and 10 (MCT10) are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT has a preference for T3 and is also a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. MCT8/10 and similar proteins belong to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340978 [Multi-domain] Cd Length: 400 Bit Score: 69.87 E-value: 9.54e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLS---SESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGT 182
Cdd:cd17420 1 GWLVMVAAFWCNGSIFGIINTYGVLHSLLLERLTKlgdPEASFKAAWVGALAMGMIFFCSPIVSCFTDKIGCRLTAFAGA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 183 VFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSmks 262
Cdd:cd17420 81 AVSFGGLLLSSFCSSIGALYFTYGIMFGCGCSFAYQPSLVILGHYFKRRLGLVNGFVTAGSSVFTVILPPLLRKLLD--- 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 263 dtdpTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILQCFDAKAFLDMKYLFCVLGTVFS 342
Cdd:cd17420 158 ----SYGLEGTLRVLSLFMFVLILCSFTYRPLHPSPEDPKSKPGRRTLHSRINLFLRKIFNVEIFKRKRYVIWALGIPLA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 343 ELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWL-PFGTNLT 421
Cdd:cd17420 234 LFGYFVPYVHLMKFVKEEFFPGKDVNVPLMCIGITSGIGRLIFGVIADMPPGVKKMYLQVLSFVSIGLMSMMiPLCNSFG 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 422 NMYVISALYGFCSGSVFSLL-PVC---CGQISKTEEFGkrystmyFVVGFGTL---VGIPITGAIISikTTADYQHYIIF 494
Cdd:cd17420 314 ILISVCLVMGLFDGCFISIMaPIAfelVGPSGASQAIG-------FLLGLMSIpmtVGPPIAGLLRD--STGSYTVAFYL 384
|
410
....*....|
gi 398366189 495 CGLATFVSAV 504
Cdd:cd17420 385 AGVPPLIGSS 394
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
110-504 |
8.17e-12 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 66.47 E-value: 8.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 110 TFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGL 189
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 190 FATANSTKYWHFILsFAIVCGFGNGIVL---SPLV--SVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLrsffsmksdt 264
Cdd:cd17316 81 LLIGLLPTPILLLV-LRFLQGIGIGGEYpgaSTYVaeFAPSKRRGFALGLLQSGWALGALLAALVASLLI---------- 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 265 dPTYGFVWGIRtLGFLDLALLTLSIILVKERLphvienskdgesrwryilrvyilqcfdakafldmkyLFCVLGTVFSEL 344
Cdd:cd17316 150 -PLLSGDWGWR-ILFLIGALPALLALLLRRRT------------------------------------LLLILLWFFISF 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 345 SINSALTYYGSY-ATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNM 423
Cdd:cd17316 192 GYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLL 271
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 424 YVISALYGFCSGSVFSLLPVCCGQISKTEEfgkRYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYIIFCGLATFVSA 503
Cdd:cd17316 272 LLLLFILSFFVGGVWGALYAYLAELFPTEV---RATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILALLAIVA 348
|
.
gi 398366189 504 V 504
Cdd:cd17316 349 L 349
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
115-433 |
1.07e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 66.49 E-value: 1.07e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 115 LGLIACFGLLNS------TGVIESHLQDNQLSSESVSTIGWLFSLFLFVCSascIISGTYFDRNGFRTIMIVGTVFHVAG 188
Cdd:cd17328 1 VAVLFLINLLNYmdrftiAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLS---PIFGYLGDRYNRKWILAVGILIWSAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 189 LFATANSTKYWHFILSFAIVcGFGNGIVLSPLVSVPAHYFFK-RRGTALAM--------ATIGGSVGGVVfpimlrsffs 259
Cdd:cd17328 78 TLLSSFAPNFWQLLLFRALV-GIGEASYSPIAPTIIADLFPKeKRTRALGVfyfaiplgSGLGYVVGGLV---------- 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 260 mksdTDPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRvyilqcfDAKAFLDMK-YLFCVLG 338
Cdd:cd17328 147 ----AQATGGWRWAFRVTGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLA-------DLKALAKNPsFILSTLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 339 TVF-----SELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNV-------AIATLLTLF 406
Cdd:cd17328 216 FTAvsfvtGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPradplvcAVGLLAAAP 295
|
330 340
....*....|....*....|....*..
gi 398366189 407 IVmFVGWLPFGTNLTNMYVISALYGFC 433
Cdd:cd17328 296 FL-FLALVLALSNLLLAWVLLFLGEFL 321
|
|
| MFS_MCT9 |
cd17428 |
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; ... |
107-504 |
6.87e-11 |
|
Monocarboxylate transporter 9 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 9 (MCT9) is also called Solute carrier family 16 member 9 (SLC16A9). It is an orphan transporter that is expressed in a number of tissues including intestine and kidney. A missense variant of MCT9 (K258T) is associated with significant increase in susceptibility to renal overload (ROL) gout with intestinal urate underexcretion. This suggests that MCT9 may have a role in intestinal urate excretion; it is possible that it transports urate. MCT9 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340986 [Multi-domain] Cd Length: 361 Bit Score: 63.68 E-value: 6.87e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIesHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17428 2 WVIVFVSFLAQFLCYGSPLAVGVL--YPEWLDAFGEGKGMTAWVGSLASGVGLIASPVCSACVSSFGARPVTIFSGFMVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMksdtdp 266
Cdd:cd17428 80 GGLMLSAFAPNIYFLIFSYGIVVGLGCGLVYAATVTITCQYFDKRRGLALGLISTGSSVGLFIYAALQRELIEL------ 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 267 tYGFVWGIRTLGFLDLALLTLSiilvkerlphvienskdgesrwrYILRVYILQCFDAkafldmkylFCVLGTVFSELSI 346
Cdd:cd17428 154 -YGLDGCLLIVGALALNLLACG-----------------------SLMRLFKNRVFSA---------LFIAILLFDIGAF 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 347 NSALtYYGSYATSHGISANDAYT-LIMIINVCGIPGRWVPGYLSDkFGRFN---VAIATLLTLFIVMFVgwLPFGTNLTN 422
Cdd:cd17428 201 PPSL-LMEDVARSENIIEEIALIpLVSIIGITTAIGKLILGVLAD-FKWVNslyLYVLTLIGMGAALLA--IPFAKSYLT 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 423 MYVISALYGFCSGSvFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYiiFCGLATFVS 502
Cdd:cd17428 277 LAVLSAILGFLSGN-WSIFPYVTTKTVGIEKLGHAYGILMFFAGLGNSLGPPIVGWFYDWTQTYDIAFY--FSGFCVLLG 353
|
..
gi 398366189 503 AV 504
Cdd:cd17428 354 GF 355
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
230-482 |
1.17e-10 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 62.96 E-value: 1.17e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 230 KRRGTALAMATIGGSVGGVVFPIMLRSFfsmksDTDPTYGFVWGIrtlgfldlALLTLSIILVKERLPHVIENSKDGESR 309
Cdd:cd17477 116 ENRGRVLGLYSTVLGLGFALGPLLLALV-----GTAGALPFLIAA--------VLLLLALVPLLLTRRAAPEIEEAESIS 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 310 WRYILRVYILqcfdakafldmkYLFCVLGTVFSELSINSALTYYGsyaTSHGISANDAYTLIMIINVCGIPGRWVPGYLS 389
Cdd:cd17477 183 LRRLLRIAPL------------ALLGAFVAGFLEGAFYSLLPLYG---LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLA 247
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 390 DKFGRFNVAIATLLTLfIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGT 469
Cdd:cd17477 248 DRFDRRRVLLGCALLG-ALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGS 326
|
250
....*....|...
gi 398366189 470 LVGIPITGAIISI 482
Cdd:cd17477 327 VIGPLLAGALMDA 339
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
333-510 |
4.13e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 4.13e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 333 LFCVLGTVFSELSINSALTYYgsYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFvg 412
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPLL--LAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLL-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 413 WLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIkttADYQHYI 492
Cdd:pfam07690 78 LLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL---FGWRAAF 154
|
170
....*....|....*...
gi 398366189 493 IFCGLATFVSAVCYIISR 510
Cdd:pfam07690 155 LILAILSLLAAVLLLLPR 172
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
148-439 |
4.84e-09 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 58.08 E-value: 4.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 148 GWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIV-CGFG----NGIVLSPLVs 222
Cdd:cd17371 37 GLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAgLGFGgewaAGAALMAEY- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFFKRRGTALAMATIGGSVGGVVFPIMLrsffsmksdtdPTYGFVWGIRTLgFLDLALLTLSIILVKERLPHVIEN 302
Cdd:cd17371 116 VPARHRGKALGYVQSGWAVGWLLATLLAALLF-----------PLLPPEIAWRVL-FLLGALPALLVLFIRRFVKEPPQW 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 303 SKDGESRWRYILRVYILQCFDaKAFLDMkYLFCVLGTVFSELSINSALTYYGSYATS-HGISANDAYTLIMIINVCGIPG 381
Cdd:cd17371 184 QAARAARRHFADRPSLRELFS-PPLLRT-TLLASLLATGALGGYYGITTWLPSYLTGeRGLSFEGSAGYLVVTILGGFLG 261
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 398366189 382 RWVPGYLSDKFGR-FNVAIATLLTLFIVMFVGWLPfgTNLTNMYVISALYGFCSGSVFS 439
Cdd:cd17371 262 YLAGGFLADRIGRrNNFALFALGSAISILLYFFLP--LSPTLILILGFPLGFFASGPFS 318
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
104-247 |
6.16e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.68 E-value: 6.16e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 104 FKAWVVTFGCFLGLIACFGLLNSTGVIESHLQDnqLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTV 183
Cdd:COG2814 204 LRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQE--VLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLL 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366189 184 FHVAGLFATANSTKYWHFILSFAIVcGFGNGIVLSPLVSVPAHYF-FKRRGTALAMATIGGSVGG 247
Cdd:COG2814 282 LLALGLLLLALAGSLWLLLLALFLL-GFGFGLLFPLLQALVAELApPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MCT2 |
cd17427 |
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; ... |
107-508 |
6.85e-09 |
|
Monocarboxylate transporter 2 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 2 (MCT2) is also called Solute carrier family 16 member 7 (SLC16A7). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It transports pyruvate and lactate outside and inside of sperm and plays roles in the regulation of spermatogenesis. Genetic variation in MCT2 has functional and clinical relevance with male infertility. MCT2 is consistently overexpressed in prostate cancer (PCa) cells and its location at peroxisomes is associated with malignant transformation. MCT2 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340985 [Multi-domain] Cd Length: 367 Bit Score: 57.51 E-value: 6.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQdnQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17427 2 WAVVFGAFISIGFSYAFPKAITVFFKEIQ--EIFHTSYSEIAWISSIMLAVMYAGGPISSILVNKYGSRPVVIAGGLLCS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGsvggvvfPIMLRSFFSMKSDTDP 266
Cdd:cd17427 80 LGMISASFCNSVMQLYLCIGVIGGLGLAFNLQPALTIIGKYFYKKRPIANGLAMAGS-------PVFLSTLAPLNQFLFN 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 267 TYGFVWGIRTLGFLDLalltlsiilvkerlphvieNSKDGESRWRYIlrvyilqcfdAKAFLDMKYLFCVLGTVFSELSI 346
Cdd:cd17427 153 QFGWRGSFLILGGLLL-------------------NCCVAGSLMRPL----------GPLFKHRGFLIYLSGNVIMFLGF 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 347 NSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKfgRFNVAIATLLTLFIVMFVG----WLPFGTNLTN 422
Cdd:cd17427 204 FAPIVFLAPYAKHMGIDEYSAAFLLSILAFVDMFARPSMGLVANS--KWIRPRIQYFFSFAVMYNGvchlLCPLAEDYTG 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 423 MYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIktTADYQHYIIFCGLATFVS 502
Cdd:cd17427 282 LVIYAVFFGFAFGMVSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLIGPPLGGKLVDV--TGNYKYMYFVCGAIVIVA 359
|
....*.
gi 398366189 503 AVCYII 508
Cdd:cd17427 360 SIWLFI 365
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
333-482 |
8.89e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 8.89e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 333 LFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLtLFIVMFVG 412
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLL-LFALGSLL 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 413 wLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISI 482
Cdd:COG2814 92 -CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
143-433 |
9.39e-09 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 57.25 E-value: 9.39e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFaIVCGFGNGIVLSPLVS 222
Cdd:cd17475 29 SLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL-FLVGAGYGSVQPGGGR 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFFKR-RGTAL----AMATIGGSVGGVVFPIMLRsffsmksdtdpTYGFVWGIRTLGFLDLALLTLSIILVKERlP 297
Cdd:cd17475 108 AIMRWFPPReRGLAMgirqTGVPLGGALAAALLPPLAL-----------HYGWRAAFVVAGLVSILAAVLFWLFYREP-P 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 298 HVIENSKDGESRWRYILRVYilqcfdakAFLDMKYLFCVLGT-VFSELSInsaLTYYGSYATSH-GISANDAYTLIMIIN 375
Cdd:cd17475 176 AASAATESASTLLRSLKEVL--------RNRDVWLIAIAGALlVAPQFAL---LTFLLLFLHDHlGLSVVAAGALLAVAQ 244
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366189 376 VCGIPGRWVPGYLSDKFGRFN-------VAIATLLTLFIVMFvgwLPFGTNLTNMYVISALYGFC 433
Cdd:cd17475 245 LGGALGRIGLGRVSDRVFGGRrrpvlviTAAIAAAALLVLSL---LSPGTPLWLLVLLLILLGLF 306
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
356-508 |
1.24e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 56.82 E-value: 1.24e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 356 YATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVgwLPFGTNLTNMYVISALYGFCSG 435
Cdd:cd17325 22 YAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLL--FAFATSYWQLLLARFLQGLASA 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366189 436 SVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIkttADYQHYIIFCGLATFVSAVCYII 508
Cdd:cd17325 100 AVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADA---LGYRAPFLVCAALALLALVLALL 169
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
109-297 |
1.84e-08 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 56.41 E-value: 1.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 109 VTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESVStiGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAG 188
Cdd:cd17321 170 FSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQA--GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVG 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 189 LFATA---NSTKYWHFILSFaIVCGFGNGIVLSP-----LVSVPAHyffkRRGTALAMAT----IGGSVGGVVFPIMLRS 256
Cdd:cd17321 248 LLLLAllgADSSVWLLLPGL-VLLGLGLGLFATPltnaaLSSVPKE----KAGAASGILNtarqLGGALGVALLGALLTA 322
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 398366189 257 FFSMKSDTDPTYGFVWGIR-------TLGFLDLALLTLSIILVKERLP 297
Cdd:cd17321 323 GLSANLGDSGVAALLSAAAaafaagfHLAFLVAAALALLAALLALLLP 370
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
143-504 |
2.37e-08 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 56.01 E-value: 2.37e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDR-NGFRTIMIVGTVFHVAG--LFATANStkyWHFILSFAIVCGFGNGIVLSP 219
Cdd:cd17370 32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRtGKRKPLVILGYGLSALAkpLLALAGS---WQLVLLLRILERLGKGIRTPP 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 220 ---LVS--VPAhyffKRRGTAL----AMATIGGSVGG-VVFPIMLRSFFSMKsdtdptYGFVWGIrTLGFLDLALLTLSI 289
Cdd:cd17370 109 rdaLLAdaTPP----SGRGKAFglhrALDTLGAVLGPlLAALLLYLLGGNYR------TIFLLAA-IPALLALLILLFVV 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 290 ILVKERLPHVIENSKDGESRWRYILRVYILQCFdakafldmkylFCVLGtvfselsiNSALTYYGSYATSHGISANDA-- 367
Cdd:cd17370 178 KEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVA-----------LFALG--------NFSFAFLILRAQELGLSAALIpl 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 368 -YTLIMIIN-VCGIPGrwvpGYLSDKFGRFNVAIATLLTLFIVMFVgwLPFGTNLTNMYVISALYGFCSGSVFSLLPVCC 445
Cdd:cd17370 239 lYALFNLVYaLAAYPA----GRLSDRIGRKKLLILGYLSLALAYLG--FALGSSLWLLLLGFILWGLYMGAQESIERAAV 312
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366189 446 GQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAI---ISIKTTadyqhyIIFCGLATFVSAV 504
Cdd:cd17370 313 ADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLwdlISPSAA------FLFSAVLALIALL 368
|
|
| MFS_MCT1 |
cd17426 |
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; ... |
107-504 |
2.41e-08 |
|
Monocarboxylate transporter 1 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 1 (MCT1) is also called Solute carrier family 16 member 1 (SLC16A1). It is a proton-coupled transporter that facilitates the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. It is widely expressed in many tissues its main function is to transport lactate into the cell. MCT1 deficiency has been identified as a cause of profound ketoacidosis, a potentially lethal condition caused by the imbalance between hepatic production and extrahepatic utilization of ketone bodies. This suggests that MCT1-mediated ketone-body transport is crucial in maintaining acid-base balance. MCT1 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340984 [Multi-domain] Cd Length: 374 Bit Score: 56.04 E-value: 2.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQdnQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:cd17426 2 WAVVLGAFISIGFSYAFPKSITVFFKEIE--VIFNATSSEVSWISSIMLAVMYAGGPISSILVNKYGSRPIMIAGGCLSG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVggvvfpimlrsFFSMKSDTDP 266
Cdd:cd17426 80 AGLIAASFCNTVEGLYFCVGVVGGLGLAFNLNPALTMIGKYFYKKRPLANGLAMAGSPV-----------FLSTLAPLNQ 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 267 TYGFVWGIRTlGFLDLALLTLSIILVKErlphvienskdgesrwryilrvyILQCFDAKAFLDMK------YLFCVLGTV 340
Cdd:cd17426 149 WFFDIFGWRG-SFLILGGLLLNCCVAGS-----------------------LMRPIGPKPFLDLTlfthrgFLLYLSGNV 204
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 341 FSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSD-KFGRFNV----AIATLLTLFIVMFVgwlP 415
Cdd:cd17426 205 IMFFGLFAPLVFLSNYAKSKQISNESAAFLLSILAFVDMVARPSMGIVANtKWVRPRIqyffAASVLYNGVCHLLA---P 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 416 FGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISIktTADYQHYIIFC 495
Cdd:cd17426 282 LSTSYVGFCIYAIFFGFAFGWLSSVLFETLMDLVGAQRFSSAVGLVTIVECCPVLLGPPLLGRLNDI--YGDYKYTYWAC 359
|
....*....
gi 398366189 496 GLATFVSAV 504
Cdd:cd17426 360 GIVLIISSI 368
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
107-481 |
3.21e-08 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 55.83 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIaCFGL-LNSTGVIESHL-QDNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVF 184
Cdd:TIGR00895 16 WRAIILSFLIML-MDGYdLAAMGFAAPAIsAEWGLDP---VQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 185 HVAGLFATANSTKYWHFILsFAIVCGFGNGIVLSPLVSVPAHYFFKR-RGTALAMA----TIGGSVGGVVFPIMLrsffs 259
Cdd:TIGR00895 92 FSVFTLLCALATNVTQLLI-LRFLAGLGLGGLMPNLNALVSEYAPKRfRGTAVGLMfcgyPIGAAVGGFLAGWLI----- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 260 mksdtdPTYG----FVWGirtlGFLDLALLTLSIILVKERLPHVIENSKDGESRWRYILRVYILQCFD------------ 323
Cdd:TIGR00895 166 ------PVFGwrslFYVG----GIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIVNAIAPQMQAEAQsalpeqkstqgt 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 324 AKAFLDMKY--------LFCVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDkfgRF 395
Cdd:TIGR00895 236 KRSVFKALFqgktaritVLLWLLYFMLLVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLAD---RL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 396 NVAIATLLTLFIVMFVGWLPFG-TNLTNMYVISALYGFCSGSVFSLLPVCCGQIskteefgkrYSTMYFVVGFGTLVGIP 474
Cdd:TIGR00895 313 GPRVTALLLLLGAVFAVLVGSTlFSPTLLLLLGAIAGFFVNGGQSGLYALMALF---------YPTAIRATGVGWAIGIG 383
|
....*..
gi 398366189 475 ITGAIIS 481
Cdd:TIGR00895 384 RLGAIIG 390
|
|
| MFS_MCT12 |
cd17424 |
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; ... |
175-504 |
6.17e-08 |
|
Monocarboxylate transporter 12 of the of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 12 (MCT12) is also called Solute carrier family 16 member 12 (SLC16A12). It is a creatine transporter encoded by the cataract and glucosuria associated gene SLC16A12. A heterozygous mutation of the gene causes a syndrome with juvenile cataracts, microcornea, and glucosuria. MCT12 may function in a basolateral exit pathway for creatine in the proximal tubule. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340982 [Multi-domain] Cd Length: 363 Bit Score: 54.82 E-value: 6.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 175 RTIMIVGTVFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVF-PI- 252
Cdd:cd17424 68 QVGIILGGLLASTGLILSSFATSLEYLYLTLGVLTGLGFALCYSPAIAMVGKYFHKRKALAYGIAMSGSGIGTFILaPVv 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 253 -MLRSFFSMKSDTDPTYGFVWGIRTLGFLDLALLTLSIILVkerlphvienskdgesrwryilrvyilqcfdAKAFLDMK 331
Cdd:cd17424 148 qLLIEQFSWRGALLILGGFVLNLCVCGALMRFLLMPDFLVL-------------------------------AVSVLFLA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 332 YlfcvlgtvfselSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSD-----KFGRFNVAIATLLTLF 406
Cdd:cd17424 197 Y------------GCSPPFVYLVPYALSVGVSHQQAAFLMSILGVIDIIGNITFGWLTDrrclkKYRYFCYLFAVGMDGL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 407 IVMFvgwLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISikTTA 486
Cdd:cd17424 265 CCLF---LPILKTFPLLVPFSFTFGYFDGAYVALIPVVTSDVVGTSSLSSALGVVYFLHAVPYLVSPPIAGWLVD--TTG 339
|
330
....*....|....*...
gi 398366189 487 DYQHYIIFCGLATFVSAV 504
Cdd:cd17424 340 TYTAAFLLSGFSMIFSSL 357
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
147-482 |
8.53e-08 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 54.62 E-value: 8.53e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 147 IGWLFSLFLFVCSASCIISGTYFDRNG-----FRTIMIVGTVFHVAG---LFATANSTKYWHFILSFAIVCGFGngiVLS 218
Cdd:pfam13347 35 VGLVLLVARLVDAFTDPIVGHIIDRTRtrwgrRRPWLLLSAIILAVSfilLFTPPELGRAPLFIWLLATYILLR---IAY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 219 PLVSVPAH-------YFFKRRGTALA---MATIGGSVGGVVFPIMLRSFFSMKSDTDPTYgfvwgiRTLGFLDLALLTLS 288
Cdd:pfam13347 112 TFFEIPYWslgpeltRDYDERTSLTSyrsFFSVGGGLLAAALAFPLVLILGGTGLERKGY------RIFALIGAVLMLLG 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 289 IILV----KERlPHVIENSKDGESRWRYILRVyILQCFDAKAFldMKYLFCVLGTVFSELSINSALTYYGSYATSHGISA 364
Cdd:pfam13347 186 VIITaagtKER-VSMRSKEDTGQKEAGSLLDM-LKEVFRNRAF--LILLASFLLAALAMGVLNGLLLYYFRYVLGNGFAA 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 365 NDAYTLIMIINVCGIPgrwVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVC 444
Cdd:pfam13347 262 SAFPLVFTIGALLGIP---LWPPLAKRIGKKNTYILGALITIAGFALALLLGPNNTLLFLVLYIIIGFGYGSSFFLPWSM 338
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 398366189 445 CGQISKTEEF--GKRYSTMY-----FVVGFGTLVGIPITGAIISI 482
Cdd:pfam13347 339 LADVVDYGELrtGKRREGTFfamwsFISKLATGVGLGVSGLLLSA 383
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
143-449 |
1.87e-07 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 53.41 E-value: 1.87e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTK-YWHFILSfAIVCGFGNGIVLSPLV 221
Cdd:cd17341 32 STSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSsYWGLLVL-GFLLGFAGANFASGQP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 222 SVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTDPTYGFVWGIRTLGFLDLALLTLSIILVKErLPHVIE 301
Cdd:cd17341 111 WASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGILLAIAAVLVLLFGDD-LPTGKA 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 302 NSKDGESRWRYILRVYILqcfdakafldmkYLFCVL--GTVFSELSINSALTYYgsYATSHGISANDAYTLIMIINVCGI 379
Cdd:cd17341 190 SALEFLKVQLAVLKNYRT------------WILSLLygVTFGSFVGFSNVLPTY--FKTRFGLPLVTAGILAALFPLAGA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 380 PGRWVPGYLSDKFGrfnvAIATLLTLFIVM-----FVGWLPFGTN------LTNMYVISALYGFCSGSVFSLLPVCCGQI 448
Cdd:cd17341 256 LARPAGGWLSDRFG----GRRRLWWLFIVMtigaaLLSLSLPTSGtnlvlfLALFVALGLGAGAGNGSVFRMVPFIFRRE 331
|
.
gi 398366189 449 S 449
Cdd:cd17341 332 L 332
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
143-504 |
2.75e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.57 E-value: 2.75e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILsFAIVCGFGNGIvLSPLVS 222
Cdd:cd17474 32 SPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLA-GRALQGIGAAG-LGPLAL 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFFKRRGTALAMATIGG--SVGGVVFPImLRSFFSMKSdtdpTYGFVWGirtLGFLDLALLTLSIILVKERLPHVI 300
Cdd:cd17474 110 TLIGDLFEGGERAKAMGLYEAalGLGIAVGPL-LGGLLAAIS----WRYPFFL---LAALIPVAFLAILFLLPEPKEKAK 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 301 ENSKDGESRWRYILRVYILQCFDAKAFLdmkYLFCvLGTVFSELSINSALTYYGSyatSHGISAndaytLIMIINVCGIP 380
Cdd:cd17474 182 SSSATKLRDLKKALRGRGLLTFLVSAFL---YFFL-YFAFLTYLPFLLELLYGIS---PIIIGL-----LFAGWSVLLAL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 381 GRWVPGYLSDKFGRFNVAIATLLTLFIVMFVgWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKrYST 460
Cdd:cd17474 250 GSLFVGRLLKKRFGARRILVIGLLLYALSLL-LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGT-ASS 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 398366189 461 MY-FVVGFGTLVGIPITGAIISIkttADYQHYIIFCGLATFVSAV 504
Cdd:cd17474 328 LYnFVRFLGQAVGPLLFGLLLEI---FGLSAPFLVGAAIALAAAV 369
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
143-375 |
3.97e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 52.23 E-value: 3.97e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAG--LFATANSTkyWHFILSFAIVcGFGNGIVLSP- 219
Cdd:cd17329 33 SASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGfaLLGFAHSP--WLFAIALVLT-GFGGGLFEPAs 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 220 ---LVSVPAHyffKRRGTALAMATIGGSVGGVVFPIMLRSFFsmksDTDPTYGFVwgIRTLGFLdLALLTLSIILVKERL 296
Cdd:cd17329 110 eamIADVTTP---ENRTRAFSLLYWAINLGVAIGPLLGGLLL----LYSFRLLFL--AAAVLFL-LAALVLLFLLPETRP 179
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398366189 297 PHVIENSKDGESRWRYILRvyilqcfdAKAFLdmkyLFCVLGTVFSeLSINSALTYYGSYATSHGISANDAYTLIMIIN 375
Cdd:cd17329 180 KRRAAEKTEILRGYKIVLR--------DRAFL----LFLLASFLIS-LIYFQLESTLPVYVVEILGLGESLLGLLLALN 245
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
143-251 |
4.74e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.74e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGL--FATANSTKYWHFILSFAIVCGFGNGIVLSPL 220
Cdd:pfam07690 233 SALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAAlgLLLLSLTLSSLWLLLALLLLGFGFGLVFPAL 312
|
90 100 110
....*....|....*....|....*....|..
gi 398366189 221 VSVPAHYF-FKRRGTALAMATIGGSVGGVVFP 251
Cdd:pfam07690 313 NALVSDLApKEERGTASGLYNTAGSLGGALGP 344
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
107-416 |
6.96e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 50.97 E-value: 6.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLqdnqlsSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHV 186
Cdd:COG0477 17 LALALGTFLEGLDFTIVNVALPSIAADL------GASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 187 AGLFATANSTKYWHFILsFAIVCGFGNGIVLSPLVSVPAHYF-FKRRGTALAMATIGGSVGGVVFPI---MLRSFFSmks 262
Cdd:COG0477 91 LASLLCGLAPSPELLIA-ARALQGIGAGGLMPGALALIAELFpARERGRALGLWGAAIGLGLALGPLlggLLVAALG--- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 263 dtdptygfvWGIrtlGFLDLALLTLSIILVKERLPhvienskdgESRWRYILRVYILqcfdAKAFLDMKYLFCVLGTVFS 342
Cdd:COG0477 167 ---------WRW---IFLINAPLGLLALVLRLRLP---------ESRGLLLALLALA----LAALLLAALALALLALLLL 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366189 343 ELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWLPF 416
Cdd:COG0477 222 LLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
336-505 |
1.20e-06 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 50.99 E-value: 1.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 336 VLGTVFSELSINS----ALTYYGSYATSH-GISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAI--ATLLTLFIV 408
Cdd:cd17369 230 LLLAIGLRLAENVlfylFTTFALSYATQTlGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLagALLAALFAF 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 409 MFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCgqiskTEEFGK--RYSTMYFVVGFGTLVGIPITGAIISIKTTA 486
Cdd:cd17369 310 PFFWLLDTGSTWLIVLAAVVVLGVLHGMMYGPQAAFL-----AELFPTrvRYTGASLGYQLGAILGGGFAPLIATALVAA 384
|
170 180
....*....|....*....|....
gi 398366189 487 DYQH-----YIIFCGLATFVSAVC 505
Cdd:cd17369 385 TGSWwpvalYLAALAVISLVAALF 408
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
143-513 |
3.50e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 49.12 E-value: 3.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILsFAIVCGFGNGIVLSPLVS 222
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL-LRFLTGLGLGAAMPNAIT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYF-FKRRGTA--LAMA--TIGGSVGGVVFPIMLrsffsmksdtdPTYGfvWgiRTLgFLDLALLTLsIILVkerlp 297
Cdd:cd17365 111 LVSEYApARRRSLAvtLMFCgyPLGAALGGFLAAALI-----------PAFG--W--RSV-FLLGGVPPL-ILLP----- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 298 hvienskdgesrwryILRVYILQCFdakAFldmkylFCVLgtvfseLSINSALTYYGSYATSHGISANDAYTLIMIINVC 377
Cdd:cd17365 169 ---------------LLRGTLLLWV---TF------FMGL------LLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 378 GIPGRWVPGYLSDKFGRFNVAIAT-LLTLFIVMFVGWLPFGTNLtnMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGK 456
Cdd:cd17365 219 GVIGSLLLGWLADRFGPKRVLALFfALGAVSLALLGVSPASLVL--LYVLVFLAGACVNGAQVGLYALAARFYPTEVRAT 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 398366189 457 RYSTMYFVVGFGTLVGIPITGAIISIKTTADYQHYIifCGLATFVSAVCYIISRAYC 513
Cdd:cd17365 297 GVGWALGVGRLGAILGPLLGGLLLAAGLGPESVFLA--LAIPAALGALAVLLLRLRR 351
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
143-432 |
6.38e-06 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 48.53 E-value: 6.38e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIvCGFGNGIVLSPLVS 222
Cdd:TIGR00881 28 SKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWAL-NGIFQGMGWPPCGR 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFFKR-RGTALAMATIGGSVGGVVFPIMLRSFFSMKSDTDPTYgFVWGIRTLGFLDLALLTLSIILVKERLP---- 297
Cdd:TIGR00881 107 TVTKWFSRSeRGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVF-IVPGIIAIIVSLICFLLLRDSPQSCGLPpaee 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 298 -------HVIENSKDGESRWryilrvyilQCFDAKAFLDMKYLFCVLGTVFSELSINSALTYYGSYAT-SHGISANDAYT 369
Cdd:TIGR00881 186 mpneepdGDAEKKEEELTKK---------QIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTqEKGFSKEKASW 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 398366189 370 LIMIINVCGIPGRWVPGYLSDKF---GRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGF 432
Cdd:TIGR00881 257 AFTLYELGGLVGTLLAGWLSDKLfngRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFALGF 322
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
143-508 |
7.01e-06 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 48.34 E-value: 7.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRT----IMIVGTVFHVAGLFATAnstkyWHFILSFAIVCGFGNGIVLS 218
Cdd:cd17319 36 SPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKvlavSMLLWSLFTALTGFATS-----LTSLYVLRFLLGVAEAGFFP 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 219 PLVSVPAHYFFKR-RGTALAMATIGGSVGGVVFPIMLrsffsmksdtdptygfVWGIRTLG----FLDLALLTLSIILVk 293
Cdd:cd17319 111 GAIKALAEWFPAReRGRATGLFNSGAPLGAAIGPPLS----------------GWLLLLFGwrwaFIIEGLLGLLLAVL- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 294 erlphvienskdgesrWRYILRVyilqcfdakafldmkylfcVLGTVFSELSINSALTYYGSY-----ATSHGISANDAY 368
Cdd:cd17319 174 ----------------WWFYLRQ-------------------VWGLALGYFGINYALYGLLTWlptylKQARGFSLKQVG 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 369 TLIMIINVCGIPGRWVPGYLSDKFGRFN----VAIATLLTLFIVMFVgwlPFGTNLTNMYVISALYGFCSGSVFSLLPVC 444
Cdd:cd17319 219 LLAAIPFLAGAIGMILGGRLSDRLLRGArrlvIIIGLLLAAVGLLLA---YLTTSPVVAVILLSLAGFGIGAASPVFWSL 295
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366189 445 CGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAIISikTTADYQHYIIFCGLATFVSAVCYII 508
Cdd:cd17319 296 PADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVD--ATGSYTAAFLFLAAVALLAALLVLL 357
|
|
| MFS_MelB_like |
cd17332 |
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ... |
237-482 |
7.20e-06 |
|
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340890 [Multi-domain] Cd Length: 424 Bit Score: 48.37 E-value: 7.20e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 237 AMATIGGSVGGVVFPIMLRSFfsmkSDTDPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGESR--WRYIL 314
Cdd:cd17332 143 FFATIGGLLVTVLPPPLVAYF----GGGNASRGYFLTALIIGIIGIILLLICFFGTRERVVPPEEEKSKLPLLksLKALL 218
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 315 RvyilqcfdAKAFLDMkylfcVLGTVFSELSINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGR 394
Cdd:cd17332 219 K--------NRPFLIL-----LLAYLLYFLAFNIVNTVLVYYFKYVLGGRAELVLLLLLILSGALLALLPWPPLKKRFGK 285
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 395 FNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEF--GKR-----YSTMYFVVGF 467
Cdd:cd17332 286 KKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADVIDYGELktGKRregifYSVMTFFRKL 365
|
250
....*....|....*
gi 398366189 468 GTLVGIPITGAIISI 482
Cdd:cd17332 366 GLALAGALVGLILSL 380
|
|
| MFS_MCT6 |
cd17425 |
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; ... |
106-255 |
7.59e-06 |
|
Monocarboxylate transporter 6 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 6 (MCT6) is also called Solute carrier family 16 member 5 (SLC16A5). MCT6 has been shown to transport bumetanide, nateglinide, probenecid, and prostaglandin F2a, but not L-lactic acid, in a pH- and membrane potential-dependent manner. It may be involved in the disposition and absorption of various drugs. MCT6 is expressed in the kidney, muscle, brain, heart, pancreas, prostate, lung, and placenta. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340983 [Multi-domain] Cd Length: 364 Bit Score: 48.23 E-value: 7.59e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESVSTigWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFH 185
Cdd:cd17425 1 AWVVLLATMIVQGLTLGFPSCIGIFFTDLQKEFQASNSETS--WFPSIMTAVLHAGGPLCSILVERFGCRVTVMLGGLLS 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 186 VAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLR 255
Cdd:cd17425 79 GVGMVASSFSHSIVQLYFTAGFITGLGFCFSFQSSVTVLGFYFVRRRALANALASTGTSIGLTLWPLLSQ 148
|
|
| MFS_Mch1p_like |
cd17354 |
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ... |
116-491 |
9.58e-06 |
|
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340912 [Multi-domain] Cd Length: 385 Bit Score: 48.02 E-value: 9.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 116 GLIACFGLlnSTGVIESHLQDNQLSSESVSTIGWLFSLFLfvcsascIISGTYFDRNGFRTIMIVGTVFHVAGLF----- 190
Cdd:cd17354 17 GSIYLFSL--YSPPLKSTLGYSQQQNNLLSVAKDLGYLVG-------PLLGLLSDRLGPWLLLLIGAILFFPGYGvlwlv 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 191 --ATANSTKYWHFILSFAIVcgfGNGIV---LSPLVSVpAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDtd 265
Cdd:cd17354 88 vtGLISDLSFWLMCLCFFLI---GNSTSslyTAALVTC-AKNFPESRGLAIGIPKGCYGLSGAIGSQLYKALFFHDSA-- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 266 ptygfvwgiRTLGFLDLALLTLSIILVkerlphvienskdgesrwrYILRVYILQCFDAKAFLDMKYLFCVLGtvfseLS 345
Cdd:cd17354 162 ---------RVFLFLAVLPAVVGLLAW-------------------FSVRIVSIEEGEFLKDIDFWLLFISLF-----LG 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 346 INSALTYYGSYA--TSHGISANDAYTLIMIINVCGIPGRWVPGYLSD----KFGRFNVAIATLLTLFIVMFVGWLPFGTN 419
Cdd:cd17354 209 VGPGEMFINNLGqiGQSLTGPSNTSTLVSLFSIFSFLGRLLSGLLSDlfvrKFRLPRPSRMVLLLLILSLGHLLQAFGLP 288
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366189 420 LTNMYVISALYGFCSGSVFSLLPvccgqISKTEEFG-KRYSTMYfvvGFGTLvGIPITGAIISIKTTADYQHY 491
Cdd:cd17354 289 SGALYVASALIGFGYGGLFSIAP-----TIVSELFGlKNFGTNY---GFLML-APAIGSLIFSVIYAGVYYDN 352
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
143-481 |
1.44e-05 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 47.17 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWhFILSFAIVCGFGNGIVLSPLVS 222
Cdd:cd17321 29 SPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLA-FLIAARALQGIGAAAIMPASLA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYF-FKRRGTALAMATIGGSVGGVVFPI---MLRSFFSmksdtdptygfvWgiRTLGFLDLALLTLSIILvkerlph 298
Cdd:cd17321 108 LIAATFpGERRGRALGLWGAVVGIGAALGPLlggLLLELFG------------W--RWIFLINVPIGLVALLL------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 299 vienskdgesrwryilrvyilqcfdAKAFLDMkyLFCVLGTVFSELSINSALTYYGSYAtsHGISANDAYTLIMIINVCG 378
Cdd:cd17321 167 -------------------------ARTFSGA--VLAAFLLGAALGGLLFLLPLYLQGV--LGYSPLQAGLALLPLALAM 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 379 IPGRWVPGYLSDKFG-RFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEFGKR 457
Cdd:cd17321 218 LVAAPLAGRLADRFGpRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAA 297
|
330 340
....*....|....*....|....
gi 398366189 458 YSTMYFVVGFGTLVGIPITGAIIS 481
Cdd:cd17321 298 SGILNTARQLGGALGVALLGALLT 321
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
111-258 |
1.44e-05 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 47.62 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 111 FGCFLGLIACFGLLNSTGVIESHLQDNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLF 190
Cdd:cd06179 1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPS---SNSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSI 77
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366189 191 ATANSTKYWHFILSFAIvCGFGNGI-VLSPLVS---VPAhyffKRRGTALAMATIGGSVGGVVFPIMLRSFF 258
Cdd:cd06179 78 VAGTAKSVNMLIGGQAL-IGIGAGTqGLGAAVAselVPN----KYRGLVQGVVNLVASPGSALGPLIAGALV 144
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
105-220 |
1.55e-05 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 47.27 E-value: 1.55e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 105 KAWVVTFGCFL-----GLIACFGLLNSTGVIESHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMI 179
Cdd:pfam00083 1 VALVAALGGFLfgydtGVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLL 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 398366189 180 VGTVFHVAGLFATANSTKYWHFILSFA--IVCGFGNGI--VLSPL 220
Cdd:pfam00083 81 IANVLFVIGAVLQGAAKGKWSVYQLIVgrVLVGIGVGGasVLAPM 125
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
143-453 |
3.51e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 46.11 E-value: 3.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILsFAIVCGFGNGIVLSPLVS 222
Cdd:cd17312 36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAV-LWGLNGLFQSMGWPPCVK 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYFF-KRRGTALAMATIGGSVGGVVFPIMLRSFFSmksdtdpTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIE 301
Cdd:cd17312 115 LLGNWFSkKERGTVYGIWSTSHNFGGILAPILAASLAS-------YYGWRAAFLVPGIVGLVVAIILFFFLRDSPPYVWV 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 302 NSkdgesrwryilrvyilqcfdakafldmkylFCVLGTVFSELSINSALTYYgsYATSHGISANDAYTLIMIINVCGIPG 381
Cdd:cd17312 188 LS------------------------------LAYAFVYIVRYACLDWGPLY--LYEVKGYSLIDAGWFSSLYEVGGIAG 235
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366189 382 RWVPGYLSDKF--GRFNVAIATLLTLFIVMFVGWLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEE 453
Cdd:cd17312 236 TILAGLLSDKLfgGRRAPIAVIYMLLMTLSLALFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGRKE 309
|
|
| MFS_MCT8 |
cd17465 |
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; ... |
107-255 |
3.72e-05 |
|
Monocarboxylate transporter 8 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 8 (MCT8) is also called Solute carrier family 16 member 2 (SLC16A2) or X-linked PEST-containing transporter. MCT8 is a very active and specific thyroid hormone transporter which stimulates the cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). Inactivating mutations in SLC16A2, the gene that encodes MCT8, lead to an X-linked syndrome with severe neurological impairment known as Allan-Herndon-Dudley syndrome (AHDS). AHDS is characterized by congenital hypotonia that progresses to spasticity with severe psychomotor delays, spastic paraplegia and dystonic movements, global developmental delay, and profound intellectual disability. MCT8 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341023 [Multi-domain] Cd Length: 367 Bit Score: 45.94 E-value: 3.72e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQ---DNQLSSESVSTIGWLFSL---FLFVCSAsciISGTYFDRNGFRTIMIV 180
Cdd:cd17465 2 WVVVFAATWCNGSIFGIQNSFGILYVMLLneqEDQKDQAVQFKTAWVGALamgMIFFCSP---VVSIFTDRFGCRKTAMG 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 398366189 181 GTVFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLR 255
Cdd:cd17465 79 GAAVAFIGLLSSSFTKSLGLRYFTYGILFGCGSSFAFQPSLVILGHYFRRRLGLANGVVTAGSSLFSMLLPFLLK 153
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
138-479 |
4.42e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 45.78 E-value: 4.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 138 QLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVG---TVFHVAGLFATANstkyWHFILSFAIVCGFGNG 214
Cdd:cd17333 24 EAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGlllISLALALIFATPS----IYLFVVLMFLAGLGAG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 215 IVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFsmksdtdpTYGFVWgirTLGFLDLALLTLSIILVKE 294
Cdd:cd17333 100 ILDTGANTFVGALFEESSATRLNVLHGFFGLGALIGPLIATSLL--------TSELSW---SWAYLIIGLIYLLLAILIL 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 295 RLphvieNSKDGESRWRYILRVYILQCFDAKAFLDMKYLFCVLGTVFSELSINSALTYYGSYAT-SHGISANDAYTLIMI 373
Cdd:cd17333 169 LT-----LFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVeKKHVSDGLAGYLLSG 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 374 INVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWlpFGTNLTNMYVISALYGFCSGSVFSLLpvccgqISKTEE 453
Cdd:cd17333 244 FWVGITIGRLLGGPISRRIKPHTLLVLSGSGALLGLLILL--LAPTLVVGLVATALLGLFMAALFPTI------LSLGIS 315
|
330 340 350
....*....|....*....|....*....|.
gi 398366189 454 FGKRYST-----MYFVVGFGTLVGIPITGAI 479
Cdd:cd17333 316 NLPYAKGkgtsvLLAAGSIGGAIIPFIMGFI 346
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
114-292 |
4.45e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 45.61 E-value: 4.45e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 114 FLGLIACFGLLNST-GVIESHLQDNQLSsesVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFAT 192
Cdd:cd17370 205 YLLAVALFALGNFSfAFLILRAQELGLS---AALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGF 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 193 ANSTKYWHFILSFAIVcGFGNGI---VLSPLVS--VPAHyffkRRGTALAMAT----IGGSVGGVVFPIMLRSFFsmksd 263
Cdd:cd17370 282 ALGSSLWLLLLGFILW-GLYMGAqesIERAAVAdlVPAE----LRGTAYGLFNtvvgIGWLLASLIAGYLWDLIS----- 351
|
170 180
....*....|....*....|....*....
gi 398366189 264 tdPTYGFVWGIrtlgfldlALLTLSIILV 292
Cdd:cd17370 352 --PSAAFLFSA--------VLALIALLLL 370
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
104-292 |
4.97e-05 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 45.64 E-value: 4.97e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 104 FKAWVVTFGCFLGLIACFGLLNSTGVIESHLQdnQLSSESVSTIGWL---FSLFLFVCSascIISGTYFDRNGFRTIMIV 180
Cdd:cd17503 175 FKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQ--NVLGYSAFESGLVlapGGLASAILS---PLVGRLLDKFGPRLLLLA 249
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 181 GTVFHVAG--LFATANSTKYWHFILSFAIVCGFGNGIVLSPLV-----SVPAHyfFKRRGTAL--AMATIGGSVGGVVFP 251
Cdd:cd17503 250 GLLLLALGtlLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNtlalnSLPPE--QIGDATALfnTIRQLGGSIGTALLA 327
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 398366189 252 IML--RSFFSMKSDTDPTYGFVWGIRTLGFLDLALLTLSIILV 292
Cdd:cd17503 328 TLLtnRTQFHHSRLSELLAQQVQKQALIIAFNDAFLVSAILLL 370
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
106-254 |
5.62e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 45.63 E-value: 5.62e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLlnsTGVIESHLQDNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDR-NGFRTIMIVGTVF 184
Cdd:COG2807 217 AWLLTLFFGLQSLLYYAV---VAWLPPILRDAGLSA---ATAGLLLSLFQLAGIPGSLLVPLLADRlGDRRPLLLLLGLL 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366189 185 HVAGLFATANSTKYWHFIlsFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTAL--AMATIGGSVGGVVFPIML 254
Cdd:COG2807 291 GLAGLLGLLLAPGSLPWL--WAVLLGLGQGGLFPLALTLIGLRARTPAEAAAlsGMAQSVGYLLAALGPLLV 360
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
361-480 |
2.87e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 2.87e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 361 GISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMfvGWLPFGTNLTNMYVISALYGFCSGSVFSL 440
Cdd:cd17329 31 GLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGF--ALLGFAHSPWLFAIALVLTGFGGGLFEPA 108
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 398366189 441 LPVCCGQISKTEEFGKRYSTMYFVVGFGTLVGIPITGAII 480
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL 148
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
108-272 |
3.36e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 43.01 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 108 VVTFGCFLGLIACFGLLnstgvIESHLQDNQLssesvsTIGWLFSLFLFVCSASCIISGTYFDRNGFR-------TIMIV 180
Cdd:cd17341 215 GVTFGSFVGFSNVLPTY-----FKTRFGLPLV------TAGILAALFPLAGALARPAGGWLSDRFGGRrrlwwlfIVMTI 283
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 181 GTVFhvAGLFATANSTKYWHFILSFaIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLrsFFSM 260
Cdd:cd17341 284 GAAL--LSLSLPTSGTNLVLFLALF-VALGLGAGAGNGSVFRMVPFIFRRELGAVTGLVGAIGGLGGFFLPLLF--GSSA 358
|
170
....*....|..
gi 398366189 261 KSDTDPTYGFVW 272
Cdd:cd17341 359 LMTGSGVGAFSL 370
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
143-252 |
3.45e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 42.93 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIvcGFGNGIVLSPLVS 222
Cdd:cd17478 228 SLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLA--GFLLFASFPVTVV 305
|
90 100 110
....*....|....*....|....*....|.
gi 398366189 223 VPAHYFFKRRGTALAMA-TIGGSVGGVVFPI 252
Cdd:cd17478 306 LAQELLPGNVGLASGLMmGLSFGLGGIGAPV 336
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
143-502 |
3.58e-04 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 42.94 E-value: 3.58e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIvCGFGNGIVLSPLVS 222
Cdd:cd17502 28 GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAI-QGIGGGGLMSLAFI 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 223 VPAHYF-FKRRGTALAMATIGGSVGGVVFPIMLRSFfsmksdtdpTYGFVWgiRTLGFLDLALLTLSIILVkerlphvie 301
Cdd:cd17502 107 IIADLVpPRERGKYQGYIGAVFGIASVAGPLIGGAF---------TDHLSW--RWCFYINLPIGGLALALL--------- 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 302 nskdgesrwRYILRVYIlqcfdakafldmkYLFCVLGTVFSelsinsALTYYGSYATS-HGISANDAyTLIMIINVCGIP 380
Cdd:cd17502 167 ---------RTILLSSI-------------FGFLFGGALFG------LIYYLPLYFQLvLGDSATKS-GVRLLPLIIGLV 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 381 -GRWVPGYLSDKFGRFNvaiATLLTLFIVMFVG-----WLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKTEEF 454
Cdd:cd17502 218 iGSIISGALISKTGRYK---PLIVIGTILMSVGaglltTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADV 294
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 398366189 455 GKRYSTMYFVVGFGTLVGIPITGAiisikttadYQHYIIFCGLATFVS 502
Cdd:cd17502 295 GVATATNTFFRSLGGTLGVAITDV---------FLVALALAALAFLLS 333
|
|
| MFS_MCT10 |
cd17464 |
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; ... |
107-255 |
6.06e-04 |
|
Monocarboxylate transporter 10 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 10 (MCT10) is also called Solute carrier family 16 member 10 (SLC16A10). In addition, human MCT10 is also called T-type amino acid transporter 1 (TAT1). MCT10 is a sodium-independent transporter that mediates the uptake or efflux of aromatic acids such as Phe, Tyr, and Trp, as well as L-3,4-di-hydroxy-phenylalanine. It is also a thyroid hormone transporter with preference for triiodothyronine (T3). MCT10 is expressed in intestine, kidney, liver, muscle, and placenta, and appears predominantly localized in the basolateral membrane. It belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341022 [Multi-domain] Cd Length: 395 Bit Score: 42.09 E-value: 6.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQD---NQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTV 183
Cdd:cd17464 2 WVVMLAAMWCNGSVFGIQNAFGVLFVSLLEefgSKDDAQMRFKTAWVGSLSMGMIFFCSPIVSVFTDLFGCRKTATGGAA 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 398366189 184 FHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSVGGVVFPIMLR 255
Cdd:cd17464 82 VGFVGLLASSFVSSIEPLYFTYGIIFACGCSFAYQPSLVILGHYFKKRLGLVNGIVTAGSSVFTITLPFLLR 153
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
107-432 |
9.89e-04 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 41.46 E-value: 9.89e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 107 WVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESvsTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFH- 185
Cdd:cd17345 2 WQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKT--EIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSa 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 186 -VAGLFATANSTKYWHFILSFAIV-CGFGNGIVLSPLVSVPAHYFFKR-RGTALAMATIGGSVGG-VVFPIMLRSFFSMK 261
Cdd:cd17345 80 iINILIGFVPSATSSVGLMFILLFlNGWFQGMGWPPSGRTMVHWFSKKeRGTWTSIWNISHNVGGgLVGPLAGLGLAIFG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 262 SDTDPTYGFVWGIRTLGFLDLALLTLSIILVKERLPHVIENSKDGE------------SRWRyILRVYILQcfdakaflD 329
Cdd:cd17345 160 DGWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPeeadgeeeeqelSAWE-IFVKYVLK--------N 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 330 MKYLFCVLGTVFSEL---SINSALTYYgsYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLF 406
Cdd:cd17345 231 KLLWYIAIANVFVYLvryGILDWAPTY--LSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIFMI 308
|
330 340
....*....|....*....|....*....
gi 398366189 407 IVM---FVGWlpFGTNLTNMYVISALYGF 432
Cdd:cd17345 309 LVIvalIVYW--LAPNVLVDLIALIALGF 335
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
146-440 |
1.08e-03 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 41.46 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 146 TIGWLfSLFLFVCSASCIISGTYF-DRNGFRTIMIVGTVFHVAG----LFATANSTKYWHFIlsFAIVCGFGNGIVLSpl 220
Cdd:cd17398 40 AVDWT-SMIYMLTYIPLIFPATWLlEKYGLRVTVLLGSFLNCLGawlkLFSSSPDLFWVAMA--GQTICALAQVFILG-- 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 221 vsVPAHY---FF--KRRGTALAMATIGGSVG---GVVFPIMLRSffSMKSDTDPTYGFVWGIRTLGFLDLALLTLSIILV 292
Cdd:cd17398 115 --IPPRLaavWFgpDEVSTATAIGVFGNQLGvalGFVLPPLLVP--NSENKDEIGKGLSILFYGVAGICTALFILVIIFF 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 293 KERLPH--------VIENSKDGESRWRYILRVYILQCFDakaFLDMKY-----LFCVLGTVFSELsinsALTYYGSYATS 359
Cdd:cd17398 191 KEKPPIppsraqaaAQELRSEDQSYLGSLKRLFKNKGFL---LLLITYgintgVYYAISTLLNQM----VLEYFPNEEVN 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 360 HGISAndaytLIMIInvCGIPGRWVPGYLSDKFGRFN-VAIATLLTLFIVM--FVGWLPFGtNLTNMYVISALYGFCSGS 436
Cdd:cd17398 264 AGWIG-----LTLVI--AGLVGSVVAGIWLDKTKKYKeTTIIVYILSFIGMvaFTFTLDLG-SIWVVFLTAGALGFFMTG 335
|
....
gi 398366189 437 VFSL 440
Cdd:cd17398 336 YLPV 339
|
|
| MFS_MCT3_4 |
cd17430 |
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator ... |
106-245 |
1.10e-03 |
|
Monocarboxylate transporters 9 and 14, and similar proteins of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 3 (MCT3) and 4 (MCT4) are also called Solute carrier family 16 members 8 (SLC16A8) and 3 (SLC16A3), respectively. They are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT3 is preferentially expressed in the basolateral membrane of the retinal pigment epithelium and plays a role in pH and ion homeostasis of the outer retina by facilitating the transport of lactate and H(+) out of the retina. Mice deficient with MCT3 display altered visual function. MCT4 is highly expressed in tissues dependent on glycolysis, and it plays an important role in lactate efflux from cells. MCT4 is expressed in neurons and astrocytes; it has been found to play a role in neuroprotective mechanism of ischemic preconditioning in animals (in the gerbil) with transient cerebral ischemia. Increased MCT4 expression has also been correlated with worse prognosis across many cancer types. MCT3/4 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340988 [Multi-domain] Cd Length: 368 Bit Score: 41.25 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIESHLQdnQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFH 185
Cdd:cd17430 1 GWAVLFGCFVITGFSYAFPKAVSVFFKELM--REFGVGYSDTAWISSILLAMLYGTGPLCSILVNRFGCRPVMLVGGLLA 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 186 VAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGGSV 245
Cdd:cd17430 79 SLGMILASFCTSIIQLYLTAGVITGLGLALNFQPSLIMLGRYFDKRRPLANGLAAAGSPV 138
|
|
| MFS_MCT5 |
cd17421 |
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; ... |
106-509 |
1.67e-03 |
|
Monocarboxylate transporter 5 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporter 5 (MCT5) is also called Solute carrier family 16 member 4 (SLC16A4). It is an orphan transporter expressed in the brain, muscle, liver, kidney, lung, ovary, placenta, and heart. It is a member of the monocarboxylate transporter (MCT) family, whose members include MCT1-4, which are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT5 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340979 [Multi-domain] Cd Length: 369 Bit Score: 40.96 E-value: 1.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 106 AWVVTFGCFLGLIACFGLLNSTGVIESHLQDN-QLSSESVSTIGWLFSLFLFvcSASCIISGTyFDRNGFRTIMIVGTVF 184
Cdd:cd17421 1 GWMIVLHFFLVNVLVMGTLKTFGIFFVAFQEEfGGSSEQISWIGSIMSSLRL--SAGPLASVA-CGRLGERWTSILGAFL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 185 HVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVSVPAHYFFKRRGTALAMATIGgsvGGVVFpiMLRSFFSMKSDt 264
Cdd:cd17421 78 VSAGFLISIFATSVPFLYVSMGLLVGLGFAFLYQAAAVMTAKYFKKRLATAYAIARSG---MGLTF--ALAPFTQLLLD- 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 265 dpTYGFVWGIRTLGFLDLALLTLSIilvkerlphvienskdgesrwryilrvyILQCFDAKAFLDMKYLFCVLGTVFSEL 344
Cdd:cd17421 152 --EYDWQGALLIFGGIMLNLVASGM----------------------------LLRPIDFSLLKDPFFCIYTWSFVFSQL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 345 SINSALTYYGSYATSHGISANDAYTLIMIINVCGIPGRWVPGYLSDK--FGRFNVAIATLLTLFIVMFVGWLPFGTNLTN 422
Cdd:cd17421 202 AYFIPYFHLVARARTLGIDPMDASFIISVAGITETVAQLASGWIADQnwIKKYHYHKAYLILCGVTNLLAPLATTYPLLM 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 423 MYVIsALYGFCSGSVFSLLPVCCGQISKTEEFGKRYSTMYFvVGFGTLVGIPITGAIISIKTTADYQHYIifcglatfvS 502
Cdd:cd17421 282 TYAV-FFAIFCGGYLALLLPVLVDLVGVTKVNSSLGFSMFF-AGIGCLTGPPLAGWLYDYTQTYDCSFYL---------A 350
|
....*..
gi 398366189 503 AVCYIIS 509
Cdd:cd17421 351 GGCYLLS 357
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
108-285 |
2.60e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 2.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 108 VVTFGCFLGLIAcfGLLNSTGVIE--SHLQDNQLSSESVstIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFH 185
Cdd:cd17473 198 RVLPIYFLAFLA--MLLFYVIPIQlpFLLQERGGGSAAL--IGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALM 273
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 186 VAGLFATANSTKYWHFILSFAIVcGFGNGIVLSPLVS-VPAHYFFKRRGTALAMATIGGSVGGVVFPIMLRSFFSMKSDT 264
Cdd:cd17473 274 ALGFLLLALASGLWVVLLGAILA-GLGFGLLLPTLNSwAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGL 352
|
170 180
....*....|....*....|.
gi 398366189 265 DPTYGFVWGIRTLGFLDLALL 285
Cdd:cd17473 353 SGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_CsbX |
cd17337 |
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed ... |
127-433 |
3.21e-03 |
|
CsbX family of the Major Facilitator Superfamily of transporters; The CsbX family is composed of Bacillus subtilis CsbX protein (also named alpha-ketoglutarate permease), Klebsiella pneumoniae D-arabinitol transporter (DalT), and similar proteins. The csbX gene is a sigmaB-controlled gene that is expressed during the stationary phase of cell growth. DalT is a pentose-specific ion symporter for D-arabinitol uptake. Most members of this family remain uncharacterized. The CsbX family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340895 [Multi-domain] Cd Length: 388 Bit Score: 39.79 E-value: 3.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 127 TGVIESHLQDNQLSSESVSTIgwlFSLFLFVCSASCIISGTYFDRNGFRTIMIVGT----VFHVAGLFATANSTKYWHFI 202
Cdd:cd17337 17 QGFLSPYLVDLGFSEAQAALL---FTVYGLTVAIASWLSGVLAELFGPRRVMLIGLiiwlVFEVLFLAFGLPSHNYPLML 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 203 LSFAIVcGFGngivlSPL----------VSVPAHyffkRRGTAL----AMATIGGSVGGVVFPimlrsffsmkSDTDPTY 268
Cdd:cd17337 94 LTYGLR-GFG-----YPLfaysflvwitYRTPAE----RLGSAVgwfwFAFTGGLPVLGSYLA----------SFTIPVI 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 269 GFV------WGIRTLGFLdlalltLSIILVKERlPHVIENSKDGESRWRYILR-VYILqcfdakaFLDMKYLFCVLGTVf 341
Cdd:cd17337 154 GEIgtlwlsLVFVALGGL------IALFLVRDR-TGEQPLANPSEEPLKELLSgITIL-------FRNPKIAIGGIVRI- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 342 selsINSaLTYYG------SYATSH-GISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNV---------AIATLLTL 405
Cdd:cd17337 219 ----INT-LSQFGfpvfmpLYFTDTgGFSTSQWLQIWGIIFLVNIFFNLIFGILGDKIGWRRTvrwfggvgcAISTLLFY 293
|
330 340
....*....|....*....|....*...
gi 398366189 406 FIVMFvgwlpFGTNLTNMYVISALYGFC 433
Cdd:cd17337 294 YVPQL-----FGHNYWAALIAAILFGIG 316
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
346-440 |
3.30e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 39.75 E-value: 3.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 346 INSALTYYGSYATSH-GISANDAYTLIMIINVCGIPGRWVPGYLSDKFGRFNVAIATLLTLFIVMFVGWlpFGTNLTNMY 424
Cdd:COG2270 254 VQTVIAFAGIYAAGVlGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKRVILVSLVIWIVVCLAAY--FLTTALAFW 331
|
90
....*....|....*.
gi 398366189 425 VISALYGFCSGSVFSL 440
Cdd:COG2270 332 ILGLLIGLVMGGIQAL 347
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
103-287 |
3.49e-03 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 39.87 E-value: 3.49e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 103 GFKAWVVTFGCFLGLIACFglLNSTGVIesHLQDNQLSSesvSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGT 182
Cdd:cd17320 202 RFLGYALALGLSFAGLFAY--LAAAPFI--YIEQLGLSP---AQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGL 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 183 VFHVAG-----LFATANSTKYWHFILSFAIVCgFGNGIVLSPLVSVPAHYFFKRRGTALAMA-----TIGGSVGGVVFPI 252
Cdd:cd17320 275 LLLLAAalvllLAALLGGLSLWPLVAPLFLIF-FGFGLIFPNATSLALEPFPHVAGTASALLgflqfLIGALAGALVGLL 353
|
170 180 190
....*....|....*....|....*....|....*
gi 398366189 253 MLRSFFSMksdtdptygfVWGIRTLGFLDLALLTL 287
Cdd:cd17320 354 PNGTALPM----------GLLILVLGLLALLLLIL 378
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
386-494 |
4.13e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 39.61 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 386 GYLSDKFGRFNVAIATLLtLFIVMFVGwLPFGTNLTNMYVISALYGFCSGSVFSLLPVCCGQISKtEEFGKRYSTMYFVV 465
Cdd:cd17333 52 GFLMKRLGRRRTLILGLL-LISLALAL-IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFE-ESSATRLNVLHGFF 128
|
90 100
....*....|....*....|....*....
gi 398366189 466 GFGTLVGIPITGAIISIKTTADYQHYIIF 494
Cdd:cd17333 129 GLGALIGPLIATSLLTSELSWSWAYLIIG 157
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
104-256 |
5.39e-03 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 39.15 E-value: 5.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 104 FKAWVVTFGCFLGLIACFGLLNSTGVIESHLQDNQLSSESVSTIGWLFSLflfvcsASCIISGTYFDRNGFRTI-MIVGT 182
Cdd:cd17327 233 PRTWLLFLFFFCSQITNNGISNFLPLILKSLGFYSLQTNLLSVPIGALGA------VSLLIAALLSDRFKKRGLfAIFAC 306
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398366189 183 VFHVAG----LFATANSTKYWhFILSFAIVCGFGNGIVLSPLVSVPAHYFfkRRGTALAMATIGGSVGGVVFPIMLRS 256
Cdd:cd17327 307 VLALVGsiilLAAPNPPGAYF-AAYILGGGSYAGFPILLSWISSNCAGYT--KRATVLAIMLIFYNVGNIVAPQIFRA 381
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
129-480 |
6.90e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 38.71 E-value: 6.90e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 129 VIESHLQDNQLSSESVSTIGWLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSfAIV 208
Cdd:cd17330 18 VLPFYVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLA-RFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 209 CGFGNGivlspLVSVPAHYF---FKRRGTALAMATIGGSVG-GVVFPIMLRSFFSmksdtdptygFVWGIRTLGFLDLAL 284
Cdd:cd17330 97 DGLTGG-----NVSVAQAYIadiTDEEERAKAFGIISAAFGlGFILGPALGGFLS----------TPYGYALPFLVAAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 285 LTLSIILVKERLPHVienskdgesrwRYILRVYILQCfdakafldmkylfcvlgtvFSELSINSALTYYGSYATshGISA 364
Cdd:cd17330 162 ALLNLVLVLFFLPPL-----------RRLLLVYFLIA-------------------LAFAGLESVFSLFLKDRF--GFSP 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 365 NDAYTLIMIINVCGIPGRW-VPGYLSDKFGRFNVAIATLLTLFIVMFvgWLPFGTNLTNMYVISALYGFCSGSVFSLLpv 443
Cdd:cd17330 210 SQIGLLLALVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAIIGLL--LLPFASSVPLLVLAAAILAFGTGIVFPAL-- 285
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 398366189 444 cCGQISK---TEEFGKRYSTMYFVVGFGTLVGiPITGAII 480
Cdd:cd17330 286 -SALLSKsvpSKEQGKAQGIIQSLQSLARIIG-PLLAGPL 323
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
149-448 |
8.35e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 38.33 E-value: 8.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 149 WLFSLFLFVCSASCIISGTYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWHFILSFAIVCGFGNGIVLSPLVsvpahyf 228
Cdd:cd17317 29 LVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFV------- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 229 fkrrgtaLAMATIGGsvggvvfpiMLRSFFSMksdtdpTYGFVWgirTLGFLDLALLTLSIilvkerlphvienskdgeS 308
Cdd:cd17317 102 -------LGMEIVGP---------KYRSFVGI------LFGLFW---ALGYMLLALLAYLI------------------R 138
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 309 RWRYILRVYILQCFdakafLDMKYLFCVLGTVFSELSIN--SALTYYGsYATSHGISANDAYTLIMIINVCGIPGRWVPG 386
Cdd:cd17317 139 DWRWLQLAISLPGL-----LFLLLLWWLPRRTIIVGLIWfvTSLVYYG-LSLNSSNLGGNLYLNFFLSGLVEIPAYFLAL 212
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 398366189 387 YLSDKFGRFNVAIATLLTLFIVM-FVGWLPFGTNLTNMyVISALYGFCSGSVFSLLPVCCGQI 448
Cdd:cd17317 213 LLLDRLGRRWTLSGSLLLAGLAClVTALLPDDENTLAL-TLALVGKFAISAAFSVIYLYTAEL 274
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
143-291 |
8.70e-03 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 38.32 E-value: 8.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398366189 143 SVSTIGWLFSLfLFVCSA-SCIISG---TYFDRNGFRTIMIVGTVFHVAGLFATANSTKYWhFILSFAIVCGFGNGIVLS 218
Cdd:cd17319 213 SLKQVGLLAAI-PFLAGAiGMILGGrlsDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPV-VAVILLSLAGFGIGAASP 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 398366189 219 PLVSVPAHYF-FKRRGTALAMATIGGSVGGVVFPIMLRSFFsmksdtDPTYGFVWGIRTLGFLDLALLTLSIIL 291
Cdd:cd17319 291 VFWSLPADLLpGEAAATAGGLINSGGNLGGFVAPLLIGYLV------DATGSYTAAFLFLAAVALLAALLVLLL 358
|
|
| |
