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Conserved domains on  [gi|398365209|ref|NP_014344|]
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Vac7p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Vac7 super family cl15068
Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is ...
 923-1001 2.94e-10

Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.


The actual alignment was detected with superfamily member pfam12751:

Pssm-ID: 432760  Cd Length: 384  Bit Score: 63.50  E-value: 2.94e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365209   923 LAFVISSLLMTGFIlGFLLATNKELQDVDVVVMDNVISSSDELIFDITVSAFNPGFFSISVSQVDLDIFAKSSYLKCDS 1001
Cdd:pfam12751  307 LLTLMLLLVISGAI-GFMFATTQPLTDVEVVKIQNVLASEQELMLDLLVGAVNPNLVAVTVDDMDVNIFAKSKHVGTDS 384
Vac7 super family cl15068
Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is ...
 424-453 6.65e-07

Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.


The actual alignment was detected with superfamily member pfam12751:

Pssm-ID: 432760  Cd Length: 384  Bit Score: 53.10  E-value: 6.65e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 398365209   424 TKADFFAARLATAVGENEISDSEETFVYES 453
Cdd:pfam12751   64 SKADIFEAKVASAVDEANSSDSDETFVYES 93
 
Name Accession Description Interval E-value
Vac7 pfam12751
Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is ...
 923-1001 2.94e-10

Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.


Pssm-ID: 432760  Cd Length: 384  Bit Score: 63.50  E-value: 2.94e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365209   923 LAFVISSLLMTGFIlGFLLATNKELQDVDVVVMDNVISSSDELIFDITVSAFNPGFFSISVSQVDLDIFAKSSYLKCDS 1001
Cdd:pfam12751  307 LLTLMLLLVISGAI-GFMFATTQPLTDVEVVKIQNVLASEQELMLDLLVGAVNPNLVAVTVDDMDVNIFAKSKHVGTDS 384
Vac7 pfam12751
Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is ...
 424-453 6.65e-07

Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.


Pssm-ID: 432760  Cd Length: 384  Bit Score: 53.10  E-value: 6.65e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 398365209   424 TKADFFAARLATAVGENEISDSEETFVYES 453
Cdd:pfam12751   64 SKADIFEAKVASAVDEANSSDSDETFVYES 93
 
Name Accession Description Interval E-value
Vac7 pfam12751
Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is ...
 923-1001 2.94e-10

Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.


Pssm-ID: 432760  Cd Length: 384  Bit Score: 63.50  E-value: 2.94e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 398365209   923 LAFVISSLLMTGFIlGFLLATNKELQDVDVVVMDNVISSSDELIFDITVSAFNPGFFSISVSQVDLDIFAKSSYLKCDS 1001
Cdd:pfam12751  307 LLTLMLLLVISGAI-GFMFATTQPLTDVEVVKIQNVLASEQELMLDLLVGAVNPNLVAVTVDDMDVNIFAKSKHVGTDS 384
Vac7 pfam12751
Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is ...
 424-453 6.65e-07

Vacuolar segregation subunit 7; Vac7 is localized at the vacuole membrane, a location which is consistent with its involvement in vacuole morphology and inheritance. Vac7 has been shown to function as an upstream regulator of the Fab1 lipid kinase pathway. The Fab1 lipid p[pathway is important for correct regulation of membrane trafficking events.


Pssm-ID: 432760  Cd Length: 384  Bit Score: 53.10  E-value: 6.65e-07
                           10        20        30
                   ....*....|....*....|....*....|
gi 398365209   424 TKADFFAARLATAVGENEISDSEETFVYES 453
Cdd:pfam12751   64 SKADIFEAKVASAVDEANSSDSDETFVYES 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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