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Conserved domains on  [gi|6323892|ref|NP_013963|]
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chromatin modification protein [Saccharomyces cerevisiae S288C]

Protein Classification

TBP-associated factor 9 domain-containing protein; TBP-associated factor 8 family protein( domain architecture ID 10790957)

TBP-associated factor 9 (TAF9) domain-containing protein is one of several TAFs with the histone fold motif that bind TBP and are involved in forming both histone acetyltransferase complex (SAGA) and TFIID complexes.| TATA binding protein (TBP)-associated factor 8 (TAF8) family protein is one of several general cofactors which are typically involved in gene activation to bring about the communication between gene-specific transcription factors and components of the general transcription machinery

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TAF9 COG5094
Transcription initiation factor TFIID, subunit TAF9 (also component of histone ...
 1-157 8.38e-80

Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription];


:

Pssm-ID: 227425  Cd Length: 145  Bit Score: 232.57  E-value: 8.38e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892    1 MNGGGknvLNKNSVgsvsevgpdstqeETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGS 80
Cdd:COG5094   1 MASGG---LNLASV-------------SGPRDVRLIHLILRSLGIEEYEPKVPLQLLEFAHRYTQDVLEDALVYAKHTGR 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323892   81 GNSAGsgLGVEDIRLAIAARTQYQFKPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDL--EDPKSM 157
Cdd:COG5094  65 GHIAT--LGVEDVRLALATKVGRHFVPPPPKEYLLELATERNSKPLPQPDGENGIRLPPEKYCLTNLDWEVlrKDPKKK 141
 
Name Accession Description Interval E-value
TAF9 COG5094
Transcription initiation factor TFIID, subunit TAF9 (also component of histone ...
 1-157 8.38e-80

Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription];


Pssm-ID: 227425  Cd Length: 145  Bit Score: 232.57  E-value: 8.38e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892    1 MNGGGknvLNKNSVgsvsevgpdstqeETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGS 80
Cdd:COG5094   1 MASGG---LNLASV-------------SGPRDVRLIHLILRSLGIEEYEPKVPLQLLEFAHRYTQDVLEDALVYAKHTGR 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323892   81 GNSAGsgLGVEDIRLAIAARTQYQFKPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDL--EDPKSM 157
Cdd:COG5094  65 GHIAT--LGVEDVRLALATKVGRHFVPPPPKEYLLELATERNSKPLPQPDGENGIRLPPEKYCLTNLDWEVlrKDPKKK 141
TFIID-31kDa pfam02291
Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of ...
 26-151 5.83e-69

Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of the 31kD subunit (42kD in drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation.


Pssm-ID: 460525  Cd Length: 122  Bit Score: 204.29  E-value: 5.83e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892     26 QEETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGsgnsaGSGLGVEDIRLAIAARTQYQF 105
Cdd:pfam02291   1 SKKRPRDARLIHLILASMGITEYEPRVPLQLLEFAYRYTTDVLEDALVYSEHAG-----KKQIDVDDVRLAIQSRVNHQF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6323892    106 KPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDL 151
Cdd:pfam02291  76 TGPPPREFLLELARERNSKPLPPVKPHYGLRLPPERYCLTAPNYDL 121
HFD_TAF9 cd07979
histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and ...
 30-129 1.70e-37

histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and similar proteins; The family includes TAF9 (also called TATA Binding Protein (TBP) associated factor 9, RNA polymerase II TBP-associated factor subunit G, STAF31/32, transcription initiation factor TFIID 31 kDa subunit, TAFII-31, TAFII31, transcription initiation factor TFIID 32 kDa subunit, TAFII-32, or TAFII32) and TAF9-like (also called transcription initiation factor TFIID subunit 9B, neuronal cell death-related protein 7, DN-7, or transcription-associated factor TAFII31L), which are essential for cell viability. They are involved in transcriptional activation as well as the repression of distinct but overlapping sets of genes. They may have roles in gene regulation associated with apoptosis. Both TAF9 and TAF9-like are TAFs that are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. TAF9 interacts directly with different transcription factors such as p53, herpes simplex virus activator vp16, and the basal transcription factor TFIIB.


Pssm-ID: 467024  Cd Length: 95  Bit Score: 123.49  E-value: 1.70e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892   30 PRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGsgnsaGSGLGVEDIRLAIAARTQYQFKPTA 109
Cdd:cd07979   1 PRDAQVIRAILKSMGVTDYEPRVVNQLLEFAYRYTTEVLQDAKVYAEHAG-----RSQIDEEDVRLAIQSRADHSFTQPP 75

                        90       100
                ....*....|....*....|
gi 6323892  110 PKELMLQLAAERNKKALPQV 129
Cdd:cd07979  76 PRELLLELAAEKNSIPLPPI 95
 
Name Accession Description Interval E-value
TAF9 COG5094
Transcription initiation factor TFIID, subunit TAF9 (also component of histone ...
 1-157 8.38e-80

Transcription initiation factor TFIID, subunit TAF9 (also component of histone acetyltransferase SAGA) [Transcription];


Pssm-ID: 227425  Cd Length: 145  Bit Score: 232.57  E-value: 8.38e-80
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892    1 MNGGGknvLNKNSVgsvsevgpdstqeETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGS 80
Cdd:COG5094   1 MASGG---LNLASV-------------SGPRDVRLIHLILRSLGIEEYEPKVPLQLLEFAHRYTQDVLEDALVYAKHTGR 64

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6323892   81 GNSAGsgLGVEDIRLAIAARTQYQFKPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDL--EDPKSM 157
Cdd:COG5094  65 GHIAT--LGVEDVRLALATKVGRHFVPPPPKEYLLELATERNSKPLPQPDGENGIRLPPEKYCLTNLDWEVlrKDPKKK 141
TFIID-31kDa pfam02291
Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of ...
 26-151 5.83e-69

Transcription initiation factor IID, 31kD subunit; This family represents the N-terminus of the 31kD subunit (42kD in drosophila) of transcription initiation factor IID (TAFII31). TAFII31 binds to p53, and is an essential requirement for p53 mediated transcription activation.


Pssm-ID: 460525  Cd Length: 122  Bit Score: 204.29  E-value: 5.83e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892     26 QEETPRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGsgnsaGSGLGVEDIRLAIAARTQYQF 105
Cdd:pfam02291   1 SKKRPRDARLIHLILASMGITEYEPRVPLQLLEFAYRYTTDVLEDALVYSEHAG-----KKQIDVDDVRLAIQSRVNHQF 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 6323892    106 KPTAPKELMLQLAAERNKKALPQVMGTWGVRLPPEKYCLTAKEWDL 151
Cdd:pfam02291  76 TGPPPREFLLELARERNSKPLPPVKPHYGLRLPPERYCLTAPNYDL 121
HFD_TAF9 cd07979
histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and ...
 30-129 1.70e-37

histone-fold domain found in transcription initiation factor TFIID subunit 9 (TAF9) and similar proteins; The family includes TAF9 (also called TATA Binding Protein (TBP) associated factor 9, RNA polymerase II TBP-associated factor subunit G, STAF31/32, transcription initiation factor TFIID 31 kDa subunit, TAFII-31, TAFII31, transcription initiation factor TFIID 32 kDa subunit, TAFII-32, or TAFII32) and TAF9-like (also called transcription initiation factor TFIID subunit 9B, neuronal cell death-related protein 7, DN-7, or transcription-associated factor TAFII31L), which are essential for cell viability. They are involved in transcriptional activation as well as the repression of distinct but overlapping sets of genes. They may have roles in gene regulation associated with apoptosis. Both TAF9 and TAF9-like are TAFs that are components of the transcription factor IID (TFIID) complex, the TBP-free TAFII complex (TFTC), the PCAF histone acetylase complex and the STAGA transcription coactivator-HAT complex. TFIID or TFTC are essential for the regulation of RNA polymerase II-mediated transcription. TAF9 interacts directly with different transcription factors such as p53, herpes simplex virus activator vp16, and the basal transcription factor TFIIB.


Pssm-ID: 467024  Cd Length: 95  Bit Score: 123.49  E-value: 1.70e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6323892   30 PRDVRLLHLLLASQSIHQYEDQVPLQLMDFAHRYTQGVLKDALVYNDYAGsgnsaGSGLGVEDIRLAIAARTQYQFKPTA 109
Cdd:cd07979   1 PRDAQVIRAILKSMGVTDYEPRVVNQLLEFAYRYTTEVLQDAKVYAEHAG-----RSQIDEEDVRLAIQSRADHSFTQPP 75

                        90       100
                ....*....|....*....|
gi 6323892  110 PKELMLQLAAERNKKALPQV 129
Cdd:cd07979  76 PRELLLELAAEKNSIPLPPI 95
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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