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Conserved domains on  [gi|6322830|ref|NP_012903|]
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anaphase promoting complex subunit CDC16 [Saccharomyces cerevisiae S288C]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 13798475)

tetratricopeptide repeat (TPR) protein with an ANAPC3 (anaphase-promoting complex, subunit 3) domain, such as Saccharomyces cerevisiae anaphase-promoting complex/cyclosome (APC/C) subunits CDC16 and CDC27

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  21153002|10517866|30708253|16896351
SCOP:  4001344

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 242-322 4.55e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


:

Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 88.08  E-value: 4.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    242 MQHMYRTAEYIADKVYN-ISNDPDDAFWLGQVYYNNNQYVRAVELITRNNLDGVNILCRYLLGLSFVKLQRFDDALDVIG 320
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAaEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80


                  ..
gi 6322830    321 EY 322
Cdd:pfam12895  81 KA 82
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 531-753 5.40e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 5.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  531 AITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFM 610
Cdd:COG2956   8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  611 AMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakkylKKALEVVKDLDPSSRTTISIQLNLGHTYRKLNEN 690
Cdd:COG2956  88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW-------EKAIEVLERLLKLGPENAHAYCELAELYLEQGDY 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322830  691 EIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALE 753
Cdd:COG2956 161 DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 361-389 2.33e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


:

Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|....*....
gi 6322830    361 LCFLRGKIYFAQNNFNKARDAFREAILVD 389
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELD 31
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 242-322 4.55e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 88.08  E-value: 4.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    242 MQHMYRTAEYIADKVYN-ISNDPDDAFWLGQVYYNNNQYVRAVELITRNNLDGVNILCRYLLGLSFVKLQRFDDALDVIG 320
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAaEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80


                  ..
gi 6322830    321 EY 322
Cdd:pfam12895  81 KA 82
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 531-753 5.40e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 5.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  531 AITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFM 610
Cdd:COG2956   8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  611 AMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakkylKKALEVVKDLDPSSRTTISIQLNLGHTYRKLNEN 690
Cdd:COG2956  88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW-------EKAIEVLERLLKLGPENAHAYCELAELYLEQGDY 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322830  691 EIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALE 753
Cdd:COG2956 161 DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 364-741 1.54e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.64  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    364 LRGKIYFAQNNFNKARDAFREAILVDIKNFEAfemllSKNLLTpqeewdlfdsLDFKEfgEDKEIMKNLYKinlskyint 443
Cdd:TIGR02917 470 LLGAIYLGKGDLAKAREAFEKALSIEPDFFPA-----AANLAR----------IDIQE--GNPDDAIQRFE--------- 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    444 editksnEILAKDYKladNVDVVRSKVDICYTQCKFNECLELCETVLENDefNTNILPAYIGCLYELSNKN--KLFLLSH 521
Cdd:TIGR02917 524 -------KVLTIDPK---NLRAILALAGLYLRTGNEEEAVAWLEKAAELN--PQEIEPALALAQYYLGKGQlkKALAILN 591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    522 RLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLP 601
Cdd:TIGR02917 592 EAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEA 671

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    602 KLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFVKAKKYLKKALEvvkdLDPSSRTTIsiqlNLG 681
Cdd:TIGR02917 672 QIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALK----RAPSSQNAI----KLH 743

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    682 HTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:TIGR02917 744 RALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDN 803
TPR_1 pfam00515
Tetratricopeptide repeat;
708-741 9.27e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 9.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 6322830    708 SEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 241-317 2.47e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 2.47e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322830  241 LMQHMYRTAEYIADKVYNIS-NDPDDAFWLGQVYYNNNQYVRAVELITR-NNLDGVNILCRYLLGLSFVKLQRFDDALD 317
Cdd:COG4235  28 LRLGRYDEALAAYEKALRLDpDNADALLDLAEALLAAGDTEEAEELLERaLALDPDNPEALYLLGLAAFQQGDYAEAIA 106
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 708-741 3.40e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.58  E-value: 3.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 6322830     708 SEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 361-389 2.33e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|....*....
gi 6322830    361 LCFLRGKIYFAQNNFNKARDAFREAILVD 389
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELD 31
 
Name Accession Description Interval E-value
ANAPC3 pfam12895
Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of ...
 242-322 4.55e-21

Anaphase-promoting complex, cyclosome, subunit 3; Apc3, otherwise known as Cdc27, is one of the subunits of the anaphase-promoting complex or cyclosome. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes. The protein members of this family contain TPR repeats just as those of Apc7 do, and it appears that these TPR units bind the C-termini of the APC co-activators CDH1 and CDC20.


Pssm-ID: 463743 [Multi-domain]  Cd Length: 82  Bit Score: 88.08  E-value: 4.55e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    242 MQHMYRTAEYIADKVYN-ISNDPDDAFWLGQVYYNNNQYVRAVELITRNNLDGVNILCRYLLGLSFVKLQRFDDALDVIG 320
Cdd:pfam12895   1 DQHQYKNAIFLAERLLAaEPESPEDAYLLAQCLFLNGQYKRAYELLRKAKLNGSSLGCRYLFAQCLLKLKKYDEALDALG 80


                  ..
gi 6322830    321 EY 322
Cdd:pfam12895  81 KA 82
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 531-753 5.40e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 5.40e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  531 AITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFM 610
Cdd:COG2956   8 ALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  611 AMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakkylKKALEVVKDLDPSSRTTISIQLNLGHTYRKLNEN 690
Cdd:COG2956  88 KAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDW-------EKAIEVLERLLKLGPENAHAYCELAELYLEQGDY 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322830  691 EIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALE 753
Cdd:COG2956 161 DEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYE 223
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
560-753 1.30e-16

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 80.44  E-value: 1.30e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  560 LDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNem 639
Cdd:COG0457   3 LDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN-- 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  640 gvmyfkknefvkakkylkkalevvkdldpssrttisiqlNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYL 719
Cdd:COG0457  81 ---------------------------------------NLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALL 121

                       170       180       190
                ....*....|....*....|....*....|....
gi 6322830  720 KTKKLQKAIDHLHKSLYLKPNNSSATALLKNALE 753
Cdd:COG0457 122 ELGRYDEAIEAYERALELDPDDADALYNLGIALE 155
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 363-649 7.54e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 78.62  E-value: 7.54e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  363 FLRGKIYFAQNNFNKARDAFREAILVDIKNFEAFEMLLSknlltpqeewdLFDSLdfKEFGEDKEIMKNLYKINlskyin 442
Cdd:COG2956  12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGN-----------LYRRR--GEYDRAIRIHQKLLERD------ 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  443 tEDITKSNEILAKDYKLADNVDvvrskvdicytqckfnECLELCETVLENDEFNTNILPAYIGCLYELSNKNKLFLLSHR 522
Cdd:COG2956  73 -PDRAEALLELAQDYLKAGLLD----------------RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLER 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  523 LAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPK 602
Cdd:COG2956 136 LLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPAL 215

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 6322830  603 LFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNeMGVMYFKKNEF 649
Cdd:COG2956 216 PRLAELYEKLGDPEEALELLRKALELDPSDDLLLA-LADLLERKEGL 261
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 564-748 6.89e-14

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 72.84  E-value: 6.89e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  564 FAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMY 643
Cdd:COG2956   7 AALGWYFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDY 86

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  644 FKKNEFvkakkylKKALEVVKDLDPSSRTTISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKK 723
Cdd:COG2956  87 LKAGLL-------DRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD 159

                       170       180
                ....*....|....*....|....*
gi 6322830  724 LQKAIDHLHKSLYLKPNNSSATALL 748
Cdd:COG2956 160 YDEAIEALEKALKLDPDCARALLLL 184
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 522-749 3.22e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 70.91  E-value: 3.22e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  522 RLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLP 601
Cdd:COG2956  33 EALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEA 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  602 KLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakKYLKKALEVVKDLDPSSrttISIQLNLG 681
Cdd:COG2956 113 LRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDY----DEAIEALEKALKLDPDC---ARALLLLA 185

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322830  682 HTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLK 749
Cdd:COG2956 186 ELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALAD 253
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 608-748 1.64e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 64.63  E-value: 1.64e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  608 QFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakKYLKKALEVVKDLDPSSrttISIQLNLGHTYRKL 687
Cdd:COG3914  87 LLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRL----EEALAALRRALALNPDF---AEAYLNLGEALRRL 159

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322830  688 NENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALL 748
Cdd:COG3914 160 GRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNL 220
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
528-649 1.92e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.95  E-value: 1.92e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  528 PKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGM 607
Cdd:COG0457  39 PDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGL 118

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 6322830  608 QFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEF 649
Cdd:COG0457 119 ALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRY 160
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 535-755 1.24e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.93  E-value: 1.24e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  535 FSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNS 614
Cdd:COG3914  82 ELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGR 161

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  615 LNLAESYFVLAYDICPNDPLVLNemgvmyfkknefvkakkylkkalevvkdldpssrttisiqlNLGHTYRKLNENEIAI 694
Cdd:COG3914 162 LEEAIAALRRALELDPDNAEALN-----------------------------------------NLGNALQDLGRLEEAI 200

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322830  695 KCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALELN 755
Cdd:COG3914 201 AAYRRALELDPDNADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLYLPDD 261
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 364-741 1.54e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 61.64  E-value: 1.54e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    364 LRGKIYFAQNNFNKARDAFREAILVDIKNFEAfemllSKNLLTpqeewdlfdsLDFKEfgEDKEIMKNLYKinlskyint 443
Cdd:TIGR02917 470 LLGAIYLGKGDLAKAREAFEKALSIEPDFFPA-----AANLAR----------IDIQE--GNPDDAIQRFE--------- 523

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    444 editksnEILAKDYKladNVDVVRSKVDICYTQCKFNECLELCETVLENDefNTNILPAYIGCLYELSNKN--KLFLLSH 521
Cdd:TIGR02917 524 -------KVLTIDPK---NLRAILALAGLYLRTGNEEEAVAWLEKAAELN--PQEIEPALALAQYYLGKGQlkKALAILN 591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    522 RLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLP 601
Cdd:TIGR02917 592 EAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEA 671

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    602 KLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFVKAKKYLKKALEvvkdLDPSSRTTIsiqlNLG 681
Cdd:TIGR02917 672 QIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALK----RAPSSQNAI----KLH 743

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    682 HTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:TIGR02917 744 RALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDN 803
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
627-753 3.23e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.48  E-value: 3.23e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  627 DICPNDPLVLNEMGVMYFKKNEFVKAKKYLkkalEVVKDLDPSSRTTISiqlNLGHTYRKLNENEIAIKCFRCVLEKNDK 706
Cdd:COG0457   2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDY----EKALELDPDDAEALY---NLGLAYLRLGRYEEALADYEQALELDPD 74

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6322830  707 NSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALE 753
Cdd:COG0457  75 DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALL 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 478-596 5.56e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.20  E-value: 5.56e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  478 KFNECLELCETVLENDEFNTNILpAYIG-CLYELSNKNKLFLLSHRLAETFPKSAITWFSVATYYMSLDRISEAQKYYSK 556
Cdd:COG4783  19 DYDEAEALLEKALELDPDNPEAF-ALLGeILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEK 97

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 6322830  557 SSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFP 596
Cdd:COG4783  98 ALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDP 137
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 476-748 7.68e-09

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 59.33  E-value: 7.68e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    476 QCKFNECLELCETVLENDEFNTNILPAYIGCLYELSNKNKLFLLSHRLAETF-PKSAITWFSVATYYMSLDRISEAQKYY 554
Cdd:TIGR02917 103 QGKFQQVLDELPGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIdPRSLYAKLGLAQLALAENRFDEARALI 182

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    555 SKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPL 634
Cdd:TIGR02917 183 DEVLTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPL 262

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    635 VLNEMGVMYFKKNEF------------------------------VKAKKYLKKALEVVKDLDPSS----RTTISIQLNL 680
Cdd:TIGR02917 263 AHYLKALVDFQKKNYedaretlqdalksapeylpalllagaseyqLGNLEQAYQYLNQILKYAPNShqarRLLASIQLRL 342

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322830    681 GHTYRKLNENEIAikcfrcvLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALL 748
Cdd:TIGR02917 343 GRVDEAIATLSPA-------LGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQL 403
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 605-741 9.01e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.81  E-value: 9.01e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  605 LGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakkylkkaLEVVKDL------DPSSRTtisIQL 678
Cdd:COG4783  10 LAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDL----------DEAIVLLhealelDPDEPE---ARL 76

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322830  679 NLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:COG4783  77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 519-633 9.61e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 54.63  E-value: 9.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  519 LSHRLAETfPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGM 598
Cdd:COG4235   6 LRQALAAN-PNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDN 84

                        90       100       110
                ....*....|....*....|....*....|....*
gi 6322830  599 HLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDP 633
Cdd:COG4235  85 PEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADA 119
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 683-755 1.32e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 54.97  E-value: 1.32e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322830  683 TYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNALELN 755
Cdd:COG5010  63 LYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
490-633 1.91e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 55.69  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  490 LENDEFNTNILPAYIGCLYELSNKNKLFLL---SHRLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAA 566
Cdd:COG4785  29 LLFAAVLALAIALADLALALAAAALAAAALaaeRIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAE 108

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 6322830  567 AWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDP 633
Cdd:COG4785 109 AYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDP 175
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 507-633 2.46e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 57.70  E-value: 2.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  507 LYELSNKNKLFLLSHRLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALT 586
Cdd:COG3914  88 LQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIA 167

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 6322830  587 AYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDP 633
Cdd:COG3914 168 ALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 665-753 4.46e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 52.89  E-value: 4.46e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  665 DLDPSSrttISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSA 744
Cdd:COG4783  32 ELDPDN---PEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108


                ....*....
gi 6322830  745 TALLKNALE 753
Cdd:COG4783 109 YLRLARAYR 117
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 522-632 9.64e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 9.64e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  522 RLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLP 601
Cdd:COG4783  29 KALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                        90       100       110
                ....*....|....*....|....*....|.
gi 6322830  602 KLFLGMQFMAMNSLNLAESYFVLAYDICPND 632
Cdd:COG4783 109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 531-656 1.07e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 1.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  531 AITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFM 610
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 6322830  611 AMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFVKAKKYL 656
Cdd:COG4783  84 KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAAL 129
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 678-748 1.58e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 50.77  E-value: 1.58e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322830  678 LNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALL 748
Cdd:COG4235  21 LLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLL 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 535-755 2.57e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 54.70  E-value: 2.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    535 FSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNS 614
Cdd:TIGR02917 503 ANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQYYLGKGQ 582

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    615 LNLAESyfvlaydicpndplVLNEMgvmyfkknefvkakkylkkalevvKDLDPSSRTTISIqlnLGHTYRKLNENEIAI 694
Cdd:TIGR02917 583 LKKALA--------------ILNEA------------------------ADAAPDSPEAWLM---LGRAQLAAGDLNKAV 621

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322830    695 KCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATALLKNaLELN 755
Cdd:TIGR02917 622 SSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQ-LLLA 681
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 541-630 6.16e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 49.96  E-value: 6.16e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  541 YMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAES 620
Cdd:COG5010  64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143

                        90
                ....*....|
gi 6322830  621 YFVLAYDICP 630
Cdd:COG5010 144 ALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
684-752 1.98e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.70  E-value: 1.98e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322830  684 YRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDhLHKSLYLKPNNSSATALLKNAL 752
Cdd:COG3063   2 YLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELL 69
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 630-753 2.81e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 47.31  E-value: 2.81e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  630 PNDPLVLNEMGVMYFKKNEFvkaKKYLKKALEVVKdLDPSSrttISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSE 709
Cdd:COG4235  14 PNDAEGWLLLGRAYLRLGRY---DEALAAYEKALR-LDPDN---ADALLDLAEALLAAGDTEEAEELLERALALDPDNPE 86

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 6322830  710 IHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSAtALLKNALE 753
Cdd:COG4235  87 ALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA-RLLEASIA 129
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 666-739 2.95e-06

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 48.03  E-value: 2.95e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322830  666 LDPSSrttISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKP 739
Cdd:COG5010  83 LDPNN---PELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
540-631 7.17e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 45.16  E-value: 7.17e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  540 YYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALtAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAE 619
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDEAL 79

                        90
                ....*....|..
gi 6322830  620 SYFVLAYDICPN 631
Cdd:COG3063  80 AYLERALELDPS 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 535-788 7.77e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 7.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    535 FSVATY-YMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFM--- 610
Cdd:TIGR02917 366 LSLLGEaYLALGDFEKAAEYLAKATELDPENAAARTQLGISKLSQGDPSEAIADLETAAQLDPELGRADLLLILSYLrsg 445

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    611 ----AMNSL-NLAESYfvlaydicPNDPLVLNEMGVMYFKKNEFVKAKKYLKKALEvvkdLDPSSRTTISiqlNLGHTYR 685
Cdd:TIGR02917 446 qfdkALAAAkKLEKKQ--------PDNASLHNLLGAIYLGKGDLAKAREAFEKALS----IEPDFFPAAA---NLARIDI 510

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    686 KLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKklqkaidhlhkslylkpNNSSATALLKNALELNVT-----LSL 760
Cdd:TIGR02917 511 QEGNPDDAIQRFEKVLTIDPKNLRAILALAGLYLRTG-----------------NEEEAVAWLEKAAELNPQeiepaLAL 573

                         250       260
                  ....*....|....*....|....*...
gi 6322830    761 dASHPLIDKSNLMSQASKDKASLNKKRS 788
Cdd:TIGR02917 574 -AQYYLGKGQLKKALAILNEAADAAPDS 600
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 522-596 1.01e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 46.49  E-value: 1.01e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6322830  522 RLAETFPKSAITWFSVATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFP 596
Cdd:COG5010  79 QALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 577-807 1.21e-05

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 48.83  E-value: 1.21e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    577 LEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNLAESYFVLAYDICPNDPLVLNEMGVMYFKKNEFvkakKYL 656
Cdd:TIGR00990 343 LKGKHLEALADLSKSIELDPRVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEF----AQA 418

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830    657 KKALEVVKDLDPSSrttISIQLNLGHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLY 736
Cdd:TIGR00990 419 GKDYQKSIDLDPDF---IFSHIQLGVTQYKEGSIASSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIE 495

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 6322830    737 LKPNNssatallkNALELNVTlsldashPLIDKSNLMSQASKDKASLNKK-RSSLTYDP------VNMAKRLRTQKEI 807
Cdd:TIGR00990 496 LEKET--------KPMYMNVL-------PLINKALALFQWKQDFIEAENLcEKALIIDPecdiavATMAQLLLQQGDV 558
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
665-740 6.07e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 6.07e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322830  665 DLDPSSrttISIQLNLGHTYRKLNENEIAIKcFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPN 740
Cdd:COG3063  20 ELDPDN---ADALNNLGLLLLEQGRYDEAIA-LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TPR_1 pfam00515
Tetratricopeptide repeat;
708-741 9.27e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 40.10  E-value: 9.27e-05
                          10        20        30
                  ....*....|....*....|....*....|....
gi 6322830    708 SEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 693-755 1.94e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 1.94e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  693 AIKCFRCVLEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSS-----------------ATALLKNALELN 755
Cdd:COG4235   2 AIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADalldlaeallaagdteeAEELLERALALD 81
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 241-317 2.47e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.92  E-value: 2.47e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 6322830  241 LMQHMYRTAEYIADKVYNIS-NDPDDAFWLGQVYYNNNQYVRAVELITR-NNLDGVNILCRYLLGLSFVKLQRFDDALD 317
Cdd:COG4235  28 LRLGRYDEALAAYEKALRLDpDNADALLDLAEALLAAGDTEEAEELLERaLALDPDNPEALYLLGLAAFQQGDYAEAIA 106
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 708-741 3.40e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 38.58  E-value: 3.40e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 6322830     708 SEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNN 741
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 538-656 3.59e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.87  E-value: 3.59e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322830  538 ATYYMSLDRISEAQKYYSKSSILDPSFAAAWLGFAHTYALEGEQDQALTAYSTASRFFPGMHLPKLFLGMQFMAMNSLNL 617
Cdd:COG5010  27 YEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDE 106

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 6322830  618 AESYFVLAYDICPNDPLVLNEMGVMYFKKNEFVKAKKYL 656
Cdd:COG5010 107 AKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145
TPR_12 pfam13424
Tetratricopeptide repeat;
673-735 8.99e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 8.99e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322830    673 TISIQLNLGHTYRKLNENEIAIKCFRCVLE--------KNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSL 735
Cdd:pfam13424   2 VATALNNLAAVLRRLGRYDEALELLEKALEiarrllgpDHPLTATTLLNLGRLYLELGRYEEALELLERAL 72
TPR_11 pfam13414
TPR repeat;
681-720 2.01e-03

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 36.68  E-value: 2.01e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 6322830    681 GHTYRKLNENEIAIKCFRCVLEKNDKNSEIHCSLGYLYLK 720
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYK 40
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 361-389 2.33e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 36.35  E-value: 2.33e-03
                          10        20
                  ....*....|....*....|....*....
gi 6322830    361 LCFLRGKIYFAQNNFNKARDAFREAILVD 389
Cdd:pfam07719   3 ALYNLGLAYYKLGDYEEALEAYEKALELD 31
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 701-747 2.45e-03

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 41.05  E-value: 2.45e-03
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*..
gi 6322830  701 LEKNDKNSEIHCSLGYLYLKTKKLQKAIDHLHKSLYLKPNNSSATAL 747
Cdd:COG3071 251 LKKHPNDPDLLLALGRLCLRNQLWGKAREYLEAALALRPSAEAYAEL 297
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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