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Conserved domains on  [gi|6322655|ref|NP_012728|]
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type 1 protein phosphatase-activating protein SDS22 [Saccharomyces cerevisiae S288C]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-332 1.56e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 96.39  E-value: 1.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  112 LTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPdsFEGLSNLEEIWLGKN 191
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  192 SIPRLINLHPLKNLKILSIQSNKLKKienleeltnleelylSHNFI---TKIEGLEKNLKltTLDVTSNKITSLENLNHL 268
Cdd:cd21340  79 RISVVEGLENLTNLEELHIENQRLPP---------------GEKLTfdpRSLAALSNSLR--VLNISGNNIDSLEPLAPL 141

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322655  269 SNLTDIWASFNKIDqSFESLGENLSALSRLETIYLEGNPIQLENKtsYRRKLTMNlPPSLQKID 332
Cdd:cd21340 142 RNLEQLDASNNQIS-DLEELLDLLSSWPSLRELDLTGNPVCKKPK--YRDKIILA-SKSLEVLD 201
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-169 6.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   49 LVHL-----KIKSLEDLNlyRFKNLKQLCLRQNLIESISEVEVLPH-----------DKIVDLDFYDNKIKHISSNvnkl 112
Cdd:cd21340  48 LTHLylqnnQIEKIENLE--NLVNLKKLYLGGNRISVVEGLENLTNleelhienqrlPPGEKLTFDPRSLAALSNS---- 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322655  113 tkLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIEN----LSTLKSLKNLELGGNKV 169
Cdd:cd21340 122 --LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-332 1.56e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.39  E-value: 1.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  112 LTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPdsFEGLSNLEEIWLGKN 191
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  192 SIPRLINLHPLKNLKILSIQSNKLKKienleeltnleelylSHNFI---TKIEGLEKNLKltTLDVTSNKITSLENLNHL 268
Cdd:cd21340  79 RISVVEGLENLTNLEELHIENQRLPP---------------GEKLTfdpRSLAALSNSLR--VLNISGNNIDSLEPLAPL 141

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322655  269 SNLTDIWASFNKIDqSFESLGENLSALSRLETIYLEGNPIQLENKtsYRRKLTMNlPPSLQKID 332
Cdd:cd21340 142 RNLEQLDASNNQIS-DLEELLDLLSSWPSLRELDLTGNPVCKKPK--YRDKIILA-SKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-313 7.58e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 7.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   36 LTQDLPDDVEVIDLVHLKIKSLEDLN-LYRFKNLKQLCLRQNLIESISEvEVLPHDKIVDLDFYDNKIKHISSNVNKLTK 114
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  115 LTSLDLSFNKIKHI-KNLENLTDLENLYFVQNSISKI-ENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNS 192
Cdd:COG4886 161 LKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  193 IPRLINLHPLKNLKILSIQSNKLKKIENLEELTNLEELYLSHNFIT--KIEGLEKNLKLTTLDVTSNKITSLENLNHLSN 270
Cdd:COG4886 240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6322655  271 LTDIWASFNKIDQSFESLGENLSALSRLETIYLEGNPIQLENK 313
Cdd:COG4886 320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR_9 pfam14580
Leucine-rich repeat;
118-213 1.10e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 50.92  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655    118 LDLSFNKIKHIKNL-ENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRL 196
Cdd:pfam14580  24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100
                  ....*....|....*....|
gi 6322655    197 INLHPL---KNLKILSIQSN 213
Cdd:pfam14580 104 GDLDPLaslKKLTFLSLLRN 123
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-306 6.31e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 6.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655    98 YDNKIKHISSNVNKLTKLTSLDLSFNKIKH--IKNLENLTDLENLYFVQNSIS-KIEN-LSTLKSLKNLELGGNKVHSIE 173
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpiPSSLGNLKNLQYLFLYQNKLSgPIPPsIFSLQKLISLDLSDNSLSGEI 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   174 PDSFEGLSNLEEIWLGKN----SIPRliNLHPLKNLKILSIQSNKLKKienleeltnleelylshnfitkieGLEKNL-- 247
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNnftgKIPV--ALTSLPRLQVLQLWSNKFSG------------------------EIPKNLgk 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322655   248 --KLTTLDVTSNKITSL--ENLNHLSNLTDIWASFNKIDqsfESLGENLSALSRLETIYLEGN 306
Cdd:PLN00113 355 hnNLTVLDLSTNNLTGEipEGLCSSGNLFKLILFSNSLE---GEIPKSLGACRSLRRVRLQDN 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-169 6.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   49 LVHL-----KIKSLEDLNlyRFKNLKQLCLRQNLIESISEVEVLPH-----------DKIVDLDFYDNKIKHISSNvnkl 112
Cdd:cd21340  48 LTHLylqnnQIEKIENLE--NLVNLKKLYLGGNRISVVEGLENLTNleelhienqrlPPGEKLTFDPRSLAALSNS---- 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322655  113 tkLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIEN----LSTLKSLKNLELGGNKV 169
Cdd:cd21340 122 --LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-332 1.56e-23

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 96.39  E-value: 1.56e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  112 LTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPdsFEGLSNLEEIWLGKN 191
Cdd:cd21340   1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  192 SIPRLINLHPLKNLKILSIQSNKLKKienleeltnleelylSHNFI---TKIEGLEKNLKltTLDVTSNKITSLENLNHL 268
Cdd:cd21340  79 RISVVEGLENLTNLEELHIENQRLPP---------------GEKLTfdpRSLAALSNSLR--VLNISGNNIDSLEPLAPL 141

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6322655  269 SNLTDIWASFNKIDqSFESLGENLSALSRLETIYLEGNPIQLENKtsYRRKLTMNlPPSLQKID 332
Cdd:cd21340 142 RNLEQLDASNNQIS-DLEELLDLLSSWPSLRELDLTGNPVCKKPK--YRDKIILA-SKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-313 7.58e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 80.75  E-value: 7.58e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   36 LTQDLPDDVEVIDLVHLKIKSLEDLN-LYRFKNLKQLCLRQNLIESISEvEVLPHDKIVDLDFYDNKIKHISSNVNKLTK 114
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLTDLPEPLGNLTN 160

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  115 LTSLDLSFNKIKHI-KNLENLTDLENLYFVQNSISKI-ENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNS 192
Cdd:COG4886 161 LKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQ 239

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  193 IPRLINLHPLKNLKILSIQSNKLKKIENLEELTNLEELYLSHNFIT--KIEGLEKNLKLTTLDVTSNKITSLENLNHLSN 270
Cdd:COG4886 240 LTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLL 319

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 6322655  271 LTDIWASFNKIDQSFESLGENLSALSRLETIYLEGNPIQLENK 313
Cdd:COG4886 320 LTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
39-281 2.01e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 76.51  E-value: 2.01e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   39 DLPDDVEVIDLVHLKIKSLEDLNLYRFKNLKQLCLRQNLIESISEVEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSL 118
Cdd:COG4886  39 LLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELSNLTNLESL 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  119 DLSFNKIKHI-KNLENLTDLENLYFVQNSISKI-ENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNSIPRL 196
Cdd:COG4886 119 DLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDL 197

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  197 -INLHPLKNLKILSIQSNKLKKIENLEELTNL-EELYLSHNFITKIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDI 274
Cdd:COG4886 198 pEPLGNLTNLEELDLSGNQLTDLPEPLANLTNlETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTL 277


                ....*..
gi 6322655  275 WASFNKI 281
Cdd:COG4886 278 DLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-324 2.17e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 73.43  E-value: 2.17e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   45 EVIDLVHLKIKSLEDlNLYRFKNLKQLCLRQNLIESISEvEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLTSLDLSFNK 124
Cdd:COG4886 139 KELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ 216

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  125 IKHI-KNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSfeGLSNLEEIWLGKNSIPRLiNLHPLK 203
Cdd:COG4886 217 LTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDL-KLKELE 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  204 NLKILSIQSNKLKKIENLEELTNLEELYLSHNFITKIEGLEKNLKLTTLDVTSNKITSLENLNHLSNLTDIWASFNKIDQ 283
Cdd:COG4886 294 LLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLG 373

                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 6322655  284 SFESLGENLSALSRLETIYLEGNPIQLENKTSYRRKLTMNL 324
Cdd:COG4886 374 LLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNTE 414
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-308 1.72e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 1.72e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   37 TQDLPDDVEVIDLVHLKIKSLEDLNLYRFKNLKQLCLRQNLIESISEVEVLPHDKIVDLDFYDNKIKHISSNVNKLTKLT 116
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  117 SLDLSFNKIKHIKNLENLTDLenlyfvqnSISKIENLSTLKSLKNLELGGNKVHSIePDSFEGLSNLEEIWLGKNSIPRL 196
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTEL--------DLSGNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDL 151

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  197 IN-LHPLKNLKILSIQSNKLKKIENLEELTNL-EELYLSHNFITKI-EGLEKNLKLTTLDVTSNKITSL-ENLNHLSNLT 272
Cdd:COG4886 152 PEpLGNLTNLKSLDLSNNQLTDLPEELGNLTNlKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLE 231

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 6322655  273 DIWASFNKIdqsfESLgENLSALSRLETIYLEGNPI 308
Cdd:COG4886 232 TLDLSNNQL----TDL-PELGNLTNLEELDLSNNQL 262
LRR_9 pfam14580
Leucine-rich repeat;
118-213 1.10e-07

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 50.92  E-value: 1.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655    118 LDLSFNKIKHIKNL-ENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRL 196
Cdd:pfam14580  24 LDLRGYKIPIIENLgATLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQEL 103

                          90       100
                  ....*....|....*....|
gi 6322655    197 INLHPL---KNLKILSIQSN 213
Cdd:pfam14580 104 GDLDPLaslKKLTFLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
158-215 1.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 1.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655    158 SLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLIN--LHPLKNLKILSIQSNKL 215
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
108-309 1.33e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 43.38  E-value: 1.33e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  108 NVNKLTKLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIW 187
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  188 LGKNSIPRLINLHPLKNLKILSIQSNKlkkieNLEELTNLEELYLSHNFITKI-EGLEKNLKLTTLDVTSNKITSL-ENL 265
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPL 155

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6322655  266 NHLSNLTDIWASFNKIdqsfESLGENLSALSRLETIYLEGNPIQ 309
Cdd:COG4886 156 GNLTNLKSLDLSNNQL----TDLPEELGNLTNLKELDLSNNQIT 195
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 98-306 6.31e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 41.76  E-value: 6.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655    98 YDNKIKHISSNVNKLTKLTSLDLSFNKIKH--IKNLENLTDLENLYFVQNSIS-KIEN-LSTLKSLKNLELGGNKVHSIE 173
Cdd:PLN00113 221 YNNLSGEIPYEIGGLTSLNHLDLVYNNLTGpiPSSLGNLKNLQYLFLYQNKLSgPIPPsIFSLQKLISLDLSDNSLSGEI 300

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   174 PDSFEGLSNLEEIWLGKN----SIPRliNLHPLKNLKILSIQSNKLKKienleeltnleelylshnfitkieGLEKNL-- 247
Cdd:PLN00113 301 PELVIQLQNLEILHLFSNnftgKIPV--ALTSLPRLQVLQLWSNKFSG------------------------EIPKNLgk 354

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6322655   248 --KLTTLDVTSNKITSL--ENLNHLSNLTDIWASFNKIDqsfESLGENLSALSRLETIYLEGN 306
Cdd:PLN00113 355 hnNLTVLDLSTNNLTGEipEGLCSSGNLFKLILFSNSLE---GEIPKSLGACRSLRRVRLQDN 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 49-169 6.32e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.54  E-value: 6.32e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655   49 LVHL-----KIKSLEDLNlyRFKNLKQLCLRQNLIESISEVEVLPH-----------DKIVDLDFYDNKIKHISSNvnkl 112
Cdd:cd21340  48 LTHLylqnnQIEKIENLE--NLVNLKKLYLGGNRISVVEGLENLTNleelhienqrlPPGEKLTFDPRSLAALSNS---- 121

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 6322655  113 tkLTSLDLSFNKIKHIKNLENLTDLENLYFVQNSISKIEN----LSTLKSLKNLELGGNKV 169
Cdd:cd21340 122 --LRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 102-308 4.24e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 38.62  E-value: 4.24e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  102 IKHISSNvnklTKLTSLDLSFNKIKH------IKNLENLTDLENLYFVQNSISK------IENLSTLKSLKNLELGGNKV 169
Cdd:COG5238 229 AEALKGN----KSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLSVNRI 304

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6322655  170 hsiepdSFEGLSNLeeiwlgknsiprlinlhplknlkilsiqsnklkkienleeltnleelylshnfitkIEGLEKNLKL 249
Cdd:COG5238 305 ------GDEGAIAL--------------------------------------------------------AEGLQGNKTL 322

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322655  250 TTLDVTSNKITS------LENLNHLSNLTDIWASFNKI-DQSFESLGENLSALSRLETIYLEGNPI 308
Cdd:COG5238 323 HTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgDEGAIALAKYLEGNTTLRELNLGKNNI 388
PLN03150 PLN03150
hypothetical protein; Provisional
 142-215 5.75e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 38.64  E-value: 5.75e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 6322655   142 FVQNSISKienlstLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSIPRLI--NLHPLKNLKILSIQSNKL 215
Cdd:PLN03150 433 FIPNDISK------LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIpeSLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
137-193 6.33e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.81  E-value: 6.33e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 6322655    137 LENLYFVQNSISKI--ENLSTLKSLKNLELGGNKVHSIEPDSFEGLSNLEEIWLGKNSI 193
Cdd:pfam13855   3 LRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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