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Conserved domains on  [gi|398365661|ref|NP_011612|]
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separase [Saccharomyces cerevisiae S288C]

Protein Classification

separin( domain architecture ID 10009105)

separin is a caspase-like protease which plays a central role in the chromosome segregation by cleaving the MCD1/SCC1 subunit of the cohesin complex at the onset of anaphase

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ESP1 COG5155
Separase, a protease involved in sister chromatid separation [Cell division and chromosome ...
 1-1630 0e+00

Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 227484 [Multi-domain]  Cd Length: 1622  Bit Score: 2366.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661    1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIE 80
Cdd:COG5155     1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661   81 DITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWND 160
Cdd:COG5155    81 DITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWND 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  161 YYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKL 240
Cdd:COG5155   161 YYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  241 PFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNM 320
Cdd:COG5155   241 PFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNM 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  321 SENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDES 400
Cdd:COG5155   321 SENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDES 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  401 AAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQ 480
Cdd:COG5155   401 AAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQ 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  481 SAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSR 560
Cdd:COG5155   481 SAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSR 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  561 MIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMD 640
Cdd:COG5155   561 MIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  641 FVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLH 720
Cdd:COG5155   641 FVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLH 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  721 ASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKIFNESAKLNIKAGNVIS-AVIDCRK 799
Cdd:COG5155   721 ASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKMFTESQKEFLEKGRFIGkPCRATST 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  800 AQNLALSLLKKKNKLSQGSRLALLKSLSFSFFQLIKIHIRIGSARDCEFY-SKELSRIISDLEEPIIVYRCLHFLHRYYM 878
Cdd:COG5155   801 RRNTEAIRMVNSILKAPTRSLGLFGLESVSCLYIYEPMLGIPRYRLCKALvSLCSKVIVRDLYEEIERRIKLHLLRMLYR 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  879 ITEQTCLQNITLGKANKAFDYLDAEADITSLTMFLYDNKEFVKLEQSLVLYFGDQLEKTFLP--NLWKLHLGKDIDDSIC 956
Cdd:COG5155   881 DVESICESMGFLDYADSSLDEIIVGYLIIRYKEYLEYNKEAWKIVERVGPRLKAKAKRTFASllNGWVGSCLLEEKIERL 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  957 LSEYMPKNVINRVHNMWQKVMSQLEEDPFF--KGMFESTLGIPSSLPVIPsTMPNNILKTPSKHSTGLKLCDSPRSSSMT 1034
Cdd:COG5155   961 LSSRRRKAAVSVEKKNITHVLTRDEVEYFFenYPLVSSFLNIPEDLPVIG-TVPYLDLRRPFNHEYFDEVCCWNGFTENT 1039

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1035 -PRGKNIRQKFDRIAAISKLKQMKELLESLKLDTLDNHELSKISSLSSLTLTILSNITSIHNAESSLITNFslTDLPRHM 1113
Cdd:COG5155  1040 sMRGGASREKLLRDLGLLKLICFRMCREREYDLELMRHELSKIKSSSSFERAFLEGITKVVCQESSAAKEF--TLRPMVL 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1114 PLLFDKVLNNIDNKNYREFRVSSLIAPNNISTITESIRVSAAQKDLMESNLNINVITIDFCpiTGNLLLSKLEPRRKrRT 1193
Cdd:COG5155  1118 EIIRGMGMASIHNIQLCEYDLSSLSHMFNGEYFESVFRLNRGVEDSCKSRLNFVAITILNC--TGKLVVSKIGGVHG-PT 1194

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1194 HLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQtTSVEVTNKIKTREERKSWWTTRYDLDKRMQQLLNNIENSWFN 1273
Cdd:COG5155  1195 HLRLPLIRSNSRDLDEMILPFHVAVNELKVIINRSNQ-NLALKDEMSNLREIRKTWWLERFALDRPSQQLLDNIEISWRL 1273

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1274 GVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPSRKLYGNPAMFIkvedWVIELFLKLNPQEIDFLSKMEDLIYFVLDILL 1353
Cdd:COG5155  1274 GRYGVFSPYCIDGSLFIKFFKGFIRIDKDNFRGAKTRMNPILAR----WVIELFLKLNPQEIDSRDILEDLIYFGLDIAR 1349

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1354 FHGEENAYDEIDFSMLHVQLEEQIKKYRATMTTNSIFHTFLVVSSSCHLFPWECLSFLKDLSITRVPSYVCLNKLLSRFH 1433
Cdd:COG5155  1350 FWGQRNAYDEIDLDALLGKLLSDIGSYFNGLSVGSIKHTILVLDESTHEFPWESLPVLRNKSVYRVPSLEYLENALSSFH 1429

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1434 YQLPLQVTIEDNISMILNPNGDLSRTESKFKGmfQKIIDAKPSSQLVMNEkPEEETLLKMLQNSNLFVYIGHGGGEQYVR 1513
Cdd:COG5155  1430 YQLPLQGASGRSFSYILNPENDLPKTQERFAG--QKFLESSGITNLVTGR-PPSDLECKMLDGCDVFLYFGHGGGEQYLK 1506

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1514 SKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDIDKFSEELFEKMGFRCNTDDLNg 1593
Cdd:COG5155  1507 SSEIKKCGEGATMLLFGCSSVALLCMGNYEPNGTILKYLRRGCPMVVGNLWDVTDKDIDSFSARIIESLGSGCNSLGEL- 1585

                        1610      1620      1630
                  ....*....|....*....|....*....|....*..
gi 398365661 1594 NSLSVSYAVSKSRGVCHLRYLNGAAPVIYGLPIKFVS 1630
Cdd:COG5155  1586 NSLSVSYAVSRSRDGCHLRYLNGAAPVIYGLPIKFVS 1622
 
Name Accession Description Interval E-value
ESP1 COG5155
Separase, a protease involved in sister chromatid separation [Cell division and chromosome ...
 1-1630 0e+00

Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227484 [Multi-domain]  Cd Length: 1622  Bit Score: 2366.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661    1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIE 80
Cdd:COG5155     1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661   81 DITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWND 160
Cdd:COG5155    81 DITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWND 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  161 YYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKL 240
Cdd:COG5155   161 YYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  241 PFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNM 320
Cdd:COG5155   241 PFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNM 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  321 SENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDES 400
Cdd:COG5155   321 SENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDES 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  401 AAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQ 480
Cdd:COG5155   401 AAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQ 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  481 SAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSR 560
Cdd:COG5155   481 SAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSR 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  561 MIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMD 640
Cdd:COG5155   561 MIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  641 FVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLH 720
Cdd:COG5155   641 FVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLH 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  721 ASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKIFNESAKLNIKAGNVIS-AVIDCRK 799
Cdd:COG5155   721 ASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKMFTESQKEFLEKGRFIGkPCRATST 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  800 AQNLALSLLKKKNKLSQGSRLALLKSLSFSFFQLIKIHIRIGSARDCEFY-SKELSRIISDLEEPIIVYRCLHFLHRYYM 878
Cdd:COG5155   801 RRNTEAIRMVNSILKAPTRSLGLFGLESVSCLYIYEPMLGIPRYRLCKALvSLCSKVIVRDLYEEIERRIKLHLLRMLYR 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  879 ITEQTCLQNITLGKANKAFDYLDAEADITSLTMFLYDNKEFVKLEQSLVLYFGDQLEKTFLP--NLWKLHLGKDIDDSIC 956
Cdd:COG5155   881 DVESICESMGFLDYADSSLDEIIVGYLIIRYKEYLEYNKEAWKIVERVGPRLKAKAKRTFASllNGWVGSCLLEEKIERL 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  957 LSEYMPKNVINRVHNMWQKVMSQLEEDPFF--KGMFESTLGIPSSLPVIPsTMPNNILKTPSKHSTGLKLCDSPRSSSMT 1034
Cdd:COG5155   961 LSSRRRKAAVSVEKKNITHVLTRDEVEYFFenYPLVSSFLNIPEDLPVIG-TVPYLDLRRPFNHEYFDEVCCWNGFTENT 1039

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1035 -PRGKNIRQKFDRIAAISKLKQMKELLESLKLDTLDNHELSKISSLSSLTLTILSNITSIHNAESSLITNFslTDLPRHM 1113
Cdd:COG5155  1040 sMRGGASREKLLRDLGLLKLICFRMCREREYDLELMRHELSKIKSSSSFERAFLEGITKVVCQESSAAKEF--TLRPMVL 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1114 PLLFDKVLNNIDNKNYREFRVSSLIAPNNISTITESIRVSAAQKDLMESNLNINVITIDFCpiTGNLLLSKLEPRRKrRT 1193
Cdd:COG5155  1118 EIIRGMGMASIHNIQLCEYDLSSLSHMFNGEYFESVFRLNRGVEDSCKSRLNFVAITILNC--TGKLVVSKIGGVHG-PT 1194

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1194 HLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQtTSVEVTNKIKTREERKSWWTTRYDLDKRMQQLLNNIENSWFN 1273
Cdd:COG5155  1195 HLRLPLIRSNSRDLDEMILPFHVAVNELKVIINRSNQ-NLALKDEMSNLREIRKTWWLERFALDRPSQQLLDNIEISWRL 1273

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1274 GVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPSRKLYGNPAMFIkvedWVIELFLKLNPQEIDFLSKMEDLIYFVLDILL 1353
Cdd:COG5155  1274 GRYGVFSPYCIDGSLFIKFFKGFIRIDKDNFRGAKTRMNPILAR----WVIELFLKLNPQEIDSRDILEDLIYFGLDIAR 1349

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1354 FHGEENAYDEIDFSMLHVQLEEQIKKYRATMTTNSIFHTFLVVSSSCHLFPWECLSFLKDLSITRVPSYVCLNKLLSRFH 1433
Cdd:COG5155  1350 FWGQRNAYDEIDLDALLGKLLSDIGSYFNGLSVGSIKHTILVLDESTHEFPWESLPVLRNKSVYRVPSLEYLENALSSFH 1429

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1434 YQLPLQVTIEDNISMILNPNGDLSRTESKFKGmfQKIIDAKPSSQLVMNEkPEEETLLKMLQNSNLFVYIGHGGGEQYVR 1513
Cdd:COG5155  1430 YQLPLQGASGRSFSYILNPENDLPKTQERFAG--QKFLESSGITNLVTGR-PPSDLECKMLDGCDVFLYFGHGGGEQYLK 1506

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1514 SKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDIDKFSEELFEKMGFRCNTDDLNg 1593
Cdd:COG5155  1507 SSEIKKCGEGATMLLFGCSSVALLCMGNYEPNGTILKYLRRGCPMVVGNLWDVTDKDIDSFSARIIESLGSGCNSLGEL- 1585

                        1610      1620      1630
                  ....*....|....*....|....*....|....*..
gi 398365661 1594 NSLSVSYAVSKSRGVCHLRYLNGAAPVIYGLPIKFVS 1630
Cdd:COG5155  1586 NSLSVSYAVSRSRDGCHLRYLNGAAPVIYGLPIKFVS 1622
Peptidase_C50 pfam03568
Peptidase family C50;
1175-1571 0e+00

Peptidase family C50;


Pssm-ID: 460974 [Multi-domain]  Cd Length: 389  Bit Score: 564.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1175 PITGNLLLSKLEPRRKRrTHLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQTTSVEVtnKIKTREERKSWWTTRY 1254
Cdd:pfam03568    1 EDRGDLLLSRLEAGSSP-FVLRLPLSRHNSRDADEEVLSFEDALDELDEIIEESNESTSSAS--DIKTKEARKEWWKERE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1255 DLDKRMQQLLNNIENSWFNGVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPSRKLYgNPAMFIKVEDWVIELFLKLNPqE 1334
Cdd:pfam03568   78 ALDKRLKELLENIENSWLGGFKGIFSPHPRDPELLARFAKKFQKILDKHLPSRKQK-APSPKLTLDDRILELFLGLGP-E 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1335 IDFLSKMEDLIYFVLDILLFHGEENAYDEIDFSMLHVQLEEQIKKYRATMTTNS-IFHTFLVVSSSCHLFPWECLSFLKD 1413
Cdd:pfam03568  156 DDFDELLEDLLYFVLDILQFHGERNAYDEIDFDQLVVELEDALRKYHSKAAPETkREHTVLVLDKALQSFPWESLPCLRG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1414 LSITRVPSYVCLNKLLSRFHYQLPLQVTIEDNISMILNPNGDLSRTESKFKGMFQKiidaKPSSQLVMNEKPEEETLLKM 1493
Cdd:pfam03568  236 RSVSRMPSLHSLRDLLEKREAQLKPRIVVDRNGYYILNPSGDLKRTQERFEDWFES----LPGWKGIVGRAPSEEEFEEA 311

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365661  1494 LQNSNLFVYIGHGGGEQYVRSKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDI 1571
Cdd:pfam03568  312 LSTSDLFLYFGHGGGEQYIRSRTIKKLPRCAASLLMGCSSGALKEAGDFEPYGTPLNYLLAGCPAVVGNLWDVTDKDI 389
 
Name Accession Description Interval E-value
ESP1 COG5155
Separase, a protease involved in sister chromatid separation [Cell division and chromosome ...
 1-1630 0e+00

Separase, a protease involved in sister chromatid separation [Cell division and chromosome partitioning / Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 227484 [Multi-domain]  Cd Length: 1622  Bit Score: 2366.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661    1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIE 80
Cdd:COG5155     1 MMVKQEEPLNEISPNTPMTSKSYLLNDTLSKVHHSGQTRPLTSVLSGDASSNSIGILAMHNNIIRDFTKIASNNIDLAIE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661   81 DITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWND 160
Cdd:COG5155    81 DITTVDHSLNSIYSLLKSHHMWGHINSTVKQHLMIIVKLINNNALGLASSEIIFLFNETNLFQAHSLKNILLADFSTWND 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  161 YYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKL 240
Cdd:COG5155   161 YYLSNLKILALQIILKRKLVDEYLPHILELFSHDKRYLLKDPNLKAHALTKIVLSFFSVTTSCKVLFGLKFLQYIKQFKL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  241 PFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNM 320
Cdd:COG5155   241 PFKKFISNITVECFSKNLLHKNYLEMGPNKIYLNSFYLSYSMLYDGLDKIMLLDILSYEETTEVQRAIKSKKEFNEYCNM 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  321 SENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDES 400
Cdd:COG5155   321 SENRLLWSCISVDDLNVILENATNFLQNKGKHISATLKCLVCLWSTIRLEGLPKNKDILRQFDCTVIYINSNIKSINDES 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  401 AAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQ 480
Cdd:COG5155   401 AAALLSELLGVLSEICIDYKEPKRLSNIISVLFNASVLFKSHSFLLKTANLEISNVLISNDSKTSHRTILKFEKFISSAQ 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  481 SAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSR 560
Cdd:COG5155   481 SAQKKIEIFSCLFNVYCMLRNDTLSFVFDFCQNAFIHCFTRLKITKFIEFSNSSEIMLSVLYGNSSIENIPSENWSQLSR 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  561 MIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMD 640
Cdd:COG5155   561 MIFCSLRGIFDLDPLELNNTFDKLHLLNKYELLIRIVYLLNLDMSKHLTTNLSKITKLYINKWLQKSDEKAERISSFEMD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  641 FVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLH 720
Cdd:COG5155   641 FVKMLLCYLNFNNFDKLSIELSLCIKSKEKYYSSIVPYADNYLLEAYLSLYMIDDALMMKNQLQKTMNLSTAKIEQALLH 720

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  721 ASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKIFNESAKLNIKAGNVIS-AVIDCRK 799
Cdd:COG5155   721 ASSLINVHLWDSDLTAFQIYFGKTLPAMKPELFDINNDHNLPMSLYIKVILLNIKMFTESQKEFLEKGRFIGkPCRATST 800

                         810       820       830       840       850       860       870       880
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  800 AQNLALSLLKKKNKLSQGSRLALLKSLSFSFFQLIKIHIRIGSARDCEFY-SKELSRIISDLEEPIIVYRCLHFLHRYYM 878
Cdd:COG5155   801 RRNTEAIRMVNSILKAPTRSLGLFGLESVSCLYIYEPMLGIPRYRLCKALvSLCSKVIVRDLYEEIERRIKLHLLRMLYR 880

                         890       900       910       920       930       940       950       960
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  879 ITEQTCLQNITLGKANKAFDYLDAEADITSLTMFLYDNKEFVKLEQSLVLYFGDQLEKTFLP--NLWKLHLGKDIDDSIC 956
Cdd:COG5155   881 DVESICESMGFLDYADSSLDEIIVGYLIIRYKEYLEYNKEAWKIVERVGPRLKAKAKRTFASllNGWVGSCLLEEKIERL 960

                         970       980       990      1000      1010      1020      1030      1040
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  957 LSEYMPKNVINRVHNMWQKVMSQLEEDPFF--KGMFESTLGIPSSLPVIPsTMPNNILKTPSKHSTGLKLCDSPRSSSMT 1034
Cdd:COG5155   961 LSSRRRKAAVSVEKKNITHVLTRDEVEYFFenYPLVSSFLNIPEDLPVIG-TVPYLDLRRPFNHEYFDEVCCWNGFTENT 1039

                        1050      1060      1070      1080      1090      1100      1110      1120
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1035 -PRGKNIRQKFDRIAAISKLKQMKELLESLKLDTLDNHELSKISSLSSLTLTILSNITSIHNAESSLITNFslTDLPRHM 1113
Cdd:COG5155  1040 sMRGGASREKLLRDLGLLKLICFRMCREREYDLELMRHELSKIKSSSSFERAFLEGITKVVCQESSAAKEF--TLRPMVL 1117

                        1130      1140      1150      1160      1170      1180      1190      1200
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1114 PLLFDKVLNNIDNKNYREFRVSSLIAPNNISTITESIRVSAAQKDLMESNLNINVITIDFCpiTGNLLLSKLEPRRKrRT 1193
Cdd:COG5155  1118 EIIRGMGMASIHNIQLCEYDLSSLSHMFNGEYFESVFRLNRGVEDSCKSRLNFVAITILNC--TGKLVVSKIGGVHG-PT 1194

                        1210      1220      1230      1240      1250      1260      1270      1280
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1194 HLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQtTSVEVTNKIKTREERKSWWTTRYDLDKRMQQLLNNIENSWFN 1273
Cdd:COG5155  1195 HLRLPLIRSNSRDLDEMILPFHVAVNELKVIINRSNQ-NLALKDEMSNLREIRKTWWLERFALDRPSQQLLDNIEISWRL 1273

                        1290      1300      1310      1320      1330      1340      1350      1360
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1274 GVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPSRKLYGNPAMFIkvedWVIELFLKLNPQEIDFLSKMEDLIYFVLDILL 1353
Cdd:COG5155  1274 GRYGVFSPYCIDGSLFIKFFKGFIRIDKDNFRGAKTRMNPILAR----WVIELFLKLNPQEIDSRDILEDLIYFGLDIAR 1349

                        1370      1380      1390      1400      1410      1420      1430      1440
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1354 FHGEENAYDEIDFSMLHVQLEEQIKKYRATMTTNSIFHTFLVVSSSCHLFPWECLSFLKDLSITRVPSYVCLNKLLSRFH 1433
Cdd:COG5155  1350 FWGQRNAYDEIDLDALLGKLLSDIGSYFNGLSVGSIKHTILVLDESTHEFPWESLPVLRNKSVYRVPSLEYLENALSSFH 1429

                        1450      1460      1470      1480      1490      1500      1510      1520
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1434 YQLPLQVTIEDNISMILNPNGDLSRTESKFKGmfQKIIDAKPSSQLVMNEkPEEETLLKMLQNSNLFVYIGHGGGEQYVR 1513
Cdd:COG5155  1430 YQLPLQGASGRSFSYILNPENDLPKTQERFAG--QKFLESSGITNLVTGR-PPSDLECKMLDGCDVFLYFGHGGGEQYLK 1506

                        1530      1540      1550      1560      1570      1580      1590      1600
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661 1514 SKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDIDKFSEELFEKMGFRCNTDDLNg 1593
Cdd:COG5155  1507 SSEIKKCGEGATMLLFGCSSVALLCMGNYEPNGTILKYLRRGCPMVVGNLWDVTDKDIDSFSARIIESLGSGCNSLGEL- 1585

                        1610      1620      1630
                  ....*....|....*....|....*....|....*..
gi 398365661 1594 NSLSVSYAVSKSRGVCHLRYLNGAAPVIYGLPIKFVS 1630
Cdd:COG5155  1586 NSLSVSYAVSRSRDGCHLRYLNGAAPVIYGLPIKFVS 1622
Peptidase_C50 pfam03568
Peptidase family C50;
1175-1571 0e+00

Peptidase family C50;


Pssm-ID: 460974 [Multi-domain]  Cd Length: 389  Bit Score: 564.88  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1175 PITGNLLLSKLEPRRKRrTHLRLPLIRSNSRDLDEVHLSFPEATKKLLSIINESNQTTSVEVtnKIKTREERKSWWTTRY 1254
Cdd:pfam03568    1 EDRGDLLLSRLEAGSSP-FVLRLPLSRHNSRDADEEVLSFEDALDELDEIIEESNESTSSAS--DIKTKEARKEWWKERE 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1255 DLDKRMQQLLNNIENSWFNGVQGFFSPEVVDNSLFEKFKDKFYEILHQNLPSRKLYgNPAMFIKVEDWVIELFLKLNPqE 1334
Cdd:pfam03568   78 ALDKRLKELLENIENSWLGGFKGIFSPHPRDPELLARFAKKFQKILDKHLPSRKQK-APSPKLTLDDRILELFLGLGP-E 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1335 IDFLSKMEDLIYFVLDILLFHGEENAYDEIDFSMLHVQLEEQIKKYRATMTTNS-IFHTFLVVSSSCHLFPWECLSFLKD 1413
Cdd:pfam03568  156 DDFDELLEDLLYFVLDILQFHGERNAYDEIDFDQLVVELEDALRKYHSKAAPETkREHTVLVLDKALQSFPWESLPCLRG 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398365661  1414 LSITRVPSYVCLNKLLSRFHYQLPLQVTIEDNISMILNPNGDLSRTESKFKGMFQKiidaKPSSQLVMNEKPEEETLLKM 1493
Cdd:pfam03568  236 RSVSRMPSLHSLRDLLEKREAQLKPRIVVDRNGYYILNPSGDLKRTQERFEDWFES----LPGWKGIVGRAPSEEEFEEA 311

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 398365661  1494 LQNSNLFVYIGHGGGEQYVRSKEIKKCTKIAPSFLLGCSSAAMKYYGKLEPTGTIYTYLLGGCPMVLGNLWDVTDKDI 1571
Cdd:pfam03568  312 LSTSDLFLYFGHGGGEQYIRSRTIKKLPRCAASLLMGCSSGALKEAGDFEPYGTPLNYLLAGCPAVVGNLWDVTDKDI 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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