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Conserved domains on  [gi|330443551|ref|NP_011391|]
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Mon1p [Saccharomyces cerevisiae S288C]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 182-308 5.45e-32

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465953  Cd Length: 125  Bit Score: 120.01  E-value: 5.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  182 KNFFIFTSAGKPIYCMHGK--DEQIMSYTGLVNTVISYFQVNGpSELKTISTltSGKRLTFLDKSPILLMAQSERGESSN 259
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDedESLLFSLFGPLNGSISFMQTQD-DTLTSITC--ENTKVVFLEKGPLLLVAISRSGESEQ 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 330443551  260 ELLNQLDFLYSYILSSLSERQLLRLFSKRENFDLRNYLESTdFENLDEI 308
Cdd:pfam19036  78 QLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGL-EDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 356-457 7.21e-26

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465954  Cd Length: 98  Bit Score: 101.92  E-value: 7.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  356 TLLYGLIIApQNKLCCVLRPRGHTLHTTDLHLLFCLISHQFQNldETQELWVPICFPKFNsSGFLYCYIKFLPndthsNE 435
Cdd:pfam19037   2 SLLFALLLV-GGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPF--KSLELWIPICLPKFN-PGVLHRYISFLG-----DI 72

                          90       100
                  ....*....|....*....|..
gi 330443551  436 KSALVLISAQKDAFFSLKSFSD 457
Cdd:pfam19037  73 NLCLLLLSGDKPAFFELSLLDD 94
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 487-633 2.30e-19

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 83.46  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  487 MVHHFIYKSKQNVQYVMPHFEVNSnialdSSQGLEYELKLKTYYQQLHGTVVRDNGNLlsrsmlnfvrwsskdnedlamd 566
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSLPTDP-----PYTTEQRRRRLRSFYQLLHSTLHSPSGPL---------------------- 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 330443551  567 etqmdfseldeyiigNSSFKQESvNMVGMAWVTPTFELYLIGnNGIVDKRVLFKSARKVANWCQKHE 633
Cdd:pfam19038  54 ---------------KLLYKVSD-YESLLAWFTDCFELYVLF-SPLVPKHALRSSANKLLKWIKKEE 103
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 182-308 5.45e-32

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 120.01  E-value: 5.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  182 KNFFIFTSAGKPIYCMHGK--DEQIMSYTGLVNTVISYFQVNGpSELKTISTltSGKRLTFLDKSPILLMAQSERGESSN 259
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDedESLLFSLFGPLNGSISFMQTQD-DTLTSITC--ENTKVVFLEKGPLLLVAISRSGESEQ 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 330443551  260 ELLNQLDFLYSYILSSLSERQLLRLFSKRENFDLRNYLESTdFENLDEI 308
Cdd:pfam19036  78 QLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGL-EDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 356-457 7.21e-26

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 101.92  E-value: 7.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  356 TLLYGLIIApQNKLCCVLRPRGHTLHTTDLHLLFCLISHQFQNldETQELWVPICFPKFNsSGFLYCYIKFLPndthsNE 435
Cdd:pfam19037   2 SLLFALLLV-GGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPF--KSLELWIPICLPKFN-PGVLHRYISFLG-----DI 72

                          90       100
                  ....*....|....*....|..
gi 330443551  436 KSALVLISAQKDAFFSLKSFSD 457
Cdd:pfam19037  73 NLCLLLLSGDKPAFFELSLLDD 94
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 487-633 2.30e-19

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 83.46  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  487 MVHHFIYKSKQNVQYVMPHFEVNSnialdSSQGLEYELKLKTYYQQLHGTVVRDNGNLlsrsmlnfvrwsskdnedlamd 566
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSLPTDP-----PYTTEQRRRRLRSFYQLLHSTLHSPSGPL---------------------- 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 330443551  567 etqmdfseldeyiigNSSFKQESvNMVGMAWVTPTFELYLIGnNGIVDKRVLFKSARKVANWCQKHE 633
Cdd:pfam19038  54 ---------------KLLYKVSD-YESLLAWFTDCFELYVLF-SPLVPKHALRSSANKLLKWIKKEE 103
 
Name Accession Description Interval E-value
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 182-308 5.45e-32

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 120.01  E-value: 5.45e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  182 KNFFIFTSAGKPIYCMHGK--DEQIMSYTGLVNTVISYFQVNGpSELKTISTltSGKRLTFLDKSPILLMAQSERGESSN 259
Cdd:pfam19036   1 KHLLILSSAGKPIFTRYGDedESLLFSLFGPLNGSISFMQTQD-DTLTSITC--ENTKVVFLEKGPLLLVAISRSGESEQ 77

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 330443551  260 ELLNQLDFLYSYILSSLSERQLLRLFSKRENFDLRNYLESTdFENLDEI 308
Cdd:pfam19036  78 QLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGL-EDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 356-457 7.21e-26

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 101.92  E-value: 7.21e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  356 TLLYGLIIApQNKLCCVLRPRGHTLHTTDLHLLFCLISHQFQNldETQELWVPICFPKFNsSGFLYCYIKFLPndthsNE 435
Cdd:pfam19037   2 SLLFALLLV-GGKLVAAYRPRWASLHPSDLLLLFLLVQSSSPF--KSLELWIPICLPKFN-PGVLHRYISFLG-----DI 72

                          90       100
                  ....*....|....*....|..
gi 330443551  436 KSALVLISAQKDAFFSLKSFSD 457
Cdd:pfam19037  73 NLCLLLLSGDKPAFFELSLLDD 94
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 487-633 2.30e-19

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 83.46  E-value: 2.30e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  487 MVHHFIYKSKQNVQYVMPHFEVNSnialdSSQGLEYELKLKTYYQQLHGTVVRDNGNLlsrsmlnfvrwsskdnedlamd 566
Cdd:pfam19038   1 GLLHFLYKSRSTVQFTAPSLPTDP-----PYTTEQRRRRLRSFYQLLHSTLHSPSGPL---------------------- 53

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 330443551  567 etqmdfseldeyiigNSSFKQESvNMVGMAWVTPTFELYLIGnNGIVDKRVLFKSARKVANWCQKHE 633
Cdd:pfam19038  54 ---------------KLLYKVSD-YESLLAWFTDCFELYVLF-SPLVPKHALRSSANKLLKWIKKEE 103
TAF1_subA pfam14929
TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I ...
 525-629 9.47e-03

TAF RNA Polymerase I subunit A; TATA box binding protein associated factor RNA Polymerase I subunit A is found in eukaryotes and is encoded by the gene TAF1A in humans. Its function is to aid transcription of DNA into RNA by binding to the promoter at the -10 TATA box site. It is a component of the transcription factor SL1/TIF-IB complex, involved in PIC assembly (pre-initiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation depends on the rate of association of this protein. This protein also stabilizes nucleolar transcription factor 1/UBTF on rDNA.


Pssm-ID: 434323  Cd Length: 365  Bit Score: 38.86  E-value: 9.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 330443551  525 KLKTYYQQLHGTVVRDNGNLLSR-----SMLN-------FVRWSSKDNEDLAMDETQMDFSELDEYIIGNSSFKQESVNM 592
Cdd:pfam14929  85 MIEEAKRNLSNAESWRYGETLMSqekliKLINaykglldYYLWYSKKPEELQLDDFEDDFSQLNSNQEMHNYFRQAAVNL 164

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 330443551  593 --------VGMAWVTPTFELYLIGNNgivdkrvlFKSARKVANWC 629
Cdd:pfam14929 165 lalistpgVWDPFVLPYVQLLEFYGD--------VDEALEVLNNY 201
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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