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Conserved domains on  [gi|6320432|ref|NP_010512|]
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adenylate kinase ADK1 [Saccharomyces cerevisiae S288C]

Protein Classification

adenylate kinase family protein( domain architecture ID 11426204)

adenylate kinase family protein such as adenylate kinase that catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP

CATH:  3.40.50.300
EC:  2.7.4.-
Gene Ontology:  GO:0019205|GO:0005524|GO:0016310|GO:0006139
PubMed:  2841070|14568537|3023080

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 8-219 3.63e-116

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


:

Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 329.78  E-value: 3.63e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNnPACKNG 87
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ-PDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320432  168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKL 219
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
 
Name Accession Description Interval E-value
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 8-219 3.63e-116

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 329.78  E-value: 3.63e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNnPACKNG 87
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ-PDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320432  168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKL 219
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 8-221 1.46e-115

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 328.26  E-value: 1.46e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELtNNPACKNG 87
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6320432   168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGK 221
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGK 214
ADK pfam00406
Adenylate kinase;
11-195 4.13e-111

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 315.79  E-value: 4.13e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     11 LIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNpACKNGFIL 90
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQN-DCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     91 DGFPRTIPQAEKLDQMLkEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDD 170
Cdd:pfam00406  80 DGFPRTVPQAEALEELL-ERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDD 158

                         170       180
                  ....*....|....*....|....*
gi 6320432    171 NADALKKRLAAYHAQTEPIVDFYKK 195
Cdd:pfam00406 159 NEETVKKRLETYHKQTKPLIDYYKK 183
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 8-220 8.56e-103

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 296.07  E-value: 8.56e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432      8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNG 87
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNENG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     88 FILDGFPRTIPQAEKLDQMLKEqgtPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEE---PIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6320432    168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLG 220
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 8-211 2.14e-96

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 279.12  E-value: 2.14e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPaCKNG 87
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   88 FILDGFPRTIPQAEKLDQMLKEqGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKifnppkedMKDDVTGEALVQR 167
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLDE-GIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQR 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6320432  168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATV 211
Cdd:cd01428 151 SDDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
 
Name Accession Description Interval E-value
Adk COG0563
Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or ...
 8-219 3.63e-116

Adenylate kinase or related kinase [Nucleotide transport and metabolism]; Adenylate kinase or related kinase is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440329 [Multi-domain]  Cd Length: 212  Bit Score: 329.78  E-value: 3.63e-116
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNnPACKNG 87
Cdd:COG0563   2 RIILLGPPGAGKGTQAKRLAEKYGIPHISTGDMLRAAVKAGTELGKKAKEYMDAGELVPDEIVIGLVKERLAQ-PDCANG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:COG0563  81 FILDGFPRTVAQAEALDELLAELGIKLDAVIELDVDDEELVERLSGRRVCPNCGATYHVKFNPPKVEGVCDKCGGELVQR 160

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 6320432  168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKL 219
Cdd:COG0563 161 ADDNEETVRKRLEVYHEQTAPLIDYYRKKGKLVEIDGEGSIEEVTADILAIL 212
adk PRK00279
adenylate kinase; Reviewed
 8-221 1.46e-115

adenylate kinase; Reviewed


Pssm-ID: 234711 [Multi-domain]  Cd Length: 215  Bit Score: 328.26  E-value: 1.46e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELtNNPACKNG 87
Cdd:PRK00279   2 RLILLGPPGAGKGTQAKFIAEKYGIPHISTGDMLRAAVKAGTELGKEAKSYMDAGELVPDEIVIGLVKERL-AQPDCKNG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:PRK00279  81 FLLDGFPRTIPQAEALDEMLKELGIKLDAVIEIDVPDEELVERLSGRRICPACGRTYHVKFNPPKVEGKCDVCGEELIQR 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6320432   168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGK 221
Cdd:PRK00279 161 ADDNEETVRKRLEVYHKQTAPLIDYYKKKGKLKKIDGTGSIDEVFADILKALGK 214
ADK pfam00406
Adenylate kinase;
11-195 4.13e-111

Adenylate kinase;


Pssm-ID: 395329 [Multi-domain]  Cd Length: 184  Bit Score: 315.79  E-value: 4.13e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     11 LIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNpACKNGFIL 90
Cdd:pfam00406   1 LLGPPGAGKGTQAEKIVQKYGLPHLSTGDLLRAEIKSGTELGKEAKEYMDKGELVPDEVVVGLVKERLEQN-DCKNGFLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     91 DGFPRTIPQAEKLDQMLkEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSDD 170
Cdd:pfam00406  80 DGFPRTVPQAEALEELL-ERGIKLDYVIEFDVPDEVLVERLTGRRIHPNSGRSYHLEFNPPKVPGKDDVTGEPLVQRSDD 158

                         170       180
                  ....*....|....*....|....*
gi 6320432    171 NADALKKRLAAYHAQTEPIVDFYKK 195
Cdd:pfam00406 159 NEETVKKRLETYHKQTKPLIDYYKK 183
adk TIGR01351
adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ...
 8-220 8.56e-103

adenylate kinase; Adenylate kinase (EC 2.7.4.3) converts ATP + AMP to ADP + ADP, that is, uses ATP as a phosphate donor for AMP. Most members of this family are known or believed to be adenylate kinase. However, some members accept other nucleotide triphosphates as donors, may be unable to use ATP, and may fail to complement adenylate kinase mutants. An example of a nucleoside-triphosphate--adenylate kinase (EC 2.7.4.10) is SP|Q9UIJ7, a GTP:AMP phosphotransferase. This family is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Nucleotide and nucleoside interconversions]


Pssm-ID: 273569 [Multi-domain]  Cd Length: 210  Bit Score: 296.07  E-value: 8.56e-103
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432      8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNG 87
Cdd:TIGR01351   1 RLVLLGPPGSGKGTQAKRIAEKYGLPHISTGDLLRAEIKAGTPLGKKAKEYMEKGELVPDEIVNQLVKERLTQNDDNENG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     88 FILDGFPRTIPQAEKLDQMLKEqgtPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQR 167
Cdd:TIGR01351  81 FILDGFPRTLSQAEALDALLEE---PIDAVIELDVPDEELVERLSGRRICPSCGRVYHLKFNPPKVPGCDDCTGELLVQR 157

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 6320432    168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLG 220
Cdd:TIGR01351 158 EDDTEEVVKKRLEVYKEQTEPLIDYYKKRGILVQIDGNGPIDEVWKRILEALK 210
ADK cd01428
Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine ...
 8-211 2.14e-96

Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for homeostasis of adenosine phosphates.


Pssm-ID: 238713 [Multi-domain]  Cd Length: 194  Bit Score: 279.12  E-value: 2.14e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPaCKNG 87
Cdd:cd01428   1 RILLLGPPGSGKGTQAERLAKKYGLPHISTGDLLREEIASGTELGKKAKEYIDSGKLVPDEIVIKLLKERLKKPD-CKKG 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   88 FILDGFPRTIPQAEKLDQMLKEqGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKifnppkedMKDDVTGEALVQR 167
Cdd:cd01428  80 FILDGFPRTVDQAEALDELLDE-GIKPDKVIELDVPDEVLIERILGRRICPVSGRVYHL--------GKDDVTGEPLSQR 150

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6320432  168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATV 211
Cdd:cd01428 151 SDDNEETIKKRLEVYKEQTAPLIDYYKKKGKLVEIDGSGDIDEV 194
PLN02674 PLN02674
adenylate kinase
 2-219 1.35e-91

adenylate kinase


Pssm-ID: 178279 [Multi-domain]  Cd Length: 244  Bit Score: 269.06  E-value: 1.35e-91
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     2 SSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIkDELTNN 81
Cdd:PLN02674  27 SSKPDKRLILIGPPGSGKGTQSPIIKDEYCLCHLATGDMLRAAVAAKTPLGIKAKEAMDKGELVSDDLVVGII-DEAMKK 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    82 PACKNGFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTG 161
Cdd:PLN02674 106 PSCQKGFILDGFPRTVVQAQKLDEMLAKQGAKIDKVLNFAIDDAILEERITGRWIHPSSGRTYHTKFAPPKVPGVDDVTG 185

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 6320432   162 EALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKL 219
Cdd:PLN02674 186 EPLIQRKDDTAAVLKSRLEAFHKQTEPVIDYYAKKGVVANLHAEKPPKEVTAEVQKAL 243
PRK14532 PRK14532
adenylate kinase; Provisional
 9-215 1.34e-56

adenylate kinase; Provisional


Pssm-ID: 184729 [Multi-domain]  Cd Length: 188  Bit Score: 178.09  E-value: 1.34e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     9 MVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACkNGF 88
Cdd:PRK14532   3 LILFGPPAAGKGTQAKRLVEERGMVQLSTGDMLRAAIASGSELGQRVKGIMDRGELVSDEIVIALIEERLPEAEAA-GGA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    89 ILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPAsgrsyhkifnppkedmkddvtgealvqRS 168
Cdd:PRK14532  82 IFDGFPRTVAQAEALDKMLASRGQKIDVVIRLKVDDEALIERIVKRFEEQG---------------------------RP 134

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 6320432   169 DDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADI 215
Cdd:PRK14532 135 DDNPEVFVTRLDAYNAQTAPLLPYYAGQGKLTEVDGMGSIEAVAASI 181
PRK13808 PRK13808
adenylate kinase; Provisional
 7-215 5.27e-55

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 178.54  E-value: 5.27e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     7 IRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELtNNPACKN 86
Cdd:PRK13808   1 MRLILLGPPGAGKGTQAQRLVQQYGIVQLSTGDMLRAAVAAGTPVGLKAKDIMASGGLVPDEVVVGIISDRI-EQPDAAN 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    87 GFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLihpASGRSyhkifnppkedmkddvTGEALvq 166
Cdd:PRK13808  80 GFILDGFPRTVPQAEALDALLKDKQLKLDAVVELRVNEGALLARVETRV---AEMRA----------------RGEEV-- 138

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 6320432   167 RSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADI 215
Cdd:PRK13808 139 RADDTPEVLAKRLASYRAQTEPLVHYYSEKRKLLTVDGMMTIDEVTREI 187
PRK14527 PRK14527
adenylate kinase; Provisional
 1-220 1.09e-54

adenylate kinase; Provisional


Pssm-ID: 237745 [Multi-domain]  Cd Length: 191  Bit Score: 173.05  E-value: 1.09e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     1 MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTN 80
Cdd:PRK14527   1 MTQTKNKVVIFLGPPGAGKGTQAERLAQELGLKKLSTGDILRDHVARGTELGQRAKPIMEAGDLVPDELILALIRDELAG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    81 NPACKngFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRlihpasgrsyhkifnppkedmkddvt 160
Cdd:PRK14527  81 MEPVR--VIFDGFPRTLAQAEALDRLLEELGARLLAVVLLEVPDEELIRRIVER-------------------------- 132

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   161 gEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLG 220
Cdd:PRK14527 133 -ARQEGRSDDNEETVRRRQQVYREQTQPLVDYYEARGHLKRVDGLGTPDEVYARILKALG 191
adk PRK02496
adenylate kinase; Provisional
 7-220 1.68e-53

adenylate kinase; Provisional


Pssm-ID: 179433 [Multi-domain]  Cd Length: 184  Bit Score: 169.93  E-value: 1.68e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     7 IRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELtNNPACKN 86
Cdd:PRK02496   2 TRLIFLGPPGAGKGTQAVVLAEHLHIPHISTGDILRQAIKEQTPLGIKAQGYMDKGELVPDQLVLDLVQERL-QQPDAAN 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    87 GFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRlihpasgrsyhkifnppkedmkddvtgealvQ 166
Cdd:PRK02496  81 GWILDGFPRKVTQAAFLDELLQEIGQSGERVVNLDVPDDVVVERLLAR-------------------------------G 129

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 6320432   167 RSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLG 220
Cdd:PRK02496 130 RKDDTEEVIRRRLEVYREQTAPLIDYYRDRQKLLTIDGNQSVEAVTTELKAALA 183
PRK14530 PRK14530
adenylate kinase; Provisional
 8-215 3.63e-53

adenylate kinase; Provisional


Pssm-ID: 237747 [Multi-domain]  Cd Length: 215  Bit Score: 169.97  E-value: 3.63e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRS-QIAKGTQLGLE---AKKIMDQGGLVSDDImVNMIKDELTNNpa 83
Cdd:PRK14530   5 RILLLGAPGAGKGTQSSNLAEEFGVEHVTTGDALRAnKQMDISDMDTEydtPGEYMDAGELVPDAV-VNEIVEEALSD-- 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    84 cKNGFILDGFPRTIPQAEKLDQMlkeqgTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFNPPKEDMKDDVTGEA 163
Cdd:PRK14530  82 -ADGFVLDGYPRNLEQAEYLESI-----TDLDVVLYLDVSEEELVDRLTGRRVCPDCGANYHVEFNQPEEEGVCDECGGE 155

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 6320432   164 LVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADI 215
Cdd:PRK14530 156 LIQRDDDTEETVRERLDVFEENTEPVIEHYRDQGVLVEVDGEQTPDEVWADI 207
PRK14528 PRK14528
adenylate kinase; Provisional
 8-203 3.35e-51

adenylate kinase; Provisional


Pssm-ID: 172994 [Multi-domain]  Cd Length: 186  Bit Score: 164.03  E-value: 3.35e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTnNPACKNG 87
Cdd:PRK14528   3 NIIFMGPPGAGKGTQAKILCERLSIPQISTGDILREAVKNQTAMGIEAKRYMDAGDLVPDSVVIGIIKDRIR-EADCKNG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPAsgrsyhkifnppkedmkddvtgealvqR 167
Cdd:PRK14528  82 FLLDGFPRTVEQADALDALLKNEGKSIDKAINLEVPDGELLKRLLGRAEIEG---------------------------R 134

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 6320432   168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVD 203
Cdd:PRK14528 135 ADDNEATIKNRLDNYNKKTLPLLDFYAAQKKLSQVN 170
PRK14531 PRK14531
adenylate kinase; Provisional
 8-204 2.48e-47

adenylate kinase; Provisional


Pssm-ID: 172997 [Multi-domain]  Cd Length: 183  Bit Score: 154.20  E-value: 2.48e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     8 RMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPAckNG 87
Cdd:PRK14531   4 RLLFLGPPGAGKGTQAARLCAAHGLRHLSTGDLLRSEVAAGSALGQEAEAVMNRGELVSDALVLAIVESQLKALNS--GG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    88 FILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRlihpasgrsyhkifnppkedmkddvtgealvQR 167
Cdd:PRK14531  82 WLLDGFPRTVAQAEALEPLLEELKQPIEAVVLLELDDAVLIERLLAR-------------------------------GR 130

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 6320432   168 SDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDA 204
Cdd:PRK14531 131 ADDNEAVIRNRLEVYREKTAPLIDHYRQRGLLQSVEA 167
PRK14526 PRK14526
adenylate kinase; Provisional
 7-205 3.65e-46

adenylate kinase; Provisional


Pssm-ID: 172992 [Multi-domain]  Cd Length: 211  Bit Score: 151.93  E-value: 3.65e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     7 IRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELtNNPACKN 86
Cdd:PRK14526   1 MKLVFLGPPGSGKGTIAKILSNELNYYHISTGDLFRENILNSTPLGKEIKQIVENGQLVPDSITIKIVEDKI-NTIKNND 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    87 GFILDGFPRTIPQAEKLDQMLKEQgtpleKAIELKVDDELLVARITGRLIhpasGRSYHKIFN----PPKEDMKDDVTGE 162
Cdd:PRK14526  80 NFILDGFPRNINQAKALDKFLPNI-----KIINFLIDEELLIKRLSGRRI----CKSCNNIFNiytlPTKEKGICDVCKG 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 6320432   163 ALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDAS 205
Cdd:PRK14526 151 DLYQRKDDKEESLKTRLQEYKLQTKPLIEFYSKCNRLNNIDAS 193
PLN02842 PLN02842
nucleotide kinase
 13-215 6.17e-41

nucleotide kinase


Pssm-ID: 178435 [Multi-domain]  Cd Length: 505  Bit Score: 145.77  E-value: 6.17e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    13 GPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFILDG 92
Cdd:PLN02842   4 GAPASGKGTQCELIVHKFGLVHISTGDLLRAEVSAGTDIGKRAKEFMNSGRLVPDEIVIAMVTGRLSREDAKEKGWLLDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    93 FPRTIPQAEKLDQMlkeQGTPlEKAIELKVDDELLVARITGRLIHPASGRSYH-KIFNPPKEDMKddvtgEALVQRSDDN 171
Cdd:PLN02842  84 YPRSFAQAQSLEKL---KIRP-DIFILLDVPDEILIDRCVGRRLDPVTGKIYHiKNFPPESEEIK-----ARLITRPDDT 154

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 6320432   172 ADALKKRLAAYHAQTEPIVDFYkkTGIWAGVDASQPPATVWADI 215
Cdd:PLN02842 155 EEKVKARLQIYKKNAEAILSTY--SDIMVKIDGNRPKEVVFEEI 196
PLN02459 PLN02459
probable adenylate kinase
 6-197 1.12e-39

probable adenylate kinase


Pssm-ID: 215253 [Multi-domain]  Cd Length: 261  Bit Score: 136.90  E-value: 1.12e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     6 SIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPA-C 84
Cdd:PLN02459  29 NVNWVFLGCPGVGKGTYASRLSKLLGVPHIATGDLVREEIKSSGPLGAQLKEIVNQGKLVPDEIIFSLLSKRLEAGEEeG 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    85 KNGFILDGFPRTIPQAEKLDQMlkeqgTPLEKAIELKVDDELLVARITGRLI-----------------HPASGRSYHKI 147
Cdd:PLN02459 109 ESGFILDGFPRTVRQAEILEGV-----TDIDLVVNLKLREEVLVEKCLGRRIcsecgknfnvadidlkgEDGRPGIVMPP 183

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 6320432   148 FNPPKEDMkddvtgEALVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTG 197
Cdd:PLN02459 184 LLPPPECA------SKLITRADDTEEVVKARLRVYKEESQPVEDFYRKRG 227
PTZ00088 PTZ00088
adenylate kinase 1; Provisional
 1-198 4.49e-36

adenylate kinase 1; Provisional


Pssm-ID: 240262 [Multi-domain]  Cd Length: 229  Bit Score: 126.84  E-value: 4.49e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     1 MSSSESIRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTN 80
Cdd:PTZ00088   1 MKLKGPLKIVLFGAPGVGKGTFAEILSKKENLKHINMGNILREEIKAKTTIGKEIQKVVTSGNLVPDNLVIAIVKDEIAK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    81 NPACK-NGFILDGFPRTIPQAEKLDQMlkeqgTPLEKAIELKVDDELLVARITGRLIHPASGRsyhkIFN---------- 149
Cdd:PTZ00088  81 VTDDCfKGFILDGFPRNLKQCKELGKI-----TNIDLFVNIYLPRNILIKKLLGRRICNTCNR----NFNiahirsdpyd 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 6320432   150 -PPKEDMKDDVTGEA---LVQRSDDNADALKKRLAAYHAQTEPIVDFYKKTGI 198
Cdd:PTZ00088 152 mPPILPPADCEGCKGnpkLQKRSDDTEEIVAHRLNTYESTNSPIIQFFKNENC 204
aden_kin_iso1 TIGR01360
adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. ...
 11-221 7.11e-34

adenylate kinase, isozyme 1 subfamily; Members of this family are adenylate kinase, EC 2.7.4.3. This clade is found only in eukaryotes and includes human adenylate kinase isozyme 1 (myokinase). Within the adenylate kinase superfamily, this set appears specifically closely related to a subfamily of eukaryotic UMP-CMP kinases (TIGR01359), rather than to the large clade of bacterial, archaeal, and eukaryotic adenylate kinase family members in TIGR01351.


Pssm-ID: 130427 [Multi-domain]  Cd Length: 188  Bit Score: 119.92  E-value: 7.11e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     11 LIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNGFIL 90
Cdd:TIGR01360   8 IVGGPGSGKGTQCEKIVEKYGFTHLSTGDLLRAEVASGSERGKQLQAIMESGDLVPLDTVLDLLKDAMVAALGTSKGFLI 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     91 DGFPRTIPQAEKLDQMLKeqgtPLEKAIELKVDDELLVARITGRliHPASGrsyhkifnppkedmkddvtgealvqRSDD 170
Cdd:TIGR01360  88 DGYPREVKQGEEFERRIG----PPTLVLYFDCSEDTMVKRLLKR--AETSG-------------------------RVDD 136

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 6320432    171 NADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILNKLGK 221
Cdd:TIGR01360 137 NEKTIKKRLETYYKATEPVIAYYETKGKLRKINAEGTVDDVFLQVCTAIDK 187
PRK14529 PRK14529
adenylate kinase; Provisional
 7-183 1.01e-33

adenylate kinase; Provisional


Pssm-ID: 237746 [Multi-domain]  Cd Length: 223  Bit Score: 120.59  E-value: 1.01e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     7 IRMVLIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPacKN 86
Cdd:PRK14529   1 MNILIFGPNGSGKGTQGALVKKKYDLAHIESGAIFREHIGGGTELGKKAKEYIDRGDLVPDDITIPMILETLKQDG--KN 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    87 GFILDGFPRTIPQAEKLDQMLKEQGTPLEKAIELKVDDELLVARITGRLIHPASGRSYHKIFN---PPKEDmKDDVTGEA 163
Cdd:PRK14529  79 GWLLDGFPRNKVQAEKLWEALQKEGMKLDYVIEILLPREVAKNRIMGRRLCKNDNNHPNNIFIdaiKPDGD-VCRVCGGE 157

                        170       180
                 ....*....|....*....|.
gi 6320432   164 LVQRSDD-NADALKKRLAAYH 183
Cdd:PRK14529 158 LSTRADDqDEEAINKRHDIYY 178
UMP_CMP_kin_fam TIGR01359
UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of ...
 12-217 9.58e-31

UMP-CMP kinase family; This subfamily of the adenylate kinase superfamily contains examples of UMP-CMP kinase, as well as others proteins with unknown specificity, some currently designated adenylate kinase. All known members are eukaryotic.


Pssm-ID: 273576 [Multi-domain]  Cd Length: 185  Bit Score: 111.69  E-value: 9.58e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     12 IGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIA-KGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPACKNgFIL 90
Cdd:TIGR01359   5 LGGPGSGKGTQCAKIVENFGFTHLSAGDLLRAEIKrEGSENGSLIESYIKEGKIVPSEVTVELLKKAIQEDGSSKK-FLI 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     91 DGFPRTipqAEKLDQMLKEQGTPLE--KAIELKVDDELLVARITGRliHPASGrsyhkifnppkedmkddvtgealvqRS 168
Cdd:TIGR01359  84 DGFPRN---EENLEAWEKLMDNKVNfkFVLFFDCPEETMIKRLLKR--GQTSG-------------------------RV 133

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 6320432    169 DDNADALKKRLAAYHAQTEPIVDFYKKTGIWAGVDASQPPATVWADILN 217
Cdd:TIGR01359 134 DDNIETLKKRFRTYNEETLPIIEHFENKGKVKEINAEGSVEEVFEDVEK 182
AAA_17 pfam13207
AAA domain;
13-144 1.10e-24

AAA domain;


Pssm-ID: 463810 [Multi-domain]  Cd Length: 136  Bit Score: 94.23  E-value: 1.10e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     13 GPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTqlGLEAKKIMDQGGLVSDDIMVNMIKDELtNNPACKNGFILDG 92
Cdd:pfam13207   2 GVPGSGKTTQLKKLAEKLGFPHISAGDLLREEAKERG--LVEDRDEMRKLPLEPQKELQKLAAERI-AEEAGEGGVIVDG 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 6320432     93 FPRTIPQAEKLDQMLKEQGTPLE--KAIELKVDDELLVARitgRLIHPASGRSY 144
Cdd:pfam13207  79 HPRIKTPAGYLPGLPVEVLRELKpdAIILLEADPEEILER---RLKDRTRGRDD 129
PLN02200 PLN02200
adenylate kinase family protein
 11-197 4.45e-20

adenylate kinase family protein


Pssm-ID: 215125 [Multi-domain]  Cd Length: 234  Bit Score: 84.94  E-value: 4.45e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    11 LIGPPGAGKGTQAPNLQERFHAAHLATGDMLRSQIAKGTQLGLEAKKIMDQGGLVSDDIMVNMIKDELTNNPacKNGFIL 90
Cdd:PLN02200  48 VLGGPGSGKGTQCEKIVETFGFKHLSAGDLLRREIASNSEHGAMILNTIKEGKIVPSEVTVKLIQKEMESSD--NNKFLI 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432    91 DGFPRTipqaekldqmlKEQGTPLEKAIELKVDDELLvaritgrlihpasgrsyhkiFNPPKEDMKDDVTGEAlVQRSDD 170
Cdd:PLN02200 126 DGFPRT-----------EENRIAFERIIGAEPNVVLF--------------------FDCPEEEMVKRVLNRN-QGRVDD 173

                        170       180
                 ....*....|....*....|....*..
gi 6320432   171 NADALKKRLAAYHAQTEPIVDFYKKTG 197
Cdd:PLN02200 174 NIDTIKKRLKVFNALNLPVIDYYSKKG 200
ADK_lid pfam05191
Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular ...
 134-169 2.14e-16

Adenylate kinase, active site lid; Comparisons of adenylate kinases have revealed a particular divergence in the active site lid. In some organizms, particularly the Gram-positive bacteria, residues in the lid domain have been mutated to cysteines and these cysteine residues are responsible for the binding of a zinc ion. The bound zinc ion in the lid domain, is clearly structurally homologous to Zinc-finger domains. However, it is unclear whether the adenylate kinase lid is a novel zinc-finger DNA/RNA binding domain, or that the lid bound zinc serves a purely structural function.


Pssm-ID: 461578 [Multi-domain]  Cd Length: 36  Bit Score: 69.80  E-value: 2.14e-16
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 6320432    134 RLIHPASGRSYHKIFNPPKEDMKDDVTGEALVQRSD 169
Cdd:pfam05191   1 RRVCPKCGRIYHVYFNPPKVEGVCDVCGGELVQRDD 36
AAA_33 pfam13671
AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the ...
 10-134 3.57e-05

AAA domain; This family of domains contain only a P-loop motif, that is characteriztic of the AAA superfamily. Many of the proteins in this family are just short fragments so there is no Walker B motif.


Pssm-ID: 463952 [Multi-domain]  Cd Length: 143  Bit Score: 42.30  E-value: 3.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432     10 VLIGPPGAGKGTQAPNLQERFHAAHLATgDMLRSQIAkgtqlGLEAKKIMDQGGLVSD--DIMVNMIKDELTNnpacKNG 87
Cdd:pfam13671   3 LLVGLPGSGKSTLARRLLEELGAVRLSS-DDERKRLF-----GEGRPSISYYTDATDRtyERLHELARIALRA----GRP 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 6320432     88 FILDGFPRTIPQAEKLDQMLKEQGTPlEKAIELKVDDELLVARITGR 134
Cdd:pfam13671  73 VILDATNLRRDERARLLALAREYGVP-VRIVVFEAPEEVLRERLAAR 118
COG0645 COG0645
Predicted kinase, contains AAA domain [General function prediction only];
10-134 8.05e-04

Predicted kinase, contains AAA domain [General function prediction only];


Pssm-ID: 440410 [Multi-domain]  Cd Length: 164  Bit Score: 38.74  E-value: 8.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6320432   10 VLIGPPGAGKGTQAPNLQERFHAAHLATgDMLRSQIAkGTQLGLEAKKiMDQGGLVsDDIMVNMIKDELtnnpacKNGF- 88
Cdd:COG0645   3 LVCGLPGSGKSTLARALAERLGAVRLRS-DVVRKRLF-GAGLAPLERS-PEATART-YARLLALARELL------AAGRs 72

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 6320432   89 -ILD-GFPRTIpQAEKLDQMLKEQGTPLEkAIELKVDDELLVARITGR 134
Cdd:COG0645  73 vILDaTFLRRA-QREAFRALAEEAGAPFV-LIWLDAPEEVLRERLEAR 118
NK cd02019
Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of ...
 8-38 6.80e-03

Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates to nucleosides/nucleotides, nucleoside monophosphates, or sugars. Members of this family play a wide variety of essential roles in nucleotide metabolism, the biosynthesis of coenzymes and aromatic compounds, as well as the metabolism of sugar and sulfate.


Pssm-ID: 238977 [Multi-domain]  Cd Length: 69  Bit Score: 34.23  E-value: 6.80e-03
                        10        20        30
                ....*....|....*....|....*....|....
gi 6320432    8 RMVLIGPPGAGKGTQAPNLQERF---HAAHLATG 38
Cdd:cd02019   1 IIAITGGSGSGKSTVAKKLAEQLggrSVVVLDEI 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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