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Conserved domains on  [gi|6320413|ref|NP_010493|]
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DNA-binding transcriptional regulator UME6 [Saccharomyces cerevisiae S288C]

Protein Classification

Zn(II)2Cys6 transcription factor domain-containing protein( domain architecture ID 10637797)

Zn(II)2Cys6 transcription factor domain-containing protein belongs to a subclass of zinc finger proteins mainly found in fungi

Gene Ontology:  GO:0008270
PubMed:  9290251

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 765-801 4.13e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


:

Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 4.13e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6320413     765 TRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYS 37
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 765-801 4.13e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 4.13e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6320413     765 TRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYS 37
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 766-801 2.46e-13

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 64.61  E-value: 2.46e-13
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6320413  766 RSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
769-801 5.26e-10

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 55.00  E-value: 5.26e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6320413    769 TGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYS 33
 
Name Accession Description Interval E-value
GAL4 smart00066
GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive ...
 765-801 4.13e-14

GAL4-like Zn(II)2Cys6 (or C6 zinc) binuclear cluster DNA-binding domain; Gal4 is a positive regulator for the gene expression of the galactose- induced genes of S. cerevisiae. Is present only in fungi.


Pssm-ID: 214501 [Multi-domain]  Cd Length: 43  Bit Score: 67.00  E-value: 4.13e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 6320413     765 TRSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:smart00066   1 KRVSKACDRCRKRKIKCDGKKPPCSNCIKLGLECTYS 37
GAL4 cd00067
GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like ...
 766-801 2.46e-13

GAL4-like Zn2Cys6 binuclear cluster DNA-binding domain; found in transcription regulators like GAL4. Domain consists of two helices organized around a Zn(2)Cys(6 )motif; Binds to sequences containing 2 DNA half sites comprised of 3-5 C/G combinations


Pssm-ID: 238023 [Multi-domain]  Cd Length: 36  Bit Score: 64.61  E-value: 2.46e-13
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 6320413  766 RSRTGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:cd00067   1 RVRRACDRCRRRKIKCDGEKPPCSNCIKLGLECTYS 36
Zn_clus pfam00172
Fungal Zn(2)-Cys(6) binuclear cluster domain;
769-801 5.26e-10

Fungal Zn(2)-Cys(6) binuclear cluster domain;


Pssm-ID: 395120 [Multi-domain]  Cd Length: 39  Bit Score: 55.00  E-value: 5.26e-10
                          10        20        30
                  ....*....|....*....|....*....|...
gi 6320413    769 TGCWICRLRKKKCTEERPHCFNCERLKLDCHYD 801
Cdd:pfam00172   1 TACDNCRKRKVKCDGKKPACSRCIKNGLECTYS 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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