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Conserved domains on  [gi|6319938|ref|NP_010019|]
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Oca4p [Saccharomyces cerevisiae S288C]

Protein Classification

protein-tyrosine phosphatase family protein; phosphatase PAP2/dual specificity phosphatase family protein( domain architecture ID 13026120)

cys-based protein-tyrosine phosphatase (PTP) family protein may be a PTP or a dual-specificity phosphatase (DUSP or DSP), and may catalyze the dephosphorylation of target phosphoproteins at tyrosine or tyrosine and serine/threonine residues, respectively| bifunctional phosphatase PAP2/dual specificity phosphatase (DSP) family protein containing a C-terminal DSP domain that may dephosphorylate phosphotyrosine, phosphoserine, and phosphothreonine residues in target proteins, and an N-terminal phosphatase PAP2 domain that may be a histidine phosphatase that catalyzes the dephosphorylation of phospholipids

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PFA-DSP_Oca4 cd17662
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; ...
 2-198 4.91e-88

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; Oxidant-induced cell-cycle arrest protein 4 (Oca4) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca4 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


:

Pssm-ID: 350500 [Multi-domain]  Cd Length: 177  Bit Score: 262.90  E-value: 4.91e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    2 LVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVPVKSSSVS 81
Cdd:cd17662   1 LVPPANFGIVEPGIYRCSKLSTLNFSFLETLNLKTIVFVGGQEPSKFFKEFFERNNIELIVLRDADFSNHHHPGKNSSSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   82 NanlysnnnstlslqeekkkstangSQNSTTGDPVIQEELAYHLTDNDDLMLIKSTCLKRTFKTLLNVDNYNVLLVDKTA 161
Cdd:cd17662  81 K------------------------LQGNTDVNDLEPINTNYHLWKNDLDMLIKSTLLQRIFEKNLPVLNHNKLLVDKTS 136

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6319938  162 LVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFL 198
Cdd:cd17662 137 TVIGCLRRIQKWNFSSIINEYRRFAGKSSNYFAETFL 173
 
Name Accession Description Interval E-value
PFA-DSP_Oca4 cd17662
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; ...
 2-198 4.91e-88

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; Oxidant-induced cell-cycle arrest protein 4 (Oca4) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca4 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350500 [Multi-domain]  Cd Length: 177  Bit Score: 262.90  E-value: 4.91e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    2 LVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVPVKSSSVS 81
Cdd:cd17662   1 LVPPANFGIVEPGIYRCSKLSTLNFSFLETLNLKTIVFVGGQEPSKFFKEFFERNNIELIVLRDADFSNHHHPGKNSSSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   82 NanlysnnnstlslqeekkkstangSQNSTTGDPVIQEELAYHLTDNDDLMLIKSTCLKRTFKTLLNVDNYNVLLVDKTA 161
Cdd:cd17662  81 K------------------------LQGNTDVNDLEPINTNYHLWKNDLDMLIKSTLLQRIFEKNLPVLNHNKLLVDKTS 136

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6319938  162 LVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFL 198
Cdd:cd17662 137 TVIGCLRRIQKWNFSSIINEYRRFAGKSSNYFAETFL 173
Y_phosphatase2 pfam03162
Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 ...
 62-198 6.77e-50

Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 families.


Pssm-ID: 397328 [Multi-domain]  Cd Length: 150  Bit Score: 164.08  E-value: 6.77e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938     62 VLRMSDFSAAAVPVKSSSVSNANLYSNNNsTLSLQEEKKKSTANGSQNSTTG-DPVIQEELAYHLTDNDD-LMLIKSTCL 139
Cdd:pfam03162   1 LVPPLNFSPVEPGLYRSSYPRANNFSFLR-SLRLKTIISLSPEPYPQDNLQFlESEHIKLYHIHMEGNKDpFVNIPSHLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319938    140 KRTFKTLLNVDNYNVLLVD-----KTALVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFL 198
Cdd:pfam03162  80 RRALKLLLNKDNYPVLIHCnrgkhRTGLVIGCLRKLQKWSLASILNEYRRFSGSKARIVDEEFI 143
 
Name Accession Description Interval E-value
PFA-DSP_Oca4 cd17662
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; ...
 2-198 4.91e-88

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 4; Oxidant-induced cell-cycle arrest protein 4 (Oca4) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca4 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350500 [Multi-domain]  Cd Length: 177  Bit Score: 262.90  E-value: 4.91e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    2 LVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVPVKSSSVS 81
Cdd:cd17662   1 LVPPANFGIVEPGIYRCSKLSTLNFSFLETLNLKTIVFVGGQEPSKFFKEFFERNNIELIVLRDADFSNHHHPGKNSSSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   82 NanlysnnnstlslqeekkkstangSQNSTTGDPVIQEELAYHLTDNDDLMLIKSTCLKRTFKTLLNVDNYNVLLVDKTA 161
Cdd:cd17662  81 K------------------------LQGNTDVNDLEPINTNYHLWKNDLDMLIKSTLLQRIFEKNLPVLNHNKLLVDKTS 136

                       170       180       190
                ....*....|....*....|....*....|....*..
gi 6319938  162 LVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFL 198
Cdd:cd17662 137 TVIGCLRRIQKWNFSSIINEYRRFAGKSSNYFAETFL 173
PFA-DSP cd14501
plant and fungi atypical dual-specificity phosphatase; Plant and fungi atypical ...
 3-198 1.14e-50

plant and fungi atypical dual-specificity phosphatase; Plant and fungi atypical dual-specificity phosphatases (PFA-DSPs) are a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds. They share structural similarity with atypical- and lipid phosphatase DSPs from mammals. The PFA-DSP group is composed of active as well as inactive phosphatases. The best characterized member is Saccharomyces Siw14, also known as Oca3, which plays a role in actin filament organization and endocytosis. Siw14 has been shown to be an inositol pyrophosphate phosphatase, hydrolyzing the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5or IP7).


Pssm-ID: 350351 [Multi-domain]  Cd Length: 149  Bit Score: 166.32  E-value: 1.14e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    3 VPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAavpvksssvsn 82
Cdd:cd14501   1 VPPLNFSIVEPGLYRSAYPTPANFPFLKTLGLKTIILLSPEPPPKPVLSFLTENGIKLIHLGMLSSKRA----------- 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   83 anlysnnnstlslqeekkkstangsqnsttgDPVIQEELAYHLTDNDDLMLIKSTCLkrtfkTLLNVDNYnvlLVDKTAL 162
Cdd:cd14501  70 -------------------------------DSVPWDPLAYELVKRALEILLDKTNY-----PVLVHCSL---GEHRTGV 110

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 6319938  163 VIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFL 198
Cdd:cd14501 111 VVGCLRKLQGWSLASILDEYRLFAGSKERYVDEQFI 146
Y_phosphatase2 pfam03162
Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 ...
 62-198 6.77e-50

Tyrosine phosphatase family; This family is closely related to the pfam00102 and pfam00782 families.


Pssm-ID: 397328 [Multi-domain]  Cd Length: 150  Bit Score: 164.08  E-value: 6.77e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938     62 VLRMSDFSAAAVPVKSSSVSNANLYSNNNsTLSLQEEKKKSTANGSQNSTTG-DPVIQEELAYHLTDNDD-LMLIKSTCL 139
Cdd:pfam03162   1 LVPPLNFSPVEPGLYRSSYPRANNFSFLR-SLRLKTIISLSPEPYPQDNLQFlESEHIKLYHIHMEGNKDpFVNIPSHLL 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6319938    140 KRTFKTLLNVDNYNVLLVD-----KTALVIGILRKIQKWNIASIINEYRLFSGKNRNYFAETFL 198
Cdd:pfam03162  80 RRALKLLLNKDNYPVLIHCnrgkhRTGLVIGCLRKLQKWSLASILNEYRRFSGSKARIVDEEFI 143
PFA-DSP_Oca1 cd14531
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 1; ...
 1-187 5.32e-25

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 1; Oxidant-induced cell-cycle arrest protein 1 (Oca1) is an atypical dual specificity phosphatase whose gene is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide. It may function in linking growth, stress responses, and the cell cycle. Oca1 belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs).


Pssm-ID: 350379 [Multi-domain]  Cd Length: 149  Bit Score: 98.91  E-value: 5.32e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    1 MLVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDfsaaavpvksssv 80
Cdd:cd14531   1 SFIPPLNFGMVEEDLYRSGQPTPINFPFLERLKLKTIIYLAPDEPSDQFLEFCEDQNINLVHLGGDD------------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   81 snanlySNNNSTLSLQEEkkkstangsqnsttgdpVIQEELayhltdnddlmlikstclkrtfKTLLNVDNYNVLLV--- 157
Cdd:cd14531  68 ------STESRQNPLSEE-----------------LVLAAL----------------------HIILDPDNYPLLVMcnl 102

                       170       180       190
                ....*....|....*....|....*....|..
gi 6319938  158 --DKTALVIGILRKIQKWNIASIINEYRLFSG 187
Cdd:cd14531 103 grHRTGTVVGCLRKLQRWNLSSIFEEYRRFAG 134
PFA-DSP_Oca2 cd17661
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 2; ...
 3-197 2.35e-12

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 2; Oxidant-induced cell-cycle arrest protein 2 (Oca2) is an atypical dual specificity phosphatase of unknown function. It has been identified as a putative negative regulator acting on cell wall integrity and mating MAPK pathways in yeast. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca2 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350499 [Multi-domain]  Cd Length: 146  Bit Score: 63.96  E-value: 2.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    3 VPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGqepskffKDFFTRSSIKWivlrmsdfsaaavpVKSSSVSN 82
Cdd:cd17661   1 VPPLNFSLVADGIYRSGHPMPINYPFLKQLNLKTIIYLGD-------KDPYRQDYLDF--------------LQSQGIEL 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   83 ANLYSNNNSTLSLQEekkkstangsqnsttGDPVIQEELayhltdnddlmlikstclkrtfKTLLNVDNYNVLLVD---- 158
Cdd:cd17661  60 YYFDFSSSSEPFTEE---------------DQERMEQAL----------------------KLLLDKRNYPILVHSnkgk 102

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 6319938  159 -KTALVIGILRKI-QKWNIASIINEYRLFSGKNRNY---FAETF 197
Cdd:cd17661 103 hRVGVLVGIMRKLlQGWCLAGIFDEYGRFAGGKGETdleFIETF 146
PFA-DSP_Siw14 cd14528
atypical dual specificity phosphatases similar to yeast Siw14; This subfamily contains ...
 1-187 7.52e-12

atypical dual specificity phosphatases similar to yeast Siw14; This subfamily contains Saccharomyces Siw14 and a novel phosphatase from the Arabidopsis thaliana gene locus At1g05000. Siw14, also known as Oca3, plays a role in actin filament organization and endocytosis. Siw14 has been shown to be an inositol pyrophosphate phosphatase, hydrolyzing the beta-phosphate from 5-diphosphoinositol pentakisphosphate (5PP-IP5or IP7). The At1g05000 protein, also called AtPFA-DSP1, has been shown to have highest activity toward olyphosphate (poly-P(12-13)) and deoxyribo- and ribonucleoside triphosphates, and less activity toward phosphoenolpyruvate, phosphotyrosine, phosphotyrosine-containing peptides, and phosphatidylinositols. This subfamily belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs).


Pssm-ID: 350377 [Multi-domain]  Cd Length: 148  Bit Score: 62.35  E-value: 7.52e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    1 MLVPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMsdfsaaavpvksssv 80
Cdd:cd14528   1 LLIPPLNFSMVDKGVYRSGYPNKKNFPFLRTLGLRSILYLCPEDYPESNLEFLKENGIKLFQFGI--------------- 65

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   81 snanlysnnnstlslqEEKKkstangsqnsttgDPVIQeelayhltdnddlmlIKSTCLKRTFKTLLNVDNYNVLL---- 156
Cdd:cd14528  66 ----------------EGNK-------------EPFVD---------------IPEELIRDALKVLLDPRNHPVLIhcnk 101

                       170       180       190
                ....*....|....*....|....*....|..
gi 6319938  157 -VDKTALVIGILRKIQKWNIASIINEYRLFSG 187
Cdd:cd14528 102 gKHRTGCLVGCLRKLQNWSLTSIFDEYRRFAG 133
PFA-DSP_Oca6 cd17663
atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; ...
 3-197 8.07e-11

atypical dual specificity phosphatases similar to oxidant-induced cell-cycle arrest protein 6; Oxidant-induced cell-cycle arrest protein 6 (Oca6) is an atypical dual specificity phosphatase of unknown function. It belongs to a group of atypical DSPs present in plants, fungi, kinetoplastids, and slime molds called plant and fungi atypical dual-specificity phosphatases (PFA-DSPs). Oca6 may be an inactive DSP-like protein as it lacks the CxxxxxR catalytic motif.


Pssm-ID: 350501 [Multi-domain]  Cd Length: 162  Bit Score: 60.01  E-value: 8.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    3 VPPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSDFSAAAVPVKSSSVSN 82
Cdd:cd17663   1 IPPFRFATVEPGLYRGAYPRLKNFRFLRRLKLKTIVSLTPEPPTEDLANFCEAENITLIHISAEKFKKGKVPLSYSTVIQ 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   83 AnlysnnnstLSLQEEKKKStangsqnsttgdPViqeelaY-HltdnddlmlikstCLkrtfktllnvDNYNVllvdkTA 161
Cdd:cd17663  81 I---------LQLLIDKDNL------------PV------YiH-------------CL----------DGRHV-----TG 105

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 6319938  162 LVIGILRKIQKWNIASIINEYRLFSG---KNRNYFAETF 197
Cdd:cd17663 106 LVVACLRKLQFWSSIAIFAEFLRFARtisSEERAFIENF 144
PFA-DSP_unk cd18538
unknown subfamily of atypical dual-specificity phosphatases from fungi; This uncharacterized ...
 4-190 4.53e-10

unknown subfamily of atypical dual-specificity phosphatases from fungi; This uncharacterized subfamily belongs to the plant and fungi atypical dual-specificity phosphatases (PFA-DSPs) group of atypical DSPs that present in plants, fungi, kinetoplastids, and slime molds. They share structural similarity with atypical- and lipid phosphatase DSPs from mammals. The PFA-DSP group is composed of active as well as inactive phosphatases. This unknown subgroup contains the conserved the CxxxxxR catalytic motif present in active cysteine phosphatases.


Pssm-ID: 350514 [Multi-domain]  Cd Length: 145  Bit Score: 57.38  E-value: 4.53e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938    4 PPANFGIAEEGIYRCSKVETLNLSFLETLNLKTAIFIGGQEPSKFFKDFFTRSSIKWIVLRMSdfsaaavpvksssvsna 83
Cdd:cd18538   2 LPPNFGVVVPGVYRSSFPKPENFGFLKSLGLRTILTLVQEEYSPEFLNFLRENGIQHFHIAML----------------- 64

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6319938   84 nlysnnnstlslqeekkkstanGSQNSTTGDPviqeelayhltdnDDLMlikstclKRTFKTLLNVDNYNVLL-----VD 158
Cdd:cd18538  65 ----------------------GNKDPKVSIP-------------DHTM-------NRILRIILDKENHPILVhcnkgKH 102

                       170       180       190
                ....*....|....*....|....*....|...
gi 6319938  159 KTALVIGILRKIQKWNIASIINEYRLFSG-KNR 190
Cdd:cd18538 103 RTGCVIACFRKLQGWDVENVLEEYLSYAHpKSR 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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