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Conserved domains on  [gi|398364587|ref|NP_009621|]
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Ecm2p [Saccharomyces cerevisiae S288C]

Protein Classification

pre-mRNA-splicing factor SLT11( domain architecture ID 10188138)

pre-mRNA-splicing factor SLT11 is a splicing factor required for spliceosome assembly in yeast

Gene Ontology:  GO:0003723
PubMed:  18515081|22278943|22516180

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RRM_SLT11 cd12265
RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; This ...
 201-295 1.31e-33

RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; This subfamily corresponds to the RRM of SLT11, also known as extracellular mutant protein 2, or synthetic lethality with U2 protein 11, and is a splicing factor required for spliceosome assembly in yeast. It contains a conserved RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). SLT11 can facilitate the cooperative formation of U2/U6 helix II in association with stem II in the yeast spliceosome by utilizing its RNA-annealing and -binding activities.


:

Pssm-ID: 409709 [Multi-domain]  Cd Length: 86  Bit Score: 119.81  E-value: 1.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364587 201 STKSFFLYNIDASIPEWKITDTVSQllgikkwkDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVtPKGLKRGV 280
Cdd:cd12265    1 SIKSFFLFGIDDDLPEWKISDYFEQ--------FGKLKSLVVSHRAKCGFVRFETRELAEAFAAAISENGL-NAGLSRGG 71

                         90
                 ....*....|....*
gi 398364587 281 LLIDRFRIFIIPWSS 295
Cdd:cd12265   72 LLVIEGRPLRVAWGK 86
 
Name Accession Description Interval E-value
RRM_SLT11 cd12265
RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; This ...
 201-295 1.31e-33

RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; This subfamily corresponds to the RRM of SLT11, also known as extracellular mutant protein 2, or synthetic lethality with U2 protein 11, and is a splicing factor required for spliceosome assembly in yeast. It contains a conserved RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). SLT11 can facilitate the cooperative formation of U2/U6 helix II in association with stem II in the yeast spliceosome by utilizing its RNA-annealing and -binding activities.


Pssm-ID: 409709 [Multi-domain]  Cd Length: 86  Bit Score: 119.81  E-value: 1.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364587 201 STKSFFLYNIDASIPEWKITDTVSQllgikkwkDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVtPKGLKRGV 280
Cdd:cd12265    1 SIKSFFLFGIDDDLPEWKISDYFEQ--------FGKLKSLVVSHRAKCGFVRFETRELAEAFAAAISENGL-NAGLSRGG 71

                         90
                 ....*....|....*
gi 398364587 281 LLIDRFRIFIIPWSS 295
Cdd:cd12265   72 LLVIEGRPLRVAWGK 86
 
Name Accession Description Interval E-value
RRM_SLT11 cd12265
RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; This ...
 201-295 1.31e-33

RNA recognition motif (RRM) found in pre-mRNA-splicing factor SLT11 and similar proteins; This subfamily corresponds to the RRM of SLT11, also known as extracellular mutant protein 2, or synthetic lethality with U2 protein 11, and is a splicing factor required for spliceosome assembly in yeast. It contains a conserved RNA recognition motif (RRM), also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain). SLT11 can facilitate the cooperative formation of U2/U6 helix II in association with stem II in the yeast spliceosome by utilizing its RNA-annealing and -binding activities.


Pssm-ID: 409709 [Multi-domain]  Cd Length: 86  Bit Score: 119.81  E-value: 1.31e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 398364587 201 STKSFFLYNIDASIPEWKITDTVSQllgikkwkDGNSLSLIVNHKAKCGGLRFQSSELGERFVSKISETLVtPKGLKRGV 280
Cdd:cd12265    1 SIKSFFLFGIDDDLPEWKISDYFEQ--------FGKLKSLVVSHRAKCGFVRFETRELAEAFAAAISENGL-NAGLSRGG 71

                         90
                 ....*....|....*
gi 398364587 281 LLIDRFRIFIIPWSS 295
Cdd:cd12265   72 LLVIEGRPLRVAWGK 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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