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Conserved domains on  [gi|5729740|ref|NP_006529|]
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bcl-2-like protein 11 isoform 6 [Homo sapiens]

Protein Classification

Bim_N and Bclx_interact domain-containing protein( domain architecture ID 10536032)

Bim_N and Bclx_interact domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 1.08e-14

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


:

Pssm-ID: 429111  Cd Length: 40  Bit Score: 63.57  E-value: 1.08e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 5729740      4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact super family cl07517
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 76-106 3.38e-07

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


The actual alignment was detected with superfamily member pfam08945:

Pssm-ID: 462643  Cd Length: 38  Bit Score: 44.10  E-value: 3.38e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 5729740     76 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 106
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 1.08e-14

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


Pssm-ID: 429111  Cd Length: 40  Bit Score: 63.57  E-value: 1.08e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 5729740      4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 76-106 3.38e-07

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


Pssm-ID: 462643  Cd Length: 38  Bit Score: 44.10  E-value: 3.38e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 5729740     76 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 106
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Name Accession Description Interval E-value
Bim_N pfam06773
Bim protein N-terminus; This family represents the N-terminal region of several mammal ...
 4-40 1.08e-14

Bim protein N-terminus; This family represents the N-terminal region of several mammal specific Bim proteins. The Bim protein is one of the BH3-only proteins, members of the Bcl-2 family that have only one of the Bcl-2 homology regions, BH3. BH3-only proteins are essential initiators of apoptotic cell death.


Pssm-ID: 429111  Cd Length: 40  Bit Score: 63.57  E-value: 1.08e-14
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 5729740      4 QPSDVSSECDREGRQLQPAERPPQ---LRPGAPTSLQTEP 40
Cdd:pfam06773   1 QPSDLSSECDREGGQLQPTERPHQhrpLRPGAPTSLQTPF 40
Bclx_interact pfam08945
Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction ...
 76-106 3.38e-07

Bcl-x interacting, BH3 domain; This domain is a long alpha helix, required for interaction with Bcl-x. It is found in BAM, Bim and Bcl2-like protein 11. This domain is also known as the BH3 domain between residues 146 and 161.


Pssm-ID: 462643  Cd Length: 38  Bit Score: 44.10  E-value: 3.38e-07
                          10        20        30
                  ....*....|....*....|....*....|.
gi 5729740     76 QAEPADMRPEIWIAQELRRIGDEFNAYYARR 106
Cdd:pfam08945   6 ASPPEDRPPEIWIAQELRRIGDEFNSSYNPR 36
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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