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Conserved domains on  [gi|192448440|ref|NP_006447|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 66-374 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467700  Cd Length: 308  Bit Score: 622.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  66 CRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFaPPRDTP 145
Cdd:cd23972    1 CPHSLHLRIQRDPHFRGLFNFDIPVLLWGQHFTPALWDRLSQRKVPYGWKGLSHQVVASTLSLLNDSANAKLF-FPRDTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 146 PKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDL 225
Cdd:cd23972   80 GKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLGFTRTPQGQDL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 226 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPST 305
Cdd:cd23972  160 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHKYFGPEASAKKFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPST 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 192448440 306 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR 374
Cdd:cd23972  240 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQLYQR 308
 
Name Accession Description Interval E-value
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 66-374 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 622.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  66 CRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFaPPRDTP 145
Cdd:cd23972    1 CPHSLHLRIQRDPHFRGLFNFDIPVLLWGQHFTPALWDRLSQRKVPYGWKGLSHQVVASTLSLLNDSANAKLF-FPRDTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 146 PKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDL 225
Cdd:cd23972   80 GKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLGFTRTPQGQDL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 226 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPST 305
Cdd:cd23972  160 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHKYFGPEASAKKFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPST 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 192448440 306 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR 374
Cdd:cd23972  240 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQLYQR 308
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-368 3.47e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 264.08  E-value: 3.47e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  109 KAPYGWRGLSHQVIASTLSLLngsesaklFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFER 188
Cdd:pfam00777  12 WIRYSEWWLPFTVTEELLELL--------PKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  189 DVGTKTSFYGFTVNTMKNSLVSYWNlgfTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPeAS 268
Cdd:pfam00777  84 DVGSKTTLRTMNPESAIDSKYGNLG---FSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIP-VD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  269 ASKFKLLHPDFISYLTERFLKSKLINThfgdlYMPSTGALMLLTALHTCDQVSAYGFIT-SNYWKFSDHYFE-RKMKPLI 346
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLKG-----RRPSTGLLMLSLALHLCDEVSLYGFGPfLDSRGNSHHYYDnVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 192448440  347 FYANHDLSLEAALWRDLHKAGI 368
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 66-374 0e+00

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 622.61  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  66 CRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFaPPRDTP 145
Cdd:cd23972    1 CPHSLHLRIQRDPHFRGLFNFDIPVLLWGQHFTPALWDRLSQRKVPYGWKGLSHQVVASTLSLLNDSANAKLF-FPRDTP 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 146 PKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDL 225
Cdd:cd23972   80 GKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLGFTRTPQGQDL 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 226 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPST 305
Cdd:cd23972  160 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHKYFGPEASAKKFKLLHPDFISYLTDRFLKSKLLNTHYGHLYMPST 239

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 192448440 306 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR 374
Cdd:cd23972  240 GALMLLTALHTCDQVSAYGFITSNYWKFSDHYYERKKKPLVFYANHDMLLEAALWRRLHKAGILQLYQR 308
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 66-373 1.36e-151

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 428.99  E-value: 1.36e-151
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  66 CRHLLHLAIQRHPHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFaPPRDTP 145
Cdd:cd23964    1 CPSSLRKKLQKSPWFRERFIPDIKVLLDSEDFNPEEYNRLSHYKLPFGWGGLNREVVERLLRNLNLTSSRYMF-VLRGGR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 146 PKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVsywnlgfTSVPQGQDL 225
Cdd:cd23964   80 PRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLL-------KHVPQDKDT 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 226 QYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKlinthfgDLYMPST 305
Cdd:cd23964  153 KYLFIPFKIRDYDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNATNVRLLHPDFIRYLFNRWLNSS-------TSYRPTT 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 192448440 306 GALMLLTALHTCDQVSAYGFITSnyWKFSDHYFERKMKPLI-FYANHDLSLEAALWRDLHKAGILQLYQ 373
Cdd:cd23964  226 GALMLLTALHTCDQVSVYGFGYD--PRFSLHYYDKTFVKFTvFYANHDFTNERKLWRKLHEEGIINLYR 292
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 80-373 1.11e-134

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 386.80  E-value: 1.11e-134
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  80 FRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPK--CIRCAVVGNG 157
Cdd:cd23974   14 FSGKFLENIPVLQWAKHATLSEYQRLKRYAGAHGWQEVDWDVLKDALNLLNSSANGQMFDWWDRPNGRspCIRCAVVGNG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 158 GILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDY 237
Cdd:cd23974   94 GILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAYAGVGFNGPPQSKETRYIFLPDHDRDY 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 238 VMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTC 317
Cdd:cd23974  174 LLVKAALTHTPIDRGRDKSKRPSKYFGKDVTAEKFKIYHPDFIRYLRNRFLWSPILNTKQRDIYRPSTGAVMLLAALHTC 253

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 192448440 318 DQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQ 373
Cdd:cd23974  254 DQVSAYGFMTPDYGKYSDHYYDKTYHKVVFYANHDLRLEMQLWQKLHKAGLIKLYM 309
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 78-374 1.78e-117

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 343.27  E-value: 1.78e-117
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  78 PHFRGLFNLSIPVLLWGDLFTPALWDRLSQHKAPYGWRGLSHQVIASTLSLLNGSESAKLFAPPRDTPPKCIRCAVVGNG 157
Cdd:cd23973   13 DWFKKLFLPNITLFLDKDHFNMSEWDRLEHFNPPFGFMGLNYTLVKEVVELIPKPKEQQLLALSPPGGDGCIRCAVVGNG 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 158 GILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNLGFTSVPQGQDLQYIFIPSDIRDY 237
Cdd:cd23973   93 GILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRGFKNIPQDKDIKYILFPEGPRDY 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 238 VMLRSAILGVPVPEGLDKGDRPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPSTGALMLLTALHTC 317
Cdd:cd23973  173 QWLEALLKNKTIPSGAYYGRRPRSYFSGDFTEDKYLVLHPDFLRYVKNRFLRSKTLKGKYWAIYRPTTGAFLLLTALHLC 252

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 192448440 318 DQVSAYGFITSNYWKFSDHYFERKMKPLIFYANHDLSLEAALWRDLHKAGILQLYQR 374
Cdd:cd23973  253 DTVSAYGFITEDYRKYPDHYYDKKKTKLVFYINHDFRLEKKLWKRLHDEKIIKLYQR 309
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 109-368 3.47e-87

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 264.08  E-value: 3.47e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  109 KAPYGWRGLSHQVIASTLSLLngsesaklFAPPRDTPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFER 188
Cdd:pfam00777  12 WIRYSEWWLPFTVTEELLELL--------PKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEK 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  189 DVGTKTSFYGFTVNTMKNSLVSYWNlgfTSVPQGQDLQYIFIPSDIRDYVMLRSAILGVPVPEGLDKGDRPHAYFGPeAS 268
Cdd:pfam00777  84 DVGSKTTLRTMNPESAIDSKYGNLG---FSHPRDPFVEFVLVPFKGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIP-VD 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  269 ASKFKLLHPDFISYLTERFLKSKLINThfgdlYMPSTGALMLLTALHTCDQVSAYGFIT-SNYWKFSDHYFE-RKMKPLI 346
Cdd:pfam00777 160 PDKVLFLHPDFLRYVANFWLRSHGLKG-----RRPSTGLLMLSLALHLCDEVSLYGFGPfLDSRGNSHHYYDnVLMKKGG 234

                         250       260
                  ....*....|....*....|..
gi 192448440  347 FYANHDLSLEAALWRDLHKAGI 368
Cdd:pfam00777 235 FYGVHDMPFEFKLLQKLHKEGV 256
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 151-363 8.64e-51

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 168.31  E-value: 8.64e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 151 CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYWNlGFTSVPQGQDLQYIFI 230
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRC-GCHPLPLEEEVVLILS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 231 PSDIRDYVMLRSAilgvpvpegldKGDRPHAyfgpeasasKFKLLH--PDFISYLTERFLKSKLINthFGDLYMPSTGAL 308
Cdd:cd19952   80 RAAAADFKRLKRR-----------KKRHDNA---------VLLLTDpaPDLLSYVRKRLEKLGLKS--FFGGNAPSSGLL 137

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 192448440 309 MLLTALHTCDQVSAYGFITS--NYWKFSDHYFERKMKPLiFYANHDLSLEAALWRDL 363
Cdd:cd19952  138 AVLLALQLCDSVDLYGFGVDsgHAPKVPYHYYDLVEAEE-GTAVHSFDLEAELLRAL 193
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 80-373 1.35e-39

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 141.65  E-value: 1.35e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440  80 FRGLFNLSIPVLLWG---DLFTPAL--WDRLSQHKApygwrglshqviastlSLLNGSEsAKLFA--PPRD-----TPPK 147
Cdd:cd23966   14 FDERFNPSIEPLLTRknkELPPDVLkwWLSLQSSKN----------------SDLREVL-EKLFQvvPGENpyrtrDPNR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTsfygftvnTMK----NSLVSYWNlgftsvpqgq 223
Cdd:cd23966   77 CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKT--------THHfmypESAVDLDP---------- 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 224 DLQYIFIPSDIRDYVMLRSAILG-------VPVPEGLDkgdrphayfgpeASASKFKLLHPDFISYLTERFLKsklintH 296
Cdd:cd23966  139 GVHLVLVPFKVLDLQWLISALTTgeitrtyTPVKRFIK------------ADKDKVLVINPAFIKYVHDNWTE------H 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 297 FGDlYmPSTGALMLLTALHTCDQVSAYGFITSNY--WkfsDHYFERKMKPLIFYAN--HDLSLEAALWRDLHKAGILQLY 372
Cdd:cd23966  201 HGR-Y-PSTGFLALIFALHICDEVSVFGFGADSKgnW---HHYWEKNRSAGAFRKTgvHDADFESDIIKKLAKEGKIRVY 275


                 .
gi 192448440 373 Q 373
Cdd:cd23966  276 R 276
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 150-371 2.25e-32

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 122.37  E-value: 2.25e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 150 RCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFygFTVNtmkNSLVSYWNLGFTSVPQ----GQDL 225
Cdd:cd23963   65 TCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNL--TTLN---PSILKRRYNSLKKNRDrdkfLNRL 139

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 226 Q-----YIFIP--SDIRDYVMLRSAILGVpvpegLDKGDRPHAYFGpeasaskfkllHPDFISyLTERFLKSKLINTHfg 298
Cdd:cd23963  140 KeyngsILWYPkfSFKSSTNLLLKAARAL-----KKNGLNLTVVYS-----------NPEHFL-AVQKFWKRRGLEKR-- 200

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 299 dlymPSTGALMLLTALHTCDQVSAYGFitsnyWKFS-D--------HYFErKMKPLIFYANHDLSLEAALWRDLHKAGIL 369
Cdd:cd23963  201 ----PSTGLYLVSLALTFCDEIHLYGF-----WPFPtDpngrpvpyHYYD-DLSPSTKNKVHNMPEEFKLLRELHKKGVL 270


                 ..
gi 192448440 370 QL 371
Cdd:cd23963  271 KL 272
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 147-363 1.70e-30

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 115.47  E-value: 1.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 147 KCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYwnlgftsvpqGQDLQ 226
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEY----------DSDWL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 227 YIFIPSDIRDYVMLRSAILGVP----------VPEGLDKgdrphayfgpeaSASKFKLLHPDFISylTERFLKSKLINTH 296
Cdd:cd23967   71 LVLVPFKSMDLLWLQAVIKGKKpngkggfwkkIATSVPK------------PPKKIRILNPYILQ--EAAFDLIGLPMNG 136

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 192448440 297 FGDLYMPSTGALMLLTALHTCDQVSAYGF-ITSNYWKFSDHYFE-RKMKPLIFYANHDLSLEAALWRDL 363
Cdd:cd23967  137 KQGKNVPTTGIIAIVMALHYCDEVDIAGFgYDPSDPNAPLHYYDsLTMKAIKRSWTHNVTKEKKYLKKL 205
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 150-364 4.95e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 99.65  E-value: 4.95e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 150 RCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTS-------------FYGFTVNTMKNSLVSYWNLGF 216
Cdd:cd23968   47 TCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTlrlinsqilskpeFNFLTDPLYRNVTLLVWDPSS 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 217 TSVPQGQDLQ---YIFIPSDIRdYVMLRsailgvpvPEgldkgdrphayfgpeasaSKFKLLHPDFISYLTE---RFLKS 290
Cdd:cd23968  127 YNVNLEKWYKkpdFDFFPNYIK-YRRRH--------PE------------------EPFYLIDPRFLWRLWDilqEYTPE 179

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 192448440 291 KLINThfgdlyMPSTGALMLLTALHTCDQVSAYGFITSNywKFSD--HYFERKMKPL-IFYANHDLSLEAALWRDLH 364
Cdd:cd23968  180 KIKPN------PPSSGFIGIVLMLHLCDWVDVYEYVPSV--RQTDrcHYYDVEKDLAcTLGAWHPLAAEKLLVRHLN 248
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 151-371 3.56e-23

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 97.85  E-value: 3.56e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 151 CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTmknsLVSYWNLGFTSvpqgQDLQYIFi 230
Cdd:cd23970   71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSI----LEKYYNNLLTI----QDRNNFF- 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 231 pSDIRDYvmlRSAILGVPVpegldkgdrphayFGPEASASKFKLLHPDFISYltERFLKSKL---------INTHF---- 297
Cdd:cd23970  142 -LSLKKL---DGAILWIPA-------------FFFHTSATVTRTLVDFFVEH--RGQLKVQLawpgnimqhVNRYWktkh 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 298 GDLYMPSTGALMLLTALHTCDQVSAYGFitsnyWKFSD---------HYFERKMKplIFYAN----HDLSLEAALWRDLH 364
Cdd:cd23970  203 LSPKRLSTGILMYTLASAICEEIHLYGF-----WPFGFdptgtplpyHYYDKKGT--KFTTKwqesHQLPAEFVLLYKMH 275


                 ....*..
gi 192448440 365 KAGILQL 371
Cdd:cd23970  276 GAGVLKL 282
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 141-373 3.33e-22

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 94.94  E-value: 3.33e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 141 PRDtPPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNslvsywnlgftsVP 220
Cdd:cd23979   74 SWD-PSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKN------------LP 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 221 qgQDLQYIFIPSDIRDYVMLRSAilgvpvpegLDKGDRPHAYfGP-----EASASKFKLLHPDFISYLTERFLKsklint 295
Cdd:cd23979  141 --ANVSFVLVPFKTLDLLWITSA---------LSTGQIRFTY-APvkqflRVDKDKVQIYNPAFFKYIHDRWTE------ 202

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 296 HFGDlyMPSTGALMLLTALHTCDQVSAYGFITSNYWKFSdHYFERKMKPLIFYAN--HDLSLEAALWRDLHKAGILQLYQ 373
Cdd:cd23979  203 HHGR--YPSTGMLVLFFALHVCDEVNVYGFGADSRGNWH-HYWENNRYAGEFRKTgvHDADFEAHIIDMLAKAGKIKVYR 279
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 145-339 2.01e-21

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 92.64  E-value: 2.01e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 145 PPKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNslvsywnlgftsvpQGQD 224
Cdd:cd23980   78 LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRE--------------LAQN 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 225 LQYIFIPSDIRDYVMLRSAILG-------VPVPEGLdkgdrphayfgpEASASKFKLLHPDFISYLTERFLKsklinthf 297
Cdd:cd23980  144 VSMILVPFKTLDLEWVISATTTgtishtyVPVPRKI------------KVKKEKILIYHPAFIKYVFDRWLQ-------- 203

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 192448440 298 GDLYMPSTGALMLLTALHTCDQVSAYGF--ITSNYWKfsdHYFE 339
Cdd:cd23980  204 GHGRYPSTGILSVIFSLHVCDEVDLYGFgaDSKGNWH---HYWE 244
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 147-357 2.32e-20

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 88.18  E-value: 2.32e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 147 KCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTS---FYgftvntmKNSLVSywNLGFTSVPqgq 223
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTirlFY-------PESAQF--DPGIENDP--- 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 224 DLQYIFIPSDIRDYVMLRSAILG-VPVPEGLDKgdRPHAYFgpEASASKFKLLHPDFISYLTERFLKsklINTHFGDLYM 302
Cdd:cd23982   69 DTLLVLVPFKPLDFYWLYEILSNeKRVRKGFWK--QPPRIW--DANPKQIRILNPYYTYVAATKLLQ---VPGQRKKKQK 141

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 192448440 303 PSTGALMLLTALHTCDQVS--AYGFITSNYWKFSDHYFE----RKMKPLIfyanHDLSLEA 357
Cdd:cd23982  142 PTTGLLAITLALHLCDEVHiaGFGYPDNGNSNQPIHYYNqitlKSMANSG----HNLNAEA 198
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 151-371 7.54e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 88.24  E-value: 7.54e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 151 CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFygftvNTMKNSLVSYWNLGFTSvpqgqdlqyifi 230
Cdd:cd23969   67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-----TTMNPSVIPHAYGDLVN------------ 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 231 PSDIRDYV----MLRSAILGVPVpeGLDKGDRPHayfgpeasaskfkllhpdfISYLTERFLKSKL-INTHFGDLYM--- 302
Cdd:cd23969  130 ATDKEKFVerlrQLGDSILWIPA--FVSKGGEEH-------------------VQWTNEIILKHKLnVKTAYPPLRLnha 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 303 --------------PSTGALMLLTALHTCDQVSAYGFitsnyWKFSD---------HYFERkmKPLIFYAN-HDLSLEAA 358
Cdd:cd23969  189 irgywlttkfrikrPSTGLLMYTLATRFCDEIHLYGF-----YPFSEdgngravkyHYYDN--RKYLTTARpHKMPEEFR 261

                        250
                 ....*....|...
gi 192448440 359 LWRDLHKAGILQL 371
Cdd:cd23969  262 ALRSLHQRGALRL 274
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 150-371 1.51e-19

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 87.31  E-value: 1.51e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 150 RCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKgFERDVGTKTSFygFTVN----TMKNSLVSYWNLGFTSVPQGQDL 225
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL--VTANpsilREKFHNLKKRRRPFVERMKVYGN 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 226 QYIFIPS---------DIRDYVMLRsailgvpvpeglDKGDRPHAYFgpeasaskfklLHPDFISYLTeRFLKSKLINTh 296
Cdd:cd23971  143 ALLLLPAfsytsntepSLRALYTLE------------DFGSPQKVLF-----------FNPEYLRNLS-RYWKSKGLKA- 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 297 fgdlYMPSTGaLMLLT-ALHTCDQVSAYGFitsnyWKFS---------DHYFE-RKMKPLIfyanHDLSLEAALWRDLHK 365
Cdd:cd23971  198 ----RRLSTG-LMLVSaALELCENVHLYGF-----WPFStdldgnpisHHYYDnVLPKKGV----HAMPEEFLRYLKLHS 263


                 ....*.
gi 192448440 366 AGILQL 371
Cdd:cd23971  264 QGVLRL 269
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 148-363 3.63e-18

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 81.89  E-value: 3.63e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTsfygftvnTMKnslVSYWNlGFTSVPQGQDLQY 227
Cdd:cd23981    2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKT--------TLR---ITYPE-GAIQKPEQYEKDS 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 228 IFIPSDIR--DYVMLRSAILGVPVpEGLDKGDRPHAYFGPEASAsKFKLLHPDFISYLTERFLKSKLINTHFGDLYMPST 305
Cdd:cd23981   70 LFVLAGFKwqDFKWLKYIVYKEKV-SASDGFWKSVATRVPREPH-EIRILNPYFIQEAAFSFIGLPFNNGLMGRGNIPTL 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 306 GALMLLTALHTCDQVSAYGF-ITSNYWKFSDHYFER-KMKPLIFYANHDLSLEAALWRDL 363
Cdd:cd23981  148 GSVAITMALHNCDEVAVAGFgYDMNTPNAPLHYYETiKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 141-371 2.34e-17

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 81.15  E-value: 2.34e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 141 PRDTPPKCIR---CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYgftvnTMKNSLVSYWNLGFT 217
Cdd:cd23988   54 PEVSPMKNRRfktCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFI-----TMNPSVVQRAFGGFR 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 218 SVPQGQDLqyifipsdIRDYVMLRSAILGVPVpeGLDKGDRPHayfgpeasaskfkllhpdfISYLTERFLKSKL-INTH 296
Cdd:cd23988  129 NESDREKF--------VHRLSMLNDSVLWIPA--FMVKGGEKH-------------------VEWVNALILKNKLkVRTA 179

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 297 FGDLYM-----------------PSTGALMLLTALHTCDQVSAYGFitsnyWKFSD---------HYFER-KMKpliFYA 349
Cdd:cd23988  180 YPSLRLihavrgywltnkvnikrPSTGLLMYTLATRFCDEIHLYGF-----WPFPKdangnpvkyHYYDDlKYR---YFS 251

                        250       260
                 ....*....|....*....|....*
gi 192448440 350 N---HDLSLEAALWRDLHKAGILQL 371
Cdd:cd23988  252 NagpHRMPLEFKTLNVLHNRGALKL 276
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 148-363 3.79e-17

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 79.40  E-value: 3.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTsfygftvnTMKnslVSYwnlgftsvPQGQDLQY 227
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKT--------TIR---MTY--------PEGAPKSE 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 228 I-FIPSDIRDYVMLRSA----ILGVPVPEGLDKGDRphAYFGPEA------SASKFKLLHPDFISYLTERFLK-SKLINT 295
Cdd:cd23983   63 QeYDPTSLFVAVLFKSVdfawLKAMVKKEPLSFWSR--LFFWKEVadsiplKPSQFRILNPLIIKETALDILQyPEPQSR 140

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 192448440 296 HFG-DLYMPSTGALMLLTALHTCDQVSAYGF-ITSNYWKFSDHYFE-RKMKPLIFYANHDLSLEAALWRDL 363
Cdd:cd23983  141 LWGwDKNVPTLGVTAVVLATHLCDEVSLAGFgYDLSQPHAPLHYYDsVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 105-371 1.29e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 79.10  E-value: 1.29e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 105 LSQHKAPYG---WRGL----SHQVIASTLSLLngsesaklfapPRDTPPK--CIRCAVVGNGGILNGSRQGPNIDAHDYV 175
Cdd:cd23989   22 VTKHNSPLGknlWFDGeflhSHTVDNETYSLF-----------PQDTPLQlpLKKCSVVGNGGILKNSGCGQQIDRADFV 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 176 FRLN-GAVIKGFERDVGTKTSFygFTVNTmknSLV--SYWNL-----GFTSVPQGQDLQYIFIPsdirdyvmlrsailGV 247
Cdd:cd23989   91 MRCNlPPLSREYTDDVGTKTQL--VTANP---SIIdkRFQNLlwsrkSFVESMKVYGRSYIYMP--------------AF 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 248 PVPEGLDKGDRphAYFGPEASASKFKLL--HPDFISYLTeRFLKSKLIntHFGDLympSTGALMLLTALHTCDQVSAYGF 325
Cdd:cd23989  152 SMKTGTDPSLR--VYYTLADVGANQTVLfaNPNFLRNVG-KFWKSKGV--HAKRL---STGLFLVSAALGLCEEVTIYGF 223

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 192448440 326 itsnyWKF---------SDHYFERKMKPLIFYANHDLSLEaaLWRdLHKAGILQL 371
Cdd:cd23989  224 -----WPFsvdldertiSHHYYDNVLPDSGFHAMPEEFLQ--LWH-LHKSGVLRM 270
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 148-344 1.33e-16

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 78.05  E-value: 1.33e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTsfygfTVNTMknslvsywnlGFTSVPQGQdLQY 227
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRT-----TIRVV----------SHSSLPRLL-RNA 64

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 228 IFIPSDIR-DYVMLrsaILGVPVPegLDKGDRPHAYFGPEASAS----KFKLLHPDFISYLTERFLKSKLINTHFGDLYM 302
Cdd:cd23965   65 ILLLAGTRaPTVVV---FWGPETK--MNKDGAGKYNLLRSLSKKypdvEFYSLTPEKMDYADELFEKETGKSRIKSGTWL 139

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 192448440 303 pSTGALMLLTALHTCDQVSAYGFITSNYWK---FSD---HYFERKMKP 344
Cdd:cd23965  140 -STGWFTMLLALDVCDEIKVYGMVPENYCRehpNSKvpyHYYEPGGLK 186
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 140-371 2.00e-16

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 78.64  E-value: 2.00e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 140 PPRDTPPKciRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKG-FERDVGTKTSFygFTVNTmknSLVS--YWNLGF 216
Cdd:cd23991   58 PFRGYPYK--QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL--VTANP---SIISikYAKLNE 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 217 TSVPQGQDLQyifipsdirdyvMLRSAILGVPVpegldKGDRPH------AYFGPEASASKFK--LLHPDFISYLTErFL 288
Cdd:cd23991  131 RRKPFLETVS------------VYGDAFLLLPA-----FSYRSNtalsfkVYYTLEDFKAKQKviFFHPIYLKHLAQ-FW 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 289 KSKLINThfgdlYMPSTGALMLLTALHTCDQVSAYGFitsnyWKFS---------DHYFERKM-KPLIfyanHDLSLEAA 358
Cdd:cd23991  193 RSKGVQV-----YRLSTGLMITSAALELCEEVKLYGF-----WPFSkntegkpisHHYYDNQLpKPGF----HSMPKEFY 258

                        250
                 ....*....|...
gi 192448440 359 LWRDLHKAGILQL 371
Cdd:cd23991  259 QLLQLHSKGILKL 271
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 147-363 9.88e-16

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 75.17  E-value: 9.88e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 147 KCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYGFTVNTMKNSLVSYwnlgftsVPQGQDLQ 226
Cdd:cd23984    1 SCKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFSDPSHY-------DPNTTVVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 227 YIFIPSDIRdyvMLRSAILGVPVPeglDKG--DRPHA---YfgpeaSASKFKLLHPDFIS-------YLTERFLKSKlIN 294
Cdd:cd23984   74 IPFKPHDLR---WLLDLLMGKKVS---AKGfwKKPALnliY-----KPNQIRILNPFILRiaayellHFPKRFPKEK-KP 141

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 192448440 295 THfgdlymPSTGALMLLTALHTCDQVSAYGFitsnYWKFSD-----HYFERK-MKPLIFYANHDLSLEAALWRDL 363
Cdd:cd23984  142 KH------PTTGIIAITLALHICNEVHIAGF----KYDFSNlnstlHYYGNEtMSVMTKNEYHNISAEQKFLKDL 206
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 150-336 4.01e-15

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 74.74  E-value: 4.01e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 150 RCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTsfygfTVNTMKNSLVSYWNLGFTSVPqgqdlqyif 229
Cdd:cd23985   47 RCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKT-----TIRLINSQLVTTEKHKFLKDS--------- 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 230 ipsdirdyvMLRSAILGV--PVPEgldKGDRPHAYFGPEAS----ASKFKLLHPDFISYLTERFLKSKL---INTHFGDL 300
Cdd:cd23985  113 ---------LYNEGILIVwdPAPY---HSDIPEWYKNPDYNffenYKTYRRLNPNQPFYILHPQMQWELwdiIQENSPEE 180

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 192448440 301 YM---PSTGALMLLTALHTCDQVSAYGFITSN--------YWKFSDH 336
Cdd:cd23985  181 IQpnpPSSGMLGIILMMTLCDQVDVYEFLPSKrktdvchyYQKFFDR 227
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 141-371 3.02e-13

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 69.20  E-value: 3.02e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 141 PRDTPPKCIR---CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFYgftvnTMKNSLV-------- 209
Cdd:cd23987   54 PRTSPLKNKHfktCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLV-----TMNPSVVqrafedlv 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 210 -SYWNLGFTSVPQGQDLQYIFIPSdirdyVMLRSailGVPVPEGLDKGDRPHAYFGPEASASkFKLLHPDFISYLTERFL 288
Cdd:cd23987  129 nETWKEKFLQRLQSLNGSILWIPA-----FMAKG---GEERVEWVNDLILKHHINVRTAYPS-LRLLHAVRGYWLTNKVH 199

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 289 KSKlinthfgdlymPSTGALMLLTALHTCDQVSAYGFitsnyWKFSD---------HYFERKMKPLIFYAN-HDLSLEAA 358
Cdd:cd23987  200 IKR-----------PTTGLLMYTLATRFCNRIHLYGF-----WPFPRdqnqnpvkyHYYDSLKYGYTSQASpHTMPLEFK 263

                        250
                 ....*....|...
gi 192448440 359 LWRDLHKAGILQL 371
Cdd:cd23987  264 ALKNLHQQGALKL 276
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 106-372 3.24e-12

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 66.01  E-value: 3.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 106 SQHKAPYGWRgLSHQVIASTLSLLNgSESAKLFapPRDTP---PKCIRCAVVGNGGILNGSRQGPNIDAHDYVFRLN-GA 181
Cdd:cd23990   23 TQKNTPLGTK-LKYEVDTSGIYHIN-SEIFKMF--PKDMPysrSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNlPP 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 182 VIKGFERDVGTKTSFygFTVN----TMKNSLVSYWNLGFTSVPQGQDLQYIFIPSdirdYVMLRSAILGVPVPEGLDKGD 257
Cdd:cd23990   99 ISEKYVRDVGVKTDV--VTINpsiiTERFHKLEKWRRPFYEVLQVYENASVVLPA----FYNTRNTDVSIRVKYVLDDFE 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 258 RPHAYFgpeasaskfkLLHPDFISYLTeRFLKSKLINTHfgdlyMPSTGALMLLTALHTCDQVSAYGFitsnyWKF---- 333
Cdd:cd23990  173 SQQAVY----------YFHPQYLLNVS-RFWLRQGVRAK-----RISSGLMLVTAALELCEEVHLYGF-----WAFpmnp 231

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 192448440 334 -----SDHYFErKMKPLIFYanHDLSLEAALWRDLHKAGILQLY 372
Cdd:cd23990  232 sgifiTHHYYD-NVKPRPGF--HAMPSEIFNFLHMHSRGILRVH 272
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 148-340 6.45e-11

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 61.80  E-value: 6.45e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFygftvntmknSLVSYwnlgfTSVP-----QG 222
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSL----------RVVSH-----TSVPlllrnQG 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 223 qdlqYIFIPSDIRDYVmlrsaILGvpvPE-GLDKGDRPHAYFGPEASASKFKLLHpdfISYLTERFL------------K 289
Cdd:cd23977   66 ----YFFQQSRDTKYV-----IWG---PErNMDRDGGGKTYRALLTLAKMYPHLQ---VYTLTEEKMaycdgvfqnetgK 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 192448440 290 SKLINTHFgdlymPSTGALMLLTALHTCDQVSAYGFITSNYWKFSD------HYFER 340
Cdd:cd23977  131 NRMKSGSF-----LSTGWFTMILALELCEEILVYGMVSDSYCRNKNhssvpyHYYEK 182
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 151-340 1.96e-09

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 57.92  E-value: 1.96e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 151 CAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTsfygfTVNTMKNSLVSYWNLGFTSVPQGQDLqyIFI 230
Cdd:cd23986   52 CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKT-----TIRIINSQILTNPNHHFIDSSLYKDV--ILV 124

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 231 PSDirdyvmlrsailgvPVPEGLD------KGD----RPHAYFGPEASASKFKLLHPDFISYLTERFLKSKLINTHFGDl 300
Cdd:cd23986  125 AWD--------------PAPYSANlhkwykKPDynlfTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNP- 189

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 192448440 301 ymPSTGALMLLTALHTCDQVSAYGFITSNYWKFSDHYFER 340
Cdd:cd23986  190 --PSSGFIGILIMMSMCREVHVYEYIPSVRQTDLCHYHER 227
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 148-339 4.80e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 53.01  E-value: 4.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSFygftvntmknSLVSYwnlgfTSVPQG-QDLQ 226
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTI----------RVVSH-----TSVPLLlKNPD 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 192448440 227 YIFIPSDIRDYVM------LRSAILGVpVPEGLDK--GDRPHAyfgpeasasKFKLLHPDFISYLTERFLKSKLINTHFG 298
Cdd:cd23975   66 YFFKETNETIYVIwgpfrnMRKDGKGI-VYNMLKKavESYPQA---------KIYVTTEKRMSYCDTVFKKETGKDRVQS 135

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 192448440 299 DLYMpSTGALMLLTALHTCDQVSAYGFI------TSNYWKFSDHYFE 339
Cdd:cd23975  136 GSYL-STGWFTLILAMDACYGIHVYGMIndtyckTEGYRKVPYHYYE 181
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 148-196 3.56e-07

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 50.64  E-value: 3.56e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSF 196
Cdd:cd23976   15 CKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSL 63
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 148-196 5.63e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 47.16  E-value: 5.63e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 192448440 148 CIRCAVVGNGGILNGSRQGPNIDAHDYVFRLNGAVIKGFERDVGTKTSF 196
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTL 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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