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Conserved domains on  [gi|45827734|ref|NP_005978|]
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cornifin-A [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Cornifin super family cl25524
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 35-87 9.39e-17

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


The actual alignment was detected with superfamily member pfam02389:

Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 69.31  E-value: 9.39e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 45827734    35 PKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVTPAPAQQKTK 87
Cdd:pfam02389  83 PKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 35-87 9.39e-17

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 69.31  E-value: 9.39e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 45827734    35 PKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVTPAPAQQKTK 87
Cdd:pfam02389  83 PKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
39-81 1.03e-06

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 44.79  E-value: 1.03e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 45827734   39 EPCHPKVPEPCHPKVPEPCQPKV--PEPCQPKVPEPC-PSTVTPAP 81
Cdd:PRK15313 559 EPDEPIIPDPVDPVIPDPVIPDPvdPDPVDPVIPDPViPDPVDPDP 604
 
Name Accession Description Interval E-value
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 35-87 9.39e-17

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 69.31  E-value: 9.39e-17
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 45827734    35 PKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVTPAPAQQKTK 87
Cdd:pfam02389  83 PKVPEPCHPKAPEPCHPKVPEPCYPKAPEPCQPKVPEPCPSTVTPGPAQQKTK 135
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 29-85 1.01e-11

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 56.60  E-value: 1.01e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 45827734    29 PQEPCIPKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTVtPAPAQQK 85
Cdd:pfam02389  13 PQEPCVPTTKEPCHSKVPEPCNPKVPEPCCPKVPEPCCPKVPEPCCPKV-PEPCCPK 68
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 35-77 4.27e-11

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 55.06  E-value: 4.27e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 45827734    35 PKTKEPCHPKVPEPCHPKVPEPCQPKVPEPCQPKVPEPCPSTV 77
Cdd:pfam02389  35 PKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCCPKVPEPCYPKV 77
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
39-81 1.03e-06

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 44.79  E-value: 1.03e-06
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 45827734   39 EPCHPKVPEPCHPKVPEPCQPKV--PEPCQPKVPEPC-PSTVTPAP 81
Cdd:PRK15313 559 EPDEPIIPDPVDPVIPDPVIPDPvdPDPVDPVIPDPViPDPVDPDP 604
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
35-81 1.91e-04

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 38.24  E-value: 1.91e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 45827734   35 PKTKEPCHPKVPEPCHPKV--PEPCQPKVPEPCqpkVPEPC-PSTVTPAP 81
Cdd:PRK15313 563 PIIPDPVDPVIPDPVIPDPvdPDPVDPVIPDPV---IPDPVdPDPVDPEP 609
PRK15313 PRK15313
intestinal colonization autotransporter adhesin MisL;
35-72 8.38e-04

intestinal colonization autotransporter adhesin MisL;


Pssm-ID: 237940 [Multi-domain]  Cd Length: 955  Bit Score: 36.32  E-value: 8.38e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 45827734   35 PKTKEPCHPKVPEPCHPKVPEPcQPKVPEPCQPKVPEP 72
Cdd:PRK15313 581 PVDPDPVDPVIPDPVIPDPVDP-DPVDPEPVDPVIPDP 617
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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