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Conserved domains on  [gi|44771198|ref|NP_005779|]
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protein arginine N-methyltransferase 3 isoform 1 [Homo sapiens]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10382869)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor; contains a C2H2-type zinc finger

CATH:  2.20.25.110
EC:  2.1.1.-
Gene Ontology:  GO:0008168|GO:1904047|GO:0008270
PubMed:  12504684|12826405|11361095|22803940
SCOP:  3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4076 super family cl44002
Predicted RNA methylase [General function prediction only];
230-393 3.98e-36

Predicted RNA methylase [General function prediction only];


The actual alignment was detected with superfamily member COG4076:

Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.39  E-value: 3.98e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 230 HEEMLKDKIRTESYRDFIYQnpHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITL 308
Cdd:COG4076  12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSDRITV 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 309 IKGKIEEVHLPvEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTislVAVSDVNKHADRIAFWDD-VY 387
Cdd:COG4076  90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERIT---NAAQPVESPVDAEGFEDWqFD 165


                ....*.
gi 44771198 388 GFKMSC 393
Cdd:COG4076 166 GFDFRL 171
zf-C2H2_2 super family cl20464
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 50-99 2.85e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


The actual alignment was detected with superfamily member pfam12756:

Pssm-ID: 463690  Cd Length: 98  Bit Score: 37.27  E-value: 2.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 44771198    50 CLFCNRLFTSAEETFSHCKSEHQFNI---DSMVHKhglefygyIKLINFIRLK 99
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIperEYLVDL--------EGLLNYLREK 45
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
230-393 3.98e-36

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.39  E-value: 3.98e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 230 HEEMLKDKIRTESYRDFIYQnpHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITL 308
Cdd:COG4076  12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSDRITV 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 309 IKGKIEEVHLPvEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTislVAVSDVNKHADRIAFWDD-VY 387
Cdd:COG4076  90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERIT---NAAQPVESPVDAEGFEDWqFD 165


                ....*.
gi 44771198 388 GFKMSC 393
Cdd:COG4076 166 GFDFRL 171
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 259-359 4.10e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.00  E-value: 4.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 259 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHL-PVEKVDVIISEWMGYFL-- 335
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLve 81

                        90       100
                ....*....|....*....|....
gi 44771198 336 LFESMLDSVLyaknKYLAKGGSVY 359
Cdd:cd02440  82 DLARFLEEAR----RLLKPGGVLV 101
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
252-327 1.82e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 70.18  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  252 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDI----IRLNKLEDTITLIKGKieevhlpvEKVDVII 327
Cdd:PRK00517 116 LVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAarenAELNGVELNVYLPQGD--------LKADVIV 184
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 259-328 1.38e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.66  E-value: 1.38e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 44771198   259 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEI-LYQAMDiiRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 328
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARE--RAAEAGLNVEFVQGDAEDLPFPDGSFDLVVS 69
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 255-327 1.34e-08

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 56.38  E-value: 1.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 44771198   255 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVD-QSEILYQAMDIIRLNKLEDTITLIKGKIEEvhlPVE-KVDVII 327
Cdd:TIGR00406 159 KDKNVIDVGCGSGILSIAALKLGAAKVVGIDiDPLAVESARKNAELNQVSDRLQVKLIYLEQ---PIEgKADVIV 230
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 50-99 2.85e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 37.27  E-value: 2.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 44771198    50 CLFCNRLFTSAEETFSHCKSEHQFNI---DSMVHKhglefygyIKLINFIRLK 99
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIperEYLVDL--------EGLLNYLREK 45
 
Name Accession Description Interval E-value
COG4076 COG4076
Predicted RNA methylase [General function prediction only];
230-393 3.98e-36

Predicted RNA methylase [General function prediction only];


Pssm-ID: 443253 [Multi-domain]  Cd Length: 230  Bit Score: 134.39  E-value: 3.98e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 230 HEEMLKDKIRTESYRDFIYQnpHIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITL 308
Cdd:COG4076  12 HHPMLNDVERNDAFKAAIER--VVKPGDVVLDIGTGSGLLSMLAARAGAKKVYAVEVNPDIAAvARRIIAANGLSDRITV 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 309 IKGKIEEVHLPvEKVDVIISEWMGYFLLFESMLDSVLYAKNKYLAKGGSVYPDICTislVAVSDVNKHADRIAFWDD-VY 387
Cdd:COG4076  90 INADATDLDLP-EKADVIISEMLDTALLDEGQVPILNHARKRLLKPGGRIIPERIT---NAAQPVESPVDAEGFEDWqFD 165


                ....*.
gi 44771198 388 GFKMSC 393
Cdd:COG4076 166 GFDFRL 171
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 259-359 4.10e-16

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 74.00  E-value: 4.10e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 259 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEEVHL-PVEKVDVIISEWMGYFL-- 335
Cdd:cd02440   2 VLDLGCGTGALALALASGPGARVTGVDISPVALELARKAAAALLADNVEVLKGDAEELPPeADESFDVIISDPPLHHLve 81

                        90       100
                ....*....|....*....|....
gi 44771198 336 LFESMLDSVLyaknKYLAKGGSVY 359
Cdd:cd02440  82 DLARFLEEAR----RLLKPGGVLV 101
PrmA COG2264
Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];
252-327 5.58e-16

Ribosomal protein L11 methylase PrmA [Translation, ribosomal structure and biogenesis];


Pssm-ID: 441865 [Multi-domain]  Cd Length: 284  Bit Score: 78.29  E-value: 5.58e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 252 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEilyQAMDI----IRLNKLEDTITLIKGKIeevhLPVEKVDVII 327
Cdd:COG2264 145 LLKPGKTVLDVGCGSGILAIAAAKLGAKRVLAVDIDP---VAVEAarenAELNGVEDRIEVVLGDL----LEDGPYDLVV 217
prmA PRK00517
50S ribosomal protein L11 methyltransferase;
252-327 1.82e-13

50S ribosomal protein L11 methyltransferase;


Pssm-ID: 234786 [Multi-domain]  Cd Length: 250  Bit Score: 70.18  E-value: 1.82e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  252 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDI----IRLNKLEDTITLIKGKieevhlpvEKVDVII 327
Cdd:PRK00517 116 LVLPGKTVLDVGCGSGILAIAAAKLGAKKVLAVD---IDPQAVEAarenAELNGVELNVYLPQGD--------LKADVIV 184
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 250-328 1.04e-12

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 65.04  E-value: 1.04e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 44771198 250 NPHIFKDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQSEilyQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 328
Cdd:COG2227  19 ARLLPAGGRVLDVGCGTGRLALALARRGA-DVTGVDISP---EALEIARERAAELNVDFVQGDLEDLPLEDGSFDLVIC 93
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 259-328 1.38e-11

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 60.66  E-value: 1.38e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 44771198   259 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEI-LYQAMDiiRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 328
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRGGARVTGVDLSPEmLERARE--RAAEAGLNVEFVQGDAEDLPFPDGSFDLVVS 69
PrmA pfam06325
Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal ...
 255-327 4.06e-11

Ribosomal protein L11 methyltransferase (PrmA); This family consists of several Ribosomal protein L11 methyltransferase (EC:2.1.1.-) sequences.


Pssm-ID: 428888 [Multi-domain]  Cd Length: 294  Bit Score: 63.82  E-value: 4.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   255 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDI----IRLNKLEDTItlikgkieEVHL----PVEKVDVI 326
Cdd:pfam06325 161 PGESVLDVGCGSGILAIAALKLGAKKVVGVD---IDPVAVRAakenAELNGVEARL--------EVYLpgdlPKEKADVV 229


                  .
gi 44771198   327 I 327
Cdd:pfam06325 230 V 230
COG2263 COG2263
Predicted RNA methylase [General function prediction only];
254-328 4.57e-11

Predicted RNA methylase [General function prediction only];


Pssm-ID: 441864 [Multi-domain]  Cd Length: 199  Bit Score: 62.23  E-value: 4.57e-11
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 44771198 254 FKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDIIRLN--KLEDTITLIKGKIEEVHLpVEKVDVIIS 328
Cdd:COG2263  44 IEGKTVLDLGCGTGMLAIGAALLGAKKVVGVD---IDPEALEIARENaeRLGVRVDFIRADVTRIPL-GGSVDTVVM 116
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 259-328 1.45e-10

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 61.31  E-value: 1.45e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 44771198 259 VLDVGCGTGILS-MFAAKAGAKKVLGVDQSEILY-QAMDIIRLNKLEDTITLIKGKIEEV--HLPVEKVDVIIS 328
Cdd:COG4123  41 VLDLGTGTGVIAlMLAQRSPGARITGVEIQPEAAeLARRNVALNGLEDRITVIHGDLKEFaaELPPGSFDLVVS 114
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 255-328 1.06e-09

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 56.93  E-value: 1.06e-09
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 44771198 255 KDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQS-EILYQAMDiiRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 328
Cdd:COG2226  22 PGARVLDLGCGTGRLALALAERGA-RVTGVDISpEMLELARE--RAAEAGLNVEFVVGDAEDLPFPDGSFDLVIS 93
Methyltransf_9 pfam08003
Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It ...
 224-433 1.45e-09

Protein of unknown function (DUF1698); This family contains many hypothetical proteins. It also includes two putative methyltransferase proteins, Swiss:Q8EEE6 and Swiss:Q88MX8.


Pssm-ID: 429781 [Multi-domain]  Cd Length: 315  Bit Score: 59.34  E-value: 1.45e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   224 YGHYGIHeemlkdkIRTESYRDFIYQN--PHI--FKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEI-LYQAMDIIR 298
Cdd:pfam08003  87 FHLFGVH-------IDTEWRSDWKWDRvlPHLspLKGRTILDVGCGNGYHMWRMLGEGAAMVVGIDPSELfLCQFEAVRK 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   299 LNKLEDTITLIKGKIEevHLP-VEKVDVIISewMGYFLLFESMLDSVLYAKNKyLAKGGSVYPDictiSLVAVSDVNK-- 375
Cdd:pfam08003 160 LLGNDQRAHLLPLGIE--QLPaLAAFDTVFS--MGVLYHRRSPLDHLLQLKDQ-LVKGGELVLE----TLVIDGDENTvl 230

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 44771198   376 -HADRIAFWDDVYgfkmscmkkaVIPEAvvevldpKTLIS--EPCGIKHIDCHTTSISDLE 433
Cdd:pfam08003 231 vPGDRYAQMRNVY----------FIPSA-------AALINwlEKCGFVDVRIVDVSVTTLE 274
prmA TIGR00406
ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an ...
 255-327 1.34e-08

ribosomal protein L11 methyltransferase; Ribosomal protein L11 methyltransferase is an S-adenosyl-L-methionine-dependent methyltransferase required for the modification of ribosomal protein L11. This protein is found in bacteria and (with a probable transit peptide) in Arabidopsis. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273061  Cd Length: 288  Bit Score: 56.38  E-value: 1.34e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 44771198   255 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVD-QSEILYQAMDIIRLNKLEDTITLIKGKIEEvhlPVE-KVDVII 327
Cdd:TIGR00406 159 KDKNVIDVGCGSGILSIAALKLGAAKVVGIDiDPLAVESARKNAELNQVSDRLQVKLIYLEQ---PIEgKADVIV 230
PRK15068 PRK15068
tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;
227-346 2.02e-08

tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB;


Pssm-ID: 237898  Cd Length: 322  Bit Score: 56.02  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  227 YGIHeemlkdkIRTESYRDFIYQN--PHIF--KDKVVLDVGCGTGiLSMF-AAKAGAKKVLGVDQSEI-LYQAMDIIRLN 300
Cdd:PRK15068  97 FGIH-------IDTEWRSDWKWDRvlPHLSplKGRTVLDVGCGNG-YHMWrMLGAGAKLVVGIDPSQLfLCQFEAVRKLL 168

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 44771198  301 KLEDTITLIKGKIEEVHlPVEKVDVIISewMGyfllfesmldsVLY 346
Cdd:PRK15068 169 GNDQRAHLLPLGIEQLP-ALKAFDTVFS--MG-----------VLY 200
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 260-331 5.67e-08

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 50.36  E-value: 5.67e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 44771198   260 LDVGCGTGILSMFAAKAGAkKVLGVDQSEilyQAMDIIRLNKLEDTITLIKGKIEEVHLPVEKVDVIISEWM 331
Cdd:pfam08241   1 LDVGCGTGLLTELLARLGA-RVTGVDISP---EMLELAREKAPREGLTFVVGDAEDLPFPDNSFDLVLSSEV 68
Nnt1 COG3897
Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, ...
 245-359 6.11e-08

Protein N-terminal and lysine N-methylase, NNT1/EFM7 family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443104 [Multi-domain]  Cd Length: 216  Bit Score: 53.35  E-value: 6.11e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 245 DFIYQNPHIfKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDIIRLNKLE--DTITLIKGKIEEVHlPVEK 322
Cdd:COG3897  61 RYLLDHPEV-AGKRVLELGCGLGLVGIAAAKAGAADVTATD---YDPEALAALRLNAALngVAITTRLGDWRDPP-AAGG 135

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 44771198 323 VDVII-SEwmgyfLLFE-SMLDSVLYAKNKYLAKGGSVY 359
Cdd:COG3897 136 FDLILgGD-----VLYErDLAEPLLPFLDRLAAPGGEVL 169
Cfa COG2230
Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport ...
 259-356 6.93e-08

Cyclopropane fatty-acyl-phospholipid synthase and related methyltransferases [Lipid transport and metabolism];


Pssm-ID: 441831 [Multi-domain]  Cd Length: 158  Bit Score: 51.85  E-value: 6.93e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 259 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQ-AMDIIRLNKLEDTITLIKGKIEEVHLPvEKVDVIIS----EWMG- 332
Cdd:COG2230  55 VLDIGCGWGGLALYLARRYGVRVTGVTLSPEQLEyARERAAEAGLADRVEVRLADYRDLPAD-GQFDAIVSigmfEHVGp 133

                        90       100
                ....*....|....*....|....*.
gi 44771198 333 --YFLLFESMLDSvlyaknkyLAKGG 356
Cdd:COG2230 134 enYPAYFAKVARL--------LKPGG 151
PRK14968 PRK14968
putative methyltransferase; Provisional
 255-359 1.33e-07

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 51.82  E-value: 1.33e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  255 KDKVVLDVGCGTGILSMFAAKAGaKKVLGVDQSEI-LYQAMDIIRLNKLE---------DTITLIKGKIEEV------HL 318
Cdd:PRK14968  23 KGDRVLEVGTGSGIVAIVAAKNG-KKVVGVDINPYaVECAKCNAKLNNIRnngvevirsDLFEPFRGDKFDVilfnppYL 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 44771198  319 PVEKvDVIISEWMGYFL--------LFESMLDSVlyakNKYLAKGGSVY 359
Cdd:PRK14968 102 PTEE-EEEWDDWLNYALsggkdgreVIDRFLDEV----GRYLKPGGRIL 145
RlmK COG1092
23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure ...
 255-327 5.65e-07

23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI [Translation, ribosomal structure and biogenesis]; 23S rRNA G2069 N7-methylase RlmK or C1962 C5-methylase RlmI is part of the Pathway/BioSystem: 23S rRNA modification


Pssm-ID: 440709 [Multi-domain]  Cd Length: 392  Bit Score: 51.72  E-value: 5.65e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44771198 255 KDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSE-ILYQAMDIIRLNKLEDTITLIKGK----IEEVHLPVEKVDVII 327
Cdd:COG1092 216 KGKRVLNLFSYTGGFSVHAAAGGAKSVTSVDLSAtALEWAKENAALNGLDDRHEFVQADafdwLRELAREGERFDLII 293
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 259-359 1.11e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 49.53  E-value: 1.11e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 259 VLDVGCGTGILSMFAAKAGAKKVLGVDQS-EILYQAMDIIRLNKLeDTITLIKGKIEEVH-LPVEKVDVIISewMGYF-L 335
Cdd:COG0500  30 VLDLGCGTGRNLLALAARFGGRVIGIDLSpEAIALARARAAKAGL-GNVEFLVADLAELDpLPAESFDLVVA--FGVLhH 106

                        90       100
                ....*....|....*....|....
gi 44771198 336 LFESMLDSVLYAKNKYLAKGGSVY 359
Cdd:COG0500 107 LPPEEREALLRELARALKPGGVLL 130
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 253-328 1.93e-06

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 47.80  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   253 IFKDKVVLDVGCGTGILSMFAAK--AGAKKVLGVDQSEILYQAMDIIRLNKLEDTITLIKGKIEE--VHLPVEKVDVIIS 328
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEelGPNAEVVGIDISEEAIEKARENAQKLGFDNVEFEQGDIEElpELLEDDKFDVVIS 80
COG4976 COG4976
Predicted methyltransferase, contains TPR repeat [General function prediction only];
241-328 5.34e-06

Predicted methyltransferase, contains TPR repeat [General function prediction only];


Pssm-ID: 444001 [Multi-domain]  Cd Length: 181  Bit Score: 46.92  E-value: 5.34e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 241 ESYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAGaKKVLGVDQSEilyqAM-DIIRLNKLEDtiTLIKGKIEEVHLP 319
Cdd:COG4976  32 ALLAEELLARLPPGPFGRVLDLGCGTGLLGEALRPRG-YRLTGVDLSE----EMlAKAREKGVYD--RLLVADLADLAEP 104


                ....*....
gi 44771198 320 VEKVDVIIS 328
Cdd:COG4976 105 DGRFDLIVA 113
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
259-328 1.24e-05

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 44.04  E-value: 1.24e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 44771198 259 VLDVGCGTGILS-MFAAKAGAKKVLGVDQSEilyqAMdIIRLNKLEDTITLIKGKIEEVHLPvEKVDVIIS 328
Cdd:COG4106   5 VLDLGCGTGRLTaLLAERFPGARVTGVDLSP----EM-LARARARLPNVRFVVADLRDLDPP-EPFDLVVS 69
Trm11 COG1041
tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 ...
 255-329 1.84e-05

tRNA G10 N-methylase Trm11 [Translation, ribosomal structure and biogenesis]; tRNA G10 N-methylase Trm11 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 440663 [Multi-domain]  Cd Length: 172  Bit Score: 45.32  E-value: 1.84e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 44771198 255 KDKVVLDVGCGTGILSMFAAKAGAkKVLGVD-QSEILYQAMDIIRLNKLEDtITLIKGKIEEVHLPVEKVDVIISE 329
Cdd:COG1041  26 EGDTVLDPFCGTGTILIEAGLLGR-RVIGSDiDPKMVEGARENLEHYGYED-ADVIRGDARDLPLADESVDAIVTD 99
BioC TIGR02072
malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin ...
 249-328 2.12e-05

malonyl-acyl carrier protein O-methyltransferase BioC; This enzyme, which is found in biotin biosynthetic gene clusters in proteobacteria, firmicutes, green-sulfur bacteria, fusobacterium and bacteroides, carries out an enzymatic step prior to the formation of pimeloyl-CoA, namely O-methylation of the malonyl group preferentially while on acyl carrier protein. The enzyme is recognizable as a methyltransferase by homology. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273953 [Multi-domain]  Cd Length: 240  Bit Score: 46.13  E-value: 2.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   249 QNPHIFKDKVVLDVGCGTGILSMFAAKAGAK-KVLGVDQSEI-LYQAMDIIRLNkledtITLIKGKIEEVHLPVEKVDVI 326
Cdd:TIGR02072  28 KEKGIFIPASVLDIGCGTGYLTRALLKRFPQaEFIALDISAGmLAQAKTKLSEN-----VQFICGDAEKLPLEDSSFDLI 102


                  ..
gi 44771198   327 IS 328
Cdd:TIGR02072 103 VS 104
cbiT PRK00377
cobalt-precorrin-6Y C(15)-methyltransferase; Provisional
 253-375 3.09e-05

cobalt-precorrin-6Y C(15)-methyltransferase; Provisional


Pssm-ID: 234740  Cd Length: 198  Bit Score: 45.17  E-value: 3.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  253 IFKDKVVLDVGCGTGILSMFAAK-AGAK-KVLGVDQSEilyQAMDIIRLN----KLEDTITLIKGKIEEVhlpvekVDVI 326
Cdd:PRK00377  38 LRKGDMILDIGCGTGSVTVEASLlVGETgKVYAVDKDE---KAINLTRRNaekfGVLNNIVLIKGEAPEI------LFTI 108

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 44771198  327 ISEWMGYFLLFESM-LDSVLYAKNKYLAKGGSVYPDICTISLV--AVSDVNK 375
Cdd:PRK00377 109 NEKFDRIFIGGGSEkLKEIISASWEIIKKGGRIVIDAILLETVnnALSALEN 160
FtsJ pfam01728
FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal ...
 252-358 4.77e-05

FtsJ-like methyltransferase; This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.


Pssm-ID: 426399  Cd Length: 179  Bit Score: 44.12  E-value: 4.77e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   252 HIFK-DKVVLDVGCGTGILSMFAAKAGAKKVLGVDqseILYQAMDIIRLNkleDTITLIKGKI--EEVHLPVE-----KV 323
Cdd:pfam01728  17 GLLKpGKTVLDLGAAPGGWSQVALQRGAGKVVGVD---LGPMQLWKPRND---PGVTFIQGDIrdPETLDLLEellgrKV 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 44771198   324 DVIISEwMGYFLLFESMLD---------SVLYAKNKYLAKGGSV 358
Cdd:pfam01728  91 DLVLSD-GSPFISGNKVLDhlrsldlvkAALEVALELLRKGGNF 133
RsmD COG0742
16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 252-359 5.66e-05

16S rRNA G966 N2-methylase RsmD [Translation, ribosomal structure and biogenesis]; 16S rRNA G966 N2-methylase RsmD is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440505 [Multi-domain]  Cd Length: 183  Bit Score: 43.92  E-value: 5.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 252 HIFKDKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSeilYQAMDIIRLN----KLEDTITLIKGKIEEV--HLPVEKVDV 325
Cdd:COG0742  38 PDIEGARVLDLFAGSGALGLEALSRGAASVVFVEKD---RKAAAVIRKNleklGLEDRARVIRGDALRFlkRLAGEPFDL 114

                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 44771198 326 IisewmgyFL-------LFESMLDSVlyAKNKYLAKGGSVY 359
Cdd:COG0742 115 V-------FLdppyakgLLEKALELL--AENGLLAPGGLIV 146
Methyltransf_23 pfam13489
Methyltransferase domain; This family appears to be a methyltransferase domain.
 236-383 7.89e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 404385 [Multi-domain]  Cd Length: 162  Bit Score: 43.19  E-value: 7.89e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   236 DKIRTESYRDFI-YQNPHIFKDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQSEILYQAMDIIRLNKLEDtitlikgkIE 314
Cdd:pfam13489   2 AHQRERLLADLLlRLLPKLPSPGRVLDFGCGTGIFLRLLRAQGF-SVTGVDPSPIAIERALLNVRFDQFD--------EQ 72

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 44771198   315 EVHLPVEKVDVIISewmgyFLLFESMLDSVLYAKN--KYLAKGGSVYpdictISLVAVSDvnKHADRIAFW 383
Cdd:pfam13489  73 EAAVPAGKFDVIVA-----REVLEHVPDPPALLRQiaALLKPGGLLL-----LSTPLASD--EADRLLLEW 131
arsM PRK11873
arsenite methyltransferase;
258-328 8.25e-05

arsenite methyltransferase;


Pssm-ID: 237007 [Multi-domain]  Cd Length: 272  Bit Score: 44.55  E-value: 8.25e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 44771198  258 VVLDVGCGTGILSMFAAKA-GAK-KVLGVDQSEilyqAM-DIIRLNKLE---DTITLIKGKIEEVHLPVEKVDVIIS 328
Cdd:PRK11873  80 TVLDLGSGGGFDCFLAARRvGPTgKVIGVDMTP----EMlAKARANARKagyTNVEFRLGEIEALPVADNSVDVIIS 152
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 260-356 3.80e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 39.66  E-value: 3.80e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   260 LDVGCGTG-ILSMFAAKAGAKKVLGVDQSEilyQAMDII--RLNKLE----DTITLIKGKIEEVHLPveKVDVIIsewMG 332
Cdd:pfam08242   1 LEIGCGTGtLLRALLEALPGLEYTGLDISP---AALEAAreRLAALGllnaVRVELFQLDLGELDPG--SFDVVV---AS 72

                          90       100
                  ....*....|....*....|....
gi 44771198   333 YFLLFESMLDSVLYAKNKYLAKGG 356
Cdd:pfam08242  73 NVLHHLADPRAVLRNIRRLLKPGG 96
PRK14967 PRK14967
putative methyltransferase; Provisional
 259-328 3.80e-04

putative methyltransferase; Provisional


Pssm-ID: 184931 [Multi-domain]  Cd Length: 223  Bit Score: 41.96  E-value: 3.80e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 44771198  259 VLDVGCGTGILSMFAAKAGAKKVLGVDQSEilyQAMDIIRLNKLED--TITLIKGKIEEvHLPVEKVDVIIS 328
Cdd:PRK14967  40 VLDLCTGSGALAVAAAAAGAGSVTAVDISR---RAVRSARLNALLAgvDVDVRRGDWAR-AVEFRPFDVVVS 107
PRK07580 PRK07580
Mg-protoporphyrin IX methyl transferase; Validated
 255-288 6.69e-04

Mg-protoporphyrin IX methyl transferase; Validated


Pssm-ID: 236059 [Multi-domain]  Cd Length: 230  Bit Score: 41.36  E-value: 6.69e-04
                         10        20        30
                 ....*....|....*....|....*....|....
gi 44771198  255 KDKVVLDVGCGTGILSMFAAKAGAkKVLGVDQSE 288
Cdd:PRK07580  63 TGLRILDAGCGVGSLSIPLARRGA-KVVASDISP 95
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 253-327 6.69e-04

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 41.68  E-value: 6.69e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 253 IFKDKVVLDVGCGTGILSMFAAKA-GAK-KVLGVDQSEilyQAMDIIRLN----KLEDTITLIKGKIEEVhLPVEKVDVI 326
Cdd:COG2519  89 IFPGARVLEAGTGSGALTLALARAvGPEgKVYSYERRE---DFAEIARKNlerfGLPDNVELKLGDIREG-IDEGDVDAV 164


                .
gi 44771198 327 I 327
Cdd:COG2519 165 F 165
RsmC COG2813
16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 259-328 7.62e-04

16S rRNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; 16S rRNA G1207 methylase RsmC is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 442062 [Multi-domain]  Cd Length: 191  Bit Score: 40.56  E-value: 7.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 259 VLDVGCGTGILSMFAAKAGAK-KVLGVDQSEilyQAMDI----IRLNKLEDTitlikgkieEVH-------LPVEKVDVI 326
Cdd:COG2813  53 VLDLGCGYGVIGLALAKRNPEaRVTLVDVNA---RAVELaranAAANGLENV---------EVLwsdglsgVPDGSFDLI 120


                ..
gi 44771198 327 IS 328
Cdd:COG2813 121 LS 122
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 255-327 1.10e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 41.32  E-value: 1.10e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44771198 255 KDKVVLDVGCGTGILSMFAAKAgAKKVLGVDQSE--ILyQAMDIIRLNKLEDtITLIKGKIEEV---HLPVEKVDVII 327
Cdd:COG2265 233 GGERVLDLYCGVGTFALPLARR-AKKVIGVEIVPeaVE-DARENARLNGLKN-VEFVAGDLEEVlpeLLWGGRPDVVV 307
HemK COG2890
Methylase of polypeptide chain release factors [Translation, ribosomal structure and ...
 258-328 1.43e-03

Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442135 [Multi-domain]  Cd Length: 282  Bit Score: 40.52  E-value: 1.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 44771198 258 VVLDVGCGTGI--LSMFAAKAGAkKVLGVDQSEilyQAMDI----IRLNKLEDTITLIKGKIEEVHLPVEKVDVIIS 328
Cdd:COG2890 115 RVLDLGTGSGAiaLALAKERPDA-RVTAVDISP---DALAVarrnAERLGLEDRVRFLQGDLFEPLPGDGRFDLIVS 187
Met_10 pfam02475
Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of ...
 258-345 1.93e-03

Met-10+ like-protein; The methionine-10 mutant allele of N. crassa codes for a protein of unknown function, Swiss:O27901. However, homologous proteins have been found in yeast suggesting this protein may be involved in methionine biosynthesis, transport and/or utilization.


Pssm-ID: 396850 [Multi-domain]  Cd Length: 198  Bit Score: 39.64  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198   258 VVLDVGCGTGILSMFAAKAG-AKKVLGVDQSEILYQAM-DIIRLNKLEDTITLIKGKIEEVhLPVEKVDVIIsewMGYFL 335
Cdd:pfam02475 102 VVVDMFAGIGPFSIPIAKHSkARRVYAIELNPESYKYLkENIKLNKVEDVVKPILGDVREV-ILEDVADRVV---MNLPG 177

                          90
                  ....*....|
gi 44771198   336 LFESMLDSVL 345
Cdd:pfam02475 178 SAHEFLDKAF 187
PRK08317 PRK08317
hypothetical protein; Provisional
 241-329 1.93e-03

hypothetical protein; Provisional


Pssm-ID: 181382 [Multi-domain]  Cd Length: 241  Bit Score: 39.92  E-value: 1.93e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  241 ESYRDFIYQNPHIFKDKVVLDVGCGTGILSM-FAAKAGAK-KVLGVDQSEILYqAMDIIRLNKLEDTITLIKGKIEEVHL 318
Cdd:PRK08317   5 RRYRARTFELLAVQPGDRVLDVGCGPGNDAReLARRVGPEgRVVGIDRSEAML-ALAKERAAGLGPNVEFVRGDADGLPF 83

                         90
                 ....*....|.
gi 44771198  319 PVEKVDVIISE 329
Cdd:PRK08317  84 PDGSFDAVRSD 94
ksgA PRK14896
16S ribosomal RNA methyltransferase A;
234-328 2.14e-03

16S ribosomal RNA methyltransferase A;


Pssm-ID: 237852 [Multi-domain]  Cd Length: 258  Bit Score: 39.88  E-value: 2.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198  234 LKDKirteSYRDFIYQNPHIFKDKVVLDVGCGTGILSMFAAKAgAKKVLGVDQSEILyqamdIIRLNKL---EDTITLIK 310
Cdd:PRK14896  12 LIDD----RVVDRIVEYAEDTDGDPVLEIGPGKGALTDELAKR-AKKVYAIELDPRL-----AEFLRDDeiaAGNVEIIE 81

                         90
                 ....*....|....*...
gi 44771198  311 GKIEEVHLPveKVDVIIS 328
Cdd:PRK14896  82 GDALKVDLP--EFNKVVS 97
PRK09328 PRK09328
N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional
 255-328 2.72e-03

N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional


Pssm-ID: 236467 [Multi-domain]  Cd Length: 275  Bit Score: 39.76  E-value: 2.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44771198  255 KDKVVLDVGCGTGILS-MFAAKAGAKKVLGVDQSEilyQAMDIIRLN---KLEDTITLIKGKIEEvHLPVEKVDVIIS 328
Cdd:PRK09328 108 EPLRVLDLGTGSGAIAlALAKERPDAEVTAVDISP---EALAVARRNakhGLGARVEFLQGDWFE-PLPGGRFDLIVS 181
zf-C2H2_2 pfam12756
C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger ...
 50-99 2.85e-03

C2H2 type zinc-finger (2 copies); This family contains two copies of a C2H2-like zinc finger domain.


Pssm-ID: 463690  Cd Length: 98  Bit Score: 37.27  E-value: 2.85e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 44771198    50 CLFCNRLFTSAEETFSHCKSEHQFNI---DSMVHKhglefygyIKLINFIRLK 99
Cdd:pfam12756   1 CLFCGHTSSTVEENLEHMFKSHGFFIperEYLVDL--------EGLLNYLREK 45
MTS pfam05175
Methyltransferase small domain; This domain is found in ribosomal RNA small subunit ...
 255-328 4.06e-03

Methyltransferase small domain; This domain is found in ribosomal RNA small subunit methyltransferase C as well as other methyltransferases.


Pssm-ID: 428349 [Multi-domain]  Cd Length: 170  Bit Score: 38.34  E-value: 4.06e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 44771198   255 KDKVVLDVGCGTGILSMFAAKAGAK-KVLGVDQSeilYQAMDI----IRLNKLEDTITLIKGKIEEVhlPVEKVDVIIS 328
Cdd:pfam05175  31 LSGKVLDLGCGAGVLGAALAKESPDaELTMVDIN---ARALESarenLAANGLENGEVVASDVYSGV--EDGKFDLIIS 104
Trm5 COG2520
tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 ...
 256-356 6.73e-03

tRNA G37 N-methylase Trm5 [Translation, ribosomal structure and biogenesis]; tRNA G37 N-methylase Trm5 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442010 [Multi-domain]  Cd Length: 333  Bit Score: 38.69  E-value: 6.73e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 44771198 256 DKVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEILYQAMDI-IRLNKLEDTITLIKGKIEEV-HLPVEKVDVIIsewMGY 333
Cdd:COG2520 181 GERVLDMFAGVGPFSIPIAKRSGAKVVAIDINPDAVEYLKEnIRLNKVEDRVTPILGDAREVaPELEGKADRII---MNL 257

                        90       100
                ....*....|....*....|...
gi 44771198 334 FLLFESMLDSVLYAknkyLAKGG 356
Cdd:COG2520 258 PHSADEFLDAALRA----LKPGG 276
COG2521 COG2521
Predicted archaeal methyltransferase [General function prediction only];
257-327 7.96e-03

Predicted archaeal methyltransferase [General function prediction only];


Pssm-ID: 442011 [Multi-domain]  Cd Length: 285  Bit Score: 38.35  E-value: 7.96e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 44771198 257 KVVLDVGCGTGILSMFAAKAGAKKVLGVDQSEIlyqAMDIIRLN----KLEDT-ITLIKGKIEEV--HLPVEKVDVII 327
Cdd:COG2521 134 DRVLDTCTGLGYTAIEALKRGAREVITVEKDPN---VLELAELNpwsrELANErIKIILGDASEVikTFPDESFDAII 208
ubiE PRK00216
bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol ...
 259-321 8.08e-03

bifunctional demethylmenaquinone methyltransferase/2-methoxy-6-polyprenyl-1,4-benzoquinol methylase UbiE;


Pssm-ID: 234689 [Multi-domain]  Cd Length: 239  Bit Score: 38.21  E-value: 8.08e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 44771198  259 VLDVGCGTGILSMFAAKAGAK--KVLGVDQSE-ILYQAMDIIRLNKLEDTITLIKGKIEevHLPVE 321
Cdd:PRK00216  55 VLDLACGTGDLAIALAKAVGKtgEVVGLDFSEgMLAVGREKLRDLGLSGNVEFVQGDAE--ALPFP 118
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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