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Conserved domains on  [gi|115430112|ref|NP_005660|]
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receptor expression-enhancing protein 5 [Homo sapiens]

Protein Classification

HVA22/TB2/DP1 family protein( domain architecture ID 10504231)

HVA22/TB2/DP1 family protein such as receptor expression enhancing proteins (REEPs), which are membrane shaping adapter proteins that modulate specific G protein-coupled receptor trafficking by affecting ER cargo capacity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TB2_DP1_HVA22 pfam03134
TB2/DP1, HVA22 family; This family includes members from a wide variety of eukaryotes. It ...
 67-144 5.70e-38

TB2/DP1, HVA22 family; This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.


:

Pssm-ID: 460820  Cd Length: 77  Bit Score: 125.31  E-value: 5.70e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115430112   67 PAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSpSNGAELLYKRIIRPF 144
Cdd:pfam03134   1 PAYASYKALESPDKDDDTQWLTYWVVFGFFTLVESFADFLLSWIPFYYEFKLLFLLWLVLPQ-TQGATYIYEKFLRPF 77
 
Name Accession Description Interval E-value
TB2_DP1_HVA22 pfam03134
TB2/DP1, HVA22 family; This family includes members from a wide variety of eukaryotes. It ...
 67-144 5.70e-38

TB2/DP1, HVA22 family; This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.


Pssm-ID: 460820  Cd Length: 77  Bit Score: 125.31  E-value: 5.70e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115430112   67 PAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSpSNGAELLYKRIIRPF 144
Cdd:pfam03134   1 PAYASYKALESPDKDDDTQWLTYWVVFGFFTLVESFADFLLSWIPFYYEFKLLFLLWLVLPQ-TQGATYIYEKFLRPF 77
YOP1 COG5052
Protein involved in membrane traffic [Intracellular trafficking and secretion];
23-176 2.90e-30

Protein involved in membrane traffic [Intracellular trafficking and secretion];


Pssm-ID: 227385  Cd Length: 186  Bit Score: 109.12  E-value: 2.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430112  23 LAKLEAKTGVNRSFIALGVIGLVALYL---VFGYGaSLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIA 99
Cdd:COG5052   25 LREIENLYNRYKKYFMAGASFLYLLNLfstVLGFG-LILTNVAGFSLPAQLSLVAFYTLNFMDDTQLLTYWMVFGFLSAI 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115430112 100 EFFSDIFLSWFPFYYMLKCGFLLWcMAPSPSNGAELLYKRIIRPFFLKHE-SQMDSVVKDLKDKAKETADAITKEAKK 176
Cdd:COG5052  104 EKYSGAILSKVPFYWTLKNVFLLW-LLLPRTEGARIIYDDIIAPDVSDHGfRTIEKTVKNGTKASAAVASSLEKKTAA 180
 
Name Accession Description Interval E-value
TB2_DP1_HVA22 pfam03134
TB2/DP1, HVA22 family; This family includes members from a wide variety of eukaryotes. It ...
 67-144 5.70e-38

TB2/DP1, HVA22 family; This family includes members from a wide variety of eukaryotes. It includes the TB2/DP1 (deleted in polyposis) protein, which in humans is deleted in severe forms of familial adenomatous polyposis, an autosomal dominant oncological inherited disease. The family also includes the plant protein of known similarity to TB2/DP1, the HVA22 abscisic acid-induced protein, which is thought to be a regulatory protein.


Pssm-ID: 460820  Cd Length: 77  Bit Score: 125.31  E-value: 5.70e-38
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115430112   67 PAYISIKAIESPNKEDDTQWLTYWVVYGVFSIAEFFSDIFLSWFPFYYMLKCGFLLWCMAPSpSNGAELLYKRIIRPF 144
Cdd:pfam03134   1 PAYASYKALESPDKDDDTQWLTYWVVFGFFTLVESFADFLLSWIPFYYEFKLLFLLWLVLPQ-TQGATYIYEKFLRPF 77
YOP1 COG5052
Protein involved in membrane traffic [Intracellular trafficking and secretion];
23-176 2.90e-30

Protein involved in membrane traffic [Intracellular trafficking and secretion];


Pssm-ID: 227385  Cd Length: 186  Bit Score: 109.12  E-value: 2.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 115430112  23 LAKLEAKTGVNRSFIALGVIGLVALYL---VFGYGaSLLCNLIGFGYPAYISIKAIESPNKEDDTQWLTYWVVYGVFSIA 99
Cdd:COG5052   25 LREIENLYNRYKKYFMAGASFLYLLNLfstVLGFG-LILTNVAGFSLPAQLSLVAFYTLNFMDDTQLLTYWMVFGFLSAI 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 115430112 100 EFFSDIFLSWFPFYYMLKCGFLLWcMAPSPSNGAELLYKRIIRPFFLKHE-SQMDSVVKDLKDKAKETADAITKEAKK 176
Cdd:COG5052  104 EKYSGAILSKVPFYWTLKNVFLLW-LLLPRTEGARIIYDDIIAPDVSDHGfRTIEKTVKNGTKASAAVASSLEKKTAA 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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