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Conserved domains on  [gi|167555127|ref|NP_005573|]
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CD180 antigen precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 221-249 2.20e-11

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


:

Pssm-ID: 408601  Cd Length: 29  Bit Score: 58.62  E-value: 2.20e-11
                          10        20
                  ....*....|....*....|....*....
gi 167555127  221 STIFQSLNFGGTPNLSVIFNGLQNSTTQS 249
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
275-553 6.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 6.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 275 SVESLNLQEHRFSDISSTTFQCfTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLcQISAANFPSLTHLYIRG 354
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 355 N-VKKLHLGvgcLEKLGNLQTLDLSHNDIEasdccSL-QLKNLSHLQTLNLSHNEPLGLQSQAfkECPQLELLDLAFTRL 432
Cdd:COG4886  215 NqLTDLPEP---LANLTNLETLDLSNNQLT-----DLpELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 433 -HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSI 511
Cdd:COG4886  285 tDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 167555127 512 DQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAAN 553
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
38-310 3.48e-09

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  38 NCENLGLSEIPDTLPNTT--EFLEFSFNFLPTIhNRTFSRLMNLTFLDLTRCQINWIHEdTFQSHHQLSTLVLTGNPLIF 115
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 116 MAEtSLNGPKSLKHLFLIQTGISNLEFIpvHNLENLESLYLGSNHISSIkfPKDFPARNLKVLDFQNNAIHYISREDMRS 195
Cdd:COG4886  220 LPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 196 LEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMS 275
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 167555127 276 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 310
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PCC super family cl28216
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 549-626 1.25e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


The actual alignment was detected with superfamily member TIGR00864:

Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.47  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127   549 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKL---SC 625
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLldsGC 80


                   .
gi 167555127   626 G 626
Cdd:TIGR00864   81 D 81
 
Name Accession Description Interval E-value
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 221-249 2.20e-11

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 58.62  E-value: 2.20e-11
                          10        20
                  ....*....|....*....|....*....
gi 167555127  221 STIFQSLNFGGTPNLSVIFNGLQNSTTQS 249
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
275-553 6.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 6.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 275 SVESLNLQEHRFSDISSTTFQCfTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLcQISAANFPSLTHLYIRG 354
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 355 N-VKKLHLGvgcLEKLGNLQTLDLSHNDIEasdccSL-QLKNLSHLQTLNLSHNEPLGLQSQAfkECPQLELLDLAFTRL 432
Cdd:COG4886  215 NqLTDLPEP---LANLTNLETLDLSNNQLT-----DLpELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 433 -HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSI 511
Cdd:COG4886  285 tDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 167555127 512 DQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAAN 553
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-310 3.48e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  38 NCENLGLSEIPDTLPNTT--EFLEFSFNFLPTIhNRTFSRLMNLTFLDLTRCQINWIHEdTFQSHHQLSTLVLTGNPLIF 115
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 116 MAEtSLNGPKSLKHLFLIQTGISNLEFIpvHNLENLESLYLGSNHISSIkfPKDFPARNLKVLDFQNNAIHYISREDMRS 195
Cdd:COG4886  220 LPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 196 LEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMS 275
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 167555127 276 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 310
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 308-501 2.17e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 308 THL----KGLPSgMKGLNLLKKL-VLSV--NHFDQLCQISaaNFPSLTHLYIRGNV-------------KKLHLGVGC-- 365
Cdd:cd21340    5 THLylndKNITK-IDNLSLCKNLkVLYLydNKITKIENLE--FLTNLTHLYLQNNQiekienlenlvnlKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 366 ----LEKLGNLQTLDLSHNDIE-----ASDCCSLQlkNLSH-LQTLNLSHNeplglqsqafkecpqlelldlaftrlHIN 435
Cdd:cd21340   82 vvegLENLTNLEELHIENQRLPpgeklTFDPRSLA--ALSNsLRVLNISGN--------------------------NID 133

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167555127 436 APqSPFQNLHFLQVLNLTYCFLDTSNQ--HLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVL 501
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVL 200
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 549-626 1.25e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.47  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127   549 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKL---SC 625
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLldsGC 80


                   .
gi 167555127   626 G 626
Cdd:TIGR00864   81 D 81
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-469 1.55e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 119 TSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNaihYISREDMRSLEQ 198
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN---SLSGEIPELVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 199 AINLS-LNFNGNNVKGIELGAFDS----TIFQ--SLNF-GGTP-------NLSVI---FNGLQNSTTQSLW-------LG 253
Cdd:PLN00113 307 LQNLEiLHLFSNNFTGKIPVALTSlprlQVLQlwSNKFsGEIPknlgkhnNLTVLdlsTNNLTGEIPEGLCssgnlfkLI 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 254 TFEDIDDEDISSAMlkGLCEmSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNH 332
Cdd:PLN00113 387 LFSNSLEGEIPKSL--GACR-SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSRKWDMPSLQMLSLARNK 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 333 FdqlcqisaanFPSLTHLYIRGNVKKLHLGVG--------CLEKLGNLQTLDLSHNDIeaSDCCSLQLKNLSHLQTLNLS 404
Cdd:PLN00113 464 F----------FGGLPDSFGSKRLENLDLSRNqfsgavprKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLS 531

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 167555127 405 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVlnltycflDTSNQHLLAGLP 469
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV--------NISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
497-555 1.89e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  497 SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSI 555
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLrYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-185 5.38e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 5.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  35 KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNltfLDLTRCQINWIHEDTFQshhQLSTLVLTGNPLI 114
Cdd:PRK15370 223 KTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKISCLPENLPE---ELRYLSVYDNSIR 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167555127 115 FMAEtslNGPKSLKHLFLIQtgiSNLEFIPVHNLENLESLYLGSNHISSIkfPKDFPARnLKVLDFQNNAI 185
Cdd:PRK15370 297 TLPA---HLPSGITHLNVQS---NSLTALPETLPPGLKTLEAGENALTSL--PASLPPE-LQVLDVSKNQI 358
LRRCT smart00082
Leucine rich repeat C-terminal domain;
577-626 1.97e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 167555127   577 NPLDCTCSNIHFLTWYKENLHkLEGSEETTCANPPSLRG--VKLSDVKLSCG 626
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRGplLELLHSEFKCP 51
 
Name Accession Description Interval E-value
LRR_11 pfam18831
Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the ...
 221-249 2.20e-11

Leucine-rich repeat; This Pfam entry includes some LRRs that fail to be detected with the pfam00560 model. This entry represents one repeat unit.


Pssm-ID: 408601  Cd Length: 29  Bit Score: 58.62  E-value: 2.20e-11
                          10        20
                  ....*....|....*....|....*....
gi 167555127  221 STIFQSLNFGGTPNLSVIFNGLQNSTTQS 249
Cdd:pfam18831   1 SKVFQSLNFGGTLNLSVIFKGLQNSTIQS 29
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
275-553 6.01e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.95  E-value: 6.01e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 275 SVESLNLQEHRFSDISSTTFQCfTQLQELDLTATHLKGLPSGMKGLNLLKKLVLSVNHFDQLcQISAANFPSLTHLYIRG 354
Cdd:COG4886  137 NLKELDLSNNQLTDLPEPLGNL-TNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 355 N-VKKLHLGvgcLEKLGNLQTLDLSHNDIEasdccSL-QLKNLSHLQTLNLSHNEPLGLQSQAfkECPQLELLDLAFTRL 432
Cdd:COG4886  215 NqLTDLPEP---LANLTNLETLDLSNNQLT-----DLpELGNLTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 433 -HINAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVLILSSCGLLSI 511
Cdd:COG4886  285 tDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLT 364

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 167555127 512 DQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAAN 553
Cdd:COG4886  365 LLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLA 406
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
342-577 6.79e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 6.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 342 ANFPSLTHLYIRGNvkKLHLGVGCLEKLGNLQTLDLSHNDIEASDccsLQLKNLSHLQTLNLSHNEPLGLqSQAFKECPQ 421
Cdd:COG4886  110 SNLTNLESLDLSGN--QLTDLPEELANLTNLKELDLSNNQLTDLP---EPLGNLTNLKSLDLSNNQLTDL-PEELGNLTN 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 422 LELLDLAFTRlhINAPQSPFQNLHFLQVLNLTYCFLdTSNQHLLAGLPVLRHLNLKGNHfqdgtITKTNLLQTVGSLEVL 501
Cdd:COG4886  184 LKELDLSNNQ--ITDLPEPLGNLTNLEELDLSGNQL-TDLPEPLANLTNLETLDLSNNQ-----LTDLPELGNLTNLEEL 255

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 167555127 502 ILSSCGLLSIDQQAfhSLGKMSHVDLSHNSLTCDSIDSLSHLKGIYLNLAANSINIISPRLLPILSQQSTINLSHN 577
Cdd:COG4886  256 DLSNNQLTDLPPLA--NLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
38-310 3.48e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.56  E-value: 3.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  38 NCENLGLSEIPDTLPNTT--EFLEFSFNFLPTIhNRTFSRLMNLTFLDLTRCQINWIHEdTFQSHHQLSTLVLTGNPLIF 115
Cdd:COG4886  142 DLSNNQLTDLPEPLGNLTnlKSLDLSNNQLTDL-PEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLTD 219

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 116 MAEtSLNGPKSLKHLFLIQTGISNLEFIpvHNLENLESLYLGSNHISSIkfPKDFPARNLKVLDFQNNAIHYISREDMRS 195
Cdd:COG4886  220 LPE-PLANLTNLETLDLSNNQLTDLPEL--GNLTNLEELDLSNNQLTDL--PPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 196 LEQAINLSLNFNGNNVKGIELGAFDSTIFQSLNFGGTPNLSVIFNGLQNSTTQSLWLGTFEDIDDEDISSAMLKGLCEMS 275
Cdd:COG4886  295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 167555127 276 VESLNLQEHRFSDISSTTFQCFTQLQELDLTATHL 310
Cdd:COG4886  375 LEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLD 409
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 308-501 2.17e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 55.18  E-value: 2.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 308 THL----KGLPSgMKGLNLLKKL-VLSV--NHFDQLCQISaaNFPSLTHLYIRGNV-------------KKLHLGVGC-- 365
Cdd:cd21340    5 THLylndKNITK-IDNLSLCKNLkVLYLydNKITKIENLE--FLTNLTHLYLQNNQiekienlenlvnlKKLYLGGNRis 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 366 ----LEKLGNLQTLDLSHNDIE-----ASDCCSLQlkNLSH-LQTLNLSHNeplglqsqafkecpqlelldlaftrlHIN 435
Cdd:cd21340   82 vvegLENLTNLEELHIENQRLPpgeklTFDPRSLA--ALSNsLRVLNISGN--------------------------NID 133

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167555127 436 APqSPFQNLHFLQVLNLTYCFLDTSNQ--HLLAGLPVLRHLNLKGNHFQDGTITKTNLLQTVGSLEVL 501
Cdd:cd21340  134 SL-EPLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVL 200
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 549-626 1.25e-07

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 55.47  E-value: 1.25e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127   549 NLAANSINIISPRLLPILSQQSTINLSHNPLDCTCSNIHFLTWYKENLHKLEGSEETTCANPPSLRGVKLSDVKL---SC 625
Cdd:TIGR00864    1 DISNNKISTIEEGICANLCNLSEIDLSGNPFECDCGLARLPRWAEEKGVKVRQPEAALCAGPGALAGQPLLGIPLldsGC 80


                   .
gi 167555127   626 G 626
Cdd:TIGR00864   81 D 81
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 119-469 1.55e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.39  E-value: 1.55e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 119 TSLNGPKSLKHLFLIQTGISNLEFIPVHNLENLESLYLGSNHISSIKFPKDFPARNLKVLDFQNNaihYISREDMRSLEQ 198
Cdd:PLN00113 230 YEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISLDLSDN---SLSGEIPELVIQ 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 199 AINLS-LNFNGNNVKGIELGAFDS----TIFQ--SLNF-GGTP-------NLSVI---FNGLQNSTTQSLW-------LG 253
Cdd:PLN00113 307 LQNLEiLHLFSNNFTGKIPVALTSlprlQVLQlwSNKFsGEIPknlgkhnNLTVLdlsTNNLTGEIPEGLCssgnlfkLI 386

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 254 TFEDIDDEDISSAMlkGLCEmSVESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNH 332
Cdd:PLN00113 387 LFSNSLEGEIPKSL--GACR-SLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGrINSRKWDMPSLQMLSLARNK 463

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 333 FdqlcqisaanFPSLTHLYIRGNVKKLHLGVG--------CLEKLGNLQTLDLSHNDIeaSDCCSLQLKNLSHLQTLNLS 404
Cdd:PLN00113 464 F----------FGGLPDSFGSKRLENLDLSRNqfsgavprKLGSLSELMQLKLSENKL--SGEIPDELSSCKKLVSLDLS 531

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 167555127 405 HNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQNLHFLQVlnltycflDTSNQHLLAGLP 469
Cdd:PLN00113 532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQV--------NISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
497-555 1.89e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 45.59  E-value: 1.89e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  497 SLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNLAANSI 555
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLrYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
420-481 4.40e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.44  E-value: 4.40e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167555127  420 PQLELLDLAFTRLHiNAPQSPFQNLHFLQVLNLTYCFLDTSNQHLLAGLPVLRHLNLKGNHF 481
Cdd:pfam13855   1 PNLRSLDLSNNRLT-SLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
35-185 5.38e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 49.70  E-value: 5.38e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  35 KTYNCENLGLSEIPDTLPNTTEFLEFSFNFLPTIHNRTFSRLMNltfLDLTRCQINWIHEDTFQshhQLSTLVLTGNPLI 114
Cdd:PRK15370 223 KTLYANSNQLTSIPATLPDTIQEMELSINRITELPERLPSALQS---LDLFHNKISCLPENLPE---ELRYLSVYDNSIR 296

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 167555127 115 FMAEtslNGPKSLKHLFLIQtgiSNLEFIPVHNLENLESLYLGSNHISSIkfPKDFPARnLKVLDFQNNAI 185
Cdd:PRK15370 297 TLPA---HLPSGITHLNVQS---NSLTALPETLPPGLKTLEAGENALTSL--PASLPPE-LQVLDVSKNQI 358
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
69-207 6.05e-06

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 49.16  E-value: 6.05e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  69 HNRTFSRLMNLTFLDLTRCQINWIhEDTFQSHHQLSTLVLTGNPLIFMAEtSLNGPKSLKHLFLIQTGISNLEfIPVHNL 148
Cdd:COG4886  105 GNEELSNLTNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDLP-EELGNL 181

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 149 ENLESLYLGSNHISSIkfPKDFPA-RNLKVLDFQNNAIHYISrEDMRSLEQAINLSLNFN 207
Cdd:COG4886  182 TNLKELDLSNNQITDL--PEPLGNlTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNN 238
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 327-541 1.02e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.04  E-value: 1.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 327 VLSVNHFDQLCQISAANfPSLTHLYIRGN-----VKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQ-LKNLSHLQT 400
Cdd:cd00116   34 TLGEEAAKALASALRPQ-PSLKELCLSLNetgriPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLEsLLRSSSLQE 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 401 LNLSHNE----PLGLQSQAFKEC-PQLELLDLAFTRLHiNAPQSP----FQNLHFLQVLNLTY-CFLDTSNQHLLAGLPV 470
Cdd:cd00116  113 LKLNNNGlgdrGLRLLAKGLKDLpPALEKLVLGRNRLE-GASCEAlakaLRANRDLKELNLANnGIGDAGIRALAEGLKA 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 471 ---LRHLNLKGNHFQD-GTITKTNLLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSH-----VDLSHNSLTCDSIDSLS 541
Cdd:cd00116  192 ncnLEVLDLNNNGLTDeGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNislltLSLSCNDITDDGAKDLA 271
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 345-426 1.24e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 44.01  E-value: 1.24e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 345 PSLTHLYIRGNvkklHLG-VGCLEKLGNLQTLDLSHNDIEASDCCSLQLKNLSHLQTLNLSHNePLGLQSQAFKE----C 419
Cdd:cd21340  120 NSLRVLNISGN----NIDsLEPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN-PVCKKPKYRDKiilaS 194


                 ....*..
gi 167555127 420 PQLELLD 426
Cdd:cd21340  195 KSLEVLD 201
LRR_8 pfam13855
Leucine rich repeat;
323-382 1.79e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.82  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127  323 LKKLVLSVNHFDQLCQISAANFPSLTHLYIRGNVKKlHLGVGCLEKLGNLQTLDLSHNDI 382
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLT-TLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
577-626 1.97e-04

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 39.34  E-value: 1.97e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 167555127   577 NPLDCTCSNIHFLTWYKENLHkLEGSEETTCANPPSLRG--VKLSDVKLSCG 626
Cdd:smart00082   1 NPFICDCELRWLLRWLQANEH-LQDPVDLRCASPSSLRGplLELLHSEFKCP 51
LRR_8 pfam13855
Leucine rich repeat;
371-432 2.98e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.98e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167555127  371 NLQTLDLSHNDIEASDccSLQLKNLSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRL 432
Cdd:pfam13855   2 NLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 126-579 2.98e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 126 SLKHLFLiqtgiSNLEF---IPVHNLENLESLYLgSNHISSIKFPKDFPA-RNLKVLDFQNNAIH---YISREDMRSLEq 198
Cdd:PLN00113 119 SLRYLNL-----SNNNFtgsIPRGSIPNLETLDL-SNNMLSGEIPNDIGSfSSLKVLDLGGNVLVgkiPNSLTNLTSLE- 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 199 ainlSLNFNGNNVKG---IELGAFDSTIFQSLNF----GGTPN----------LSVIFNGLQNSTTQSLwlGTFEDIdde 261
Cdd:PLN00113 192 ----FLTLASNQLVGqipRELGQMKSLKWIYLGYnnlsGEIPYeiggltslnhLDLVYNNLTGPIPSSL--GNLKNL--- 262

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 262 dissamlkglcemsvESLNLQEHRFSDISSTTFQCFTQLQELDLTATHLKG-LPSGMKGLNLLKKLVLSVNHFDQLCQIS 340
Cdd:PLN00113 263 ---------------QYLFLYQNKLSGPIPPSIFSLQKLISLDLSDNSLSGeIPELVIQLQNLEILHLFSNNFTGKIPVA 327

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 341 AANFPSLTHLYIRGNvkKLHLGV-GCLEKLGNLQTLDLSHND----IEASDCCSLQL---------------KNLSHLQT 400
Cdd:PLN00113 328 LTSLPRLQVLQLWSN--KFSGEIpKNLGKHNNLTVLDLSTNNltgeIPEGLCSSGNLfklilfsnslegeipKSLGACRS 405

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 401 LN---LSHNEPLGLQSQAFKECPQLELLDLAFTRLHINApQSPFQNLHFLQVLNLtycfldtSNQHLLAGLP------VL 471
Cdd:PLN00113 406 LRrvrLQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRI-NSRKWDMPSLQMLSL-------ARNKFFGGLPdsfgskRL 477

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 472 RHLNLKGNHFQdGTITKTnlLQTVGSLEVLILSSCGLLSIDQQAFHSLGKMSHVDLSHNSLTCDSIDSLSHLKGI-YLNL 550
Cdd:PLN00113 478 ENLDLSRNQFS-GAVPRK--LGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLsQLDL 554

                        490       500
                 ....*....|....*....|....*....
gi 167555127 551 AANSINIISPRLLPILSQQSTINLSHNPL 579
Cdd:PLN00113 555 SQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN03150 PLN03150
hypothetical protein; Provisional
 395-472 8.47e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 8.47e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167555127 395 LSHLQTLNLSHNEPLGLQSQAFKECPQLELLDLAFTRLHINAPQSPFQnLHFLQVLNLTYCFLDTSNQHLLAGLPVLR 472
Cdd:PLN03150 441 LRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQ-LTSLRILNLNGNSLSGRVPAALGGRLLHR 517
LRR_8 pfam13855
Leucine rich repeat;
345-406 8.97e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.89  E-value: 8.97e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 167555127  345 PSLTHLYIRGNvKKLHLGVGCLEKLGNLQTLDLSHNDIEASDCCSLQlkNLSHLQTLNLSHN 406
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFS--GLPSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 344-555 1.01e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 1.01e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 344 FPSLTHLYIRGN-VKKLhlgvGCLEKLGNLQTLDLSHNDIEasdccSLQ-LKNLSHLQTLNLSHNEplglqsqafkecpq 421
Cdd:cd21340   23 CKNLKVLYLYDNkITKI----ENLEFLTNLTHLYLQNNQIE-----KIEnLENLVNLKKLYLGGNR-------------- 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 422 lelldlaFTRLhinapqSPFQNLHFLQVLNLtycfldtSNQHLLAGLPVLrhlnlkgnhFQDGTITKTnllqtVGSLEVL 501
Cdd:cd21340   80 -------ISVV------EGLENLTNLEELHI-------ENQRLPPGEKLT---------FDPRSLAAL-----SNSLRVL 125

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 167555127 502 ILSSCGLLSIDQqaFHSLGKMSHVDLSHNSLT-----CDSIDSLSHLKgiYLNLAANSI 555
Cdd:cd21340  126 NISGNNIDSLEP--LAPLRNLEQLDASNNQISdleelLDLLSSWPSLR--ELDLTGNPV 180
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 323-432 5.20e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 5.20e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 323 LKKLVLSVNH-----FDQLCQISAANfPSLTHLYIRGNVKKlHLGV----GCLEKLGNLQTLDLSHNDIEASDCCSL--Q 391
Cdd:cd00116  167 LKELNLANNGigdagIRALAEGLKAN-CNLEVLDLNNNGLT-DEGAsalaETLASLKSLEVLNLGDNNLTDAGAAALasA 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*.
gi 167555127 392 LKNLSH-LQTLNLSHNE--PLGLQS--QAFKECPQLELLDLAFTRL 432
Cdd:cd00116  245 LLSPNIsLLTLSLSCNDitDDGAKDlaEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
298-355 6.06e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 6.06e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 167555127  298 TQLQELDLTATHLKGLPSGM-KGLNLLKKLVLSVNHFDQLCQISAANFPSLTHLYIRGN 355
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGN 59
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 267-479 6.31e-03

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 39.39  E-value: 6.31e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 267 MLKGLCEMSVESLNLQEHRFSDISSTTFqCFTQLQELDLTATHLKGLPSGMKGLNLLKKlVLSVNHfdqlcqisaanfpS 346
Cdd:COG5238  173 MAKALQNNSVETVYLGCNQIGDEGIEEL-AEALTQNTTVTTLWLKRNPIGDEGAEILAE-ALKGNK-------------S 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 167555127 347 LTHLYIRGNvkklHLGVGCLEKLG-------NLQTLDLSHNDIEASDCCSL--QLKNLSHLQTLNLSHNePLGLQS---- 413
Cdd:COG5238  238 LTTLDLSNN----QIGDEGVIALAealknntTVETLYLSGNQIGAEGAIALakALQGNTTLTSLDLSVN-RIGDEGaial 312

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 167555127 414 -QAFKECPQLELLDLAFTRLHINAPQSPFQNLHflqvLNLTYCFLD-TSNQ----------HLLAGLPVLRHLNLKGN 479
Cdd:COG5238  313 aEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQ----ENTTLHSLDlSDNQigdegaialaKYLEGNTTLRELNLGKN 386
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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